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Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin

  • Authors:
    • Lini Shan
    • Shixian Bai
    • Min Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Yidu Central Hospital of Weifang, Qingzhou, Shandong 262500, P.R. China, Intensive Care Unit, Yidu Central Hospital of Weifang, Qingzhou, Shandong 262500, P.R. China
    Copyright: © Shan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 324
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    Published online on: February 5, 2021
       https://doi.org/10.3892/etm.2021.9755
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Abstract

Acute pancreatitis (AP) is a common gastrointestinal disease that can become severe, so that intensive care may be required. This study was to examine serum soluble intercellular adhesion molecule‑1 (sICAM‑1), and soluble receptor for advanced glycation end products (sRAGE) for efficacy and prognosis prediction of glutamine (Glu) combined with ulinastatin (UTI) on severe acute pancreatitis (SAP). Fifty‑four mild acute pancreatitis (MAP) patients admitted to Yidu Central Hospital of Weifang were selected as the MAP group (MAPG), 80 with SAP were divided as the SAP group (SAPG), and 60 healthy individuals who came to Yidu Central Hospital of Weifang for physical examination during the same period were included to the normal group (NG). Serum sICAM‑1 and sRAGE were measured and their predictive value of efficacy and prognosis were analyzed. In view of the treatment effectiveness and prognosis, the patients were divided into effective group (EG) and ineffective group (IG), good prognosis group (GPG) and poor prognosis group (PPG). The levels of D‑lactate, diamine oxidase (DAO), endotoxin and T‑lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) were measured and the changes before and after treatment were analyzed. The AUC values of NG and MAPG, NG and SAPG, MAPG and SAPG were 0.857, 0.939 and 0.856, respectively, those of predicting efficacy were 0.920 and 0.874, respectively, and those of poor prognosis in the SAPG were 0.914 and 0.879, respectively. In the SAPG, D‑lactate, DAO, endotoxin and CD8+ decreased markedly after treatment, but CD3+, CD4+, and CD4+/CD8+ were opposite. SICAM‑1 and sRAGE were also independent risk factors for poor prognosis in the SAPG. Serum sICAM‑1 and sRAGE have high predictive value for early diagnosis, efficacy and prognosis of Glu combined with UTI.
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1 

Van Dijk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ and Besselink MG: Dutch Pancreatitis Study Group. Acute pancreatitis: Recent advances through randomised trials. Gut. 66:2024–2032. 2017.PubMed/NCBI View Article : Google Scholar

2 

Vege SS, DiMagno MJ, Forsmark CE, Martel M and Barkun AN: Initial medical treatment of acute pancreatitis: American gastroenterological association institute technical review. Gastroenterology. 154:1103–1139. 2018.PubMed/NCBI View Article : Google Scholar

3 

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, et al: Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med. 22:202–209. 2016.PubMed/NCBI View Article : Google Scholar

4 

Maheshwari R and Subramanian RM: Severe acute pancreatitis and necrotizing pancreatitis. Crit Care Clin. 32:279–290. 2016.PubMed/NCBI View Article : Google Scholar

5 

Nesvaderani M, Eslick GD and Cox MR: Acute pancreatitis: Update on management. Med J Aust. 202:420–423. 2015.PubMed/NCBI View Article : Google Scholar

6 

Shah AP, Mourad MM and Bramhall SR: Acute pancreatitis: Current perspectives on diagnosis and management. J Inflamm Res. 11:77–85. 2018.PubMed/NCBI View Article : Google Scholar

7 

Shamoon M, Deng Y, Chen YQ, Bhatia M and Sun J: Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 20:73–87. 2016.PubMed/NCBI View Article : Google Scholar

8 

Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F and Wu Z: Glutamine and intestinal barrier function. Amino Acids. 47:2143–2154. 2015.PubMed/NCBI View Article : Google Scholar

9 

Cruzat V, Macedo Rogero M, Noel Keane K, Curi R and Newsholme P: Glutamine: Metabolism and immune function, supplementation and clinical translation. Nutrients. 10(1564)2018.PubMed/NCBI View Article : Google Scholar

10 

Alhan E, Usta A, Türkyılmaz S, Kural BV and Erçin C: Effects of glutamine alone on the acute necrotizing pancreatitis in rats. J Surg Res. 193:161–167. 2015.PubMed/NCBI View Article : Google Scholar

11 

Pan LL, Li J, Shamoon M, Bhatia M and Sun J: Recent advances on nutrition in treatment of acute pancreatitis. Front Immunol. 8(762)2017.PubMed/NCBI View Article : Google Scholar

12 

Yong L, Lu QP, Liu SH and Fan H: Efficacy of glutamine-enriched nutrition support for patients with severe acute pancreatitis: A meta-Analysis. JPEN J Parenter Enteral Nutr. 40:83–94. 2016.PubMed/NCBI View Article : Google Scholar

13 

Liu B, Huang W, Xiao X, Xu Y, Ma S and Xia Z: Neuroprotective effect of ulinastatin on spinal cord ischemia-reperfusion injury in rabbits. Oxid Med Cell Longev. 2015(624819)2015.PubMed/NCBI View Article : Google Scholar

14 

Xu R, Jiang S, Zhou H and Jin W: Clinical efficacy of ulinastatin combined with somatostatin for treatment of severe acute pancreatitis and effects on immune function. Int J Clin Exp Med. 12:11333–11341. 2019.

15 

Li C, Ma D, Chen M, Zhang L, Zhang L, Zhang J, Qu X and Wang C: Ulinastatin attenuates LPS-induced human endothelial cells oxidative damage through suppressing JNK/c-Jun signaling pathway. Biochem Biophys Res Commun. 474:572–578. 2016.PubMed/NCBI View Article : Google Scholar

16 

Wei F, Liu SY, Luo L, Gu N, Zeng Y, Chen X, Xu S and Zhang D: Anti-inflammatory mechanism of ulinastatin: Inhibiting the hyperpermeability of vascular endothelial cells induced by TNF-α via the RhoA/ROCK signal pathway. Int Immunopharmacol. 46:220–227. 2017.PubMed/NCBI View Article : Google Scholar

17 

Schellerer VS, Langheinrich MC, Zver V, Grützmann R, Stürzl M, Gefeller O, Naschberger E and Merkel S: Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma. Int J Colorectal Dis. 34:309–317. 2019.PubMed/NCBI View Article : Google Scholar

18 

Staubli SM, Oertli D and Nebiker CA: Laboratory markers predicting severity of acute pancreatitis. Crit Rev Clin Lab Sci. 52:273–283. 2015.PubMed/NCBI View Article : Google Scholar

19 

Bopp C, Hofer S, Weitz J, Bierhaus A, Nawroth PP, Martin E, Büchler MW and Weigand MA: sRAGE is elevated in septic patients and associated with patients outcome. J Surg Res. 147:79–83. 2008.PubMed/NCBI View Article : Google Scholar

20 

Zhao B, Chen Y, Sun WW, Chen WW, Ma L, Yang ZT, Huang J, Chen EZ, Fei J and Mao EQ: Effect of S100A12 and soluble receptor for advanced glycation end products on the occurrence of severe acute pancreatitis. J Dig Dis. 17:475–482. 2016.PubMed/NCBI View Article : Google Scholar

21 

Greenberg JA, Hsu J, Bawazeer M, Marshall J, Friedrich JO, Nathens A, Coburn N, May GR, Pearsall E and McLeod RS: Clinical practice guideline: Management of acute pancreatitis. Can J Surg. 59:128–140. 2016.PubMed/NCBI View Article : Google Scholar

22 

Akavipat P, Thinkhamrop J, Thinkhamrop B and Sriraj W: Acute physiology and chronic health evaluation (APACHE) II score-the clinical predictor in neurosurgical intensive care unit. Acta Clin Croat. 58:50–56. 2019.PubMed/NCBI View Article : Google Scholar

23 

Hornbeck PV: Enzyme linked immunosorbent assays. Curr Protoc Immunol. 110:2.1.1–2.1.23. 2015.PubMed/NCBI View Article : Google Scholar

24 

Yang ZW, Meng XX and Xu P: Central role of neutrophil in the pathogenesis of severe acute pancreatitis. J Cell Mol Med. 19:2513–2520. 2015.PubMed/NCBI View Article : Google Scholar

25 

Manohar M, Verma AK, Venkateshaiah SU, Sanders NL and Mishra A: Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther. 8:10–25. 2017.PubMed/NCBI View Article : Google Scholar

26 

Saluja A and Maitra A: Pancreatitis and pancreatic cancer. Gastroenterology. 156:1937–1940. 2019.PubMed/NCBI View Article : Google Scholar

27 

Shen X and Li WQ: High-mobility group box 1 protein and its role in severe acute pancreatitis. World J Gastroenterol. 21:1424–1435. 2015.PubMed/NCBI View Article : Google Scholar

28 

Yang C, Wen J, Xia M and Wang SR: Effect of glutamine nutrition support on the intestinal mucosal barrier function and inflammatory response in patients with severe acute pancreatitis. J Hainan Med Univ. 23:17–21. 2017.

29 

Pan Y, Fang H, Lu F, Pan M, Chen F, Xiong P, Yao Y and Huang H: Ulinastatin ameliorates tissue damage of severe acute pancreatitis through modulating regulatory T cells. J Inflamm (Lond). 14(7)2017.PubMed/NCBI View Article : Google Scholar

30 

Kuessel L, Wenzl R, Proestling K, Balendran S, Pateisky P, Yotova I, Yerlikaya G, Streubel B and Husslein H: Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis. Hum Reprod. 32:770–779. 2017.PubMed/NCBI View Article : Google Scholar

31 

Budnik A, Grewe M, Gyufko K and Krutmann J: Analysis of the production of soluble ICAM-1 molecules by human cells. Exp Hematol. 24:352–359. 1996.PubMed/NCBI

32 

Scavello F, Zeni F, Tedesco CC, Mensà E, Veglia F, Procopio AD, Bonfigli AR, Olivieri F and Raucci A: Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging. Aging (Albany NY). 11:1648–1663. 2019.PubMed/NCBI View Article : Google Scholar

33 

Park JY, Jeon TJ, Ha TH, Hwang JT, Sinn DH, Oh TH, Shin WC and Choi WC: Bedside index for severity in acute pancreatitis: Comparison with other scoring systems in predicting severity and organ failure. Hepatobiliary Pancreat Dis Int. 12:645–650. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shan L, Bai S and Zhao M: Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin. Exp Ther Med 21: 324, 2021.
APA
Shan, L., Bai, S., & Zhao, M. (2021). Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin. Experimental and Therapeutic Medicine, 21, 324. https://doi.org/10.3892/etm.2021.9755
MLA
Shan, L., Bai, S., Zhao, M."Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin". Experimental and Therapeutic Medicine 21.4 (2021): 324.
Chicago
Shan, L., Bai, S., Zhao, M."Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin". Experimental and Therapeutic Medicine 21, no. 4 (2021): 324. https://doi.org/10.3892/etm.2021.9755
Copy and paste a formatted citation
x
Spandidos Publications style
Shan L, Bai S and Zhao M: Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin. Exp Ther Med 21: 324, 2021.
APA
Shan, L., Bai, S., & Zhao, M. (2021). Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin. Experimental and Therapeutic Medicine, 21, 324. https://doi.org/10.3892/etm.2021.9755
MLA
Shan, L., Bai, S., Zhao, M."Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin". Experimental and Therapeutic Medicine 21.4 (2021): 324.
Chicago
Shan, L., Bai, S., Zhao, M."Early diagnosis of serum sICAM‑1 and sRAGE in severe acute pancreatitis, and efficacy and prognosis prediction of glutamine combined with ulinastatin". Experimental and Therapeutic Medicine 21, no. 4 (2021): 324. https://doi.org/10.3892/etm.2021.9755
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