Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)

  • Authors:
    • Gabriela Lupuşoru
    • Mircea Lupuşoru
    • Ioana Ailincăi
    • Lavinia Bernea
    • Andreea Berechet
    • Radu Spătaru
    • Gener Ismail
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania, Department of Physiology I, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Pediatric Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Lupuşoru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 984
    |
    Published online on: July 12, 2021
       https://doi.org/10.3892/etm.2021.10416
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hantavirus infection belongs to a group of zoonoses rare in the Balkan Peninsula, causing two major syndromes, depending on the viral serotype involved: Hemorrhagic fever with renal syndrome (HFRS) also known as endemic nephropathy and cardiopulmonary syndrome (CPS). Because there is no specific treatment or vaccine for this condition approved in the USA or Europe, the key to minimizing the risk of adverse progression to chronic kidney disease, secondary hypertension or even death is primarily the recognition and early diagnosis of this condition with prompt therapeutic intervention. The aim of this study was to review the literature data on the epidemiology, pathogenesis and management of this disease and to identify several aspects related to the difficulties encountered in diagnosing this pathology, taking into consideration that the disease is not endemic in this geographical area.
View Figures

Figure 1

View References

1 

Zeier M, Handermann M, Bahr U, Rensch B, Muller S, Kehm R, Muranyi W and Darai G: New ecological aspects of hantavirus infection: A change of A paradigm and a challenge of prevention-a review. Virus Genes. 30:157–180. 2005.PubMed/NCBI View Article : Google Scholar

2 

Avšič-Županc T, Saksida A and Korva M: Hantavirus infections. Clin Microbiol Infect. 21S:e6–e16. 2019.PubMed/NCBI View Article : Google Scholar

3 

Satoskar A, Nadasdy T and Silva F: Acute postinfectious glomerulonephritis and glomerulonephritis caused by persistent bacterial infection. In Heptinstall's Pathology of the Kidney, 7th edition. Jannette JG, Olson JL, Silva FG and D'Agati VD (eds). Lippincott Williams and Wilkins, Philadelphia, pp678-798, 2015.

4 

van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR and Wickner RB (eds): Virus Taxonomy. Seventh Report of the International Committee on Taxonomy of Viruses. 1st edition. Academic Press, San Diego, San Francisco, New York, Boston, London, Sydney, Tokyo, 2000.

5 

Lee HW, Lee PW and Johnson KM: Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis. 137:298–308. 1978.PubMed/NCBI View Article : Google Scholar

6 

Vapalahti O, Mustonen J, Lundqvist Å, Henttonen H, Plyusnin A and Vaheri A: Hantavirus infections in Europe. Lancet Infect Dis. 3:653–661. 2003.PubMed/NCBI View Article : Google Scholar

7 

Avsic-Zupanc T, Petrovec M, Furlan P, Kaps R, Elgh F and Lundkvist A: Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia-a 10-year survey. Clin Infect Dis. 28:860–865. 1999.PubMed/NCBI View Article : Google Scholar

8 

Steer A: Pathogenesis of renal changes in epidemic hemorrhagic fever. In: The Kidney. IAP Monograph. Mostofi FK and Smith DE (eds). Williams & Wilkins, Baltimore, pp476-486, 1996.

9 

Jokinen EJ, Lähdevirta J and Collan Y: Nephropathia epidemica: Immunohistochemical study of pathogenesis. Clin Nephrol. 9:1–5. 1978.PubMed/NCBI

10 

Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumvalt RE, Miller GL, Khan AS, et al: Hantavirus pulmonary syndrome: Pathogenesis of an emerging infectious disease. Am J Pathol. 146:552–579. 1995.PubMed/NCBI

11 

Kim S, Kang ET, Kim YG, Han JS, Lee JS, Kim JI, Hall WC, Dalrymple JM and Peters CJ: Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H. Am J Clin Pathol. 100:398–403. 1993.PubMed/NCBI View Article : Google Scholar

12 

Groen J, Bruijn JA, Gerding MN, Jordans JG, Moll van Charante AW and Osterhaus AD: Hantavirus antigen detection in kidney biopsies from patients with nephropathia epidemica. Clin Nephrol. 46:379–383. 1996.PubMed/NCBI

13 

Poljak M and Avšič Županc T: Immunohistochemical detection of Hantaan virus antigen in renal tissue from patient with hemorrhagic fever with renal syndrome. Nephron. 67(252)1994.PubMed/NCBI View Article : Google Scholar

14 

Padula PJ, Edelstein A, Miguel SD, López NM, Rossi CM and Rabinovich RD: Hantavirus pulmonary syndrome outbreak in Argentina: Molecular evidence for person-to-person transmission of Andes virus. Virology. 241:323–330. 1998.PubMed/NCBI View Article : Google Scholar

15 

Martinez VP, Bellomo C, San Juan J, Pinna D, Forlenza R, Elder M and Padula PJ: Person-to-person transmission of Andes virus. Emerg Infect Dis. 11:1848–1853. 2005.PubMed/NCBI View Article : Google Scholar

16 

European Centre for Disease Prevention and Control: https://www.ecdc.europa.eu/en/publications-data/hantavirus-infection-annual-epidemiological-report-2018. Accessed June 25, 2020.

17 

Antoine M, Langlois ME, Bres E, Rabeyrin M, Reynes JM and Deeb A: Imported haemorrhagic fever with renal syndrome caused by Dobrava-Belgrade hantavirus in France. Clin Kidney J. 14:1014–1016. 2020.PubMed/NCBI View Article : Google Scholar

18 

Shirai H, Yashima J, Tojimbara T and Honda K: Thrombotic microangiopathy caused by oral contraceptives in a kidney transplant recipient. Nephrology (Carlton). 21 (Suppl 1):S41–S43. 2016.PubMed/NCBI View Article : Google Scholar

19 

Douron E, Moriniere B, Matheron S, Girard PM, Gonzalez JP, Hirsch F and McCormick JB: HFRS after a wild rodent bite in the Haute-Savoie- and risk of exposure to Hantaan-like virus in a Paris laboratory. Lancet. 1:676–677. 1984.PubMed/NCBI View Article : Google Scholar

20 

Mustonen J, Partanen J, Kanerva M, Pietilä K, Vapalahti O, Pasternack A and Vaheri A: Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int. 49:217–221. 1996.PubMed/NCBI View Article : Google Scholar

21 

Mäkelä S, Mustonen J, Ala-Houhala I, Hurme M, Partanen J, Vapalahti O, Vaheri A and Pasternack A: Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha (308) G/A polymorphism. J Infect Dis. 186:843–846. 2002.PubMed/NCBI View Article : Google Scholar

22 

Paakkala A, Mäkelä S, Hurme M, Partanen J, Huhtala H and Mustonen J: Association of chest radiography findings with hostrelated genetic factors in patients with nephropathia epidemica. Scand J Infect Dis. 40:254–258. 2008.PubMed/NCBI View Article : Google Scholar

23 

Mustonen J, Partanen J, Kanerva M, Pietilä K, Vapalahti O, Pasternack A and Vaheri A: Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus. Scand J Immunol. 47:277–279. 1998.PubMed/NCBI View Article : Google Scholar

24 

Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T and Vapalahti O: Hantavirus infections in Europe and their impact on public health. Rev Med Virol. 23:35–49. 2013.PubMed/NCBI View Article : Google Scholar

25 

Gavrilovskaya IN, Gorbunova EE and Mackow ER: Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol. 84:4832–4839. 2010.PubMed/NCBI View Article : Google Scholar

26 

Gavrilovskaya IN, Brown EJ, Ginsberg MH and Mackow ER: Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol. 73:3951–3959. 1999.PubMed/NCBI View Article : Google Scholar

27 

Krautkramer E, Grouls S, Stein N, Reiser J and Zeier M: Pathogenic old word hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts. J Virol. 85:9811–9823. 2011.PubMed/NCBI View Article : Google Scholar

28 

Boehlke C, Hartleben B, Huber T, Hopfer H, Walz G and Neumann-Haefelin E: Hantavirus infection with severe proteinuria and podocyte foot-process effacement. Am J Kidney Dis. 64:452–456. 2014.PubMed/NCBI View Article : Google Scholar

29 

Krautkramer E, Zeier M and Plyusnin A: Hantavirus infection: An emerging infectious disease causing acute renal failure. Kidney Int. 83:23–27. 2013.PubMed/NCBI View Article : Google Scholar

30 

Peebles RS Jr and Graham BS: Viruses, dendritic cells and the lung. Respir Res. 2:245–249. 2001.PubMed/NCBI View Article : Google Scholar

31 

Schonrich G, Rang A, Lutteke N, Raftery MJ, Charbonnel N and Ulrich RG: Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev. 225:163–189. 2008.PubMed/NCBI View Article : Google Scholar

32 

Terajima M and Ennis FA: T cells and pathogenesis of hantavirus and cardiopulmonary syndrome and hemorrhagic fever with renal syndrome. Viruses. 3:1059–1073. 2011.PubMed/NCBI View Article : Google Scholar

33 

Safronetz D, Zivcec M, Lacasse R, Feldmann F, Rosenke R, Long D, Haddock E, Brining D, Gardner D, Feldmann H and Ebihara H: Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus. PLoS Pathog. 7(e1002426)2011.PubMed/NCBI View Article : Google Scholar

34 

Saksida A, Wraber B and Avsic-Zupanc T: Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome. BMC Infect Dis. 11(142)2011.PubMed/NCBI View Article : Google Scholar

35 

Hägele S, Müller A, Nusshag C, Reiser J, Zeier M and Krautkrämer E: Motility of human renal cells is disturbed by infection with pathogenic hantaviruses. BMC Infect Dis. 18(645)2018.PubMed/NCBI View Article : Google Scholar

36 

Mustonen J, Mäkelä S, Heli H, Helanterä A, Miettinen M, Partanen J and Pasternack A: Mesangiocapillary glomerulonephritis caused by Puumala hantavirus infection. Nephron. 89:402–407. 2001.PubMed/NCBI View Article : Google Scholar

37 

Papadimitriou M: Hantavirus nephropathy. Kidnei Int. 48:887–902. 1995.PubMed/NCBI View Article : Google Scholar

38 

Li XZ, Jin XM and Li H: Semi-thin sections and electron microscopy in epidemic hemorrhagic fever. Trans Harbin Med Univ. 3:43–46. 1984.

39 

Clement J, Lee APK, Verpooten GA, Laenen L, Vergote V, De Samblanx H, Berneman ZN, Van Ranst M and Maes P: Acute hantavirus infection presenting as haemolytic-uraemic syndrome (HUS): The importance of early clinical diagnosis. Eur J Clin Microbiol Infect Dis. 37:135–140. 2018.PubMed/NCBI View Article : Google Scholar

40 

Gheorghe G, Ceobanu G, Gheorghe F, Bratu OG, Bacalbasa N, Bungau S and Diaconu CC: Fever of unknown origin. Rom J Mil Med. 123(213)2020.

41 

Hautala N, Kauma H, Vapalahti O, Mähönen SM, Vainio O, Vaheri A and Hautala T: Prospective study on ocular findings in acute Puumala hantavirus infection in hospitalised patients. Br J Ophthalmol. 95:559–562. 2011.PubMed/NCBI View Article : Google Scholar

42 

McCaughey C and Hart CA: Hantaviruses. J Med Microbiol. 49:587–599. 2000.PubMed/NCBI View Article : Google Scholar

43 

Linderholm M and Elgh F: Clinical characteristics of hantavirus infections on the Eurasian continent. Curr Top Microbiol Immunol. 256:135–151. 2001.PubMed/NCBI View Article : Google Scholar

44 

Kruger DH, Ulrich R and Lundkvist AA: Hantavirus infections and their prevention. Microbes Infect. 3:1129–1144. 2001.PubMed/NCBI View Article : Google Scholar

45 

Jereb M, Lunacek NK, Kotar T, Saksida A, Petrovec M and Avsic-Zupanc T: Procalcitonin in hantavirus infections. Scand J Clin Lab Invest. 71:287–291. 2011.PubMed/NCBI View Article : Google Scholar

46 

Outinen TK, Mäkelä SM, Ala-Houhala IO, Huhtala HS, Hurme M, Paakkala AS, Pörsti IH, Syrjänen JT and Mustonen JT: The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations. BMC Infect Dis. 10(132)2010.PubMed/NCBI View Article : Google Scholar

47 

Mäkelä S, Mustonen J, Ala-Houhala I, Hurme M, Koivisto AM, Vaheri A and Pasternack A: Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis. Am J Kidney Dis. 43:809–816. 2004.PubMed/NCBI View Article : Google Scholar

48 

Paakkala A, Mustonen J, Viander M, Huhtala H and Pasternack A: Complement activation in nephropathia epidemica caused by Puumala hantavirus. Clin Nephrol. 53:424–431. 2000.PubMed/NCBI

49 

Sane J, Laine O, Mäkelä S, Paakkala A, Jarva H, Mustonen J, Vapalahti O, Meri A and Vaheri A: Complement activation in Puumala hantavirus infection correlates with disease severity. Ann Med. 44:468–475. 2012.PubMed/NCBI View Article : Google Scholar

50 

Laine O, Mäkelä S, Mustonen J, Huhtala H, Szanto T, Vaheri A, Lassila R and Joutsi-Korhonen L: Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection. Thromb Res. 126:154–158. 2010.PubMed/NCBI View Article : Google Scholar

51 

Wang M, Wang J, Wang T, Li J, Hui L and Ha X: Thrombocytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections. PLoS One. 8(e53236)2013.PubMed/NCBI View Article : Google Scholar

52 

Rasche FM, Uhel B, Krüger DH, Karges W, Czock D, Hampl W, Keller F, Meisel H and von Müller L: Thrombocytopenia and acute renal failure in Puumala hantavirus infections. Emerg Infect Dis. 10:420–425. 2004.PubMed/NCBI View Article : Google Scholar

53 

Braun N, Haap M, Overkamp D, Kimmel M, Alscher MD, Lehnert H and Haas CS: Characterization and outcome following Puumala virus infection: A retrospective analysis of 75 cases. Nephrol Dial Transplant. 25:2997–3003. 2010.PubMed/NCBI View Article : Google Scholar

54 

Hukic M, Valjevac A, Tulumovic D, Numanovic F and Heyman P: Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: The impact on renal function. Eur J Clin Microbiol Infect Dis. 30:381–385. 2011.PubMed/NCBI View Article : Google Scholar

55 

Clement J, Maes P, Lagrou K, Van Ranst M and Lameire N: A unifying hypothesis and a single name for a complex globally emerging infection: Hantavirus disease. Eur J Clin Microbiol Infect Dis. 31:1–5. 2012.PubMed/NCBI View Article : Google Scholar

56 

Mäkelä S, Kokkonen L, Ala-Houhala I, Groundstroem K, Harmoinen A, Huhtala H, Hurme M, Paakkala A, Porsti I, Virtanen V, et al: More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings. Scand J Infect Dis. 41:57–62. 2009.PubMed/NCBI View Article : Google Scholar

57 

Mustonen J, Brummer-Korvenkontio M, Hedman K, Pasternack A, Pietilä K and Vaheri A: Nephropathia epidemica in Finland: A retrospective study of 126 cases. Scand J Infect Dis. 26:7–13. 1994.PubMed/NCBI View Article : Google Scholar

58 

Bergmann F, Krone B, Bleich S, Prange H and Paulus W: Encephalitis due to a hantavirus infection. J Infect. 45:58–59. 2002.PubMed/NCBI View Article : Google Scholar

59 

Ahlm C, Lindén C, Linderholm M, Alexeyev OA, Billhedent J, Elgh F, Fagerlund M, Zetterlund B and Settergren B: Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome). J Infect. 36:149–155. 1998.PubMed/NCBI View Article : Google Scholar

60 

Hautala T, Mähönen SM, Sironen T, Hautala N, Pääkkö E, Karttunen A, Salmela PI, Ilonen J, Vainio O, Glumoff V, et al: Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection. Ann Med. 42:344–351. 2010.PubMed/NCBI View Article : Google Scholar

61 

Launes J and Hautanen A: Nephropathia epidemica encephalitis. Acta Neurol Scand. 78:234–235. 1988.PubMed/NCBI View Article : Google Scholar

62 

Alexeyev OA and Morozov VG: Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: Review of 811 cases. Clin Infect Dis. 20:255–258. 1995.PubMed/NCBI View Article : Google Scholar

63 

Cerar D, Avsic-Zuapanc T, Jereb M and Strle F: Case report: Severe neurological manifestation of Dobrava hantavirus infection. J Med Virol. 79:1841–1843. 2007.PubMed/NCBI View Article : Google Scholar

64 

Settergren B, Boman J, Linderholm M, Wiström J, Hägg E and Arvidsson PA: A case of nephropathia epidemica associated with panhypopituitarism and nephrotic syndrome. Nephron. 61:234–235. 1992.PubMed/NCBI View Article : Google Scholar

65 

Kilit TP, Kilit C and Erarslan S: A rare cause of acute pancreatitis: Hantavirus infection. Acta Gastroenterol Belg. 80:59–61. 2017.PubMed/NCBI

66 

Hoier S, Aberle SW, Langner C, Schnedl W, Högenauer C, Reisinger EC, Krejs GJ and Krause R: Puumala virus RNA in patient with multiorgan failure. Emerg Infect Dis. 12:356–357. 2006.PubMed/NCBI View Article : Google Scholar

67 

Miettinen MH, Makela SM, Ala-Houhala IO, Huhtala HS, Koobi T, Vaheri AI, Pasternack AI, Porsti IH and Mustonen JT: Tubular proteinuria and glomerular filtration 6 years after Puumala hantavirus-induced acute interstitial nephritis. Nephron Clin Pract. 112:c115–c120. 2009.PubMed/NCBI View Article : Google Scholar

68 

Miettinen M, Mäkelä S, Haapala M, Helanterä A, Helin H, Vänttinen T and Mustonen J: Glomerulonephritis emerging shortly after Puumala hantavirus infection: A report of 7 patients. Clin Nephrol. 75:550–556. 2011.PubMed/NCBI View Article : Google Scholar

69 

Tulumovic D, Imamovic G, Mesic E, Hukic M, Tulumovic A, Imamovic A and Zerem E: Comparison of the effects of Puumala and Dobrava viruses on early and long-term renal outcomes in patients with haemorrhagic fever with renal syndrome. Nephrology (Carlton). 15:340–343. 2010.PubMed/NCBI View Article : Google Scholar

70 

Mäkelä S, Jaatinen P, Miettinen M, Salmi J, Ala-Houhala I, Huhtala H, Hurme M, Pörsti I, Vaheri A and Mustonen J: Hormonal deficiencies during and after Puumala hantavirus infection. Eur J Clin Microbiol Infect Dis. 29:705–713. 2010.PubMed/NCBI View Article : Google Scholar

71 

Pekic S, Cvijovic G, Stojanovic M, Kendereski A, Micic D and Popovic V: Hypopituitarism as a late complication of hemorrhagic fever. Endocrine. 26:79–82. 2005.PubMed/NCBI View Article : Google Scholar

72 

Stojanovic M, Pekic S, Cvijovic G, Miljic D, Doknic M, Nikolic-Djurovic M, Micic D, Hrvacevic R, Nesic V and Popovic V: High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome. J Clin Endocrinol Metab. 93:2722–2728. 2008.PubMed/NCBI View Article : Google Scholar

73 

Miettinen MH, Mäkelä SM, Ala-Houhala IO, Huhtala HS, Kööbi T, Vaheri AI, Pasternack AI, Pörsti IH and Mustonen JT: Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis. Kidney Int. 69:2043–2048. 2006.PubMed/NCBI View Article : Google Scholar

74 

Plyusnin A, Hörling J, Kanerva M, Mustonen J, Cheng Y, Partanen J, Vapalahti O, Kukkonen SK, Niemimaa J, Henttonen H, et al: Puumala hantavirus genome in patients with nephropathia epidemica: Correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents. J Clin Microbiol. 35:1090–1096. 1997.PubMed/NCBI View Article : Google Scholar

75 

Evander M, Eriksson I, Pettersson L, Juto P, Ahlm C, Olsson GE, Bucht G and Allard A: Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol. 45:2491–2497. 2007.PubMed/NCBI View Article : Google Scholar

76 

Saksida A, Duh D, Korva M and Avsic-Zupanc T: Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. J Infect Dis. 197:681–685. 2008.PubMed/NCBI View Article : Google Scholar

77 

Xiao R, Yang S, Koster F, Ye C, Stidley C and Hjelle B: Sin Nombre viral RNA load in patients with hantavirus cardiopulmonary syndrome. J Infect Dis. 194:1403–1409. 2006.PubMed/NCBI View Article : Google Scholar

78 

Laslo CL, Bacalbasa N, Ana MAS, Carsote M, Bungau S, Rus M, Bratu OG and Diaconu CC: New oral anticoagulants-possible extension to other indications (Review). Exp Ther Med. 20:2401–2405. 2020.PubMed/NCBI View Article : Google Scholar

79 

Outinen TK, Mäkelä S, Clement J, Paakkala A, Pörsti I and Mustonen J: Community acquired severe acute kidney injury caused by hantavirus-induced hemorrhagic fever with renal syndrome has a favorable outcome. Nephron. 130:182–190. 2015.PubMed/NCBI View Article : Google Scholar

80 

Huggins JW: Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug. Rev Infect Dis. 11 (Suppl 4):S750–S761. 1989.PubMed/NCBI View Article : Google Scholar

81 

Huggins JW, Hsiang CM, Cosgriff TM, Guang MY, Smith JI, Wu ZO, LeDuc JW, Zheng ZM, Meegan JM, Wang QN, et al: Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis. 164:1119–1127. 1991.PubMed/NCBI View Article : Google Scholar

82 

Rusnak JM, Byrne WR, Chung KN, Gibbs PH, Kim TT, Boudreau EF, Cosgriff T, Pittman P, Kim KY, Erlichman MS, et al: Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea. Antiviral Res. 81:68–76. 2009.PubMed/NCBI View Article : Google Scholar

83 

Antonen J, Leppänen I, Tenhunen J, Arvola P, Mäkelä S, Vaheri A and Mustonen J: A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant. Scand J Infect Dis. 45:494–496. 2013.PubMed/NCBI View Article : Google Scholar

84 

Sironen T, Sane J, Lokki ML, Meri S, Andersson LC, Hautala T, Kauma H, Vuorinen S, Rasmuson J, Evander M, et al: Fatal Puumala hantavirus disease: Involvement of complement activation and vascular leakage in the pathobiology. Open Forum Infect Dis. 4(ofx229)2017.PubMed/NCBI View Article : Google Scholar

85 

Tapia M, Mansilla C, Jose TM and Vera M: Hantavirus pulmonary syndrome, clinical experience in diagnosis and treatment. Hospital Coyhaique-Chile. Rev Chil Infect. 17:258–269. 2000.

86 

Vial PA, Valdivieso F, Ferres M, Riquelme R, Rioseco ML, Calvo M, Castillo C, Díaz R, Scholz L, Cuiza A, et al: High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: A double-blind, randomized controlled clinical trial. Clin Infect Dis. 57:943–951. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lupuşoru G, Lupuşoru M, Ailincăi I, Bernea L, Berechet A, Spătaru R and Ismail G: Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review). Exp Ther Med 22: 984, 2021.
APA
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., & Ismail, G. (2021). Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review). Experimental and Therapeutic Medicine, 22, 984. https://doi.org/10.3892/etm.2021.10416
MLA
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., Ismail, G."Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 984.
Chicago
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., Ismail, G."Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 984. https://doi.org/10.3892/etm.2021.10416
Copy and paste a formatted citation
x
Spandidos Publications style
Lupuşoru G, Lupuşoru M, Ailincăi I, Bernea L, Berechet A, Spătaru R and Ismail G: Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review). Exp Ther Med 22: 984, 2021.
APA
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., & Ismail, G. (2021). Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review). Experimental and Therapeutic Medicine, 22, 984. https://doi.org/10.3892/etm.2021.10416
MLA
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., Ismail, G."Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 984.
Chicago
Lupuşoru, G., Lupuşoru, M., Ailincăi, I., Bernea, L., Berechet, A., Spătaru, R., Ismail, G."Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 984. https://doi.org/10.3892/etm.2021.10416
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team