Recent advances on polaprezinc for medical use (Review)

  • Authors:
    • Mingru Li
    • Zhen Sun
    • Hong Zhang
    • Zhaoyang Liu
  • View Affiliations

  • Published online on: October 14, 2021     https://doi.org/10.3892/etm.2021.10880
  • Article Number: 1445
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Abstract

The present study described the chemical and biological properties of zinc complex of L‑carnosine (L‑CAZ; generic name, polaprezinc; chemical name, catena‑(S)‑[µ‑[N(α)‑(3‑aminopropionyl) histidinato (2‑) N1, N2, O: N(τ)]‑zinc], molecular formula, C9H14N4O3Zn; molecular weight, 291.6404; CAS registry number, 107667‑60‑7). Characterized as a white or yellowish white crystalline powder, this drug is insoluble in glacial acetic acid and almost insoluble in water, methanol, ethanol and ether. It is soluble in dilute hydrochloric acid, dilute nitric acid and sodium hydroxide solution, and its melting point is 260‑270˚C. Polaprezinc is an anti‑ulcer drug that was jointly studied and developed by Hamari Chemicals Co., Ltd. and Zeria Pharmaceutical Co., Ltd., and was first approved in Japan in 1994. This review article summarizes the research advances of polaprezinc, including the patents, preparations, synthetic routes, pharmacokinetics, pharmacological effects and application in clinical research.

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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li M, Sun Z, Zhang H and Liu Z: Recent advances on polaprezinc for medical use (Review). Exp Ther Med 22: 1445, 2021
APA
Li, M., Sun, Z., Zhang, H., & Liu, Z. (2021). Recent advances on polaprezinc for medical use (Review). Experimental and Therapeutic Medicine, 22, 1445. https://doi.org/10.3892/etm.2021.10880
MLA
Li, M., Sun, Z., Zhang, H., Liu, Z."Recent advances on polaprezinc for medical use (Review)". Experimental and Therapeutic Medicine 22.6 (2021): 1445.
Chicago
Li, M., Sun, Z., Zhang, H., Liu, Z."Recent advances on polaprezinc for medical use (Review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1445. https://doi.org/10.3892/etm.2021.10880