Open Access

Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia

  • Authors:
    • Yuyan Bai
    • Hefan He
    • Peisen Zhang
    • Weifeng Liu
    • Lirong Huang
  • View Affiliations

  • Published online on: February 25, 2021     https://doi.org/10.3892/etm.2021.9837
  • Article Number: 406
  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study was designed to determine the effects of dexmedetomidine on immune function, renal function and inflammatory factors in patients undergoing percutaneous nephrolithotomy under general anesthesia. A total of 177 patients with kidney calculi who underwent percutaneous nephrolithotomy in The Second Affiliated Hospital of Fujian Medical University were enrolled, in which 91 patients were treated with dexmedetomidine during surgery (research group) and 86 patients were not sedated during surgery (control group). The vital signs, renal function, inflammatory factors and immune function during surgery between the two groups were compared. Patients in the research group showed improved vital signs, renal function, inflammatory factors and immune function compared with the control group (P<0.05), and also experienced a significantly shorter hospitalization time (P<0.001). Therefore, the present results suggested that with a relatively high safety profile, use of dexmedetomidine for sedation can effectively protect renal and immune functions, and reduce the inflammatory response of patients during percutaneous nephrolithotomy. Thus, dexmedetomidine may have be potentially applied in clinical practice.
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April-2021
Volume 21 Issue 4

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Spandidos Publications style
Bai Y, He H, Zhang P, Liu W and Huang L: Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia. Exp Ther Med 21: 406, 2021
APA
Bai, Y., He, H., Zhang, P., Liu, W., & Huang, L. (2021). Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia. Experimental and Therapeutic Medicine, 21, 406. https://doi.org/10.3892/etm.2021.9837
MLA
Bai, Y., He, H., Zhang, P., Liu, W., Huang, L."Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia". Experimental and Therapeutic Medicine 21.4 (2021): 406.
Chicago
Bai, Y., He, H., Zhang, P., Liu, W., Huang, L."Effects of dexmedetomidine on immune function, renal function and inflammatory factors of patients undergoing percutaneous nephrolithotomy under general anesthesia". Experimental and Therapeutic Medicine 21, no. 4 (2021): 406. https://doi.org/10.3892/etm.2021.9837