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Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma

  • Authors:
    • An-Du Zhang
    • Xiao-Hua Su
    • Yan-Fei Wang
    • Gao-Feng Shi
    • Chun Han
    • Nan Zhang
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    Affiliations: Department of Radiotherapy, Hebei Medical University Fourth Affiliated Hospital/Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei 050011, P.R. China, Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050011, P.R. China, Department of CT and MRI, Hebei Medical University Fourth Affiliated Hospital/Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 327
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    Published online on: February 5, 2021
       https://doi.org/10.3892/etm.2021.9758
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Abstract

The aim of the present study was to assess the predictive value of diffusion kurtosis imaging (DKI) on the effects of radiotherapy in a xenograft model of esophageal cancer. A total of 40 tumor‑bearing mice, established by injection of Eca‑109 cells in nude mice, were used. The experimental group (n=24) received a single dose of 15 Gy (6 MV by X‑ray), and the control group (n=16) did not receive any treatment. Tumor volume, apparent diffusion coefficient (ADC), mean kurtosis (MK) and mean diffusivity (MD) of the two groups were compared, and the expression of aquaporin (AQP) 3 and necrosis ratio at matched time points in xenografts were also observed. There was a significant difference between the two groups from the 7th day of radiotherapy onwards; the xenograft volume of the experimental group was significantly smaller compared with the control group (P<0.05). On the 3rd day, the ADC and MD of the experimental group was significantly higher compared with the control group, and MK was significantly lower compared with the control group (P<0.05). On the 3rd day, AQP3 expression in the experimental group was lower compared with the control group, and the proportion of necrotic cells was higher compared with the control group (P<0.05). Single large fraction dose radiotherapy inhibited the growth of a xenografted esophageal tumor. Changes in ADC, MK and MD were observed prior to morphological changes in the tumor. The change in AQP3 expression and necrosis ratio was in also agreement with the DKI parameters assessed. DKI may thus provide early predictive ability on the effect of radiotherapy in esophageal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang A, Su X, Wang Y, Shi G, Han C and Zhang N: Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma. Exp Ther Med 21: 327, 2021.
APA
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., & Zhang, N. (2021). Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma. Experimental and Therapeutic Medicine, 21, 327. https://doi.org/10.3892/etm.2021.9758
MLA
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., Zhang, N."Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma". Experimental and Therapeutic Medicine 21.4 (2021): 327.
Chicago
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., Zhang, N."Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma". Experimental and Therapeutic Medicine 21, no. 4 (2021): 327. https://doi.org/10.3892/etm.2021.9758
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang A, Su X, Wang Y, Shi G, Han C and Zhang N: Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma. Exp Ther Med 21: 327, 2021.
APA
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., & Zhang, N. (2021). Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma. Experimental and Therapeutic Medicine, 21, 327. https://doi.org/10.3892/etm.2021.9758
MLA
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., Zhang, N."Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma". Experimental and Therapeutic Medicine 21.4 (2021): 327.
Chicago
Zhang, A., Su, X., Wang, Y., Shi, G., Han, C., Zhang, N."Predicting the effects of radiotherapy based on diffusion kurtosis imaging in a xenograft mouse model of esophageal carcinoma". Experimental and Therapeutic Medicine 21, no. 4 (2021): 327. https://doi.org/10.3892/etm.2021.9758
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