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Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis

  • Authors:
    • Yu-Ming Wang
    • Ying Chen
    • Yan-Jun Zheng
    • Yun-Chuan Huang
    • Wei-Wei Chen
    • Ran Ji
    • Li-Li Xu
    • Zhi-Tao Yang
    • Hui-Qiu Sheng
    • Hong-Ping Qu
    • En-Qiang Mao
    • Er-Zhen Chen
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 387
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    Published online on: February 23, 2021
       https://doi.org/10.3892/etm.2021.9818
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Abstract

For patients with sepsis and septic shock, it remains controversial when to restrict fluid intake and achieve a negative fluid balance. The present study aimed to evaluate the effects of the fluid intake volume during the first 24 h as well as fluid balance for 7 days on the prognosis of sepsis or septic shock. A total of 337 patients diagnosed with sepsis or septic shock at Ruijin Hospital (Shanghai, China) were enrolled in the present retrospective study. Patients with a low fluid intake volume during the first 24 h (fluid intake, 28.1±10.6 ml/kg) had lower in‑hospital mortality rates (18.0 vs. 27.3%, P=0.043) and a shorter duration of mechanical ventilation [0 (0‑6) vs. 3 (0‑11), P=0.025] than the high‑fluid volume intake group (62.6±17.6 ml/kg). Furthermore, survivors exhibited a daily negative net fluid balance from the second day (48 h), whereas non‑survivors had a daily positive net fluid balance for 7 days, where fluid balance volumes were significantly lower in survivors compared with those in non‑survivors. Finally, binary logistic regression analysis was used to determine whether the mean daily fluid balance (P<0.001) and the Acute Physiologic and Chronic Health Evaluation II score (P=0.048) were independent prognostic factors for patients with sepsis or septic shock. It was indicated that a low fluid intake volume during the first 24 h and a persistent negative fluid balance from the second day were associated with favorable outcomes. The mean daily fluid balance was an independent prognostic factor or patients with sepsis or septic shock.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Chen Y, Zheng Y, Huang Y, Chen W, Ji R, Xu L, Yang Z, Sheng H, Qu H, Qu H, et al: Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis. Exp Ther Med 21: 387, 2021.
APA
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R. ... Chen, E. (2021). Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis. Experimental and Therapeutic Medicine, 21, 387. https://doi.org/10.3892/etm.2021.9818
MLA
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R., Xu, L., Yang, Z., Sheng, H., Qu, H., Mao, E., Chen, E."Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis". Experimental and Therapeutic Medicine 21.4 (2021): 387.
Chicago
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R., Xu, L., Yang, Z., Sheng, H., Qu, H., Mao, E., Chen, E."Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis". Experimental and Therapeutic Medicine 21, no. 4 (2021): 387. https://doi.org/10.3892/etm.2021.9818
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Chen Y, Zheng Y, Huang Y, Chen W, Ji R, Xu L, Yang Z, Sheng H, Qu H, Qu H, et al: Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis. Exp Ther Med 21: 387, 2021.
APA
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R. ... Chen, E. (2021). Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis. Experimental and Therapeutic Medicine, 21, 387. https://doi.org/10.3892/etm.2021.9818
MLA
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R., Xu, L., Yang, Z., Sheng, H., Qu, H., Mao, E., Chen, E."Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis". Experimental and Therapeutic Medicine 21.4 (2021): 387.
Chicago
Wang, Y., Chen, Y., Zheng, Y., Huang, Y., Chen, W., Ji, R., Xu, L., Yang, Z., Sheng, H., Qu, H., Mao, E., Chen, E."Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis". Experimental and Therapeutic Medicine 21, no. 4 (2021): 387. https://doi.org/10.3892/etm.2021.9818
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