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Review Open Access

Overview of the pathogenesis of COVID‑19 (Review)

  • Authors:
    • Chao Li
    • Qifang He
    • Hebu Qian
    • Jun Liu
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China, Department of Critical Care Medicine, Suzhou Ninth People's Hospital, The Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu 215001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1011
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    Published online on: July 15, 2021
       https://doi.org/10.3892/etm.2021.10444
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Abstract

At present, the pathogenesis of the novel coronavirus disease 2019 (COVID‑19) has not been fully elucidated. Clinical and experimental findings from studies investigating COVID‑19 have suggested that the immune‑inflammatory response has a crucial role in severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection. The present article aimed to systematically review the available literature on the pathogenesis of COVID‑19. Severe COVID‑19 is characterized by organ dysfunction, hypercytokinemia and lymphopenia. It is assumed that the direct cytopathological damage of host cells and the dysregulated immune response caused by SARS‑CoV‑2 may be the primary underlying mechanisms of COVID‑19. Based on the published literature, this review attempts to provide an integrated view of the immunological mechanisms and the potential pathogenesis of COVID‑19, providing an in‑depth summary of the host‑pathogen interaction and host immune responses. It is of great importance to elucidate the possible pathogenesis of COVID‑19 to determine the direction of future research.
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Spandidos Publications style
Li C, He Q, Qian H and Liu J: Overview of the pathogenesis of COVID‑19 (Review). Exp Ther Med 22: 1011, 2021.
APA
Li, C., He, Q., Qian, H., & Liu, J. (2021). Overview of the pathogenesis of COVID‑19 (Review). Experimental and Therapeutic Medicine, 22, 1011. https://doi.org/10.3892/etm.2021.10444
MLA
Li, C., He, Q., Qian, H., Liu, J."Overview of the pathogenesis of COVID‑19 (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 1011.
Chicago
Li, C., He, Q., Qian, H., Liu, J."Overview of the pathogenesis of COVID‑19 (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1011. https://doi.org/10.3892/etm.2021.10444
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, He Q, Qian H and Liu J: Overview of the pathogenesis of COVID‑19 (Review). Exp Ther Med 22: 1011, 2021.
APA
Li, C., He, Q., Qian, H., & Liu, J. (2021). Overview of the pathogenesis of COVID‑19 (Review). Experimental and Therapeutic Medicine, 22, 1011. https://doi.org/10.3892/etm.2021.10444
MLA
Li, C., He, Q., Qian, H., Liu, J."Overview of the pathogenesis of COVID‑19 (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 1011.
Chicago
Li, C., He, Q., Qian, H., Liu, J."Overview of the pathogenesis of COVID‑19 (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1011. https://doi.org/10.3892/etm.2021.10444
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