Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2022 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2022 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases

  • Authors:
    • Anastasios Tentolouris
    • Christos Stafylidis
    • Christos Siafarikas
    • Maria N. Dimopoulou
    • Sotiria Makrodimitri
    • Stelios Bousi
    • Petros Papalexis
    • Christos Damaskos
    • Nikolaos Trakas
    • Pagona Sklapani
    • Demetrios A. Spandidos
    • Vasiliki Epameinondas Georgakopoulou
  • View Affiliations / Copyright

    Affiliations: First Department of Propedeutic and Internal Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Hemoglobinopathies Reference Center, Laiko General Hospital, 11527 Athens, Greece, Department of Infectious Diseases‑COVID‑19 Unit, Laiko General Hospital, 11527 Athens, Greece, Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Department of Cytology, Mitera Hospital, 15123 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Tentolouris et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 338
    |
    Published online on: March 21, 2022
       https://doi.org/10.3892/etm.2022.11268
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sickle cell disease (SCD) is one of the most frequent and severe monogenic disorders, affecting millions of individuals worldwide. SCD represents a fatal hematological illness, characterized by veno‑occlusive events and hemolytic anemia. Hemolytic anemia is caused by abnormal sickle‑shaped erythrocytes, which induce parenchymal destruction and persistent organ damage, resulting in considerable morbidity and mortality. During the coronavirus disease 2019 (COVID‑19) pandemic, patients with SCD were characterized as a ‘high‑risk’ group due to their compromised immune system, caused by functional hyposplenism, as well as systemic vasculopathy. COVID‑19 is characterized by endothelial damage and a procoagulant condition. The present study describes the clinical features, management and outcomes of 3 patients with SCD who were hospitalized due to COVID‑19, who all had favorable outcomes despite the complications.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Aygun B and Odame I: A global perspective on sickle cell disease. Pediatr Blood Cancer. 59:386–390. 2012.PubMed/NCBI View Article : Google Scholar

2 

Ware RE, de Montalembert M, Tshilolo L and Abboud MR: Sickle cell disease. Lancet. 390:311–323. 2017.PubMed/NCBI View Article : Google Scholar

3 

Shet AS, Lizarralde-Iragorri MA and Naik RP: The molecular basis for the prothrombotic state in sickle cell disease. Haematologica. 105:2368–2379. 2020.PubMed/NCBI View Article : Google Scholar

4 

Glassberg J: Evidence-based management of sickle cell disease in the emergency department. Emerg Med Pract. 13:1–20; quiz 20. 2011.PubMed/NCBI

5 

Paul RN, Castro OL, Aggarwal A and Oneal PA: Acute chest syndrome: Sickle cell disease. Eur J Haematol. 87:191–207. 2011.PubMed/NCBI View Article : Google Scholar

6 

Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, et al: Causes and outcomes of the acute chest syndrome in sickle cell disease. National acute chest syndrome study group. N Engl J Med. 342:1855–1865. 2000.PubMed/NCBI View Article : Google Scholar

7 

McCloskey KA, Meenan J, Hall R and Tsitsikas DA: COVID-19 infection and sickle cell disease: A UK centre experience. Br J Haematol. 190:e57–e58. 2020.PubMed/NCBI View Article : Google Scholar

8 

Beerkens F, John M, Puliafito B, Corbett V, Edwards C and Tremblay D: COVID-19 pneumonia as a cause of acute chest syndrome in an adult sickle cell patient. Am J Hematol. 95:E154–E156. 2020.PubMed/NCBI View Article : Google Scholar

9 

Giannis D, Ziogas IA and Gianni P: Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 127(104362)2020.PubMed/NCBI View Article : Google Scholar

10 

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F and Moch H: Endothelial cell infection and endotheliitis in COVID-19. Lancet. 395:1417–1418. 2020.PubMed/NCBI View Article : Google Scholar

11 

White RH and Keenan CR: Effects of race and ethnicity on the incidence of venous thromboembolism. Thromb Res. 123 (Suppl 4):S11–S17. 2009.PubMed/NCBI View Article : Google Scholar

12 

Teulier M, Elabbadi A, Gerotziafas G, Lionnet F, Voiriot G and Fartoukh M: Severe COVID-19 with acute respiratory distress syndrome (ARDS) in a sickle cell disease adult patient: Case report. BMC Pulm Med. 21(46)2021.PubMed/NCBI View Article : Google Scholar

13 

Silva-Pinto AC, Santos-Oliveira L, Santos FLS, Kashima Haddad S, De Santis GC and do Tocantins Calado R: COVID-19 infection in sickle cell patients in a developing Country: A case series. Acta Haematol. 145:1–4. 2022.PubMed/NCBI View Article : Google Scholar

14 

Hussain FA, Njoku FU, Saraf SL, Molokie RE, Gordeuk VR and Han J: COVID-19 infection in patients with sickle cell disease. Br J Haematol. 189:851–852. 2020.PubMed/NCBI View Article : Google Scholar

15 

Arlet JB, de Luna G, Khimoud D, Odièvre MH, de Montalembert M, Joseph L, Chantalat-Auger C, Flamarion E, Bartolucci P, Lionnet F, et al: Prognosis of patients with sickle cell disease and COVID-19: A French experience. Lancet Haematol. 7:e632–e634. 2020.PubMed/NCBI View Article : Google Scholar

16 

Balanchivadze N, Kudirka AA, Askar S, Almadhoun K, Kuriakose P, Fadel R and Dabak V: Impact of COVID-19 infection on 24 patients with sickle cell disease. One center urban experience, Detroit, MI, USA. Hemoglobin. 44:284–289. 2020.PubMed/NCBI View Article : Google Scholar

17 

Chen-Goodspeed A and Idowu M: COVID-19 presentation in patients with sickle cell disease: A case series. Am J Case Rep. 22(e931758)2021.PubMed/NCBI View Article : Google Scholar

18 

Telfer P, De la Fuente J, Sohal M, Brown R, Eleftheriou P, Roy N, Piel FB, Chakravorty S, Gardner K, Velangi M, et al: Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients. Haematologica. 105:2651–2654. 2020.PubMed/NCBI View Article : Google Scholar

19 

Arlet JB, Lionnet F, Khimoud D, Joseph L, de Montalembert M, Morisset S, Garou A, Cannas G, Cougoul P, Guitton C, et al: Risk factors for severe COVID-19 in hospitalized sickle cell disease patients: A study of 319 patients in France. Am J Hematol. 97:E86–E91. 2022.PubMed/NCBI View Article : Google Scholar

20 

Panepinto JA, Brandow A, Mucalo L, Yusuf F, Singh A, Taylor B, Woods K, Payne AB, Peacock G and Schieve LA: Coronavirus disease among persons with sickle cell disease, United States, March 20-May 21, 2020. Emerg Infect Dis. 26:2473–2476. 2020.PubMed/NCBI View Article : Google Scholar

21 

Minniti CP, Zaidi AU, Nouraie M, Manwani D, Crouch GD, Crouch AS, Callaghan MU, Carpenter S, Jacobs C, Han J, et al: Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection. Blood Adv. 5:207–215. 2021.PubMed/NCBI View Article : Google Scholar

22 

Singh A, Brandow AM and Panepinto JA: COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals. Blood Adv. 5:1915–1921. 2021.PubMed/NCBI View Article : Google Scholar

23 

Clift AK, Saatci D, Coupland CAC, Dambha-Miller H and Hippisley-Cox J: International Investigator Group for Ethnicity and COVID-19. Sickle cell disorders and severe COVID-19 outcomes: A cohort study. Ann Intern Med. 174:1483–1487. 2021.PubMed/NCBI View Article : Google Scholar

24 

Mucalo L, Brandow AM, Dasgupta M, Mason SF, Simpson PM, Singh A, Taylor BW, Woods KJ, Yusuf FI and Panepinto JA: Comorbidities are risk factors for hospitalization and serious COVID-19 illness in children and adults with sickle cell disease. Blood Adv. 5:2717–2724. 2021.PubMed/NCBI View Article : Google Scholar

25 

Menapace LA and Thein SL: COVID-19 and sickle cell disease. Haematologica. 105:2501–2504. 2020.PubMed/NCBI View Article : Google Scholar

26 

Griffin JB, Haddix M, Danza P, Fisher R, Koo TH, Traub E, Gounder P, Jarashow C and Balter S: SARS-CoV-2 infections and hospitalizations among persons aged ≥16 Years, by vaccination status-los angeles county, California, May 1-July 25, 2021. MMWR Morb Mortal Wkly Rep. 70:1170–1176. 2021.PubMed/NCBI View Article : Google Scholar

27 

Jan H, Waheeb A, AlAhwal H, Almohammadi A, Al-Marzouki A, Barefah A, Bahashawan S and Radhwi O: COVID-19 vaccine perception and hesitancy among patients with sickle cell disease in the western region of Saudi Arabia. Cureus. 14(e21026)2022.PubMed/NCBI View Article : Google Scholar

28 

Guillon P, Clément M, Sébille V, Rivain JG, Chou CF, Ruvoën-Clouet N and Le Pendu J: Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 18:1085–1093. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tentolouris A, Stafylidis C, Siafarikas C, Dimopoulou MN, Makrodimitri S, Bousi S, Papalexis P, Damaskos C, Trakas N, Sklapani P, Sklapani P, et al: Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases. Exp Ther Med 23: 338, 2022.
APA
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M.N., Makrodimitri, S., Bousi, S. ... Georgakopoulou, V.E. (2022). Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases. Experimental and Therapeutic Medicine, 23, 338. https://doi.org/10.3892/etm.2022.11268
MLA
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M. N., Makrodimitri, S., Bousi, S., Papalexis, P., Damaskos, C., Trakas, N., Sklapani, P., Spandidos, D. A., Georgakopoulou, V. E."Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases". Experimental and Therapeutic Medicine 23.5 (2022): 338.
Chicago
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M. N., Makrodimitri, S., Bousi, S., Papalexis, P., Damaskos, C., Trakas, N., Sklapani, P., Spandidos, D. A., Georgakopoulou, V. E."Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases". Experimental and Therapeutic Medicine 23, no. 5 (2022): 338. https://doi.org/10.3892/etm.2022.11268
Copy and paste a formatted citation
x
Spandidos Publications style
Tentolouris A, Stafylidis C, Siafarikas C, Dimopoulou MN, Makrodimitri S, Bousi S, Papalexis P, Damaskos C, Trakas N, Sklapani P, Sklapani P, et al: Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases. Exp Ther Med 23: 338, 2022.
APA
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M.N., Makrodimitri, S., Bousi, S. ... Georgakopoulou, V.E. (2022). Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases. Experimental and Therapeutic Medicine, 23, 338. https://doi.org/10.3892/etm.2022.11268
MLA
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M. N., Makrodimitri, S., Bousi, S., Papalexis, P., Damaskos, C., Trakas, N., Sklapani, P., Spandidos, D. A., Georgakopoulou, V. E."Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases". Experimental and Therapeutic Medicine 23.5 (2022): 338.
Chicago
Tentolouris, A., Stafylidis, C., Siafarikas, C., Dimopoulou, M. N., Makrodimitri, S., Bousi, S., Papalexis, P., Damaskos, C., Trakas, N., Sklapani, P., Spandidos, D. A., Georgakopoulou, V. E."Favorable outcomes of patients with sickle cell disease hospitalized due to COVID‑19: A report of three cases". Experimental and Therapeutic Medicine 23, no. 5 (2022): 338. https://doi.org/10.3892/etm.2022.11268
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team