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Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway

  • Authors:
    • Qiong Yu
    • Haofei Dai
    • Yinan Jiang
    • Yifeng Zha
    • Jie Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Nursing, Huashan Hospital‑North, Fudan University, Shanghai 201907, P.R. China, Department of Anesthesia, Huashan Hospital‑North, Fudan University, Shanghai 201907, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 376
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    Published online on: February 19, 2021
       https://doi.org/10.3892/etm.2021.9807
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Abstract

Sevoflurane (Sev), a volatile anesthetic, has been reported to exhibit beneficial effects on different ischemia/reperfusion (I/R)‑injured organs. However, the neuroprotective effect of Sev on cerebral I/R injury is poorly understood. In the present study, the effects of Sev on HT22 cells exposed to oxygen‑glucose deprivation/reperfusion (OGD/R) injury are investigated. The present study demonstrated that OGD/R suppressed the cell viability and increased lactate dehydrogenase (LDH) release from the cells, and these effects were attenuated by Sev treatment. The results also demonstrated that Sev alleviated OGD/R‑induced cell apoptosis via flow cytometry and caspase‑3 activity determination. Biochemical analysis results revealed that Sev significantly protected against OGD/R‑induced oxidative stress by reducing ROS generation and improving antioxidant defense markers. Western blot analysis demonstrated that Sev reactivated the PI3K/AKT/glycogen synthase kinase‑3β (GSK3β) signaling pathway, which was inhibited by OGD/R. In addition, wortmannin, a selective PI3K inhibitor was used to investigate the underlying pathways. Notably, the neuroprotective effect of Sev on apoptosis and reactive oxygen species production was found to be suppressed by wortmannin. Collectively, these results demonstrated that Sev may protect neuronal cells against OGD/R‑induced injury through the activation of the PI3K/AKT/GSK3β signaling pathway. The findings from the present study provide a novel insight into understanding the neuroprotective effect of Sev on cerebral I/R injury.
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1 

Feigin VL: Stroke epidemiology in the developing world. Lancet. 365:2160–2161. 2005.PubMed/NCBI View Article : Google Scholar

2 

Surinkaew P, Sawaddiruk P, Apaijai N, Chattipakorn N and Chattipakorn SC: Role of microglia under cardiac and cerebral ischemia/reperfusion (I/R) injury. Metab Brain Dis. 33:1019–1030. 2018.PubMed/NCBI View Article : Google Scholar

3 

Schrepfer E and Scorrano L: Mitofusins, from mitochondria to metabolism. Mol Cell. 61:683–694. 2016.PubMed/NCBI View Article : Google Scholar

4 

Wu H, Tang C, Tai LW, Yao W, Guo P, Hong J, Yang X, Li X, Jin Z, Ke J and Wang Y: Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. Biosci Rep. 38(BSR20171562)2018.PubMed/NCBI View Article : Google Scholar

5 

Zhang Y, Li D, Luo J, Chen S, Dou X, Han M and Zhang H: Pharmacological postconditioning with sevoflurane activates PI3K/AKT signaling and attenuates cardiopulmonary bypass-induced lung injury in dog. Life Sci. 173:68–72. 2017.PubMed/NCBI View Article : Google Scholar

6 

Lu CC, Tsai CS, Ho ST, Chen WY, Wong CS, Wang JJ, Hu OYP and Lin CY: Pharmacokinetics of sevoflurane uptake into the brain and body. Anaesthesia. 58:951–956. 2003.PubMed/NCBI View Article : Google Scholar

7 

Xiong XQ, Lin LN, Wang LR and Jin LD: Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice. Int J Nanomedicine. 6:1075–1081. 2013.PubMed/NCBI View Article : Google Scholar

8 

Li XQ, Cao XZ, Wang J, Fang B, Tan WF and Ma H: Sevoflurane preconditioning ameliorates neuronal deficits by inhibiting microglial MMP-9 expression after spinal cord ischemia/reperfusion in rats. Mol Brain. 7(69)2014.PubMed/NCBI View Article : Google Scholar

9 

Park HP, Jeong EJ, Kim MH, Hwang JW, Lim YJ, Min SW, Kim CS and Jeon YT: Effects of sevoflurane on neuronal cell damage after severe cerebral ischemia in rats. Korean J Anesthesiol. 61:327–331. 2011.PubMed/NCBI View Article : Google Scholar

10 

Canas PT, Velly LJ, Labrande CN, Guillet BA, Sautou-Miranda V, Masmejean FM, Nieoullon AL, Gouin FM, Bruder NJ and Pisano PS: Sevoflurane protects rat mixed cerebrocortical neuronal-glial cell cultures against transient oxygen-glucose deprivation: Involvement of glutamate uptake and reactive oxygen species. Anesthesiology. 105:990–998. 2006.PubMed/NCBI View Article : Google Scholar

11 

Wang Z, Ye Z, Huang G, Wang N, Wang E and Guo Q: Sevoflurane post-conditioning enhanced hippocampal neuron resistance to global cerebral ischemia induced by cardiac arrest in rats through PI3K/Akt survival pathway. Front Cell Neurosci. 10(271)2016.PubMed/NCBI View Article : Google Scholar

12 

Hu X, Zhang Y, Li W, Liu J and Li Y: Preconditioning with sevoflurane ameliorates spatial learning and memory deficit after focal cerebral ischemia-reperfusion in rats. Int J Dev Neurosci. 31:328–333. 2013.PubMed/NCBI View Article : Google Scholar

13 

Wang G, Wang T, Zhang Y, Li F, Yu B and Kou J: Schizandrin protects against OGD/R-induced neuronal injury by suppressing autophagy: Involvement of the AMPK/mTOR pathway. Molecules. 24(3624)2019.PubMed/NCBI View Article : Google Scholar

14 

Liang H, Gu M, Yang C, Wang H, Wen X and Zhou Q: Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway. J Anesth. 26:381–392. 2012.PubMed/NCBI View Article : Google Scholar

15 

Pyo H, Yang MS, Jou I and Joe EH: Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats. Neurosci Lett. 346:141–144. 2003.PubMed/NCBI View Article : Google Scholar

16 

Rössler OG, Giehl KM and Thiel G: Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. J Neurochem. 88:1240–1252. 2004.PubMed/NCBI View Article : Google Scholar

17 

Tang Y, Vater C, Jacobi A, Liebers C, Zou X and Stiehler M: Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways. Br J Pharmacol. 171:2440–2456. 2014.PubMed/NCBI View Article : Google Scholar

18 

Landucci E, Lattanzi R, Gerace E, Scartabelli T, Balboni G, Negri L and Pellegrini-Giampietro DE: Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro. Neuropharmacology. 108:39–48. 2016.PubMed/NCBI View Article : Google Scholar

19 

Ye Z, Xia P, Cheng ZG and Guo Q: Neuroprotection induced by sevoflurane-delayed post-conditioning is attributable to increased phosphorylation of mitochondrial GSK-3β through the PI3K/Akt survival pathway. J Neurol Sci. 348:216–225. 2015.PubMed/NCBI View Article : Google Scholar

20 

Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H, Maier CM, Narasimhan P, Goeders CE and Chan PH: Oxidative stress in ischemic brain damage: Mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal. 14:1505–1517. 2011.PubMed/NCBI View Article : Google Scholar

21 

Xu HX, Pan W, Qian JF, Liu F, Dong HQ and Liu QJ: MicroRNA-21 contributes to the puerarin-induced cardioprotection via suppression of apoptosis and oxidative stress in a cell model of ischemia/reperfusion injury. Mol Med Rep. 20:719–727. 2019.PubMed/NCBI View Article : Google Scholar

22 

Siti HN, Kamisah Y and Kamsiah J: The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (Review). Vascul Pharmacol. 71:40–56. 2015.PubMed/NCBI View Article : Google Scholar

23 

Lai Z, Zhang L, Su J, Cai D and Xu Q: Sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3K/Akt-mPTP pathway. Brain Res. 1630:25–37. 2016.PubMed/NCBI View Article : Google Scholar

24 

Li P, Zhang Y and Liu H: The role of Wnt/β-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia/reperfusion injury in rats. Life Sci. 236(116921)2019.PubMed/NCBI View Article : Google Scholar

25 

Patel SS and Goa KL: Sevoflurane. A review of its pharmacodynamic and pharmacokinetic properties and its clinical use in general anaesthesia. Drugs. 51:658–700. 1996.PubMed/NCBI View Article : Google Scholar

26 

Wise-Faberowski L, Raizada MK and Sumners C: Desflurane and sevoflurane attenuate oxygen and glucose deprivation-induced neuronal cell death. J Neurosurg Anesthesiol. 15:193–199. 2003.PubMed/NCBI View Article : Google Scholar

27 

Wen XR, Fu YY, Liu HZ, Wu J, Shao XP, Zhang XB, Tang M, Shi Y, Ma K, Zhang F, et al: Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting JNK3/caspase-3 by enhancing akt signaling pathway. Mol Neurobiol. 53:1661–1671. 2016.PubMed/NCBI View Article : Google Scholar

28 

Coyle JT and Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science. 262:689–695. 1993.PubMed/NCBI View Article : Google Scholar

29 

Shen MH, Zhang CB, Zhang JH and Li PF: Electroacupuncture attenuates cerebral ischemia and reperfusion injury in middle cerebral artery occlusion of rat via modulation of apoptosis, inflammation, oxidative stress, and excitotoxicity. Evid Based Complement Alternat Med. 2016(9438650)2016.PubMed/NCBI View Article : Google Scholar

30 

Sosunov SA, Ameer X, Niatsetskaya ZV, Utkina-Sosunova I, Ratner VI and Ten VS: Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury. PLoS One. 10(e0120456)2015.PubMed/NCBI View Article : Google Scholar

31 

Chen L, Wei X, Hou Y, Liu X, Li S, Sun B, Liu X and Liu H: Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats. Neurochem Int. 66:27–32. 2014.PubMed/NCBI View Article : Google Scholar

32 

Liu H, Liu X, Wei X, Chen L, Xiang Y, Yi F and Zhang X: Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation. Brain Res Bull. 89:65–70. 2012.PubMed/NCBI View Article : Google Scholar

33 

Zhang J, Deng Z, Liao J, Song C, Liang C, Xue H, Wang L, Zhang K and Yan G: Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway. J Cereb Blood Flow Metab. 33:567–574. 2013.PubMed/NCBI View Article : Google Scholar

34 

Martin M, Rehani K, Jope RS and Michalek SM: Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol. 6:777–784. 2005.PubMed/NCBI View Article : Google Scholar

35 

Jope RS and Johnson GVW: The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci. 29:95–102. 2004.PubMed/NCBI View Article : Google Scholar

36 

Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor ENE, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, et al: Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res. 10:301–312. 2013.PubMed/NCBI View Article : Google Scholar

37 

Li Y, Zhu W, Tao J, Xin P, Liu M, Li J and Wei M: Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: The differential role for PI3K/Akt and JAK2/STAT3 signaling pathways. PLoS One. 7(e48115)2012.PubMed/NCBI View Article : Google Scholar

38 

Zhang JF, Zhang L, Shi LL, Zhao ZH, Xu H, Liang F, Li HB, Zhao Y, Xu X, Yang K and Tian YF: Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells. Biomed Pharmacother. 89:1159–1165. 2017.PubMed/NCBI View Article : Google Scholar

39 

Gerace E, Scartabelli T, Pellegrini-Giampietro DE and Landucci E: Tolerance induced by (S)-3,5-dihydroxyphenylglycine postconditioning is mediated by the PI3K/Akt/GSK3β signalling pathway in an in vitro model of cerebral ischemia. Neuroscience. 433:221–229. 2020.PubMed/NCBI View Article : Google Scholar

40 

Lee DH, Lee YJ and Kwon KH: Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. J Clin Biochem Nutr. 47:121–129. 2010.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yu Q, Dai H, Jiang Y, Zha Y and Zhang J: Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway. Exp Ther Med 21: 376, 2021.
APA
Yu, Q., Dai, H., Jiang, Y., Zha, Y., & Zhang, J. (2021). Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway. Experimental and Therapeutic Medicine, 21, 376. https://doi.org/10.3892/etm.2021.9807
MLA
Yu, Q., Dai, H., Jiang, Y., Zha, Y., Zhang, J."Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway". Experimental and Therapeutic Medicine 21.4 (2021): 376.
Chicago
Yu, Q., Dai, H., Jiang, Y., Zha, Y., Zhang, J."Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway". Experimental and Therapeutic Medicine 21, no. 4 (2021): 376. https://doi.org/10.3892/etm.2021.9807
Copy and paste a formatted citation
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Spandidos Publications style
Yu Q, Dai H, Jiang Y, Zha Y and Zhang J: Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway. Exp Ther Med 21: 376, 2021.
APA
Yu, Q., Dai, H., Jiang, Y., Zha, Y., & Zhang, J. (2021). Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway. Experimental and Therapeutic Medicine, 21, 376. https://doi.org/10.3892/etm.2021.9807
MLA
Yu, Q., Dai, H., Jiang, Y., Zha, Y., Zhang, J."Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway". Experimental and Therapeutic Medicine 21.4 (2021): 376.
Chicago
Yu, Q., Dai, H., Jiang, Y., Zha, Y., Zhang, J."Sevoflurane alleviates oxygen‑glucose deprivation/reoxygenation‑induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway". Experimental and Therapeutic Medicine 21, no. 4 (2021): 376. https://doi.org/10.3892/etm.2021.9807
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