Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Experimental research in topical psoriasis therapy (Review)

  • Authors:
    • Diana Ana-Maria Nițescu
    • Alina Mușetescu
    • Maria Nițescu
    • Monica Costescu
    • Oana-Andreia Coman
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatovenereology, ‘Dr. Victor Babes’ Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania, Department of Hygiene and Medical Ecology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
    Copyright: © Nițescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 971
    |
    Published online on: July 8, 2021
       https://doi.org/10.3892/etm.2021.10403
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Psoriasis, one of the most prevalent inflammatory diseases in dermatologic pathology, remains a challenge in regards to the therapeutic approach. Topical therapy for psoriasis is a current trending subject as it implies good compliance for the patient, few adverse systemic reactions and a targeted effect. Numerous substances are now being tested, from natural to synthetic compounds and already known substances in improved formulas such as vesicular systems. The aim of this article was to conduct a literature review regarding the topical therapy of psoriasis in animal models, between June, 27, 2019 and July 9, 2020. For this article, the authors conducted extensive research in PubMed with the following keywords: Psoriasis AND (topical OR local) and (therapy OR treatment) AND (mice OR rats). The main new studied substances included lycopene, sodium butyrate, salvianolic acid B, small interfering RNAs (siRNAs) in ionic liquids, albendazole, phosphodiesterase inhibitors, biomimetic reconstituted high-density lipoprotein nanocarrier gel containing microRNA (miRNA)-210 antisense, thymoquinone in ethosomal vesicle, Sea buckthorn oil (Hippophae rhamnoides), nitidine chloride, Melissa officinalis spp. Altissima extract and [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM). New formulas of already known anti-psoriasis substances such as: Cyclosporine, methotrexate, calcipotriol, tazarotene, protein kinase p38 and integrin α5β1 as a target, are also reviewed. Recent research in topical psoriasis underlines the importance of animal experimental research in dermatology, providing a starting point for developing new therapeutic approaches in one of the most frequently diagnosed chronic dermatologic diseases. Vesicular systems are now providing the best vehicle for topical therapy, thus easing the action of the active substances at their target sites.
View Figures

Figure 1

Figure 2

View References

1 

Bologna JL, Schaffer JV and Cerroni L: Dermatology. 4th edition. Elsevier, Amsterdam, pp138-159, 2018.

2 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomark Med. 9:513–528. 2015.PubMed/NCBI View Article : Google Scholar

3 

Rendon A and Schäkel K: Psoriasis pathogenesis and treatment. Int J Mol Sci. 20(1475)2019.PubMed/NCBI View Article : Google Scholar

4 

Alecu M, Coman G, Mușetescu Cojoacă ME and Coman OA: Dermatology facing autoinflammatory syndrome. Rom J Morphol Embryol. 56:7–14. 2015.PubMed/NCBI

5 

Costescu M, Coman OA, Tampa M, Tudose I, Coman L and Georgescu SR: Axillary basal cell carcinoma-a rare form of a frequent kind of carcinoma. Rom J Morphol Embryol. 54 (Suppl 3):S851–S856. 2013.PubMed/NCBI

6 

Nicolae I, Nicolae CD, Coman OA, Stefanescu M, Coman L and Ardeleanu C: Serum total gangliosides level: Clinical prognostic implication. Rom J Morphol Embryol. 52:1277–1281. 2011.PubMed/NCBI

7 

Algahtani M, Ahmad M, Nourein I and Ahmad J: Co-delivery of imiquimod and curcumin by nanoemugel for improved topical delivery and reduced psoriasis-like skin lesions. Biomolecules. 10(968)2020.PubMed/NCBI View Article : Google Scholar

8 

Evans EA, Sayers SR, Kodji X, Xia Y, Shaikh M, Rizvi A, Frame J, Brain SD, Philpott MP, Hannen RF and Caton PW: Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome. Mol Metab. 41(101047)2020.PubMed/NCBI View Article : Google Scholar

9 

Xu Z, Qin Z, Zhang J and Wang Y: Microglia-mediated chronic psoriatic itch induced by imiquimod. Mol Pain: Jun 24, 2020 (Epub ahead of print). doi: 10.1177/1744806920934998.

10 

Bai X, Yu C, Yang L, Luo Y, Zhi D, Wang G and Dang E: Anti-psoriatic properties of paeoniflorin: Suppression of the NF-kappaB pathway and Keratin 17. Eur J Dermatol. 30:243–250. 2020.PubMed/NCBI View Article : Google Scholar

11 

Ren F, Zhang M, Zhang C and Sang H: Psoriasis-like inflammation induced renal dysfunction through the TLR/NF-κB signal pathway. Biomed Res Int. 2020(3535264)2020.PubMed/NCBI View Article : Google Scholar

12 

Duan X, Liu X, Liu N, Huang Y, Jin Z, Zhang S, Ming Z and Chen H: Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. Cell Death Dis. 11(134)2020.PubMed/NCBI View Article : Google Scholar

13 

Yu S, Wu X, Shi Z, Huynh M, Jena PK, Sheng L, Zhou Y, Han D, Wan YY and Hwang ST: Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer. J Dermatol Sci. 97:194–200. 2020.PubMed/NCBI View Article : Google Scholar

14 

Man MQ and Elias PM: Could inflammaging and its sequelae be prevented or mitigated? Clin Interv Aging. 14:2301–2304. 2019.PubMed/NCBI View Article : Google Scholar

15 

Shankar GM, Alex VV, Nisthul AA, Bava SV, Sundaram S, Retnakumari AP, Chittalakkottu S and Anto RJ: Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer. Cell Prolif. 53(e12710)2020.PubMed/NCBI View Article : Google Scholar

16 

Chiang CC, Cheng WJ, Lin CY, Lai KH, Ju SC, Lee C, Yang SH and Hwang TL: Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation. J Ethnopharmacol. 246(112246)2020.PubMed/NCBI View Article : Google Scholar

17 

Rapalli VK, Singhvi G, Gorantla S, Waghule T, Dubey SK, Saha RN, Hasnain MS and Nayak AK: Stability indicating liquid chromatographic method for simultaneous quantification of betamethasone valerate and tazarotene in in vitro and ex vivo studies of complex nanoformulation. J Sep Sci. 42:3413–3420. 2019.PubMed/NCBI View Article : Google Scholar

18 

Shih CM, Hsieh CK, Huang CY, Huang CY, Wang KH, Fong TH, Trang NT, Liu KT and Lee AW: Lycopene inhibit IMQ-induced psoriasis-like inflammation by inhibiting ICAM-1 production in mice. Polymers (Basel). 12(1521)2020.PubMed/NCBI View Article : Google Scholar

19 

Li Q, Li F, Qi X, Wei F, Chen H and Wang T: Pluronic® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies. Colloids Surf B Biointerfaces. 195(111246)2020.PubMed/NCBI View Article : Google Scholar

20 

Shinde G, Desai P, Shelke S, Patel R, Bangale G and Kulkarni D: Mometasone furoate-loaded aspasomal gel for topical treatment of psoriasis: Formulation, optimization, in vitro and in vivo performance. J Dermatolog Treat: Jul 8, 2020 (Epub ahead of print). doi: 10.1080/09546634.2020.1789043.

21 

Schwarz A, Philippsen R and Schwarz T: Induction of regulatory T cells and correction of cytokine dysbalance by short-chain fatty acids: Implications for psoriasis therapy. J Invest Dermatol. 141:95–104.e2. 2021.PubMed/NCBI View Article : Google Scholar

22 

Guo JW, Cheng YP, Liu CY, Thong HY, Huang CJ, Lo Y, Wu CY and Jee SH: Salvianolic acid B in microemulsion formulation provided sufficient hydration for dry skin and ameliorated the severity of imiquimod-induced psoriasis-like dermatitis in mice. Pharmaceutics. 12(457)2020.PubMed/NCBI View Article : Google Scholar

23 

Dharamdasani V, Mandal A, Qi QM, Suzuki I, Bentley MV and Mitragotri S: Topical delivery of siRNA into skin using ionic liquids. J Control Release. 323:475–482. 2020.PubMed/NCBI View Article : Google Scholar

24 

Li H, Li J, Zhang X, Feng C, Fan C, Yang X, Zhang R, Zhu F, Zhou Y, Xu Y, et al: DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling. Biochem Pharmacol. 177(113958)2020.PubMed/NCBI View Article : Google Scholar

25 

Di Fusco D, Stolfi C, Di Grazia A, Dinallo V, Laudisi F, Marafini I, Colantoni A, Monteleone I and Monteleone G: Albendazole negatively regulates keratinocyte proliferation. Clin Sci (Lond). 134:907–920. 2020.PubMed/NCBI View Article : Google Scholar

26 

Song B, Song R, Cheng M, Chu H, Yan F and Wang Y: Preparation of calcipotriol emulsion using bacterial exopolysaccharides as emulsifier for percutaneous treatment of psoriasis vulgaris. Int J Mol Sci. 21(77)2020.PubMed/NCBI View Article : Google Scholar

27 

Lee WR, Lin YK, Alalaiwe A, Wang PW, Liu PY and Fang JY: Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol Ther Nucleic Acid. 19:240–251. 2020.PubMed/NCBI View Article : Google Scholar

28 

Feng H, Wu R, Zhang S, Kong Y, Liu Z, Wu H, Wang H, Su Y, Zhao M and Lu Q: Topical administration of nanocarrier miRNA-210 antisense ameliorates imiquimod-induced psoriasis-like dermatitis in mice. J Dermatol. 47:147–154. 2020.PubMed/NCBI View Article : Google Scholar

29 

Negi P, Sharma I, Hemrajani C, Rathore C, Bisht A, Raza K and Katare OP: Thymoquinone-loaded lipid vesicles: A promising nanomedicine for psoriasis. BMC Complement Altern Med. 19(334)2019.PubMed/NCBI View Article : Google Scholar

30 

Balkrishna A, Sakat SS, Joshi K, Joshi K, Sharma V, Ranjan R, Bhattacharya K and Varshney A: Cytokines driven anti-inflammatory and anti-psoriasis like efficacies of nutraceutical sea buckthorn (Hippophae rhamnoides) oil. Front Pharmacol. 10(1186)2019.PubMed/NCBI View Article : Google Scholar

31 

Zhai H, Hu S, Liu T, Wang F, Wang X, Wu G, Zhang Y, Sui M, Liu H and Jiang L: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway. Mol Med Rep. 13:2536–2542. 2016.PubMed/NCBI View Article : Google Scholar

32 

Yang XG, Jiang BW, Jing QQ, Li WJ, Tan LP, Bao YL, Song ZB, Yu CL, Liu L, Liu YC and Li YX: Nitidine chloride induces S phase cell cycle arrest and mitochondria-dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis-like mouse models. Eur J Pharmacol. 863(172680)2019.PubMed/NCBI View Article : Google Scholar

33 

Weng JR, Huang TH, Lin ZC, Alalaiwe A and Fang JY: Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed Pharmacother. 119(109398)2019.PubMed/NCBI View Article : Google Scholar

34 

Chandra A, Aggarwal G, Manchanda S and Narula A: Development of topical gel of methotrexate incorporated ethosomes and salicylic acid for the treatment of psoriasis. Pharm Nanotechnol. 7:362–374. 2019.PubMed/NCBI View Article : Google Scholar

35 

Dimitris D, Ekaterina-Michaela T, Christina K, Ioannis S, Ioanna SK, Aggeliki L, Sophia H, Michael R and Helen S: Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice. J Ethnopharmacol. 246(112208)2020.PubMed/NCBI View Article : Google Scholar

36 

Bahramizadeh M, Bahramizadeh M, Kiafar B, Jafarian AH, Nikpoor AR, Hatamipour M, Esmaily H, Rezaeemehr Z, Golmohammadzadeh S, Moosavian SA and Jafari MR: Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model. Int J Pharm. 569(118623)2019.PubMed/NCBI View Article : Google Scholar

37 

Negrei C, Ginghină O, Caruntu C, Burcea Dragomiroiu G, Jinescu G and Boda D: Investigation relevance of methotrexate polyglutamates in biological systems by high performance liquid chromatography. Rev Chim Bucharest. 66:766–768. 2015.

38 

Negrei C, Caruntu C, Ginghina O, Dragomiroiu GT, Toderescu CD and Boda D: Qualitative and quantitative determination of methotrexate polyglutamates in erythrocytes by high performance liquid chromatography. Rev Chim-Bucharest. 66:607–610. 2015.

39 

Boda D, Negrei C, Nicolescu F and Badalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

40 

Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, et al: Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. J Allergy Clin Immunol. 144:1036–1049. 2019.PubMed/NCBI View Article : Google Scholar

41 

Elmowafy E, El-Gogary RI, Ragai MH and Nasr M: Novel antipsoriatic fluidized spanlastic nanovesicles: In vitro physicochemical characterization, ex vivo cutaneous retention and exploratory clinical therapeutic efficacy. Int J Pharm. 568(118556)2019.PubMed/NCBI View Article : Google Scholar

42 

Gad SC, Sullivan DW Jr, Mujer CV, Spainhour CB and Crapo JD: Nonclinical safety and toxicokinetics of MnTE-2-PyP (BMX-010), a topical agent in phase 2 trials for psoriasis and atopic dermatitis. Int J Toxicol. 38:291–302. 2019.PubMed/NCBI View Article : Google Scholar

43 

Meng S, Sun L, Wang L, Lin Z, Liu Z, Xi L, Wang Z and Zheng Y: Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity. Colloids Surf B Biointerfaces. 182(110352)2019.PubMed/NCBI View Article : Google Scholar

44 

Ho TC, Yeh SI, Chen SL and Tsao YP: The psoriasis therapeutic potential of a novel short laminin peptide C16. Int J Mol Sci. 20(3144)2019.PubMed/NCBI View Article : Google Scholar

45 

Căruntu C, Boda D, Caruntu A, Rotaru M, Baderca F and Zurac S: In vivo imaging techniques for psoriatic lesions. Rom J Morphol Embryol. 55 (Suppl 3):S1191–S1196. 2014.PubMed/NCBI

46 

Batani A, Branisteanu DE, Ilie MA, Boda D, Ianosi S, Ianosi G and Caruntu C: Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 15:1241–1246. 2018.PubMed/NCBI View Article : Google Scholar

47 

Swindell WR, Michaels KA, Sutter AJ, Diaconu D, Fritz Y, Xing X, Sarkar MK, Liang Y, Tsoi A, Gudjonsson JE and Ward NL: Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis. Genome Med. 9(24)2017.PubMed/NCBI View Article : Google Scholar

48 

Akbarzadeh A, Rezaei-Sadabad R, Davaran S, Joo SW, Zargami N, Hanifehpour Y, Samiei M, Kouhi M and Nejati-Koshki K: Liposome: Classification, preparation, and applications. Nanoscale Ress Lett. 8(102)2013.PubMed/NCBI View Article : Google Scholar

49 

Verma P and Pathak K: Therapeutic and cosmeceutical potential of ethosomes: An overview. J Adv Pharm Technol Res. 1:274–282. 2010.PubMed/NCBI View Article : Google Scholar

50 

Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M and Kuotsu K: Niosome: A future of targeted drug delivery systems. J Adv Pharm Technol Res. 1:374–380. 2010.PubMed/NCBI View Article : Google Scholar

51 

Wang Y, Li P, Zhang L, Fu J, Di T, Li N, Meng Y, Guo J and Zhao J: Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasia and IL-1β/IL-23p40 production. J Leukoc Biol. 108:267–281. 2020.PubMed/NCBI View Article : Google Scholar

52 

Iwano R, Iwashita N, Takagi Y and Fukuyama T: Estrogen receptor α activation aggravates imiquimod-induced psoriasis-like dermatitis in mice by enhancing dendritic cell interleukin-23 secretion. J Appl Toxicol. 40:1353–1361. 2020.PubMed/NCBI View Article : Google Scholar

53 

Pu J, Wang R, Zhang G and Wang J: FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 51:1056–1063. 2019.PubMed/NCBI View Article : Google Scholar

54 

Borek I, Köffel R, Feichtinger J, Spies M, Glitzner-Zeis E, Hochgerner M, Sconocchia T, Krump C, Tam-Amersdorfer C, Passegger C, et al: BMP7 aberrantly induced in the psoriatic epidermis instructs inflammation-associated langerhans cells. J Allergy Clin Immunol. 145:1194–1207.e11. 2020.PubMed/NCBI View Article : Google Scholar

55 

Ju N, Shimamura M, Hayashi H, Ikeda Y, Yoshida S, Nakamura A, Morishita R, Rakugi H and Nakagami H: Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis. Scic Rep. 9(15434)2019.PubMed/NCBI View Article : Google Scholar

56 

Liu C, Liu H, Lu C, Deng J, Yan Y, Chen H, Wang Y, Liang C, Wei J, Han L and Dai Z: Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model. Clin Exp Immunol. 198:403–415. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nițescu DA, Mușetescu A, Nițescu M, Costescu M and Coman O: Experimental research in topical psoriasis therapy (Review). Exp Ther Med 22: 971, 2021.
APA
Nițescu, D.A., Mușetescu, A., Nițescu, M., Costescu, M., & Coman, O. (2021). Experimental research in topical psoriasis therapy (Review). Experimental and Therapeutic Medicine, 22, 971. https://doi.org/10.3892/etm.2021.10403
MLA
Nițescu, D. A., Mușetescu, A., Nițescu, M., Costescu, M., Coman, O."Experimental research in topical psoriasis therapy (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 971.
Chicago
Nițescu, D. A., Mușetescu, A., Nițescu, M., Costescu, M., Coman, O."Experimental research in topical psoriasis therapy (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 971. https://doi.org/10.3892/etm.2021.10403
Copy and paste a formatted citation
x
Spandidos Publications style
Nițescu DA, Mușetescu A, Nițescu M, Costescu M and Coman O: Experimental research in topical psoriasis therapy (Review). Exp Ther Med 22: 971, 2021.
APA
Nițescu, D.A., Mușetescu, A., Nițescu, M., Costescu, M., & Coman, O. (2021). Experimental research in topical psoriasis therapy (Review). Experimental and Therapeutic Medicine, 22, 971. https://doi.org/10.3892/etm.2021.10403
MLA
Nițescu, D. A., Mușetescu, A., Nițescu, M., Costescu, M., Coman, O."Experimental research in topical psoriasis therapy (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 971.
Chicago
Nițescu, D. A., Mușetescu, A., Nițescu, M., Costescu, M., Coman, O."Experimental research in topical psoriasis therapy (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 971. https://doi.org/10.3892/etm.2021.10403
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team