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Case Report Open Access

Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report

  • Authors:
    • Cristina Marinela Oprean
    • Nusa Alina Segarceanu
    • Alexandra Stan
    • Cristian Silviu Suciu
    • Daciana Grujic
    • Ioana Alexandra Rivis
    • Alis Liliana Carmen Dema
    • Ana Cristina Bredicean
  • View Affiliations / Copyright

    Affiliations: Discipline of Morpho‑Pathology, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, Department of Oncology, OncoHelp Hospital, 300239 Timisoara, Romania, Department of Oncology, Emergency City Hospital, 300254 Timisoara, Romania, Discipline of Histology, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, Department of Plastic and Reconstructive Surgery, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, Neurosciences Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, ANAPATMOL Research Center, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, NEUROPSY‑COG Center for Cognitive Research in Neuropsychiatric Pathology, Neurosciences Department, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania
    Copyright: © Oprean et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1026
    |
    Published online on: July 16, 2021
       https://doi.org/10.3892/etm.2021.10458
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Abstract

Abstract. Nasopharyngeal carcinoma (NPC) is a rare form of malignancy, accounting for 2% of all cancers of the head and neck in Europe. Axillary lymph node metastases are very rare in these cases. This is a case report of a 40‑year‑old premenopausal woman diagnosed in May 2015 with T1N2M0 stage III NPC, treated with induction chemotherapy, followed by chemo‑radiotherapy. Post‑therapeutic computed tomography (CT) scan showed partial response (PR) on the primary tumor and complete response (CR) on the latero‑cervical lymph nodes. In 2017, our patient developed left carcinomatous‑like mastitis with axillary lymphadenopathy. This raised suspicions of a carcinomatous mastitis. The pathology report with immunohistochemistry (IHC) of the third biopsy highlighted axillary metastasis of a non‑keratinizing squamous cell carcinoma (NSCC). There are very few references in the literature regarding axillary metastases from squamous cell carcinoma of the head and neck (HNSCC). As far as we know, this is the first case report of mastitis due to NPC. To conclude, treatment consisted of two surgical excisions of axillary lymphadenopathy associated with local radiotherapy and chemotherapy (neo‑adjuvant, adjuvant). The second surgery, performed after radiotherapy, required plastic surgery. A psychiatric evaluation was necessary, revealing a reactive anxiety disorder. This case required multidisciplinary management, where oncology, plastic surgery, pathology and psychiatric specialists collaborated in deciding the therapeutic approach.
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View References

1 

Kuo DY, Chang MH, Wang SY, Hsieh PY and Shueng PW: Unusual axillary metastasis of recurrent nasopharyngeal cancer: A case report. Medicine (Baltimore). 96(e6854)2017.PubMed/NCBI View Article : Google Scholar

2 

Mahdavifar N, Ghoncheh M, Mohammadian-Hafshejani A, Khosravi B and Salehiniya H: Epidemiology and inequality in the incidence and mortality of nasopharynx cancer in Asia. Osong Public Health Res Perspect. 7:360–372. 2016.PubMed/NCBI View Article : Google Scholar

3 

Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, et al: Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up †. Ann Oncol. 32:452–465. 2021.PubMed/NCBI View Article : Google Scholar

4 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005.PubMed/NCBI View Article : Google Scholar

5 

Chang ET and Adami HO: The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15:1765–1777. 2006.PubMed/NCBI View Article : Google Scholar

6 

Zhou X, Cui J, Macias V, Kajdacsy-Balla AA, Ye H, Wang J and Rao PN: The progress on genetic analysis of nasopharyngeal carcinoma. Comp Funct Genomics. 2007(57513)2007.PubMed/NCBI View Article : Google Scholar

7 

Fernandes Q, Merhi M, Raza A, Inchakalody VP, Abdelouahab N, Zar Gul AR, Uddin S and Dermime S: Role of Epstein-Barr virus in the pathogenesis of head and neck cancers and its potential as an immunotherapeutic target. Front Oncol. 8(257)2018.PubMed/NCBI View Article : Google Scholar

8 

Pezzuto F, Buonaguro L, Caponigro F, Ionna F, Starita N, Annunziata C, Buonaguro FM and Tornesello ML: Update on head and neck cancer: Current knowledge on epidemiology, risk factors, molecular features and novel therapies. Oncology. 89:125–136. 2015.PubMed/NCBI View Article : Google Scholar

9 

Sturgis EM, Wei Q and Spitz MR: Descriptive epidemiology and risk factors for head and neck cancer. Semin Oncol. 31:726–733. 2004.PubMed/NCBI View Article : Google Scholar

10 

Nelson WR and Sisk M: Axillary metastases from carcinoma of the larynx: A 25-year survival. Head Neck. 16:83–87. 1994.PubMed/NCBI View Article : Google Scholar

11 

McKenzie BJ and Loock JW: Axillary nodal metastasis at primary presentation of an oropharyngeal primary carcinoma: A case report and review of the literature. J Med Case Rep. 3(7230)2009.PubMed/NCBI View Article : Google Scholar

12 

Rayatt SS, Dancey AL, Fagan J and Srivastava S: Axillary metastases from recurrent oral carcinoma. Br J Oral Maxillofac Surg. 42:264–266. 2004.PubMed/NCBI View Article : Google Scholar

13 

Ho FC, Tham IW, Earnest A, Lee KM and Lu JJ: Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence. BMC Cancer. 12(98)2012.PubMed/NCBI View Article : Google Scholar

14 

Brennan B: Nasopharyngeal carcinoma. Orphanet J Rare Dis. 1(23)2006.PubMed/NCBI View Article : Google Scholar

15 

Dangore-Khasbage S: Local metastasis in head and neck cancer-an overview. Contemporary Issues in Head and Neck Cancer Management. IntechOpen, pp152-167, 2015. https://doi.org/10.5772/60072. Accessed 8th July, 2015.

16 

Alavi S, Namazie A, Sercarz JA, Wang MB and Blackwell KE: Distant lymphatic metastasis from head and neck cancer. Ann Otol Rhinol Laryngol. 108:860–863. 1999.PubMed/NCBI View Article : Google Scholar

17 

Chen MY, Jiang R, Guo L, Zou X, Liu Q, Sun R, Qiu F, Xia ZJ, Huang HQ, Zhang L, et al: Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer. 32:604–613. 2013.PubMed/NCBI View Article : Google Scholar

18 

Tomao F, Miele E, Spinelli GP, Caprio G, Ranieri E, Mingazzini P, Zullo A and Tomao S: Axillary and subcutaneous breast metastases from rhinopharyngeal carcinoma: A case report and literature review. Anticancer Res. 28:419–424. 2008.PubMed/NCBI

19 

Chan AT, Teo PM and Johnson PJ: Nasopharyngeal carcinoma. Ann Oncol. 13:1007–1015. 2002.PubMed/NCBI View Article : Google Scholar

20 

Ahmad A and Stefani S: Distant metastases of nasopharyngeal carcinoma: A study of 256 male patients. J Surg Oncol. 33:194–197. 1986.PubMed/NCBI View Article : Google Scholar

21 

Koch WM: Axillary nodal metastases in head and neck cancer. Head Neck. 21:269–272. 1999.PubMed/NCBI View Article : Google Scholar

22 

Wormald R, Sheahan P and Timon C: A case of head and neck cancer metastasizing to the axillary lymph nodes. Ear Nose Throat J. 89:E24–E26. 2010.PubMed/NCBI View Article : Google Scholar

23 

Islam S, Cole CV, Hoffman GR and Brennan PA: Bilateral axillary metastasis from a primary ethmoidal squamous cell carcinoma. J Laryngol Otol. 120:353–355. 2006.PubMed/NCBI View Article : Google Scholar

24 

Kowalski LP: Noncervical lymph node metastasis from head and neck cancer. ORL J Otorhinolaryngol Relat Spec. 63:252–255. 2001.PubMed/NCBI View Article : Google Scholar

25 

Oo AL, Yamaguchi S, Iwaki H and Amagasa T: Axillary nodal metastasis from oral and maxillofacial cancers: A report of 3 cases. J Oral Maxillofac Surg. 62:1019–1024. 2004.PubMed/NCBI View Article : Google Scholar

26 

Koker MM and Kleer CG: p63 expression in breast cancer: A highly sensitive and specific marker of metaplastic carcinoma. Am J Surg Pathol. 28:1506–1512. 2004.PubMed/NCBI View Article : Google Scholar

27 

Wargotz ES and Norris HJ: Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin. Cancer. 65:272–276. 1990.PubMed/NCBI View Article : Google Scholar

28 

Fukusumi T and Califano JA: The notch pathway in head and neck squamous cell carcinoma. J Dent Res. 97:645–653. 2018.PubMed/NCBI View Article : Google Scholar

29 

El-Naggar AK, Chan JKC, Grandis JR, Takata T and Slootweg PJ (eds): WHO Classification of Head and Neck Tumours. Vol. 9. 4th edition. International Agency for Research on Cancer. IARC, Lyon, 2017.

30 

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, et al: Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 333:1154–1157. 2011.PubMed/NCBI View Article : Google Scholar

31 

Solomon I, Voiculescu V, Caruntu C, Lupu M, Popa A, Ilie M, Albulescu R, Caruntu A, Tanase C, Constantin C, et al: Neuroendocrine factors and head and neck squamous cell carcinoma: An affair to remember. Dis Markers. 2018(9787831)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Oprean CM, Segarceanu NA, Stan A, Suciu CS, Grujic D, Rivis IA, Dema AC and Bredicean AC: Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. Exp Ther Med 22: 1026, 2021.
APA
Oprean, C.M., Segarceanu, N.A., Stan, A., Suciu, C.S., Grujic, D., Rivis, I.A. ... Bredicean, A.C. (2021). Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. Experimental and Therapeutic Medicine, 22, 1026. https://doi.org/10.3892/etm.2021.10458
MLA
Oprean, C. M., Segarceanu, N. A., Stan, A., Suciu, C. S., Grujic, D., Rivis, I. A., Dema, A. C., Bredicean, A. C."Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report". Experimental and Therapeutic Medicine 22.3 (2021): 1026.
Chicago
Oprean, C. M., Segarceanu, N. A., Stan, A., Suciu, C. S., Grujic, D., Rivis, I. A., Dema, A. C., Bredicean, A. C."Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1026. https://doi.org/10.3892/etm.2021.10458
Copy and paste a formatted citation
x
Spandidos Publications style
Oprean CM, Segarceanu NA, Stan A, Suciu CS, Grujic D, Rivis IA, Dema AC and Bredicean AC: Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. Exp Ther Med 22: 1026, 2021.
APA
Oprean, C.M., Segarceanu, N.A., Stan, A., Suciu, C.S., Grujic, D., Rivis, I.A. ... Bredicean, A.C. (2021). Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report. Experimental and Therapeutic Medicine, 22, 1026. https://doi.org/10.3892/etm.2021.10458
MLA
Oprean, C. M., Segarceanu, N. A., Stan, A., Suciu, C. S., Grujic, D., Rivis, I. A., Dema, A. C., Bredicean, A. C."Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report". Experimental and Therapeutic Medicine 22.3 (2021): 1026.
Chicago
Oprean, C. M., Segarceanu, N. A., Stan, A., Suciu, C. S., Grujic, D., Rivis, I. A., Dema, A. C., Bredicean, A. C."Carcinomatous‑like mastitis due to axillary lymphadenopathy in a case of nasopharyngeal carcinoma: A case report". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1026. https://doi.org/10.3892/etm.2021.10458
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