Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

  • Authors:
    • Roxana Adriana Stoica
    • Robert Ancuceanu
    • Adrian Costache
    • Simona Diana Ștefan
    • Anca Pantea Stoian
    • Cristian Guja
    • Raluca Ioana Stefan‑Van Staden
    • Ioana Popa‑Tudor
    • Cristian Serafinceanu
    • Constantin Ionescu‑Tîrgoviște
  • View Affiliations / Copyright

    Affiliations: Department of Diabetes, Nutrition and Metabolic Diseases, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Botanical Pharmaceutics, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania
  • Article Number: 1033
    |
    Published online on: July 19, 2021
       https://doi.org/10.3892/etm.2021.10465
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Longitudinal studies have indicated an association between thyroid function and insulin resistance (IR) or a neutral relationship. Both the lowest tertile of free thyroxine (fT4) and the highest tertile of free triiodothyronine (fT3) were found to be associated with IR in cross‑sectional studies. The aim of the present study was to analyze the association between IR and subclinical hypothyroidism in a female adult population from Bucharest, Romania. This is a retrospective pilot case‑control study that included female patients examined by two endocrinologists and a diabetologist in an outpatient clinic. The retrospective follow‑up had a one‑year duration and included the evaluation of thyroid function tests and IR indices based on fasting insulinemia and C‑peptide. The study included 176 women, 91 with subclinical hypothyroidism, with a median age of 60±17 years and a mean body mass index (BMI) of 27.79±4.76 kg/m2. The majority of the population (50%) was diagnosed with autoimmune thyroiditis, and 17.05% with goitre. The univariate logistic regression using hypothyroidism as the explaining variable found no evidence of a significant relationship between a decreased thyroid function and IR (OR 1.32; P=0.36). Metabolic syndrome was probably the most important determinant of IR in the population group studied. Thus, it was not the thyroid function per se, but the coexistence of other elements of this syndrome that prevailed in determining IR. Advantages to the study are the design that permitted evaluation of IR and the thyroid function at different moments in time as well as the uniformity of the blood tests. The multivariate analyses were adjusted for age, lipid profile and treatment; however, one limiting factor was the absence of other hormonal blood tests. In summary, there was no association between the thyroid function tests (TSH, fT4) and IR indices in adult Romanian women in a case‑control study with one‑year retrospective follow‑up.
View Figures

Figure 1

Figure 2

View References

1 

Schwartsburd P: Insulin resistance is a two-sided mechanism acting under opposite catabolic and anabolic conditions. Med Hypotheses. 89:8–10. 2016.PubMed/NCBI View Article : Google Scholar

2 

Yazıcı D and Sezer H: Insulin resistance, obesity and lipotoxicity. Adv Exp Med Biol. 960:277–304. 2017.PubMed/NCBI View Article : Google Scholar

3 

Suceveanu AI, Mazilu L, Katsiki N, Parepa I, Voinea F, Pantea-Stoian A, Rizzo M, Botea F, Herlea V, Serban D and Suceveanu AP: NLRP3 inflammasome biomarker-could be the new tool for improved cardiometabolic syndrome outcome. Metabolites. 10(448)2020.PubMed/NCBI View Article : Google Scholar

4 

Di Sebastiano KM, Pinthus JH, Duivenvoorden WCM and Mourtzakis M: Glucose impairments and insulin resistance in prostate cancer: The role of obesity, nutrition and exercise. Obes Rev. 19:1008–1016. 2018.PubMed/NCBI View Article : Google Scholar

5 

Pu D, Tan R, Yu Q and Wu J: Metabolic syndrome in menopause and associated factors: A meta-analysis. Climacteric. 20:583–591. 2017.PubMed/NCBI View Article : Google Scholar

6 

Abdul-Ghani MA and DeFronzo RA: Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol. 2010(476279)2010.PubMed/NCBI View Article : Google Scholar

7 

Popa S, Mota M, Popa A, Mota E, Timar R, Serafinceanu C, Cheta D, Graur M and Hancu N: Prevalence of dyslipidemia and its association with cardiometabolic factors and kidney function in the adult Romanian population: The PREDATORR study. Diabetes Metab Syndr. 13:596–602. 2019.PubMed/NCBI View Article : Google Scholar

8 

Roos A, Bakker SJ, Links TP, Gans RO and Wolffenbuttel BH: Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. J Clin Endocrinol Metab. 92:491–496. 2007.PubMed/NCBI View Article : Google Scholar

9 

Ferrannini E, Iervasi G, Cobb J, Ndreu R and Nannipieri M: Insulin resistance and normal thyroid hormone levels: Prospective study and metabolomic analysis. Am J Physiol Endocrinol Metab. 312:E429–E436. 2017.PubMed/NCBI View Article : Google Scholar

10 

Rochon C, Tauveron I, Dejax C, Benoit P, Capitan P, Fabricio A, Berry C, Champredon C, Thieblot P and Grizard J: Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism. Clin Sci (Lond). 104:7–15. 2003.PubMed/NCBI

11 

Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, Mitrou P, Lambadiari V, Boutati E, Nikzas D, et al: Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 160:785–790. 2009.PubMed/NCBI View Article : Google Scholar

12 

Dimitriadis G, Mitrou P, Lambadiari V, Boutati E, Maratou E, Panagiotakos DB, Koukkou E, Tzanela M, Thalassinos N and Raptis SA: Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol and Metab. 91:4930–4937. 2006.PubMed/NCBI View Article : Google Scholar

13 

Havekes B and Sauerwein HP: Adipocyte-myocyte crosstalk in skeletal muscle insulin resistance; is there a role for thyroid hormone? Curr Opin Clin Nutr Metab Care. 13:641–646. 2010.PubMed/NCBI View Article : Google Scholar

14 

Pearce EN: Hypothyroidism and dyslipidemia: Modern concepts and approaches. Curr Cardiol Rep. 6:451–456. 2004.PubMed/NCBI View Article : Google Scholar

15 

Pandrc MS, Ristić A, Kostovski V, Stanković M, Antić V, Milin-Lazović J and Ćirić J: The effect of early substitution of subclinical hypothyroidism on biochemical blood parameters and the quality of life. J Med Biochem. 36:127–136. 2017.PubMed/NCBI View Article : Google Scholar

16 

Răcătăianu N, Bolboacă SD, Sitar-Tăut AV, Mârza S, Moga D, Valea A and Ghervan C: The effect of Metformin treatment in obese insulin-resistant patients with euthyroid goiter. Acta Clin Belg. 73:317–323. 2018.PubMed/NCBI View Article : Google Scholar

17 

Owecki M, Nikisch E and Sowiński J: Hypothyroidism has no impact on insulin sensitivity assessed with HOMA-IR in totally thyroidectomized patients. Acta Clin Belg. 61:69–73. 2006.PubMed/NCBI View Article : Google Scholar

18 

Brenta G, Berg G, Arias P, Zago V, Schnitman M, Muzzio ML, Sinay I and Schreier L: Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: Response to L-T(4) treatment. Thyroid. 17:453–460. 2007.PubMed/NCBI View Article : Google Scholar

19 

Khan HA, Sobki SH, Ekhzaimy A, Khan I and Almusawi MA: Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi J Biol Sci. 25:1729–1732. 2018.PubMed/NCBI View Article : Google Scholar

20 

Diabetes Trials Unit, The Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford. https://www.dtu.ox.ac.uk/ToolsSoftware/. Accessed Nov 28, 2020.

21 

Hennessey JV and Espaillat R: Subclinical hypothyroidism: A historical view and shifting prevalence. Int J Clin Pract. 69:771–782. 2015.PubMed/NCBI View Article : Google Scholar

22 

Stoica RA, Guja C, Pantea-Stoian A, Staden RIȘ, Popa-Tudor I, Ștefan SD, Ancuceanu R, Serafinceanu C and Ionescu Tîrgoviște C: No Association between 25-Hydroxyvitamin D and insulin resistance or thyroid hormone concentrations in a Romanian observational study. Medicina (Kaunas). 57(25)2020.PubMed/NCBI View Article : Google Scholar

23 

Mitchell HG: Sample size logistic case control: Sample Size Calculations for Case-Control Studies. R package version 0.0.6., 2017. https://CRAN.R-project.org/package=samplesizelogisticcasecontro. Accessed Feb 19, 2021.

24 

Dardis C: LogisticDx: Diagnostic Tests for Models with a Binomial Response. R package version 0.2., 2015. https://CRAN.R-project.org/package=LogisticDx. Accessed Feb 19, 2021.

25 

Solt F and Hu Y: interplot: Plot the effects of variables in interaction terms. R package version 0.2.3., 2021. https://CRAN.R-project.org/package=interplot. Accessed Feb 19, 2021.

26 

Vyakaranam S, Vanaparthy S, Nori S, Palarapu S and Bhongir AV: Study of insulin resistance in subclinical hypothyroidism. Int J Health Sci Res. 4:147–153. 2014.PubMed/NCBI

27 

Al Sayed A, Al Ali N, Bo Abbas Y and Alfadhli E: Subclinical hypothyroidism is associated with insulin resistance in Kuwaiti women. Endocr J. 53:653–657. 2006.PubMed/NCBI View Article : Google Scholar

28 

Guzel S, Seven A, Guzel EC, Buyuk B, Celebi A and Aydemir B: Visfatin, leptin, and TNF-α: Interrelated adipokines in insulin-resistant clinical and subclinical hypothyroidism. Endocr Res. 38:184–194. 2013.PubMed/NCBI View Article : Google Scholar

29 

Răcătăianu N, Leach N, Bondor CI, Mârza S, Moga D, Valea A and Ghervan C: Thyroid disorders in obese patients. Does insulin resistance make a difference? Arch Endocrinol Metab. 61:575–583. 2017.PubMed/NCBI View Article : Google Scholar

30 

Ahirwar AK, Singh A, Jain A, Patra SK, Goswami B, Bhatnagar MK and Bhattacharjee J: Role of subclinical hypothyroidism in association with adiponectin levels causing insulin resistance in metabolic syndrome: A case control study. Tokai J Exp Clin Med. 42:96–103. 2017.PubMed/NCBI

31 

Ebrahimpour A, Vaghari-Tabari M, Qujeq D, Moein S and Moazezi Z: Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism: Does subclinical hypothyroidism increase the risk of diabetes and cardio vascular disease together? Diabetes Metab Syndr. 12:863–867. 2018.PubMed/NCBI View Article : Google Scholar

32 

Eftekharzadeh A, Khamseh ME, Farshchi A and Malek M: The association between subclinical hypothyroidism and metabolic syndrome as defined by the ATP III criteria. Metab Syndr Relat Disord. 14:137–144. 2016.PubMed/NCBI View Article : Google Scholar

33 

Răcătăianu N, Leach NV, Bolboacă SD, Soran ML, Opriş O, Dronca E, Valea A and Ghervan C: Interplay between metabolic and thyroid parameters in obese pubertal children. Does visceral adipose tissue make the first move? Acta Clin Belg. 76:40–48. 2021.PubMed/NCBI View Article : Google Scholar

34 

Garduño-Garcia Jde J, Camarillo Romero E, Loe Ochoa A, Romero-Figueroa S, Huitron Bravo G, Torres García R, Montenegro-Morales P and Mendieta-Zerón H: Thyroid function is associated with insulin resistance markers in healthy adolescents with risk factors to develop diabetes. Diabetol Metab Syndr. 7(16)2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Stoica RA, Ancuceanu R, Costache A, Ștefan SD, Stoian AP, Guja C, Staden RI, Popa‑Tudor I, Serafinceanu C, Ionescu‑Tîrgoviște C, Ionescu‑Tîrgoviște C, et al: Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Exp Ther Med 22: 1033, 2021.
APA
Stoica, R.A., Ancuceanu, R., Costache, A., Ștefan, S.D., Stoian, A.P., Guja, C. ... Ionescu‑Tîrgoviște, C. (2021). Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Experimental and Therapeutic Medicine, 22, 1033. https://doi.org/10.3892/etm.2021.10465
MLA
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22.3 (2021): 1033.
Chicago
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1033. https://doi.org/10.3892/etm.2021.10465
Copy and paste a formatted citation
x
Spandidos Publications style
Stoica RA, Ancuceanu R, Costache A, Ștefan SD, Stoian AP, Guja C, Staden RI, Popa‑Tudor I, Serafinceanu C, Ionescu‑Tîrgoviște C, Ionescu‑Tîrgoviște C, et al: Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Exp Ther Med 22: 1033, 2021.
APA
Stoica, R.A., Ancuceanu, R., Costache, A., Ștefan, S.D., Stoian, A.P., Guja, C. ... Ionescu‑Tîrgoviște, C. (2021). Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study. Experimental and Therapeutic Medicine, 22, 1033. https://doi.org/10.3892/etm.2021.10465
MLA
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22.3 (2021): 1033.
Chicago
Stoica, R. A., Ancuceanu, R., Costache, A., Ștefan, S. D., Stoian, A. P., Guja, C., Staden, R. I., Popa‑Tudor, I., Serafinceanu, C., Ionescu‑Tîrgoviște, C."Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1033. https://doi.org/10.3892/etm.2021.10465
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team