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Review Open Access

Animal models of vertical bone augmentation (Review)

  • Authors:
    • Zepeng Zhang
    • Yaxin Gan
    • Yarong Guo
    • Xuguang Lu
    • Xianqi Li
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi 030001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 919
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    Published online on: June 30, 2021
       https://doi.org/10.3892/etm.2021.10351
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Abstract

Vertical bone augmentation is an important challenge in dental implantology. Existing vertical bone augmentation techniques, along with bone grafting materials, have achieved certain clinical progress but continue to have numerous limitations. In order to evaluate the possibility of using biomaterials to develop bone substitutes, medical devices and/or new bone grafting techniques for vertical bone augmentation, it is essential to establish clinically relevant animal models to investigate their biocompatibility, mechanical properties, applicability and safety. The present review discusses recent animal experiments related to vertical bone augmentation. In addition, surgical protocols for establishing relevant preclinical models with various animal species were reviewed. The present study aims to provide guidance for selecting experimental animal models of vertical bone augmentation.
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1 

Yim HJ, Lim HC, Hong JY, Shin SI, Chung JH, Herr Y and Shin SY: Primary stability of implants with peri-implant bone defects of various widths: An in vitro investigation. J Periodontal Implant Sci. 49:39–46. 2019.PubMed/NCBI View Article : Google Scholar

2 

Moy PK, Medina D, Shetty V and Aghaloo TL: Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants. 20:569–577. 2005.PubMed/NCBI

3 

Urban IA, Montero E, Monje A and Sanz-Sánchez I: Effectiveness of vertical ridge augmentation interventions: A systematic review and meta-analysis. J Clin Periodontol. 46 (Suppl 21):S319–S339. 2019.PubMed/NCBI View Article : Google Scholar

4 

Elnayef B, Monje A, Gargallo-Albiol J, Galindo-Moreno P, Wang HL and Hernández-Alfaro F: Vertical ridge augmentation in the atrophic mandible: A Systematic review and meta-analysis. Int J Oral Maxillofac Implants. 32:291–312. 2017.PubMed/NCBI View Article : Google Scholar

5 

Wang HL and Boyapati L: ‘PASS’ principles for predictable bone regeneration. Implant Dent. 15:8–17. 2006.PubMed/NCBI View Article : Google Scholar

6 

Artzi Z, Nemcovsky CE, Tal H, Weinberg E, Weinreb M, Prasad H, Rohrer MD and Kozlovsky A: Simultaneous versus two-stage implant placement and guided bone regeneration in the canine: Histomorphometry at 8 and 16 months. J Clin Periodontol. 37:1029–1038. 2010.PubMed/NCBI View Article : Google Scholar

7 

Kon K, Shiota M, Ozeki M and Kasugai S: The effect of graft bone particle size on bone augmentation in a rabbit cranial vertical augmentation model: A microcomputed tomography study. Int J Oral Maxillofac Implants. 29:402–406. 2014.PubMed/NCBI View Article : Google Scholar

8 

Kim JW, Jeong IH, Lee KI, Jung UW, Kim CS, Choi SH, Cho KS and Yun JH: Volumetric bone regenerative efficacy of biphasic calcium phosphate-collagen composite block loaded with rhBMP-2 in vertical bone augmentation model of a rabbit calvarium. J Biomed Mater Res A. 100:3304–3313. 2012.PubMed/NCBI View Article : Google Scholar

9 

Nkenke E and Neukam FW: Autogenous bone harvesting and grafting in advanced jaw resorption: Morbidity, resorption and implant survival. Eur J Oral Implantol. 7 (Suppl 2):S203–S217. 2014.PubMed/NCBI

10 

Zigdon-Giladi H, Bick T, Morgan EF, Lewinson D and Machtei EE: Peripheral blood-derived endothelial progenitor cells enhance vertical bone formation. Clin Implant Dent Relat Res. 17:83–92. 2015.PubMed/NCBI View Article : Google Scholar

11 

Rachmiel A, Shilo D, Aizenbud D and Emodi O: Vertical alveolar distraction osteogenesis of the atrophic posterior mandible before dental implant insertion. J Oral Maxillofac Surg. 75:1164–1175. 2017.PubMed/NCBI View Article : Google Scholar

12 

Tamimi F, Torres J, Gbureck U, Lopez-Cabarcos E, Bassett DC, Alkhraisat MH and Barralet JE: Craniofacial vertical bone augmentation: A comparison between 3D printed monolithic monetite blocks and autologous onlay grafts in the rabbit. Biomaterials. 30:6318–6326. 2009.PubMed/NCBI View Article : Google Scholar

13 

Giesenhagen B, Martin N, Donkiewicz P, Perić Kačarević Ž, Smeets R, Jung O, Schnettler R and Barbeck M: Vertical bone augmentation in a single-tooth gap with an allogenic bone ring: Clinical considerations. J Esthet Restor Dent. 30:480–483. 2018.PubMed/NCBI View Article : Google Scholar

14 

Giesenhagen B, Martin N, Jung O and Barbeck M: Bone augmentation and simultaneous implant placement with allogenic bone rings and analysis of its purification success. Materials (Basel). 12(1291)2019.PubMed/NCBI View Article : Google Scholar

15 

Stevens MR, Emam HA, Alaily ME and Sharawy M: Implant bone rings. One-stage three-dimensional bone transplant technique: A case report. J Oral Implantol. 36:69–74. 2010.PubMed/NCBI View Article : Google Scholar

16 

Nakahara K, Haga-Tsujimura M, Sawada K, Kobayashi E, Mottini M, Schaller B and Saulacic N: Single-staged vs. two-staged implant placement using bone ring technique in vertically deficient alveolar ridges-Part 1: Histomorphometric and micro-CT analysis. Clin Oral Implants Res. 27:1384–1391. 2016.PubMed/NCBI View Article : Google Scholar

17 

Nakahara K, Haga-Tsujimura M, Sawada K, Kobayashi E, Schaller B and Saulacic N: Single-staged vs. two-staged implant placement in vertically deficient alveolar ridges using bone ring technique-Part 2: Implant osseointegration. Clin Oral Implants Res. 28:e31–e38. 2017.PubMed/NCBI View Article : Google Scholar

18 

Sakkas A, Wilde F, Heufelder M, Winter K and Schramm A: Autogenous bone grafts in oral implantology-is it still a ‘gold standard’? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent. 3(23)2017.PubMed/NCBI View Article : Google Scholar

19 

Yang Y, Cheng Y, Peng S, Xu L, He C, Qi F, Zhao M and Shuai C: Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold. Bioact Mater. 6:1230–1241. 2021.PubMed/NCBI View Article : Google Scholar

20 

Zeeshan S, Corneliu S and Michael G: Bone replacement materials and techniques used for achieving vertical alveolar bone augmentation. Materials. 8:2953–2993. 2015.

21 

Donos N, Dereka X and Mardas N: Experimental models for guided bone regeneration in healthy and medically compromised conditions. Periodontol. 68:99–121. 2015.PubMed/NCBI View Article : Google Scholar

22 

Li Y, Chen SK, Li L, Qin L, Wang XL and Lai YX: Bone defect animal models for testing efficacy of bone substitute biomaterials. J Orthop Translat. 3:95–104. 2015.PubMed/NCBI View Article : Google Scholar

23 

Newman E, Turner AS and Wark JD: The potential of sheep for the study of osteopenia: Current status and comparison with other animal models. Bone. 16 (Suppl 4):277S–284S. 1995.PubMed/NCBI View Article : Google Scholar

24 

Gomes PS and Fernandes MH: Rodent models in bone-related research: The relevance of calvarial defects in the assessment of bone regeneration strategies. Lab Anim. 45:14–24. 2011.PubMed/NCBI View Article : Google Scholar

25 

Schlegel KA, Lang FJ, Donath K, Kulow JT and Wiltfang J: The monocortical critical size bone defect as an alternative experimental model in testing bone substitute materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 102:7–13. 2006.PubMed/NCBI View Article : Google Scholar

26 

Aerssens J, Boonen S, Lowet G and Dequeker J: Interspecies differences in bone composition, density, and quality: Potential implications for in vivo bone research. Endocrinology. 139:663–670. 1998.PubMed/NCBI View Article : Google Scholar

27 

Hoornaert A, Maazouz Y, Pastorino D, Aparicio C, de Pinieux G, Fellah BH, Ginebra MP and Layrolle P: Vertical bone regeneration with synthetic biomimetic calcium phosphate onto the calvaria of rats. Tissue Eng Part C Methods. 25:1–11. 2019.PubMed/NCBI View Article : Google Scholar

28 

Zhang P, Ding L and Kasugai S: Effect of doxycycline doped bone substitute on vertical bone augmentation on rat calvaria. Dent Mater J. 38:211–217. 2019.PubMed/NCBI View Article : Google Scholar

29 

Shino H, Hasuike A, Arai Y, Honda M, Isokawa K and Sato S: Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces. Med Oral Patol Oral Cir Bucal. 21:e122–e126. 2016.PubMed/NCBI View Article : Google Scholar

30 

Zigdon H, Lewinson D, Bick T and Machtei EE: Vertical bone augmentation using different osteoconductive scaffolds combined with barrier domes in the rat calvarium. Clin Implant Dent Relat Res. 16:138–144. 2014.PubMed/NCBI View Article : Google Scholar

31 

Zigdon-Giladi H, Lewinson D, Bick T and Machtei EE: Mesenchymal stem cells combined with barrier domes enhance vertical bone formation. J Clin Periodontol. 40:196–202. 2013.PubMed/NCBI View Article : Google Scholar

32 

Hao J, Chou J, Kuroda S, Otsuka M, Kasugai S and Lang NP: Strontium hydroxyapatite in situ gel-forming system-a new approach for minimally invasive bone augmentation. Clin Oral Implants Res. 26:581–585. 2015.PubMed/NCBI View Article : Google Scholar

33 

Hao J, Chou J, Kuroda S, Otsuka M, Kasugai S and Lang NP: Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat. Clin Oral Implants Res. 29:227–234. 2018.PubMed/NCBI View Article : Google Scholar

34 

Berendsen AD and Olsen BR: Bone development. Bone. 80:14–18. 2015.PubMed/NCBI View Article : Google Scholar

35 

Marger L, Barone A, Martinelli-Kläy CP, Schaub L, Strasding M, Mekki M, Sailer I, Scherrer SS and Durual S: Calvarial model of bone augmentation in rabbit for assessment of bone growth and neovascularization in bone substitution materials. J Vis Exp: Aug 13, 2019 doi: 10.3791/59976.

36 

Verna C, Dalstra M, Wikesjö UM and Trombelli L: Healing patterns in calvarial bone defects following guided bone regeneration in rats. A micro-CT scan analysis. J Clin Periodontol. 29:865–870. 2002.PubMed/NCBI View Article : Google Scholar

37 

Lundgren D, Lundgren AK, Sennerby L and Nyman S: Augmentation of intramembraneous bone beyond the skeletal envelope using an occlusive titanium barrier. An experimental study in the rabbit. Clin Oral Implants Res. 6:67–72. 1995.PubMed/NCBI View Article : Google Scholar

38 

Bigham-Sadegh A and Oryan A: Selection of animal models for pre-clinical strategies in evaluating the fracture healing, bone graft substitutes and bone tissue regeneration and engineering. Connect Tissue Res. 56:175–194. 2015.PubMed/NCBI View Article : Google Scholar

39 

Zakaria O, Madi M and Kasugai S: A novel osteogenesis technique: The expansible guided bone regeneration. J Tissue Eng. 3(2041731412441194)2012.PubMed/NCBI View Article : Google Scholar

40 

Kim JM, Kim JH, Lee BH and Choi SH: Vertical bone augmentation using three-dimensionally printed cap in the rat calvarial partial defect. In Vivo. 32:1111–1117. 2018.PubMed/NCBI View Article : Google Scholar

41 

Lee SH, Lim P and Yoon HJ: The influence of cortical perforation on guided bone regeneration using synthetic bone substitutes: A study of rabbit cranial defects. Int J Oral Maxillofac Implants. 29:464–471. 2014.PubMed/NCBI View Article : Google Scholar

42 

Majzoub Z, Berengo M, Giardino R, Aldini NN and Cordioli G: Role of intramarrow penetration in osseous repair: A pilot study in the rabbit calvaria. J Periodontol. 70:1501–1510. 1999.PubMed/NCBI View Article : Google Scholar

43 

Kinard LA, Dahlin RL, Henslee AM, Spicer PP, Chu CY, Tabata Y, van den Beucken JJ, Jansen JA, Young S, Wong ME, et al: Tissue response to composite hydrogels for vertical bone augmentation in the rat. J Biomed Mater Res A. 102:2079–2088. 2014.PubMed/NCBI View Article : Google Scholar

44 

Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Carlson ME, Gonzalez O and Boechat MI: Effect of sex steroids on peak bone density of growing rabbits. Am J Physiol. 255:e416–e421. 1988.PubMed/NCBI View Article : Google Scholar

45 

Castañeda S, Largo R, Calvo E, Rodríguez-Salvanés F, Marcos ME, Díaz-Curiel M and Herrero-Beaumont G: Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits. Skeletal Radiol. 35:34–41. 2006.PubMed/NCBI View Article : Google Scholar

46 

Campillo VE, Langonnet S, Pierrefeu A and Chaux-Bodard AG: Anatomic and histological study of the rabbit mandible as an experimental model for wound healing and surgical therapies. Lab Anim. 48:273–277. 2014.PubMed/NCBI View Article : Google Scholar

47 

Namli H, Erdogan Ö, Gönlüşen G, Kahraman OE, Aydin HM, Karabag S and Tatli U: Vertical bone augmentation using bone marrow-derived stem cells: An in vivo study in the rabbit calvaria. Implant Dent. 25:54–62. 2016.PubMed/NCBI View Article : Google Scholar

48 

Polo CI, Sendyk WR, Correa L, Sendyk D, Deboni MCZ and Naclério-Homem MDG: Synergism between recombinant human bone morphogenetic protein 2/absorbable collagen sponge and bone substitutes favors vertical bone augmentation and the resorption rate of the biomaterials: Histomorphometric and 3D microcomputed tomography analysis. J Periodontol. 91:1295–1306. 2020.PubMed/NCBI View Article : Google Scholar

49 

Sudheesh Kumar PT, Hashimi S, Saifzadeh S, Ivanovski S and Vaquette C: Additively manufactured biphasic construct loaded with BMP-2 for vertical bone regeneration: A pilot study in rabbit. Mater Sci Eng C Mater Biol Appl. 92:554–564. 2018.PubMed/NCBI View Article : Google Scholar

50 

Lee JS, Lee JS, Kang MH, Jung UW, Choi SH and Cho KS: Proof-of-concept study of vertical augmentation using block-type allogenic bone grafts: A preclinical experimental study on rabbit calvaria. J Biomed Mater Res B Appl Biomater. 106:2700–2707. 2018.PubMed/NCBI View Article : Google Scholar

51 

Sheikh Z, Drager J, Zhang YL, Abdallah MN, Tamimi F and Barralet J: Controlling bone graft substitute microstructure to improve bone augmentation. Adv Healthc Mater. 5:1646–1655. 2016.PubMed/NCBI View Article : Google Scholar

52 

Sheikh Z, Chen G, Thévenin M, Young RN, Grynpas MD and Glogauer M: A novel anabolic conjugate (C3) in the matrix of dicalcium phosphate onlay block grafts for achieving vertical bone augmentation: An experimental study on rabbit calvaria. Int J Oral Maxillofac Implants. 34:e51–e63. 2019.PubMed/NCBI View Article : Google Scholar

53 

Tamimi F, Torres J, Al-Abedalla K, Lopez-Cabarcos E, Alkhraisat MH, Bassett DC, Gbureck U and Barralet JE: Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site. Biomaterials. 35:5436–5445. 2014.PubMed/NCBI View Article : Google Scholar

54 

Draenert FG, Kammerer PW, Palarie V and Wagner W: Vertical bone augmentation with simultaneous dental implantation using crestal biomaterial rings: A rabbit animal study. Clin Implant Dent Relat Res. 14 (Suppl 1):e169–e174. 2012.PubMed/NCBI View Article : Google Scholar

55 

Kim YJ, de Molon RS, Horiguti FR, Contador GP, Coelho MA, Mascarenhas VI, de Souza Faloni AP, Cirelli JA and Sendyk WR: Vertical bone augmentation using deproteinized bovine bone mineral, absorbable collagen sponge, and recombinant human bone morphogenetic protein-2: An in vivo study in rabbits. Int J Oral Maxillofac Implants. 33:512–522. 2018.PubMed/NCBI View Article : Google Scholar

56 

Veis A, Dabarakis N, Koutrogiannis C, Barlas I, Petsa E and Romanos G: Evaluation of vertical bone regeneration using block and particulate forms of Bio-oss bone graft: A histologic study in the rabbit mandible. J Oral Implantol. 41:e66–e72. 2015.PubMed/NCBI View Article : Google Scholar

57 

Pripatnanont P, Balabid F, Pongpanich S and Vongvatcharanon S: Effect of osteogenic periosteal distraction by a modified Hyrax device with and without platelet-rich fibrin on bone formation in a rabbit model: A pilot study. Int J Oral Maxillofac Surg. 44:656–663. 2015.PubMed/NCBI View Article : Google Scholar

58 

Thoma DS, Kruse A, Ghayor C, Jung RE and Weber FE: Bone augmentation using a synthetic hydroxyapatite/silica oxide-based and a xenogenic hydroxyapatite-based bone substitute materials with and without recombinant human bone morphogenetic protein-2. Clin Oral Implants Res. 26:592–598. 2015.PubMed/NCBI View Article : Google Scholar

59 

Lai CH, Zhou L, Wang ZL, Lu HB and Gao Y: Use of a collagen membrane loaded with recombinant human bone morphogenetic protein-2 with collagen-binding domain for vertical guided bone regeneration. J Periodontol. 84:950–957. 2013.PubMed/NCBI View Article : Google Scholar

60 

de Molon RS, Sakakura CE, Faeda RS, Sartori R, Palhares D, Margonar R and Marcantonio E Jr: Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia. Microsc Res Tech. 80:1000–1008. 2017.PubMed/NCBI View Article : Google Scholar

61 

Cohen DJ, Cheng A, Kahn A, Aviram M, Whitehead AJ, Hyzy SL, Clohessy RM, Boyan BD and Schwartz Z: Novel osteogenic Ti-6Al-4V device for restoration of dental function in patients with large bone deficiencies: Design, development and implementation. Sci Rep. 6(20493)2016.PubMed/NCBI View Article : Google Scholar

62 

Wancket LM: Animal models for evaluation of bone implants and devices: Comparative bone structure and common model uses. Vet Pathol. 52:842–850. 2015.PubMed/NCBI View Article : Google Scholar

63 

Reitan K and Kvam E: Comparative behavior of human and animal tissue during experimental tooth movement. Angle Orthod. 41:1–14. 1971.PubMed/NCBI View Article : Google Scholar

64 

Kimmel DB and Jee WS: A quantitative histologic study of bone turnover in young adult beagles. Anat Rec. 203:31–45. 1982.PubMed/NCBI View Article : Google Scholar

65 

Carrel JP, Wiskott A, Scherrer S and Durual S: Large bone vertical augmentation using a three-dimensional printed TCP/HA bone graft: A pilot study in dog mandible. Clin Implant Dent Relat Res. 18:1183–1192. 2016.PubMed/NCBI View Article : Google Scholar

66 

Teng F, Wei L, Yu D, Deng L, Zheng Y, Lin H and Liu Y: Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP-2. Clin Oral Implants Res. 31:215–228. 2020.PubMed/NCBI View Article : Google Scholar

67 

Schwarz F, Mihatovic I, Popal-Jensen I, Parvini P and Sader R: Influence of autoclavation on the efficacy of extracted tooth roots used for vertical alveolar ridge augmentation. J Clin Periodontol. 46:502–509. 2019.PubMed/NCBI View Article : Google Scholar

68 

Parvini P, Schwarz F, Hüfner MK, Rauch N, Nienkemper M and Becker K: Microstructural volumetric analysis of vertical alveolar ridge augmentation using autogenous tooth roots. Clin Implant Dent Relat Res. 22:647–653. 2020.PubMed/NCBI View Article : Google Scholar

69 

Parvini P, Schliephake C, Al-Maawi S, Schwarz K, Sader R, Ghanaati S and Schwarz F: Histomorphometrical assessment of vertical alveolar ridge augmentation using extracted tooth roots in the canine. Clin Oral Investig. 24:317–323. 2020.PubMed/NCBI View Article : Google Scholar

70 

Hsu YT, Al-Hezaimi K, Galindo-Moreno P, O'Valle F, Al-Rasheed A and Wang HL: Effects of recombinant human bone morphogenetic protein-2 on vertical bone augmentation in a canine model. J Periodontol. 88:896–905. 2017.PubMed/NCBI View Article : Google Scholar

71 

Xuan F, Lee CU, Son JS, Fang Y, Jeong SM and Choi BH: Vertical ridge augmentation using xenogenous bone blocks: A comparison between the flap and tunneling procedures. J Oral Maxillofac Surg. 72:1660–1670. 2014.PubMed/NCBI View Article : Google Scholar

72 

Esposito M, Trullenque-Eriksson A, Vila CN, Peñarrocha M, García A, Sánchez A, Muñoz-Guzón F and Martínez Martín JM: Vertical osseodistraction with a new intraosseous alveolar distractor prototype for dental implant rehabilitation: A pilot study in dogs. Int J Oral Maxillofac Implants. 32:838–848. 2017.PubMed/NCBI View Article : Google Scholar

73 

Terbish M, Yoo SH, Kim HJ, Yu HS, Hwang CJ, Baik HS and Cha JY: Accelerated bone formation in distracted alveolar bone after injection of recombinant human bone morphogenetic protein-2. J Periodontol. 86:1078–1086. 2015.PubMed/NCBI View Article : Google Scholar

74 

Kaner D, Zhao H, Terheyden H and Friedmann A: Improvement of microcirculation and wound healing in vertical ridge augmentation after pre-treatment with self-inflating soft tissue expanders-a randomized study in dogs. Clin Oral Implants Res. 26:720–724. 2015.PubMed/NCBI View Article : Google Scholar

75 

Kaner D, Zhao H, Arnold W, Terheyden H and Friedmann A: Pre-augmentation soft tissue expansion improves scaffold-based vertical bone regeneration-a randomized study in dogs. Clin Oral Implants Res. 28:640–647. 2017.PubMed/NCBI View Article : Google Scholar

76 

Sawada K, Nakahara K, Haga-Tsujimura M, Iizuka T, Fujioka-Kobayashi M, Igarashi K and Saulacic N: Comparison of three block bone substitutes for bone regeneration: Long-term observation in the beagle dog. Odontology. 106:398–407. 2018.PubMed/NCBI View Article : Google Scholar

77 

Bianchini MA, Pontual MA, Bez L, Benfatti CA, Boabaid F, Somerman MJ and Magini RS: The use of bovine screws to promote bone formation using a tibia model in dogs. Oral Surg Oral Med Oral Pathol Oral Radiol. 116:e215–e220. 2013.PubMed/NCBI View Article : Google Scholar

78 

Pearce AI, Richards RG, Milz S, Schneider E and Pearce SG: Animal models for implant biomaterial research in bone: A review. Eur Cell Mater. 13:1–10. 2007.PubMed/NCBI View Article : Google Scholar

79 

Khojasteh A, Behnia H, Hosseini FS, Dehghan MM, Abbasnia P and Abbas FM: The effect of PCL-TCP scaffold loaded with mesenchymal stem cells on vertical bone augmentation in dog mandible: A preliminary report. J Biomed Mater Res B Appl Biomater. 101:848–854. 2013.PubMed/NCBI View Article : Google Scholar

80 

Mosekilde L, Weisbrode SE, Safron JA, Stills HF, Jankowsky ML, Ebert DC, Danielsen CC, Sogaard CH, Franks AF, Stevens ML, et al: Calcium-restricted ovariectomized Sinclair S-1 minipigs: An animal model of osteopenia and trabecular plate perforation. Bone. 14:379–382. 1993.PubMed/NCBI View Article : Google Scholar

81 

Harper RA, Pfeiffer FM and Choma TJ: The minipig as a potential model for pedicle screw fixation: Morphometry and mechanics. J Orthop Surg Res. 14(246)2019.PubMed/NCBI View Article : Google Scholar

82 

Bonucci E and Ballanti P: Osteoporosis-bone remodeling and animal models. Toxicol Pathol. 42:957–969. 2014.PubMed/NCBI View Article : Google Scholar

83 

Moest T, Koehler F, Prechtl C, Schmitt C, Watzek G and Schlegel KA: Bone formation in peri-implant defects grafted with microparticles: A pilot animal experimental study. J Clin Periodontol. 41:990–998. 2014.PubMed/NCBI View Article : Google Scholar

84 

Reichert JC, Saifzadeh S, Wullschleger ME, Epari DR, Schütz MA, Duda GN, Schell H, van Griensven M, Redl H and Hutmacher DW: The challenge of establishing preclinical models for segmental bone defect research. Biomaterials. 30:2149–2163. 2009.PubMed/NCBI View Article : Google Scholar

85 

Schorn L, Sproll C, Ommerborn M, Naujoks C, Kübler NR and Depprich R: Vertical bone regeneration using rhBMP-2 and VEGF. Head Face Med. 13(11)2017.PubMed/NCBI View Article : Google Scholar

86 

Moest T, Frabschka J, Kesting MR, Schmitt CM, Frohwitter G, Lutz R and Schlegel KA: Osseous ingrowth in allogeneic bone blocks applied for vertical bone augmentation: A preclinical randomised controlled study. Clin Oral Investig. 24:2867–2879. 2020.PubMed/NCBI View Article : Google Scholar

87 

Freilich M, Wen B, Shafer D, Schleier P, Dard M, Pendrys D, Ortiz D and Kuhn L: Implant-guided vertical bone growth in the mini-pig. Clin Oral Implants Res. 23:751–757. 2012.PubMed/NCBI View Article : Google Scholar

88 

Wen B, Shafer D, Schleier P, Pendrys D, Kuhn L and Freilich M: Implant-guided supracrestal alveolar bone growth using scaffolds, BMP-2, and novel scaffold-retaining device. Clin Oral Implants Res. 28:1411–1420. 2017.PubMed/NCBI View Article : Google Scholar

89 

Jinno Y, Jimbo R, Lindström M, Sawase T, Lilin T and Becktor JP: Vertical bone augmentation using ring technique with three different materials in the sheep mandible bone. Int J Oral Maxillofac Implants. 33:1057–1063. 2018.PubMed/NCBI View Article : Google Scholar

90 

Moussa M, Carrel JP, Scherrer S, Cattani-Lorente M, Wiskott A and Durual S: Medium-term function of a 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation: A simulation by BMP-2 activation. Materials. 8:2174–2190. 2015.

91 

Eitel F, Klapp F, Jacobson W and Schweiberer L: Bone regeneration in animals and in man. A contribution to understanding the relative value of animal experiments to human pathophysiology. Arch Orthop Trauma Surg. 99:59–64. 1981.PubMed/NCBI View Article : Google Scholar

92 

Carrel JP, Wiskott A, Moussa M, Rieder P, Scherrer S and Durual S: A 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation. Clin Oral Implants Res. 27:55–62. 2016.PubMed/NCBI View Article : Google Scholar

93 

Benlidayi ME, Tatli U, Salimov F, Tükel HC and Yüksel O: Comparison of autogenous and allograft bone rings in surgically created vertical bone defects around implants in a sheep model. Clin Oral Implants Res. 29:1155–1162. 2018.PubMed/NCBI View Article : Google Scholar

94 

Çolpak HA, Gönen ZB, Özdamar S, Alkan A and Kütük N: Vertical ridge augmentation using guided bone regeneration procedure and dental pulp derived mesenchymal stem cells with simultaneous dental implant placement: A histologic study in a sheep model. J Stomatol Oral Maxillofac Surg. 120:216–223. 2019.PubMed/NCBI View Article : Google Scholar

95 

Hurtig MB, Buschmann MD, Fortier LA, Hoemann CD, Hunziker EB, Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL and Whiteside RA: Preclinical studies for cartilage repair: Recommendations from the international cartilage repair society. Cartilage. 2:137–152. 2011.PubMed/NCBI View Article : Google Scholar

96 

Hoemann C, Kandel R, Roberts S, Saris DB, Creemers L, Mainil-Varlet P, Méthot S, Hollander AP and Buschmann MD: International cartilage repair society (ICRS) recommended guidelines for histological endpoints for cartilage repair studies in animal models and clinical trials. Cartilage. 2:153–172. 2011.PubMed/NCBI View Article : Google Scholar

97 

Polo CI, Lima JL, De Lucca L, Piacezzi CB, Naclério-Homem Mda G, Arana-Chavez VE and Sendyk WR: Effect of recombinant human bone morphogenetic protein 2 associated with a variety of bone substitutes on vertical guided bone regeneration in rabbit calvarium. J Periodontol. 84:360–370. 2013.PubMed/NCBI View Article : Google Scholar

98 

Greenstein G, Greenstein B, Cavallaro J and Tarnow D: The role of bone decortication in enhancing the results of guided bone regeneration: A literature review. J Periodontol. 80:175–189. 2009.PubMed/NCBI View Article : Google Scholar

99 

Kim DH, Cha JK, Song YW, Woo KM and Jung UW: Bone augmentation using small molecules with biodegradable calcium sulfate particles in a vertical onlay graft model in the rabbit calvarium. J Biomed Mater Res B Appl Biomater. 108:1343–1350. 2020.PubMed/NCBI View Article : Google Scholar

100 

Kim JW, Jung IH, Lee KI, Jung UW, Kim CS, Choi SH, Cho KS and Yun JH: Volumetric bone regenerative efficacy of biphasic calcium phosphate-collagen composite block loaded with rhBMP-2 in vertical bone augmentation model of a rabbit calvarium. J Biomed Mater Res A. 100:3304–3313. 2012.PubMed/NCBI View Article : Google Scholar

101 

Zere E, Einy S, Asbi T, Aizenbud Y, Gutmacher Z, Katzhandler E and Aizenbud D: Orthodontic extraction space closure with and without socket preservation: A comparative case analysis. Quintessence Int. 50:306–314. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Gan Y, Guo Y, Lu X and Li X: Animal models of vertical bone augmentation (Review). Exp Ther Med 22: 919, 2021.
APA
Zhang, Z., Gan, Y., Guo, Y., Lu, X., & Li, X. (2021). Animal models of vertical bone augmentation (Review). Experimental and Therapeutic Medicine, 22, 919. https://doi.org/10.3892/etm.2021.10351
MLA
Zhang, Z., Gan, Y., Guo, Y., Lu, X., Li, X."Animal models of vertical bone augmentation (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 919.
Chicago
Zhang, Z., Gan, Y., Guo, Y., Lu, X., Li, X."Animal models of vertical bone augmentation (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 919. https://doi.org/10.3892/etm.2021.10351
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Gan Y, Guo Y, Lu X and Li X: Animal models of vertical bone augmentation (Review). Exp Ther Med 22: 919, 2021.
APA
Zhang, Z., Gan, Y., Guo, Y., Lu, X., & Li, X. (2021). Animal models of vertical bone augmentation (Review). Experimental and Therapeutic Medicine, 22, 919. https://doi.org/10.3892/etm.2021.10351
MLA
Zhang, Z., Gan, Y., Guo, Y., Lu, X., Li, X."Animal models of vertical bone augmentation (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 919.
Chicago
Zhang, Z., Gan, Y., Guo, Y., Lu, X., Li, X."Animal models of vertical bone augmentation (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 919. https://doi.org/10.3892/etm.2021.10351
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