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Article Open Access

MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer

Retraction in: /10.3892/etm.2025.12872
  • Authors:
    • Man Luo
    • Zuowei Hu
    • Yuefeng Kong
    • Lingyi Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China, Department of Radiology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 301
    |
    Published online on: January 29, 2021
       https://doi.org/10.3892/etm.2021.9732
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Abstract

MicroRNAs (miRNAs) play an important role in the occurrence and development of colorectal cancer (CRC). Evidence shows that miR‑432‑5p expression is decreased in various tumors and cancer cell lines. miR‑432‑5p can inhibit tumor invasion and metastasis, but its role in colorectal cancer is unclear. The present study demonstrated that miR‑432‑5p expression was decreased in colorectal cancer tissue and cell lines, and is negatively associated with invasion classification, lymph node metastasis and Tumor‑Node‑Metastasis stage. Kaplan‑Meier survival analysis showed that low miR‑432‑5p expression was associated with a poor survival rate in patients with CRC. In addition, SW480 and HT‑29 cells transfected with miR‑432‑5p mimics had decreased migration and invasion abilities, whereas miR‑432‑5p inhibitors had the opposite effect. The expression of C‑X‑C motif chemokine ligand 5 (CXCL5), a direct target of miR‑432‑5p, was negatively associated with miR‑432‑5p expression. When CXCL5 was introduced into miR‑432‑5p mimic‑transfected SW480 and HT‑29 cells, miR‑432‑5p‑mediated inhibition of CRC migration and invasion was reversed. Thus, the present results suggest that miR‑432‑5p can inhibit the migration and invasion of CRC cells by targeting CXCL5.
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Copy and paste a formatted citation
Spandidos Publications style
Luo M, Hu Z, Kong Y and Li L: MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872. Exp Ther Med 21: 301, 2021.
APA
Luo, M., Hu, Z., Kong, Y., & Li, L. (2021). MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872. Experimental and Therapeutic Medicine, 21, 301. https://doi.org/10.3892/etm.2021.9732
MLA
Luo, M., Hu, Z., Kong, Y., Li, L."MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872". Experimental and Therapeutic Medicine 21.4 (2021): 301.
Chicago
Luo, M., Hu, Z., Kong, Y., Li, L."MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872". Experimental and Therapeutic Medicine 21, no. 4 (2021): 301. https://doi.org/10.3892/etm.2021.9732
Copy and paste a formatted citation
x
Spandidos Publications style
Luo M, Hu Z, Kong Y and Li L: MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872. Exp Ther Med 21: 301, 2021.
APA
Luo, M., Hu, Z., Kong, Y., & Li, L. (2021). MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872. Experimental and Therapeutic Medicine, 21, 301. https://doi.org/10.3892/etm.2021.9732
MLA
Luo, M., Hu, Z., Kong, Y., Li, L."MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872". Experimental and Therapeutic Medicine 21.4 (2021): 301.
Chicago
Luo, M., Hu, Z., Kong, Y., Li, L."MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer Retraction in /10.3892/etm.2025.12872". Experimental and Therapeutic Medicine 21, no. 4 (2021): 301. https://doi.org/10.3892/etm.2021.9732
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