Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model

  • Authors:
    • Isamu Murata
    • Tsugumi Sugai
    • Yumiko Murakawa
    • Yoshiaki Miyamoto
    • Jun Kobayashi
    • Yutaka Inoue
    • Ikuo Kanamoto
  • View Affiliations

  • Published online on: March 10, 2022     https://doi.org/10.3892/etm.2022.11249
  • Article Number: 320
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Abstract

Crush syndrome (CS) is a potentially lethal condition characterized by muscle cell damage resulting from decompression following compression. Patients with CS can develop cardiac failure, kidney dysfunction, shock, systemic inflammation and sepsis. Salvianolic acid B (SalB) has cardiac and kidney protective effects and anti‑oxidative, anti‑inflammatory, anti‑apoptotic and anti‑bacterial properties. The present study aimed to demonstrate the survival benefit of SalB in the CS rat model, which comprised anesthetized rats with bilateral hindlimb compression by a rubber tourniquet for 5 h. The rats examined were randomly divided into four groups: i) Sham; ii) sham treated with SalB; iii) CS rat model without treatment; and iv) CS rat model treated with SalB. Under continuous monitoring and recording of arterial blood pressures, blood and tissue samples were collected for biochemical analyses at designated timepoints before and after reperfusion. SalB administration improved the survival rate, kidney function (by treating shock and metabolic acidosis) and inflammation (by reducing mitochondrial dysfunction and endothelial damage). Reduced incidence of cardiac failure due to hyperkalemia was associated with reduced muscle injury via the prevention of mitochondrial dysfunction. Additionally, indirect antibacterial action by the neutrophil extracellular trap system (NETs) was observed. SalB administration to the CS rat model led to a substantial improvement in survival following CS by decreasing kidney and cardiac dysfunctions, inflammation, and endothelial dysfunction by improving the mitochondrial function and through antibacterial effects via NETs.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Murata I, Sugai T, Murakawa Y, Miyamoto Y, Kobayashi J, Inoue Y and Kanamoto I: Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model. Exp Ther Med 23: 320, 2022
APA
Murata, I., Sugai, T., Murakawa, Y., Miyamoto, Y., Kobayashi, J., Inoue, Y., & Kanamoto, I. (2022). Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model. Experimental and Therapeutic Medicine, 23, 320. https://doi.org/10.3892/etm.2022.11249
MLA
Murata, I., Sugai, T., Murakawa, Y., Miyamoto, Y., Kobayashi, J., Inoue, Y., Kanamoto, I."Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model". Experimental and Therapeutic Medicine 23.5 (2022): 320.
Chicago
Murata, I., Sugai, T., Murakawa, Y., Miyamoto, Y., Kobayashi, J., Inoue, Y., Kanamoto, I."Salvianolic acid B improves the survival rate, acute kidney dysfunction, inflammation and NETosis‑mediated antibacterial action in a crush syndrome rat model". Experimental and Therapeutic Medicine 23, no. 5 (2022): 320. https://doi.org/10.3892/etm.2022.11249