The dynamic changes in the pattern of liver function tests in pregnant obese women

Teodorescu,Cristina Oana Daciana; Șandru,Florica; Charkaoui,Adham; Teodorescu,Andrei; Popa,Amorin Remus; Miron,Andreea-Iuliana

doi:10.3892/etm.2021.10418

The dynamic changes in the pattern of liver function tests in pregnant obese women

Authors:
- Cristina Oana Daciana Teodorescu
- Florica Șandru
- Adham Charkaoui
- Andrei Teodorescu
- Amorin Remus Popa
- Andreea-Iuliana Miron
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Affiliations: Department of Obstetrics and Gynecology, ‘Polizu’ Clinical Hospital, 011061 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800008 Galati, Romania, Department of Morphology, University of Medicine and Pharmacy, 410028 Oradea, Romania, Department of Diabetes, Nutrition, Metabolic and Internal Diseases, University of Medicine and Pharmacy, 410033 Oradea, Romania
Published online on: July 13, 2021 https://doi.org/10.3892/etm.2021.10418
Article Number: 986

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Abstract

Obesity is an important problem in healthcare regarding gestating women. The objective of the present study was to highlight the impact that obesity has on the hepatic function in pregnant women by comparing the functional tests used in current practice. In addition, the aim was to identify possible predictors of liver damage by analyzing specific anthropometric data. The present study was descriptive, observational, retrospective, and based on the observation sheets found in the database of the Institute for the Health of the Mother and Child, the Obstetrics Gynecology Department of Polizu Hospital. Patients who presented for consultation in each trimester of pregnancy were included in the study. Demographic data taken into account included age, body mass index (BMI), provenance environment, anthropometric data: Abdominal circumference and the complete set of paraclinical data from which we extracted these specific liver tests: Aspartate aminotransferase (AST), alanine transferase (ALT), direct bilirubin (BD), serum albumin and gamma‑glutamyl transferase (GGT). The present study included 157 patients divided into two groups, distributed as follows: Group A: 66 obese pregnant women (BMI >25 kg/m²) and group B: 91 patients with normal weight (BMI <25 kg/m²). Measurement of serum ALT and AST were the most useful tests for routine diagnosis of liver disease. The effects of pregnancy on serum levels of ALT and AST are controversial. In some studies, there was a slight increase in ALT and AST during the second and third trimesters, a fact confirmed by our study, albeit the result was not statistically significant Most published studies claim that serum ALT and AST levels do not change during pregnancy. In conclusion, obesity during pregnancy does not drastically influence liver function. However, patients with greater abdominal circumference are prone to developing minor hepatic cytolysis syndrome during the gestation period. The liver functional tests described in the aforementioned groups agree with the results provided by the specialized studies.

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