Open Access

Current advances in metabolomic studies on non‑motor psychiatric manifestations of Parkinson's disease (Review)

  • Authors:
    • Adela Magdalena Ciobanu
    • Ioana Ionita
    • Mihaela Buleandra
    • Iulia Gabriela David
    • Dana Elena Popa
    • Anton Alexandru Ciucu
    • Magdalena Budisteanu
  • View Affiliations

  • Published online on: July 15, 2021     https://doi.org/10.3892/etm.2021.10443
  • Article Number: 1010
  • Copyright: © Ciobanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Life expectancy has increased worldwide and, along with it, a greater prevalence of age‑dependent disorders, chronic illnesses and comorbidities can be observed. In 2019, in both Europe and the Americas, dementias ranked 3rd among the top 10 causes of death. Parkinson's disease (PD) is the second most frequent type of neurodegenerative disease. In the last decades, globally, the number of people suffering from PD has more than doubled to over 6 million. Of all the neurological disorders, PD increased with the fastest rate. This troubling trend highlights the stringent need for accurate diagnostic biomarkers, especially in the early stages of the disease and to evaluate treatment response. To gain a broad and complex understanding of the recent advances in the ‘‑omics’ research fields, electronic databases such as PubMed, Google Academic, and Science Direct were searched for publications regarding metabolomic studies on PD to identify specific biomarkers for PD, and especially PD with associated psychiatric symptomatology. Discoveries in the fields of metagenomics, transcriptomics and proteomics, may lead to an improved comprehension of the metabolic pathways involved in disease etiology and progression and contribute to the discovery of novel therapeutic targets for effective treatment options.

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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ciobanu AM, Ionita I, Buleandra M, David IG, Popa DE, Ciucu AA and Budisteanu M: Current advances in metabolomic studies on non‑motor psychiatric manifestations of Parkinson's disease (Review). Exp Ther Med 22: 1010, 2021
APA
Ciobanu, A.M., Ionita, I., Buleandra, M., David, I.G., Popa, D.E., Ciucu, A.A., & Budisteanu, M. (2021). Current advances in metabolomic studies on non‑motor psychiatric manifestations of Parkinson's disease (Review). Experimental and Therapeutic Medicine, 22, 1010. https://doi.org/10.3892/etm.2021.10443
MLA
Ciobanu, A. M., Ionita, I., Buleandra, M., David, I. G., Popa, D. E., Ciucu, A. A., Budisteanu, M."Current advances in metabolomic studies on non‑motor psychiatric manifestations of Parkinson's disease (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 1010.
Chicago
Ciobanu, A. M., Ionita, I., Buleandra, M., David, I. G., Popa, D. E., Ciucu, A. A., Budisteanu, M."Current advances in metabolomic studies on non‑motor psychiatric manifestations of Parkinson's disease (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1010. https://doi.org/10.3892/etm.2021.10443