Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report

  • Authors:
    • Oana-Viola Badulescu
    • Diana Popescu
    • Manuela Ciocoiu
    • Ciprian Rezus
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
  • Article Number: 1043
    |
    Published online on: July 21, 2021
       https://doi.org/10.3892/etm.2021.10475
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Since the first appearance of coronavirus disease 2019 (COVID‑19), multiple studies have focused on this novel coronavirus. Within a few months, the clinical and paraclinical manifestations and the mechanisms by which these changes are induced were elaborated. Clinically, the virus mainly causes the common cold, but can also result in severe or fatal pneumonia/acute respiratory syndrome. Regarding the biological changes, similar to any other virus, it can lead to a reduced lymphocyte count. The second most common change is represented by a reduced thrombocyte count. Furthermore, most patients have blood clotting abnormalities, inflammatory syndrome, raised D‑dimer and lactate dehydrogenase levels. Detection of immune thrombocytopenia in asymptomatic patients who tested positive for COVID‑19 justifies the need to perform differential diagnosis and testing for COVID‑19. Typically, patients with severe forms of COVID‑19 develop mild thrombocytopenia, while severe thrombocytopenia is rarely reported. The aim of this case report was to present the situation in which one asymptomatic patient who tested positive for COVID‑19 developed severe immune thrombocytopenia.
View Figures
View References

1 

Xu P, Zhou Q and Xu J: Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 99:1205–1208. 2020.PubMed/NCBI View Article : Google Scholar

2 

Phan LT, Nguyen TV, Luong QC, Nguyen TV, Nguyen HT, Le HQ, Nguyen TT, Cao TM and Pham QD: Importation and human-to-human transmission of a novel coronavirus in Vietnam. N Engl J Med. 382:872–874. 2020.PubMed/NCBI View Article : Google Scholar

3 

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, et al: First case of 2019 novel coronavirus in the United States. N Engl J Med. 382:929–936. 2020.PubMed/NCBI View Article : Google Scholar

4 

Chan JF, Yuan S, Kok KH, Wang KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, et al: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet. 395:514–523. 2020.PubMed/NCBI View Article : Google Scholar

5 

Docea AO, Tsatsakis A, Albulescu D, Cristea O, Zlatian O, Vinceti M, Moschos SA, Tsoukalas D, Goumenou M, Drakoulis N, et al: A new threat from an old enemy: Re-emergence of coronavirus (Review). Int J Mol Med. 45:1631–1643. 2020.PubMed/NCBI View Article : Google Scholar

6 

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 365:507–513. 2020.PubMed/NCBI View Article : Google Scholar

7 

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323:1061–1069. 2020.PubMed/NCBI View Article : Google Scholar

8 

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Lui L, Shan H, Lei CL, Hui DSC, et al: Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 382:1708–1720. 2020.PubMed/NCBI View Article : Google Scholar

9 

Zhang Y, Zeng X, Jiao Y, Li Z, Liu Q, Ye J and Yang M: Mechanisms involved in the development of thrombocytopenia in patients with COVID-19. Thromb Res. 193:110–115. 2020.PubMed/NCBI View Article : Google Scholar

10 

Wool GD and Miller JL: The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 88:15–27. 2020.PubMed/NCBI View Article : Google Scholar

11 

Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, Long D and Yu L: Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 31:490–496. 2020.PubMed/NCBI View Article : Google Scholar

12 

Calina D, Docea AO, Petrakis D, Egorov AM, Ishmukhametov AA, Gabibov AG, Shtilman MI, Kostoff R, Carvalho F, Vinceti M, et al: Towards effective COVID-19 vaccines: Updates, perspectives and challenges (Review). Int J Mol Med. 46:3–16. 2020.PubMed/NCBI View Article : Google Scholar

13 

Martinic Z, Skopec B, Rener K, Mavric M, Vovko T, Jereb M and Lukic M: Severe immune thrombocytopenia in a critically ill COVID-19 patient. Int J Infect Dis. 99:269–271. 2020.PubMed/NCBI View Article : Google Scholar

14 

Bao C, Tao X, Cui W, Yi B, Pan T, Young KH and Qian W: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 9(16)2020.PubMed/NCBI View Article : Google Scholar

15 

Bomhof G, Mutsaers PGNJ, Leebeek FWG, Te Boekhorst PAW, Hofland J, Croles FN and Jansen AJG: COVID-19-associated immune thrombocytopenia. Br J Haematol. 190:e61–e64. 2020.PubMed/NCBI View Article : Google Scholar

16 

Humber S, Razanamahery J, Payet-Revest C, Bouiller K and Chirouze C: COVID-19 as a cause of immune thrombocytopenia. Med Mal Infect. 50:459–460. 2020.PubMed/NCBI View Article : Google Scholar

17 

De la Cruz-Benito B, Rivas-Pollmar MI, Alvarez Roman MT, Trelles-Martinez R, Martin-Salces M, Lazaro-del Campo P, Ramirez-Lopez A, Garcia-Bacenilla S, Cebanu T, Acuna-Butta P, et al: Paradoxical effect of SARS-CoV-2 infection in patients with immune thrombocytopenia. Br J Haematol. 192:973–977. 2021.PubMed/NCBI View Article : Google Scholar

18 

Maquet J, Lafaurie M, Sommet A and Moulis G: Thrombocytopenia is independently associated with poor outcome in patients hospitalized for COVID-19. Br J Haematol. 190:e276–e279. 2020.PubMed/NCBI View Article : Google Scholar

19 

Pavord S, Thachil J, Hunt BJ, Murphy M, Lowe G, Laffan M, Makris M, Newland AC, Provan D, Grainger JD and Hill QA: Practical guidance for the management of adults with immune thrombocytopenia during the COVID-19 pandemic. Br J Haematol. 189:1038–1043. 2020.PubMed/NCBI View Article : Google Scholar

20 

Hu Z, Chen W, Liang W, Xu C, Sun W and Yi Y: Severe exacerbation of immune thrombocytopenia and COVID-19: The favorable response to corticosteroid-based therapy-a case report. Ann Hematol. 1–3. 2020.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

21 

Mahevas M, Moulis G, Andres E, Riviere E, Garzano M, Crickx E, Guillotin V, Malphettes M, Galicier L, Noel N, et al: Clinical characteristics, management and outcome of COVID-19-associated immune thrombocytopenia: A French multicentre series. Br J Haematol. 190:e224–e229. 2020.PubMed/NCBI View Article : Google Scholar

22 

Bhattacharjee S and Banerjee M: Immune thrombocytopenia secondary to COVID-19: A systematic review. SN Compr Clin Med: Sep 19, 2020 (Epub ahead of print).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Badulescu O, Popescu D, Ciocoiu M and Rezus C: Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report. Exp Ther Med 22: 1043, 2021.
APA
Badulescu, O., Popescu, D., Ciocoiu, M., & Rezus, C. (2021). Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report. Experimental and Therapeutic Medicine, 22, 1043. https://doi.org/10.3892/etm.2021.10475
MLA
Badulescu, O., Popescu, D., Ciocoiu, M., Rezus, C."Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report". Experimental and Therapeutic Medicine 22.3 (2021): 1043.
Chicago
Badulescu, O., Popescu, D., Ciocoiu, M., Rezus, C."Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1043. https://doi.org/10.3892/etm.2021.10475
Copy and paste a formatted citation
x
Spandidos Publications style
Badulescu O, Popescu D, Ciocoiu M and Rezus C: Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report. Exp Ther Med 22: 1043, 2021.
APA
Badulescu, O., Popescu, D., Ciocoiu, M., & Rezus, C. (2021). Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report. Experimental and Therapeutic Medicine, 22, 1043. https://doi.org/10.3892/etm.2021.10475
MLA
Badulescu, O., Popescu, D., Ciocoiu, M., Rezus, C."Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report". Experimental and Therapeutic Medicine 22.3 (2021): 1043.
Chicago
Badulescu, O., Popescu, D., Ciocoiu, M., Rezus, C."Immune thrombocytopenia, severe hematological consequence in a patient with COVID‑19: A case report". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1043. https://doi.org/10.3892/etm.2021.10475
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team