Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression

  • Authors:
    • Huafeng Pan
    • Xin Rui
    • Wei Wei
    • Siliang Shao
    • Yudi Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China
  • Article Number: 390
    |
    Published online on: February 24, 2021
       https://doi.org/10.3892/etm.2021.9821
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prostate cancer places a serious health burden on males. The present study aimed to explore the potential prognostic significance and biological function of microRNA (miR)‑339‑5p in patients with prostate cancer. The expression of miR‑339‑5p was detected in prostate cancer tissues and cell lines by using reverse transcription‑quantitative PCR. Kaplan‑Meier survival curves and Cox regression analyses were used to investigate the prognostic significance of miR‑339‑5p in prostate cancer. The Cell Counting Kit‑8 assay was used to determine the effect of miR‑339‑5p on prostate cancer cell proliferation. Transwell assays were used to assess the effect of miR‑339‑5p on cell migration and invasion. The results indicated that the expression of miR‑339‑5p was downregulated in prostate cancer tissues and cell lines. Downregulation of miR‑339‑5p was significantly associated with the Gleason score, lymph node metastasis and TNM stage. Patients with high miR‑339‑5p expression levels had a longer survival time than those with low expression levels. Multivariate Cox regression analysis indicated that miR‑339‑5p may be an independent prognostic factor for the overall survival of patients with prostate cancer. Overexpression of miR‑339‑5p inhibited the proliferation, migration and invasion of prostate cancer cells. Taken together, these results indicated that miR‑339‑5p functions as a suppressor gene in prostate cancer and acts by inhibiting cell proliferation, migration and invasion of prostate cancer cells. miR‑339‑5p may serve as an independent prognostic biomarker and therapeutic target for the treatment of prostate cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hoffman RM, Meisner AL, Barry M, Shah SK, Zeliadt SB and Wiggins CL: Trends in United States prostate cancer incidence rates by age and stage, 1995-2012. Cancer Epidemiol Biomarkers Prev. 25:259–263. 2016.PubMed/NCBI View Article : Google Scholar

2 

Hayes JH and Barry MJ: Screening for prostate cancer with the prostate-specific antigen test: A review of current evidence. JAMA. 311:1143–1149. 2014.PubMed/NCBI View Article : Google Scholar

3 

Winter A, Sirri E, Jansen L, Wawroschek F, Kieschke J, Castro FA, Krilaviciute A, Holleczek B, Emrich K, Waldmann A, et al: Comparison of prostate cancer survival in Germany and the USA: Can differences be attributed to differences in stage distributions? BJU Int. 119:550–559. 2017.PubMed/NCBI View Article : Google Scholar

4 

Wong MC, Goggins WB, Wang HH, Fung FD, Leung C, Wong SY, Ng CF and Sung JJ: Global incidence and mortality for prostate cancer: Analysis of temporal patterns and trends in 36 countries. Eur Urol. 70:862–874. 2016.PubMed/NCBI View Article : Google Scholar

5 

Reulen RC, de Vogel S, Zhong W, Zhong Z, Xie LP, Hu Z, Deng Y, Yang K, Liang Y, Zeng X, et al: Physical activity and risk of prostate and bladder cancer in China: The South and East China case-control study on prostate and bladder cancer. PLoS One. 12(e0178613)2017.PubMed/NCBI View Article : Google Scholar

6 

Qi JL, Wang LJ, Zhou MG, Liu YN, Liu JM, Liu SW, Zeng XY and Yin P: Disease burden of prostate cancer among men in China, from 1990 to 2013. Zhonghua Liu Xing Bing Xue Za Zhi. 37:778–782. 2016.PubMed/NCBI View Article : Google Scholar : (In Chinese).

7 

Lin C, Bai S, Du T, Lai Y, Chen X, Peng S, Ma X, Wu W, Guo Z and Huang H: Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer. Cancer Manag Res. 11:1517–1524. 2019.PubMed/NCBI View Article : Google Scholar

8 

Downing A, Wright P, Hounsome L, Selby P, Wilding S, Watson E, Wagland R, Kind P, Donnelly DW, Butcher H, et al: Quality of life in men living with advanced and localised prostate cancer in the UK: A population-based study. Lancet Oncol. 20:436–447. 2019.PubMed/NCBI View Article : Google Scholar

9 

Park SH, Eber MR and Shiozawa Y: Models of prostate cancer bone metastasis. Methods Mol Biol. 1914:295–308. 2019.PubMed/NCBI View Article : Google Scholar

10 

Liu B, Li J and Cairns MJ: Identifying miRNAs, targets and functions. Brief Bioinform. 15:1–19. 2014.PubMed/NCBI View Article : Google Scholar

11 

Zhang Q, Zhang K, Zhang C, Ge H, Yin Y, Feng H and Hu R: MicroRNAs as big regulators of neural stem/progenitor cell proliferation, differentiation and migration: A potential treatment for stroke. Curr Pharm Des. 23:2252–2257. 2017.PubMed/NCBI View Article : Google Scholar

12 

Liu H, Cao B, Zhao Y, Liang H and Liu X: Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. Cancer Biomark. 22:621–629. 2018.PubMed/NCBI View Article : Google Scholar

13 

Peng P, Chen T, Wang Q, Zhang Y, Zheng F, Huang S, Tang Y, Yang C, Ding W, Ren D, et al: Decreased miR-218-5p levels as a serum biomarker in bone metastasis of prostate cancer. Oncol Res Treat. 42:165–185. 2019.PubMed/NCBI View Article : Google Scholar

14 

Nagahama Y and Fukui T: Dementia with Lewy bodies presenting as frontotemporal dementia phenotype. Psychogeriatrics. 19:505–509. 2019.PubMed/NCBI View Article : Google Scholar

15 

Moya L, Meijer J, Schubert S, Matin F and Batra J: Assessment of miR-98-5p, miR-152-3p, miR-326 and miR-4289 expression as biomarker for prostate cancer diagnosis. Int J Mol Sci. 20(1154)2019.PubMed/NCBI View Article : Google Scholar

16 

Malla RR, Kumari S, Gavara MM, Badana AK, Gugalavath S, Kumar DKG and Rokkam P: A perspective on the diagnostics, prognostics, and therapeutics of microRNAs of triple-negative breast cancer. Biophys Rev. 11:227–234. 2019.PubMed/NCBI View Article : Google Scholar

17 

Bertoli G, Cava C and Castiglioni I: MicroRNAs: New biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 5:1122–1143. 2015.PubMed/NCBI View Article : Google Scholar

18 

Yang L, Belaguli N and Berger DH: MicroRNA and colorectal cancer. World J Surg. 33:638–646. 2009.PubMed/NCBI View Article : Google Scholar

19 

Foj L and Filella X: Identification of potential miRNAs biomarkers for high-grade prostate cancer by integrated bioinformatics analysis. Pathol Oncol Res. 25:1445–1456. 2019.PubMed/NCBI View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

21 

Quiroz-Munoz M, Izadmehr S, Arumugam D, Wong B, Kirschenbaum A and Levine AC: Mechanisms of osteoblastic bone metastasis in prostate cancer: Role of prostatic acid phosphatase. J Endocr Soc. 3:655–664. 2019.PubMed/NCBI View Article : Google Scholar

22 

Loberg RD, Logothetis CJ, Keller ET and Pienta KJ: Pathogenesis and treatment of prostate cancer bone metastases: Targeting the lethal phenotype. J Clin Oncol. 23:8232–8241. 2005.PubMed/NCBI View Article : Google Scholar

23 

Kelly SP, Anderson WF, Rosenberg PS and Cook MB: Past, current, and future incidence rates and burden of metastatic prostate cancer in the United States. Eur Urol Focus. 4:121–127. 2018.PubMed/NCBI View Article : Google Scholar

24 

Costa-Pinheiro P, Montezuma D, Henrique R and Jeronimo C: Diagnostic and prognostic epigenetic biomarkers in cancer. Epigenomics. 7:1003–1015. 2015.PubMed/NCBI View Article : Google Scholar

25 

Quan Y, Huang X and Quan X: Expression of miRNA-206 and miRNA-145 in breast cancer and correlation with prognosis. Oncol Lett. 16:6638–6642. 2018.PubMed/NCBI View Article : Google Scholar

26 

Nan P, Niu Y, Wang X and Li Q: MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis. Onco Targets Ther. 12:6917–6925. 2019.PubMed/NCBI View Article : Google Scholar

27 

Casanova-Salas I, Rubio-Briones J, Calatrava A, Mancarella C, Masiá E, Casanova J, Fernández-Serra A, Rubio L, Ramírez-Backhaus M, Armiñán A, et al: Identification of miR-187 and miR-182 as biomarkers of early diagnosis and prognosis in patients with prostate cancer treated with radical prostatectomy. J Urol. 192:252–259. 2014.PubMed/NCBI View Article : Google Scholar

28 

Goto Y, Kurozumi A, Arai T, Nohata N, Kojima S, Okato A, Kato M, Yamazaki K, Ishida Y, Naya Y, et al: Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. Br J Cancer. 117:409–420. 2017.PubMed/NCBI View Article : Google Scholar

29 

Sun Y, Mei H, Xu C, Tang H and Wei W: Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma. Pathol Res Pract. 214:119–125. 2018.PubMed/NCBI View Article : Google Scholar

30 

Wang YL, Chen CM, Wang XM and Wang L: Effects of miR-339-5p on invasion and prognosis of hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 40:51–56. 2016.PubMed/NCBI View Article : Google Scholar

31 

Gan CZ, Li G, Luo QS and Li HM: MiR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting α1,2-fucosyltransferase 1. IUBMB Life. 69:841–849. 2017.PubMed/NCBI View Article : Google Scholar

32 

Shan W, Li J, Bai Y and Lu X: MiR-339-5p inhibits migration and invasion in ovarian cancer cell lines by targeting NACC1 and BCL6. Tumour Biol. 37:5203–5211. 2016.PubMed/NCBI View Article : Google Scholar

33 

Jansson MD, Damas ND, Lees M, Jacobsen A and Lund AH: MiR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2. Oncogene. 34:1908–1918. 2015.PubMed/NCBI View Article : Google Scholar

34 

Zhou C, Liu G, Wang L, Lu Y, Yuan L, Zheng L, Chen F, Peng F and Li X: MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1. PLoS One. 8(e63142)2013.PubMed/NCBI View Article : Google Scholar

35 

Luo A, Zhou X, Shi X, Zhao Y, Men Y, Chang X, Chen H, Ding F, Li Y, Su D, et al: Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma. Oncogene. 38:4990–5006. 2019.PubMed/NCBI View Article : Google Scholar

36 

Li P, Liu H, Li Y, Wang Y, Zhao L and Wang H: MiR-339-5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6. Oncol Lett. 16:5785–5790. 2018.PubMed/NCBI View Article : Google Scholar

37 

Sun X, Liu H, Li T and Qin L: MicroRNA-339-5p inhibits cell proliferation of acute myeloid leukaemia by directly targeting SOX4. Mol Med Rep. 18:5261–5269. 2018.PubMed/NCBI View Article : Google Scholar

38 

Grimm D, Bauer J, Wise P, Krüger M, Simonsen U, Wehland M, Infanger M and Corydon TJ: The role of SOX family members in solid tumours and metastasis. Semin Cancer Biol. S1044-579X(18)30141-X:2019.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

39 

Moran JD, Kim HH, Li Z and Moreno CS: SOX4 regulates invasion of bladder cancer cells via repression of WNT5a. Int J Oncol. 55:359–370. 2019.PubMed/NCBI View Article : Google Scholar

40 

Liu Y, Zeng S, Jiang X, Lai D and Su Z: SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer. Tumour Biol. 39(1010428317694539)2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pan H, Rui X, Wei W, Shao S and Zhu Y: Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Exp Ther Med 21: 390, 2021.
APA
Pan, H., Rui, X., Wei, W., Shao, S., & Zhu, Y. (2021). Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Experimental and Therapeutic Medicine, 21, 390. https://doi.org/10.3892/etm.2021.9821
MLA
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21.4 (2021): 390.
Chicago
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21, no. 4 (2021): 390. https://doi.org/10.3892/etm.2021.9821
Copy and paste a formatted citation
x
Spandidos Publications style
Pan H, Rui X, Wei W, Shao S and Zhu Y: Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Exp Ther Med 21: 390, 2021.
APA
Pan, H., Rui, X., Wei, W., Shao, S., & Zhu, Y. (2021). Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression. Experimental and Therapeutic Medicine, 21, 390. https://doi.org/10.3892/etm.2021.9821
MLA
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21.4 (2021): 390.
Chicago
Pan, H., Rui, X., Wei, W., Shao, S., Zhu, Y."Prognostic value of miR‑339‑5p in patients with prostate cancer and its effects on tumor progression". Experimental and Therapeutic Medicine 21, no. 4 (2021): 390. https://doi.org/10.3892/etm.2021.9821
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team