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4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice

  • Authors:
    • Wenkai Yi
    • Tao Liu
    • Xinfeng Gao
    • Yonghua Xie
    • Ming Liu
  • View Affiliations / Copyright

    Affiliations: Department of Spine Surgery, Pu Ai Hospital of Wuhan City, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 354
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    Published online on: February 11, 2021
       https://doi.org/10.3892/etm.2021.9785
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Abstract

4‑Hexylresorcinol (4HR) is a small organic compound that is widely used as an antiseptic and antioxidant. In the present study, its role in osteoclastogenesis was investigated. Bone marrow‑derived macrophages from mice were used to examine the role of 4HR in osteogenesis. An ovariectomy (OVX) mouse model was constructed to examine the effect of 4HR in vivo, followed by hematoxylin and eosin and tartrate resistant acid phosphatase staining. In the present study, 4HR effectively suppressed receptor activator of NF‑κB ligand‑induced osteoclastogenesis in a dose‑dependent manner. 4HR was also found to significantly suppress the expression of osteoclast (OC)‑specific markers, including tartrate‑resistant acid phosphatase, cathepsin K, nuclear factor of activated T‑cell cytoplasmic 1 and c‑Fos in the presence of RANKL in BMMs. Furthermore, 4HR inhibited osteoclastogenesis by inhibiting the activation of the NF‑κB signaling pathway in BMMs. Consistent with the in vitro results, 4HR effectively ameliorated OVX‑induced bone loss and markedly reduced OC number in the proximal tibia in vivo. In conclusion, the present results suggested that 4HR inhibited osteoclastogenesis in vitro and rescued bone loss in vivo, suggesting that 4HR may serve as a novel therapeutic agent for osteoporosis treatment.
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1 

Kanis JA: Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report. WHO study group. Osteoporos Int. 4:368–381. 1994.PubMed/NCBI View Article : Google Scholar

2 

Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B and Kanis JA: Osteoporosis in the European union: Medical management, epidemiology and economic burden. A report prepared in collaboration with the international osteoporosis foundation (IOF) and the European federation of pharmaceutical industry associations (EFPIA). Arch Osteoporos. 8(136)2013.PubMed/NCBI View Article : Google Scholar

3 

Tom SE, Adachi JD, Anderson FA Jr, Boonen S, Chapurlat RD, Compston JE, Cooper C, Gehlbach SH, Greenspan SL, Hooven FH, et al: Frailty and fracture, disability, and falls: A multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc. 61:327–334. 2013.PubMed/NCBI View Article : Google Scholar

4 

Johnell O and Kanis J: Epidemiology of osteoporotic fractures. Osteoporos Int. 16 (Suppl 2):S3–S7. 2005.PubMed/NCBI View Article : Google Scholar

5 

Eriksen EF: Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord. 11:219–227. 2010.PubMed/NCBI View Article : Google Scholar

6 

Chen X, Wang Z, Duan N, Zhu G, Schwarz EM and Xie C: Osteoblast-osteoclast interactions. Connect Tissue Res. 59:99–107. 2018.PubMed/NCBI View Article : Google Scholar

7 

Kikuta J and Ishii M: Bone imaging: Osteoclast and osteoblast dynamics. Methods Mol Biol. 1763:1–9. 2018.PubMed/NCBI View Article : Google Scholar

8 

Roodman GD: Cell biology of the osteoclast. Exp Hematol. 27:1229–1241. 1999.PubMed/NCBI View Article : Google Scholar

9 

Datta HK, Ng WF, Walker JA, Tuck SP and Varanasi SS: The cell biology of bone metabolism. J Clin Pathol. 61:577–587. 2008.PubMed/NCBI View Article : Google Scholar

10 

Zaidi M: Skeletal remodeling in health and disease. Nat Med. 13:791–801. 2007.PubMed/NCBI View Article : Google Scholar

11 

Trouvin AP and Goëb V: Receptor activator of nuclear factor-κB ligand and osteoprotegerin: Maintaining the balance to prevent bone loss. Clin Interv Aging. 5:345–354. 2010.PubMed/NCBI View Article : Google Scholar

12 

Boyce BF and Xing L: Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 473:139–146. 2008.PubMed/NCBI View Article : Google Scholar

13 

Lewiecki EM: Denosumab: A promising drug for the prevention and treatment of osteoporosis. Womens Health (Lond). 2:517–525. 2006.PubMed/NCBI View Article : Google Scholar

14 

Eastell R, Christiansen C, Grauer A, Kutilek S, Libanati C, McClung MR, Reid IR, Resch H, Siris E, Uebelhart D, et al: Effects of denosumab on bone turnover markers in postmenopausal osteoporosis. J Bone Miner Res. 26:530–537. 2011.PubMed/NCBI View Article : Google Scholar

15 

Kendler DL, Roux C, Benhamou CL, Brown JP, Lillestol M, Siddhanti S, Man HS, San Martin J and Bone HG: Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res. 25:72–81. 2010.PubMed/NCBI View Article : Google Scholar

16 

Gupta G and Aronow WS: Treatment of postmenopausal osteoporosis. Compr Ther. 33:114–119. 2007.PubMed/NCBI View Article : Google Scholar

17 

Lewiecki EM: Denosumab in postmenopausal osteoporosis: What the clinician needs to know. Ther Adv Musculoskelet Dis. 1:13–26. 2009.PubMed/NCBI View Article : Google Scholar

18 

Silva I and Branco JC: Denosumab: Recent update in postmenopausal osteoporosis. Acta Reumatol Port. 37:302–313. 2012.PubMed/NCBI

19 

Kim MK, Yoon CS, Kim SG, Park YW, Lee SS and Lee SK: Effects of 4-hexylresorcinol on protein expressions in RAW 264.7 cells as determined by immunoprecipitation high performance liquid chromatography. Sci Rep. 9(3379)2019.PubMed/NCBI View Article : Google Scholar

20 

Rabbani GH, Gilman RH, Kabir I and Mondel G: The treatment of fasciolopsis buski infection in children: A comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene. Trans R Soc Trop Med Hyg. 79:513–515. 1985.PubMed/NCBI View Article : Google Scholar

21 

Kim SG, Lee SW, Park YW, Jeong JH and Choi JY: 4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells. Oncol Rep. 26:1527–1532. 2011.PubMed/NCBI View Article : Google Scholar

22 

He J, Zhu Q, Dong X, Pan H, Chen J and Zheng ZP: Oxyresveratrol and ascorbic acid O/W microemulsion: Preparation, characterization, anti-isomerization and potential application as antibrowning agent on fresh-cut lotus root slices. Food Chem. 214:269–276. 2017.PubMed/NCBI View Article : Google Scholar

23 

Choi KH, Kim DW, Lee SK, Kim SG and Kim TW: The administration of 4-hexylresorcinol accelerates orthodontic tooth movement and increases the expression level of bone turnover markers in ovariectomized rats. Int J Mol Sci. 21(1526)2020.PubMed/NCBI View Article : Google Scholar

24 

Zhao L, Guan H, Song C, Wang Y, Liu C, Cai C, Zhu H, Liu H, Zhao L and Xiao J: YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism. Bone. 110:177–186. 2018.PubMed/NCBI View Article : Google Scholar

25 

Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M and Park-Min KH: MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα. J Clin Invest. 127:2555–2568. 2017.PubMed/NCBI View Article : Google Scholar

26 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987.PubMed/NCBI View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Sun X, Gao X, Deng Z, Zhang L, McGilvray K, Gadomski BC, Amra S, Bao G and Huard J: High bone microarchitecture, strength, and resistance to bone loss in MRL/MpJ mice correlates with activation of different signaling pathways and systemic factors. FASEB J. 34:789–806. 2020.PubMed/NCBI View Article : Google Scholar

29 

Farahzadi R, Fathi E and Vietor I: Mesenchymal stem cells could be considered as a candidate for further studies in cell-based therapy of alzheimer's disease via targeting the signaling pathways. ACS Chem Neurosci. 11:1424–1435. 2020.PubMed/NCBI View Article : Google Scholar

30 

Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, Ho KK, Qin L, Song H and Mak KK: Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation. Nat Commun. 9(4564)2018.PubMed/NCBI View Article : Google Scholar

31 

Idris AI: Ovariectomy/orchidectomy in rodents. Methods Mol Biol. 816:545–551. 2012.PubMed/NCBI View Article : Google Scholar

32 

Huo J and Sun X: Effect of astragalus polysaccharides on ovariectomy-induced osteoporosis in mice. Genet Mol Res. 15:2016.PubMed/NCBI View Article : Google Scholar

33 

Gao X, Usas A, Tang Y, Lu A, Tan J, Schneppendahl J, Kozemchak AM, Wang B, Cummins JH, Tuan RS and Huard J: A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP. Biomaterials. 35:6859–6870. 2014.PubMed/NCBI View Article : Google Scholar

34 

Lee Y, Kim HJ, Park CK, Kim YG, Lee HJ, Kim JY and Kim HH: MicroRNA-124 regulates osteoclast differentiation. Bone. 56:383–389. 2013.PubMed/NCBI View Article : Google Scholar

35 

Takada J, Dinavahi R, Miyauchi A, Hamaya E, Hirama T, Libanati C, Nakamura Y, Milmont CE and Grauer A: Relationship between P1NP, a biochemical marker of bone turnover, and bone mineral density in patients transitioned from alendronate to romosozumab or teriparatide: A post hoc analysis of the STRUCTURE trial. J Bone Miner Metab. 38:310–315. 2020.PubMed/NCBI View Article : Google Scholar

36 

Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, et al: TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 25:1549–1566. 2018.PubMed/NCBI View Article : Google Scholar

37 

Zhang Y, Xu S, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, et al: mTORC1 inhibits NF-κB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. J Bone Miner Res. 32:1829–1840. 2017.PubMed/NCBI View Article : Google Scholar

38 

Lorenzo J, Horowitz M and Choi Y: Osteoimmunology: Interactions of the bone and immune system. Endocr Rev. 29:403–440. 2008.PubMed/NCBI View Article : Google Scholar

39 

Lin TH, Pajarinen J, Lu L, Nabeshima A, Cordova LA, Yao Z and Goodman SB: NF-κB as a therapeutic target in inflammatory-associated bone diseases. Adv Protein Chem Struct Biol. 107:117–154. 2017.PubMed/NCBI View Article : Google Scholar

40 

Abu-Amer Y: NF-κB signaling and bone resorption. Osteoporos Int. 24:2377–2386. 2013.PubMed/NCBI View Article : Google Scholar

41 

Liu TT, Liu DM, Xuan Y, Zhao L, Sun LH, Zhao DD, Wang XF, He Y, Guo XZ, Du R, et al: The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years. Bone Res. 5(17020)2017.PubMed/NCBI View Article : Google Scholar

42 

Thurairaja R, Iles RK, Jefferson K, McFarlane JP and Persad RA: Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: A potential predictor of bone metastases and prognosticator for disease progression and survival. Urol Int. 76:67–71. 2006.PubMed/NCBI View Article : Google Scholar

43 

Boyle WJ, Simonet WS and Lacey DL: Osteoclast differentiation and activation. Nature. 423:337–342. 2003.PubMed/NCBI View Article : Google Scholar

44 

Boyce BF, Xiu Y, Li J, Xing L and Yao Z: NF-κB-mediated regulation of osteoclastogenesis. Endocrinol Metab (Seoul). 30:35–44. 2015.PubMed/NCBI View Article : Google Scholar

45 

Silva I and Branco JC: Rank/Rankl/opg: Literature review. Acta Reumatol Port. 36:209–218. 2011.PubMed/NCBI

46 

Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC and O'Brien CA: Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 287:29851–29860. 2012.PubMed/NCBI View Article : Google Scholar

47 

Salamanna F, Borsari V, Contartese D, Nicoli Aldini N and Fini M: Link between estrogen deficiency osteoporosis and susceptibility to bone metastases: A way towards precision medicine in cancer patients. Breast. 41:42–50. 2018.PubMed/NCBI View Article : Google Scholar

48 

Kanis JA, Cooper C, Rizzoli R and Reginster JY: Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 30:3–44. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yi W, Liu T, Gao X, Xie Y and Liu M: 4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice. Exp Ther Med 21: 354, 2021.
APA
Yi, W., Liu, T., Gao, X., Xie, Y., & Liu, M. (2021). 4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice. Experimental and Therapeutic Medicine, 21, 354. https://doi.org/10.3892/etm.2021.9785
MLA
Yi, W., Liu, T., Gao, X., Xie, Y., Liu, M."4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice". Experimental and Therapeutic Medicine 21.4 (2021): 354.
Chicago
Yi, W., Liu, T., Gao, X., Xie, Y., Liu, M."4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice". Experimental and Therapeutic Medicine 21, no. 4 (2021): 354. https://doi.org/10.3892/etm.2021.9785
Copy and paste a formatted citation
x
Spandidos Publications style
Yi W, Liu T, Gao X, Xie Y and Liu M: 4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice. Exp Ther Med 21: 354, 2021.
APA
Yi, W., Liu, T., Gao, X., Xie, Y., & Liu, M. (2021). 4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice. Experimental and Therapeutic Medicine, 21, 354. https://doi.org/10.3892/etm.2021.9785
MLA
Yi, W., Liu, T., Gao, X., Xie, Y., Liu, M."4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice". Experimental and Therapeutic Medicine 21.4 (2021): 354.
Chicago
Yi, W., Liu, T., Gao, X., Xie, Y., Liu, M."4‑Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF‑κB signaling pathway and reverses bone loss in ovariectomized mice". Experimental and Therapeutic Medicine 21, no. 4 (2021): 354. https://doi.org/10.3892/etm.2021.9785
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