Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

  • Authors:
    • Roxana Adriana Stoica
    • Robert Ancuceanu
    • Adrian Costache
    • Simona Diana Ștefan
    • Anca Pantea Stoian
    • Cristian Guja
    • Raluca Ioana Stefan‑Van Staden
    • Ioana Popa‑Tudor
    • Cristian Serafinceanu
    • Constantin Ionescu‑Tîrgoviște
  • View Affiliations

  • Published online on: July 19, 2021     https://doi.org/10.3892/etm.2021.10465
  • Article Number: 1033
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Abstract

Longitudinal studies have indicated an association between thyroid function and insulin resistance (IR) or a neutral relationship. Both the lowest tertile of free thyroxine (fT4) and the highest tertile of free triiodothyronine (fT3) were found to be associated with IR in cross‑sectional studies. The aim of the present study was to analyze the association between IR and subclinical hypothyroidism in a female adult population from Bucharest, Romania. This is a retrospective pilot case‑control study that included female patients examined by two endocrinologists and a diabetologist in an outpatient clinic. The retrospective follow‑up had a one‑year duration and included the evaluation of thyroid function tests and IR indices based on fasting insulinemia and C‑peptide. The study included 176 women, 91 with subclinical hypothyroidism, with a median age of 60±17 years and a mean body mass index (BMI) of 27.79±4.76 kg/m2. The majority of the population (50%) was diagnosed with autoimmune thyroiditis, and 17.05% with goitre. The univariate logistic regression using hypothyroidism as the explaining variable found no evidence of a significant relationship between a decreased thyroid function and IR (OR 1.32; P=0.36). Metabolic syndrome was probably the most important determinant of IR in the population group studied. Thus, it was not the thyroid function per se, but the coexistence of other elements of this syndrome that prevailed in determining IR. Advantages to the study are the design that permitted evaluation of IR and the thyroid function at different moments in time as well as the uniformity of the blood tests. The multivariate analyses were adjusted for age, lipid profile and treatment; however, one limiting factor was the absence of other hormonal blood tests. In summary, there was no association between the thyroid function tests (TSH, fT4) and IR indices in adult Romanian women in a case‑control study with one‑year retrospective follow‑up.

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September-2021
Volume 22 Issue 3

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Spandidos Publications style
Stoica RA, Ancuceanu R, Costache A, Ștefan SD, Stoian AP, Guja C, Staden RI, Popa‑Tudor I, Serafinceanu C, Ionescu‑Tîrgoviște C, Ionescu‑Tîrgoviște C, et al: Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Exp Ther Med 22: 1033, 2021
APA
Stoica, R.A., Ancuceanu, R., Costache, A., Ștefan, S.D., Stoian, A.P., Guja, C. ... Ionescu‑Tîrgoviște, C. (2021). Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Experimental and Therapeutic Medicine, 22, 1033. https://doi.org/10.3892/etm.2021.10465
MLA
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22.3 (2021): 1033.
Chicago
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1033. https://doi.org/10.3892/etm.2021.10465