MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2
- Wei Liu
- Longan Ma
- Jie Zhang
Affiliations: Department of General Surgery, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi 710061, P.R. China
- Published online on: July 21, 2021 https://doi.org/10.3892/etm.2021.10473
Copyright: © Liu
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Increasing evidence demonstrates that dysregulation of microRNAs (miRNAs/miRs) is implicated in the development of colorectal cancer. However, the biological functions of several differentially expressed miRNAs remain unknown. In the present study, a bioinformatic analysis of a previously published microarray data and reverse transcription‑quantitative PCR analysis demonstrated that miR‑934 expression was upregulated in colorectal cancer samples collected from patients. Mechanistically, Dickkopf‑related protein 2 (DDK2) was identified as a novel target gene of miR‑934 in colorectal cancer cells. Knockdown of DDK2 reversed the inactivation of Wnt signaling pathway induced using miR‑934 inhibitor in colorectal cancer cells. In addition, DDK2 silencing reversed miR‑934 inhibitor‑induced cell proliferation inhibition and elevation of cell apoptosis. The results demonstrated that DDK2 mRNA expression was negatively associated with miR‑934 expression in colorectal tumors. Collectively, the results of the present study demonstrated that the miR‑934/DDK2 axis regulated colorectal cancer cell proliferation, suggesting that miR‑934 may be a biomarker for patients with colorectal cancer.