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Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China

  • Authors:
    • Haoming Xu
    • Zhitao Ou
    • Yongjian Zhou
    • Yingfei Li
    • Hongli Huang
    • Hailan Zhao
    • Jing Xu
    • Meijuan Luo
    • Youlian Zhou
    • Yuqiang Nie
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China, Department of Internal Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong 510180, P.R. China, Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 391
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    Published online on: February 24, 2021
       https://doi.org/10.3892/etm.2021.9822
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Abstract

Acquired immune deficiency syndrome, caused by the human immunodeficiency virus (HIV), has been associated with intestinal dysbiosis, which includes an increase in the number of mucosa‑associated pathobionts. In the present study, the intestinal mucosal microbiota patterns of HIV‑infected patients were compared with those of healthy individuals in a population from Guangzhou, China. The gut microbiota of intestinal mucosal samples from 12 patients with HIV (transmission routes included sex and intravenous drug abuse) was compared with that of 12 healthy age‑ and sex‑matched controls. Gut microbial communities were profiled via sequencing of the bacterial 16S ribosomal RNA genes. Dysbiosis in HIV‑infected individuals was characterized by decreased α‑diversity, decreased levels of Firmicutes and increased levels of Proteobacteria. Furthermore, low mean counts of Lachnoclostridium, Roseburia, Thauera, Dorea and Roseburia inulinivorans, and high mean counts of Halomonas and Shewanella bacteria, were indicated to be HIV‑associated mucosal bacterial alterations. The relative abundance of Fusobacterium and Lachnoclostridium was significantly decreased, while that of Halomonas and Shewanella was significantly increased in patients with sexually transmitted HIV‑infection compared with healthy controls. Alterations of the gut microbiota during HIV infection were also indicated to be associated with the route of HIV transmission. Certain bacteria may be potential biomarkers for HIV infection in patients from Guangzhou, China.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Ou Z, Zhou Y, Li Y, Huang H, Zhao H, Xu J, Luo M, Zhou Y, Nie Y, Nie Y, et al: Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China. Exp Ther Med 21: 391, 2021.
APA
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H. ... Nie, Y. (2021). Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China. Experimental and Therapeutic Medicine, 21, 391. https://doi.org/10.3892/etm.2021.9822
MLA
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H., Xu, J., Luo, M., Zhou, Y., Nie, Y."Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China". Experimental and Therapeutic Medicine 21.4 (2021): 391.
Chicago
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H., Xu, J., Luo, M., Zhou, Y., Nie, Y."Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China". Experimental and Therapeutic Medicine 21, no. 4 (2021): 391. https://doi.org/10.3892/etm.2021.9822
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Ou Z, Zhou Y, Li Y, Huang H, Zhao H, Xu J, Luo M, Zhou Y, Nie Y, Nie Y, et al: Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China. Exp Ther Med 21: 391, 2021.
APA
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H. ... Nie, Y. (2021). Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China. Experimental and Therapeutic Medicine, 21, 391. https://doi.org/10.3892/etm.2021.9822
MLA
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H., Xu, J., Luo, M., Zhou, Y., Nie, Y."Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China". Experimental and Therapeutic Medicine 21.4 (2021): 391.
Chicago
Xu, H., Ou, Z., Zhou, Y., Li, Y., Huang, H., Zhao, H., Xu, J., Luo, M., Zhou, Y., Nie, Y."Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in Guangzhou, China". Experimental and Therapeutic Medicine 21, no. 4 (2021): 391. https://doi.org/10.3892/etm.2021.9822
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