Differential expression of long non‑coding RNAs SRA, HCG22 and MHRT in children with Kawasaki disease

  • Authors:
    • Qianqin Zhou
    • Jiayi Chen
    • Danyang Wu
    • Haiyian Yan
    • Fang Liu
    • Yang Xi
    • Fuyan Wang
    • Junhua Wu
    • Haiyan Qiu
    • Shizhong Bu
  • View Affiliations

  • Published online on: July 15, 2021     https://doi.org/10.3892/etm.2021.10454
  • Article Number: 1022
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Abstract

Kawasaki disease (KD) is an acute, self‑limited inflammatory illness during childhood that may lead to thrombosis in the coronary arteries (CA). The major aims of the present study were to estimate the serum levels of long non‑coding RNAs (lncRNAs) and the metabolic profiles of patients with KD. A total of 40 specimens were obtained from pediatric patients (40 specimens before and 40 specimens after treatment) who were diagnosed with KD (n=40). The controls comprised healthy children without KD (n=40). The serum levels of lncRNAs steroid receptor RNA activator (SRA), human leukocyte antigen complex group 22 (HCG22) and myosin heavy chain‑associated RNA transcript (MHRT) were determined using reverse transcription‑quantitative PCR. Subsequently, the correlation between the expression levels of lncRNAs and biochemical parameters of patients was assessed. Receiver operating characteristic curves were constructed to determine the diagnostic value of the lncRNAs. The results indicated that the serum levels of lncRNAs SRA and HCG22 were higher in patients with acute KD compared with those in healthy controls. B‑type natriuretic peptide (BNP) and C‑reactive protein were positively correlated with HCG22 in patients with acute KD, while total cholesterol and low‑density lipoprotein were negatively correlated with HCG22 in patients with acute KD. The lncRNA MHRT was significantly upregulated in convalescent KD compared with acute KD following intravenous immunoglobulin therapy. In patients with convalescent KD, creatine kinase was positively correlated with MHRT, while BNP and adenosine deaminase were negatively correlated with MHRT. In conclusion, to the best of our knowledge, the present study was the first to identify that the serum levels of lncRNAs SRA and HCG22 in patients with acute KD were higher compared with those in control subjects. MHRT levels in patients with convalescent KD were higher than those in the acute phase. LncRNAs SRA and HCG22 may have crucial roles in KD and are potential novel diagnostic biomarkers for KD. LncRNA MHRT may be considered a novel biomarker for predicting the clinical prognosis of patients with KD.

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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou Q, Chen J, Wu D, Yan H, Liu F, Xi Y, Wang F, Wu J, Qiu H, Bu S, Bu S, et al: Differential expression of long non‑coding RNAs SRA, HCG22 and MHRT in children with Kawasaki disease. Exp Ther Med 22: 1022, 2021
APA
Zhou, Q., Chen, J., Wu, D., Yan, H., Liu, F., Xi, Y. ... Bu, S. (2021). Differential expression of long non‑coding RNAs SRA, HCG22 and MHRT in children with Kawasaki disease. Experimental and Therapeutic Medicine, 22, 1022. https://doi.org/10.3892/etm.2021.10454
MLA
Zhou, Q., Chen, J., Wu, D., Yan, H., Liu, F., Xi, Y., Wang, F., Wu, J., Qiu, H., Bu, S."Differential expression of long non‑coding RNAs SRA, HCG22 and MHRT in children with Kawasaki disease". Experimental and Therapeutic Medicine 22.3 (2021): 1022.
Chicago
Zhou, Q., Chen, J., Wu, D., Yan, H., Liu, F., Xi, Y., Wang, F., Wu, J., Qiu, H., Bu, S."Differential expression of long non‑coding RNAs SRA, HCG22 and MHRT in children with Kawasaki disease". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1022. https://doi.org/10.3892/etm.2021.10454