Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Xu,Xiao-Heng; Liu,Yang; Feng,Lu; Yang,Yin-Shen; Liu,Shu-Guang; Guo,Wei; Zhou,Hui-Xi; Li,Zhi-Qiang; Zhang,Lin; Meng,Wen-Xia

doi:10.3892/etm.2021.9722

Interleukin‑6 released by oral lichen planus myofibroblasts promotes angiogenesis

Authors:
- Xiao-Heng Xu
- Yang Liu
- Lu Feng
- Yin-Shen Yang
- Shu-Guang Liu
- Wei Guo
- Hui-Xi Zhou
- Zhi-Qiang Li
- Lin Zhang
- Wen-Xia Meng
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Affiliations: Department of Oral Medicine, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Department of Oral Pathology, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
Published online on: January 27, 2021 https://doi.org/10.3892/etm.2021.9722
Article Number: 291
Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral lichen planus (OLP), defined as a potential for malignant transformation, is a chronic inflammatory disease in which abnormal angiogenesis serves a role in the malignant changes of the disease. OLP‑associated fibroblasts (OLP‑MFs), derived from the stroma of OLP tissues, are characterized by the presence of myofibroblasts and contribute to the secretion of pro‑inflammatory cytokines, which may be involved in the molecular pathogenesis of OLP. However, the associated mechanisms of angiogenesis in OLP remain unknown. The present study aimed to verify the expression of intercellular adhesion molecular 1, vascular cell adhesion molecule 1, VEGF and CD34 in OLP, and to investigate whether IL‑6 secreted by OLP‑MFs promoted OLP angiogenesis and the effect of its corresponding antibody inhibition. The results of the experiments demonstrated that inflammation was present and OLP upregulated the secretion of IL‑6 by OLP stromal fibroblasts, thereby enhancing OLP angiogenesis. Anti‑IL‑6 receptor antibody inhibited OLP‑stroma IL‑6 signaling and suppressed OLP angiogenesis. The antibody inhibited the inflammatory response by inhibiting the secretion of inflammatory factors, including IL‑6, to suppress angiogenesis and reduce disease progression, thus indicating that this could be a potential target to develop a treatment for OLP.

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