Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review

  • Authors:
    • Oana Viola Badulescu
    • Paul Dan Sirbu
    • Carmen Ungureanu
    • Alin Pȋnzariu
    • Elena Cojocaru
    • Nina Filip
    • Iris Bararu‑Bojan
    • Maria Vladeanu
    • Manuela Ciocoiu
  • View Affiliations

  • Published online on: July 14, 2021     https://doi.org/10.3892/etm.2021.10427
  • Article Number: 995
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Abstract

Hemophilia is a hereditary coagulopathy caused by factor VIII (hemophilia type A) or by coagulation factor IX (hemophilia type B) dysfunction, characterized by an increased bleeding predisposition, which is either spontaneous or secondary to minimal trauma. Currently, hemophilia may also be considered an ‘orthopedic’ condition, due to the fact that it affects the musculoskeletal system of most hemophilic patients. In recent years, constant prophylaxis using coagulation factors has led to a significant improvement in the hemophilic patient's quality of life, by reducing both life‑threatening hemorrhagic phenomena, as well as the occurrence of chronic complications. Nevertheless, progressive joint bleeding remains unavoidable in this category of patients, and the onset of chronic arthropathy with secondary motor deficiency remains the main complication with an invalidating character. In such cases, orthopedic management is imperative; osteoarticular complications being managed most often with the help of conservative or surgical techniques. The purpose of this review is to provide an overview of modern orthopedic practices which are useful in the management of hemophilic patients suffering from osteoarticular disorders.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Badulescu OV, Sirbu PD, Ungureanu C, Pȋnzariu A, Cojocaru E, Filip N, Bararu‑Bojan I, Vladeanu M and Ciocoiu M: Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review. Exp Ther Med 22: 995, 2021.
APA
Badulescu, O.V., Sirbu, P.D., Ungureanu, C., Pȋnzariu, A., Cojocaru, E., Filip, N. ... Ciocoiu, M. (2021). Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review. Experimental and Therapeutic Medicine, 22, 995. https://doi.org/10.3892/etm.2021.10427
MLA
Badulescu, O. V., Sirbu, P. D., Ungureanu, C., Pȋnzariu, A., Cojocaru, E., Filip, N., Bararu‑Bojan, I., Vladeanu, M., Ciocoiu, M."Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review". Experimental and Therapeutic Medicine 22.3 (2021): 995.
Chicago
Badulescu, O. V., Sirbu, P. D., Ungureanu, C., Pȋnzariu, A., Cojocaru, E., Filip, N., Bararu‑Bojan, I., Vladeanu, M., Ciocoiu, M."Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review". Experimental and Therapeutic Medicine 22, no. 3 (2021): 995. https://doi.org/10.3892/etm.2021.10427