Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis

  • Authors:
    • Ying Li
    • Suyu Wang
    • Yihan Xiao
    • Bing Liu
    • Jianliang Pang
  • View Affiliations

  • Published online on: July 15, 2021     https://doi.org/10.3892/etm.2021.10445
  • Article Number: 1013
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Abstract

Patients with diabetes frequently suffer from periodontitis, which progresses rapidly and is difficult to cure. Mesenchymal stem cell (MSC) transplantation may effectively treat periodontitis, but high glucose limits its therapeutic effect in diabetes. Nerve growth factor (NGF) has the functions of cell protection, anti‑apoptosis and immune regulation, and may have potential application in diabetic periodontitis. In the present study, flow cytometry indicated that NGF inhibited MSC apoptosis induced by high glucose. Of note, high glucose promoted the transformation of MSCs into the proinflammatory type. NGF inhibited this transformation of MSCs under diabetic conditions and further decreased the proportion of T cells and monocytes/macrophages among lymphocytes. An animal model of diabetic periodontitis was constructed and MSC transplantation was demonstrated to reduce alveolar bone loss caused by diabetes. NGF enhanced the therapeutic effect of MSCs and maintained transplanted MSC survival in periodontal tissue of diabetic mice. Immunohistochemical analysis of periodontal tissues suggested that in the NGF group, infiltration of T cells and macrophages was reduced. Neurotrophic receptor tyrosine kinase 1 was indicated to have a key role in these effects of NGF. In conclusion, NGF may enhance the therapeutic effect of MSCs on diabetic periodontitis by protecting the cells and promoting the transformation of MSCs into the immunosuppressive type.

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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Y, Wang S, Xiao Y, Liu B and Pang J: Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis. Exp Ther Med 22: 1013, 2021
APA
Li, Y., Wang, S., Xiao, Y., Liu, B., & Pang, J. (2021). Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis. Experimental and Therapeutic Medicine, 22, 1013. https://doi.org/10.3892/etm.2021.10445
MLA
Li, Y., Wang, S., Xiao, Y., Liu, B., Pang, J."Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis". Experimental and Therapeutic Medicine 22.3 (2021): 1013.
Chicago
Li, Y., Wang, S., Xiao, Y., Liu, B., Pang, J."Nerve growth factor enhances the therapeutic effect of mesenchymal stem cells on diabetic periodontitis". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1013. https://doi.org/10.3892/etm.2021.10445