Open Access

Therapeutic hypothermia effect on asphyxial cardiac arrest‑induced renal ischemia/reperfusion injury via change of Nrf2/HO‑1 levels

  • Authors:
    • Ali Jawad
    • Yeo-Jin Yoo
    • Jeong-Hwi Cho
    • Jae Chol Yoon
    • Weishun Tian
    • Mohammad Sadikul Islam
    • Eui-Yong Lee
    • Ha-Young Shin
    • So Eun Kim
    • Kyunghwa Kim
    • Dongchoon Ahn
    • Byung-Yong Park
    • In-Shik Kim
    • Jun Ho Lee
    • Hyun-Jin Tae
  • View Affiliations

  • Published online on: July 18, 2021     https://doi.org/10.3892/etm.2021.10463
  • Article Number: 1031
  • Copyright: © Jawad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the renoprotective effect of therapeutic hypothermia (TH) on renal ischemia‑reperfusion injury (RI/RI) induced by asphyxial cardiac arrest (CA) in rats. A total of 48 male rats were randomly divided into five groups: i) Sham (n=6); ii) Normothermia + CA (Normo.) (n=14); iii) Normo. and 2 h of TH after return of spontaneous circulation (ROSC) (n=12); iv) Normo. and 4 h of TH after ROSC (n=9); and v) Normo. and 6 h of TH after ROSC (n=7). All rats except the Sham group underwent asphyxia CA and were sacrificed 1 day after ROSC. The survival rate increased from 42.8% in the Normo. group to 50, 66.6 and 85.7% in the groups with 2, 4 and 6 h of TH after CA, respectively. TH attenuated the histopathological changes of the renal tissues following ROSC and the levels of blood urea nitrogen, serum creatinine and malondialdehyde in renal tissues. On immunohistochemistry, the relative optical density of nuclear erythroid‑related factor‑2 (Nrf2) and heme oxygenase (HO‑1) expression in renal tissues increased in the Normo. group compared with that in the Sham group and exhibited further significant increases at 6 h of TH after ROSC. In conclusion, TH attenuated renal injury and increased the expression of Nrf2 and HO‑1 in a TH treatment time‑dependent manner.

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September-2021
Volume 22 Issue 3

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Spandidos Publications style
Jawad A, Yoo Y, Cho J, Yoon JC, Tian W, Islam MS, Lee E, Shin H, Kim SE, Kim K, Kim K, et al: Therapeutic hypothermia effect on asphyxial cardiac arrest‑induced renal ischemia/reperfusion injury via change of Nrf2/HO‑1 levels. Exp Ther Med 22: 1031, 2021
APA
Jawad, A., Yoo, Y., Cho, J., Yoon, J.C., Tian, W., Islam, M.S. ... Tae, H. (2021). Therapeutic hypothermia effect on asphyxial cardiac arrest‑induced renal ischemia/reperfusion injury via change of Nrf2/HO‑1 levels. Experimental and Therapeutic Medicine, 22, 1031. https://doi.org/10.3892/etm.2021.10463
MLA
Jawad, A., Yoo, Y., Cho, J., Yoon, J. C., Tian, W., Islam, M. S., Lee, E., Shin, H., Kim, S. E., Kim, K., Ahn, D., Park, B., Kim, I., Lee, J. H., Tae, H."Therapeutic hypothermia effect on asphyxial cardiac arrest‑induced renal ischemia/reperfusion injury via change of Nrf2/HO‑1 levels". Experimental and Therapeutic Medicine 22.3 (2021): 1031.
Chicago
Jawad, A., Yoo, Y., Cho, J., Yoon, J. C., Tian, W., Islam, M. S., Lee, E., Shin, H., Kim, S. E., Kim, K., Ahn, D., Park, B., Kim, I., Lee, J. H., Tae, H."Therapeutic hypothermia effect on asphyxial cardiac arrest‑induced renal ischemia/reperfusion injury via change of Nrf2/HO‑1 levels". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1031. https://doi.org/10.3892/etm.2021.10463