Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways

  • Authors:
    • Qiang Li
    • Yao Ming
    • Hu Jia
    • Gang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 289
    |
    Published online on: January 27, 2021
       https://doi.org/10.3892/etm.2021.9720
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Renal interstitial fibrosis is the most important pathological process in chronic renal failure. Previous studies have shown that poricoic acid A (PAA), the main chemical constituent on the surface layer of the mushroom Poria cocos, has protective effects against oxidative stress and acute kidney injury. The present study aimed to investigate the potential roles of PAA on the pathological process of renal fibrosis and the associated molecular mechanism. The NRK‑49F cell line was treated with transforming growth factor‑β1 (TGF‑β1) with or without PAA or platelet‑derived growth factor C (PDGF‑C). Cell Counting Kit‑8 assay, western blotting and 5‑ethynyl‑2'‑deoxyuridine immunofluorescence staining were performed to examine cell growth, protein expression and cell proliferation, respectively. Data from the present study showed that 10 µM PAA attenuated TGF‑β1‑induced NRK‑49F cell extracellular matrix (ECM) accumulation, fibrosis formation and proliferation. Renal fibrosis with the activation of Smad3 and mitogen‑activated protein kinase (MAPK) pathways were also inhibited by PAA treatment. PDGF‑C reversed the inhibitory effects of PAA on TGF‑β1‑induced renal fibroblast proliferation and activation of the Smad3/MAPK pathway. The present study suggested that suppression of TGF‑β1‑induced renal fibroblast ECM accumulation, fibrosis formation and proliferation by PAA is mediated via the inhibition of the PDGF‑C, Smad3 and MAPK pathways. The present findings not only revealed the potential anti‑fibrotic effects of PAA on renal fibroblasts, but also provided a new insight into the prevention of fibrosis formation via regulation of the PDGF‑C, Smad3 and MAPK signaling pathways.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Shiber S, Eliakim-Raz N and Yair M: Retroperitoneal fibrosis: Case series of five patients and review of the literature. Rev Bras Reumatol Engl Ed. 56:101–104. 2016.PubMed/NCBI View Article : Google Scholar

2 

Zhou D and Liu Y: Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis. Nat Rev Nephrol. 12:68–70. 2016.PubMed/NCBI View Article : Google Scholar

3 

Hu C, Sun L, Xiao L, Han Y, Fu X, Xiong X, Xu X, Liu Y, Yang S, Liu F and Kanwar YS: Insights into the mechanisms involved in the expression and regulation of extracellular matrix proteins in diabetic nephropathy. Curr Med Chem. 22:2858–2870. 2015.PubMed/NCBI View Article : Google Scholar

4 

Wang J, Yang Q, Nie Y, Guo H, Zhang F, Zhou X and Yin X: Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy. J Pharm Pharmacol. 69:182–190. 2017.PubMed/NCBI View Article : Google Scholar

5 

Klinkhammer BM, Goldschmeding R, Floege J and Boor P: Treatment of renal fibrosis-turning challenges into opportunities. Adv Chronic Kidney Dis. 24:117–129. 2017.PubMed/NCBI View Article : Google Scholar

6 

Sandner P and Stasch JP: Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence. Respir Med. 122 (Suppl 1):S1–S9. 2017.PubMed/NCBI View Article : Google Scholar

7 

Wang Y, Cai J, Tang C and Dong Z: Mitophagy in acute kidney injury and kidney repair. Cells. 9: pii(E338)2020.PubMed/NCBI View Article : Google Scholar

8 

Tang J, Goldschmeding R, Samarakoon R and Higgins PJ: Protein phosphatase Mg(2+)/Mn(2+) dependent-1A and PTEN deregulation in renal fibrosis: Novel mechanisms and co-dependency of expression. FASEB J. 34:2641–2656. 2020.PubMed/NCBI View Article : Google Scholar

9 

Marko L, Park JK, Henke N, Rong S, Balogh A, Klamer S, Bartolomaeus H, Wilck N, Ruland J, Forslund SK, et al: B-cell lymphoma/leukemia 10 (Bcl10) and angiotensin II-induced kidney injury. Cardiovasc Res. 116:1059–1070. 2019.

10 

Li O, Ma Q, Li F, Cai GY, Chen XM and Hong Q: Progress of small ubiquitin-related modifiers in kidney diseases. Chin Med J (Engl). 132:466–473. 2019.PubMed/NCBI View Article : Google Scholar

11 

Genovese F, Manresa AA, Leeming DJ, Karsdal MA and Boor P: The extracellular matrix in the kidney: A source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair. 7(4)2014.PubMed/NCBI View Article : Google Scholar

12 

Castellone MD and Laukkanen MO: TGF-beta1, WNT, and SHH signaling in tumor progression and in fibrotic diseases. Front Biosci (Schol Ed). 9:31–45. 2017.PubMed/NCBI View Article : Google Scholar

13 

van Roeyen CRC, Martin IV, Drescher A, Schuett KA, Hermert D, Raffetseder U, Otten S, Buhl EM, Braun GS, Kuppe C, et al: Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int. 95:1103–1119. 2019.PubMed/NCBI View Article : Google Scholar

14 

Ghayur A, Padwal MK, Liu L, Zhang J and Margetts PJ: SMAD3-dependent and-independent pathways in glomerular injury associated with experimental glomerulonephritis. Am J Physiol Renal Physiol. 317:F152–F62. 2019.PubMed/NCBI View Article : Google Scholar

15 

Breyer MD and Susztak K: The next generation of therapeutics for chronic kidney disease. Nat Rev Drug Discov. 15:568–588. 2016.PubMed/NCBI View Article : Google Scholar

16 

Mencke R, Olauson H and Hillebrands JL: Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies. Adv Drug Deliv Rev. 121:85–100. 2017.PubMed/NCBI View Article : Google Scholar

17 

Li S, Wang Z, Gu R, Zhao Y, Huang W, Wang Z and Xiao W: A new epidioxy-tetracyclic triterpenoid from Poria cocos Wolf. Nat Prod Res. 30:1712–1717. 2016.PubMed/NCBI View Article : Google Scholar

18 

Lee SR, Lee S, Moon E, Park HJ, Park HB and Kim KH: Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorg Chem. 70:94–99. 2017.PubMed/NCBI View Article : Google Scholar

19 

Li S, Zhang J, Li S, Liu C, Liu S and Liu Z: Extraction and separation of lactate dehydrogenase inhibitors from Poria cocos (Schw.) Wolf based on a hyphenated technique and in vitro methods. J Sep Sci. 40:1773–1783. 2017.PubMed/NCBI View Article : Google Scholar

20 

Zhao YY, Feng YL, Du X, Xi ZH, Cheng XL and Wei F: Diuretic activity of the ethanol and aqueous extracts of the surface layer of Poria cocos in rat. J Ethnopharmacol. 144:775–778. 2012.PubMed/NCBI View Article : Google Scholar

21 

Feng YL, Lei P, Tian T, Yin L, Chen DQ, Chen H, Mei Q, Zhao YY and Lin RC: Diuretic activity of some fractions of the epidermis of Poria cocos. J Ethnopharmacol. 150:1114–1118. 2013.PubMed/NCBI View Article : Google Scholar

22 

Zhao YY, Feng YL, Bai X, Tan XJ, Lin RC and Mei Q: Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. PLoS One. 8(e59617)2013.PubMed/NCBI View Article : Google Scholar

23 

Chen DQ, Feng YL, Chen L, Liu JR, Wang M, Vaziri ND and Zhao YY: Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFkappaB/Nrf2 axis. Free Radic Biol Med. 134:484–497. 2019.PubMed/NCBI View Article : Google Scholar

24 

Chen DQ, Cao G, Zhao H, Chen L, Yang T, Wang M, Vaziri ND, Guo Y and Zhao YY: Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and beta-catenin pathway in AKI-to-CKD continuum. Ther Adv Chronic Dis. 10(2040622319869116)2019.PubMed/NCBI View Article : Google Scholar

25 

Wang M, Chen DQ, Chen L, Cao G, Zhao H, Liu D, Vaziri ND, Guo Y and Zhao YY: Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. Br J Pharmacol. 175:2689–2708. 2018.PubMed/NCBI View Article : Google Scholar

26 

Wang M, Chen DQ, Chen L, Liu D, Zhao H, Zhang ZH, Vaziri ND, Guo Y, Zhao YY and Cao G: Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH attenuate renal fibrosis via a Wnt/β-catenin pathway and targeted phosphorylation of smad3 Signaling. J Agric Food Chem. 66:1828–1842. 2018.PubMed/NCBI View Article : Google Scholar

27 

Tan RJ, Zhou D and Liu Y: Signaling crosstalk between tubular epithelial cells and interstitial fibroblasts after kidney injury. Kidney Dis (Basel). 2:136–144. 2016.PubMed/NCBI View Article : Google Scholar

28 

Tang N, Cunningham K and Enger MD: TGF beta elicits opposite responses in clonal subpopulations of NRK-49F cells. Exp Cell Res. 196:13–19. 1991.PubMed/NCBI View Article : Google Scholar

29 

Floege J, Eitner F and Alpers CE: A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol. 19:12–23. 2008.PubMed/NCBI View Article : Google Scholar

30 

Huang C, Day ML, Poronnik P, Pollock CA and Chen XM: Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways. Int J Biochem Cell Biol. 47:1–10. 2014.PubMed/NCBI View Article : Google Scholar

31 

Liu M, Ning X, Li R, Yang Z, Yang X, Sun S and Qian Q: Signalling pathways involved in hypoxia-induced renal fibrosis. J Cell Mol Med. 21:1248–1259. 2017.PubMed/NCBI View Article : Google Scholar

32 

Waasdorp M, de Rooij DM, Florquin S, Duitman J and Spek CA: Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy. J Cell Mol Med. 23:1268–1279. 2019.PubMed/NCBI View Article : Google Scholar

33 

Liu W, Lin S, Cai Q, Zhang L, Shen A, Chen Y, Chu J and Peng J: Qingxuan jiangya decoction mitigates renal interstitial fibrosis in spontaneously hypertensive rats by regulating transforming growth factor-β1/Smad signaling pathway. Evid Based Complement Alternat Med. 2017(1576328)2017.PubMed/NCBI View Article : Google Scholar

34 

Lawson JS, Liu HH, Syme HM, Purcell R, Wheeler-Jones CPD and Elliott J: The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1. PLoS One. 13(e0202577)2018.PubMed/NCBI View Article : Google Scholar

35 

Xu J, Yu TT, Zhang K, Li M, Shi HJ, Meng XJ, Zhu LS and Zhu LK: HGF alleviates renal interstitial fibrosis via inhibiting the TGF-β1/SMAD pathway. Eur Rev Med Pharmacol Sci. 22:7621–7627. 2018.PubMed/NCBI View Article : Google Scholar

36 

Loeffler I: MKP2 suppresses TGF-β1-induced epithelial-to-mesenchymal transition through JNK inhibition. Clin Sci (Lond). 133:545–550. 2019.PubMed/NCBI View Article : Google Scholar

37 

Okuda S, Languino LR, Ruoslahti E and Border WA: Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest. 86:453–462. 1990.PubMed/NCBI View Article : Google Scholar

38 

Choi HI, Kim DH, Park JS, Kim IJ, Kim CS, Bae EH, Ma SK, Lee TH and Kim SW: Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3. Sci Rep. 9(8751)2019.PubMed/NCBI View Article : Google Scholar

39 

Vincenti F, Fervenza FC, Campbell KN, Diaz M, Gesualdo L, Nelson P, Praga M, Radhakrishnan J, Sellin L, Singh A, et al: A phase 2, double-blind, placebo-controlled, randomized study of fresolimumab in patients with steroid-resistant primary focal segmental glomerulosclerosis. Kidney Int Rep. 2:800–810. 2017.PubMed/NCBI View Article : Google Scholar

40 

Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, Rota S, Remuzzi G, Rump LC, Sellin LK, et al: A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int. 79:1236–1243. 2011.PubMed/NCBI View Article : Google Scholar

41 

McGaraughty S, Davis-Taber RA, Zhu CZ, Cole TB, Nikkel AL, Chhaya M, Doyle KJ, Olson LM, Preston GM, Grinnell CM, et al: Targeting Anti-TGF-β therapy to fibrotic kidneys with a dual specificity antibody approach. J Am Soc Nephrol. 28:3616–3626. 2017.PubMed/NCBI View Article : Google Scholar

42 

Zhang ZH, He JQ, Zhao YY, Chen HC and Tan NH: Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Acta Pharmacol Sin. 41:373–382. 2020.PubMed/NCBI View Article : Google Scholar

43 

Bian X, Bai Y, Su X, Zhao G, Sun G and Li D: Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats. J Cell Physiol. 234:22857–22873. 2019.PubMed/NCBI View Article : Google Scholar

44 

Li X, Ponten A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, et al: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol. 2:302–309. 2000.PubMed/NCBI View Article : Google Scholar

45 

Eitner F, Bucher E, van Roeyen C, Kunter U, Rong S, Seikrit C, Villa L, Boor P, Fredriksson L, Bäckström G, et al: PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis. J Am Soc Nephrol. 19:281–289. 2008.PubMed/NCBI View Article : Google Scholar

46 

Boor P, Babickova J, Steegh F, Hautvast P, Martin IV, Djudjaj S, Nakagawa T, Ehling J, Gremse F, Bücher E, et al: Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis. Am J Pathol. 185:2132–2142. 2015.PubMed/NCBI View Article : Google Scholar

47 

Wang Y, Abu-Asab MS, Yu CR, Tang Z, Shen D, Tuo J, Li X and Chan CC: Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration. Lab Invest. 94:674–682. 2014.PubMed/NCBI View Article : Google Scholar

48 

Chen CL, Chou KJ, Lee PT, Chen YS, Chang TY, Hsu CY, Huang WC, Chung HM and Fang HC: Erythropoietin suppresses epithelial to mesenchymal transition and intercepts Smad signal transduction through a MEK-dependent mechanism in pig kidney (LLC-PK1) cell lines. Exp Cell Res. 316:1109–1118. 2010.PubMed/NCBI View Article : Google Scholar

49 

Grynberg K, Ma FY and Nikolic-Paterson DJ: The JNK signaling pathway in renal fibrosis. Front Physiol. 8(829)2017.PubMed/NCBI View Article : Google Scholar

50 

Xu ZJ, Shu S, Li ZJ, Liu YM, Zhang RY and Zhang Y: Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-β/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues. Medicine (Baltimore). 96(e5879)2017.PubMed/NCBI View Article : Google Scholar

51 

Nakagawa T, Lan HY, Glushakova O, Zhu HJ, Kang DH, Schreiner GF, Böttinger EP, Johnson RJ and Sautin YY: Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts. J Am Soc Nephrol. 16:899–904. 2005.PubMed/NCBI View Article : Google Scholar

52 

Okano K, Hibi A, Miyaoka T, Inoue T, Sugimoto H, Tsuchiya K, Akiba T and Nitta K: Inhibitory effects of the transcription factor Ets-1 on the expression of type I collagen in TGF-β1-stimulated renal epithelial cells. Mol Cell Biochem. 369:247–254. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Q, Ming Y, Jia H and Wang G: Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways. Exp Ther Med 21: 289, 2021.
APA
Li, Q., Ming, Y., Jia, H., & Wang, G. (2021). Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways. Experimental and Therapeutic Medicine, 21, 289. https://doi.org/10.3892/etm.2021.9720
MLA
Li, Q., Ming, Y., Jia, H., Wang, G."Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways". Experimental and Therapeutic Medicine 21.4 (2021): 289.
Chicago
Li, Q., Ming, Y., Jia, H., Wang, G."Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways". Experimental and Therapeutic Medicine 21, no. 4 (2021): 289. https://doi.org/10.3892/etm.2021.9720
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Ming Y, Jia H and Wang G: Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways. Exp Ther Med 21: 289, 2021.
APA
Li, Q., Ming, Y., Jia, H., & Wang, G. (2021). Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways. Experimental and Therapeutic Medicine, 21, 289. https://doi.org/10.3892/etm.2021.9720
MLA
Li, Q., Ming, Y., Jia, H., Wang, G."Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways". Experimental and Therapeutic Medicine 21.4 (2021): 289.
Chicago
Li, Q., Ming, Y., Jia, H., Wang, G."Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways". Experimental and Therapeutic Medicine 21, no. 4 (2021): 289. https://doi.org/10.3892/etm.2021.9720
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team