Open Access

MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2

  • Authors:
    • Wei Liu
    • Longan Ma
    • Jie Zhang
  • View Affiliations

  • Published online on: July 21, 2021     https://doi.org/10.3892/etm.2021.10473
  • Article Number: 1041
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increasing evidence demonstrates that dysregulation of microRNAs (miRNAs/miRs) is implicated in the development of colorectal cancer. However, the biological functions of several differentially expressed miRNAs remain unknown. In the present study, a bioinformatic analysis of a previously published microarray data and reverse transcription‑­quantitative PCR analysis demonstrated that miR‑934 expression was upregulated in colorectal cancer samples collected from patients. Mechanistically, Dickkopf‑related protein 2 (DDK2) was identified as a novel target gene of miR‑934 in colorectal cancer cells. Knockdown of DDK2 reversed the inactivation of Wnt signaling pathway induced using miR‑934 inhibitor in colorectal cancer cells. In addition, DDK2 silencing reversed miR‑934 inhibitor‑induced cell proliferation inhibition and elevation of cell apoptosis. The results demonstrated that DDK2 mRNA expression was negatively associated with miR‑934 expression in colorectal tumors. Collectively, the results of the present study demonstrated that the miR‑934/DDK2 axis regulated colorectal cancer cell proliferation, suggesting that miR‑934 may be a biomarker for patients with colorectal cancer.

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September-2021
Volume 22 Issue 3

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Copy and paste a formatted citation
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Spandidos Publications style
Liu W, Ma L and Zhang J: MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2. Exp Ther Med 22: 1041, 2021
APA
Liu, W., Ma, L., & Zhang, J. (2021). MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2. Experimental and Therapeutic Medicine, 22, 1041. https://doi.org/10.3892/etm.2021.10473
MLA
Liu, W., Ma, L., Zhang, J."MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2". Experimental and Therapeutic Medicine 22.3 (2021): 1041.
Chicago
Liu, W., Ma, L., Zhang, J."MicroRNA‑934 promotes colorectal cancer cell proliferation by directly targeting Dickkopf‑related protein 2". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1041. https://doi.org/10.3892/etm.2021.10473