Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2022 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2022 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population

  • Authors:
    • Efthimios Dimitrakis
    • Martha-Spyridoula Katsarou
    • Maria Lagiou
    • Vasiliki Papastefanopoulou
    • Evangelia Stanitsa
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Socratis Papageorgiou
    • Paraskevi Moutsatsou
    • Katerina Antoniou
    • Christos Kroupis
    • Nikolaos Drakoulis
  • View Affiliations / Copyright

    Affiliations: Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece, Department of Clinical Biochemistry, University General Hospital ‘ATTIKON’, 12462 Athens, Greece, Second Department of Neurology, University General Hospital ‘ATTIKON’, 12462 Athens, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Forensic Sciences and Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
    Copyright: © Dimitrakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 341
    |
    Published online on: March 22, 2022
       https://doi.org/10.3892/etm.2022.11271
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The role of vitamin D in Alzheimer's Disease (AD) has been studied over the past years. The results from numerous studies have indicated that the molecular pathways involved in the development of AD are closely related to the molecular pathways of the mechanisms of action of vitamin D. However, only a limited number of studies have described the key role of vitamin D receptor (VDR) in the regulation of the functions of vitamin D and the potential effect of single nucleotide polymorphisms (SNPs) of the VDR gene. Thus, the aim of the present study was to investigate the VDR TaqI polymorphism in relation to AD in a Southeastern European Caucasian (SEC) cohort. Further, the present study aimed to compare the results obtained with those of other AD populations. For this purpose, blood samples from 90 confirmed patients with AD [median age, 74 years; median mini‑mental state examination (MMSE) score of 21; median frontal assessment battery (FAB) score of 10] and 103 healthy controls (median age, 57 years) were analyzed to determine the genotypes of TaqI (rs731236) using quantitative PCR. The frequencies (%) of the TaqI TT, TC and CC genotypes in the controls/patients were 34/48.9, 47.6/41.1 and 18.4/10.0, respectively. Statistically significant differences were observed for the TaqI C allele [odds ratio (OR). 0.54; 95% confidence interval (CI), 0.30‑0.96; P=0.035], the TaqI TT genotype (OR, 1.86; 95% CI, 1.04‑3.32; P=0.035) and the TaqI CC genotype (OR, 0.119; 95% CI, 0.014‑0.995; P=0.032,) in relation to the MMSE score <21 in the patient's group. The TaqI TT allele was found to increase the risk of developing AD by 1.86‑fold in the SEC population, while the TaqI C allele may act protectively, with a 46% lower risk of developing the disease. Patients with the TaqI CC genotype were found to have an 88% less likelihood of developing severe cognitive impairment based on the MMSE score. On the whole, the present study did not confirm the results of previous studies on the VDR TaqI C allele in patients with AD.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Global Action Plan on the Public Health Response to Dementia 2017-2025. World Health Organization, Geneva, 2017.

2 

Orme RP, Middleditch C, Waite L and Fricker RA: The Role of Vitamin D3 in the development and neuroprotection of midbrain dopamine neurons. Vitam Horm. 100:273–297. 2016.PubMed/NCBI View Article : Google Scholar

3 

Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piątkiewicz P, Radziwoń-Zaleska M, Wojnar M and Nowicka G: Vitamin D and the central nervous system. Pharmacol Rep. 65:271–278. 2013.PubMed/NCBI View Article : Google Scholar

4 

Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al: Vitamin D and the risk of dementia and Alzheimer disease. Neurology. 83:920–928. 2014.PubMed/NCBI View Article : Google Scholar

5 

Afzal S, Bojesen SE and Nordestgaard BG: Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimers Dement. 10:296–302. 2014.PubMed/NCBI View Article : Google Scholar

6 

Gezen-Ak D, Yilmazer S and Dursun E: Why Vitamin D in Alzheimer's Disease? The Hypothesis. J Alzheimers Dis. 40:257–269. 2014.PubMed/NCBI View Article : Google Scholar

7 

Landel V, Annweiler C, Millet P, Morello M and Féron F: Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic benefit is in the D-Tails. J Alzheimers Dis. 53:419–444. 2016.PubMed/NCBI View Article : Google Scholar

8 

Mavraki E, Ioannidis P, Tripsianis G, Gioka T, Kolousi M and Vadikolias K: Vitamin D in mild cognitive impairment and Alzheimer's disease. A study in older Greek adults. Hippokratia. 24:120–126. 2020.PubMed/NCBI

9 

Gezen-Ak D, Dursun E and Yilmazer S: The effect of Vitamin D treament On Nerve Growth Factor (NGF) Release from Hippocampal Neurons. Noro Psikiyatr Ars. 51:157–162. 2014.PubMed/NCBI View Article : Google Scholar

10 

Dursun E, Gezen-Ak D and Yilmazer S: The Influence of Vitamin D treatment on the Inducible Nitric Oxide Synthase (INOS) Expression in Primary Hippocampal Neurons. Noro Psikiyatr Ars. 51:163–168. 2014.PubMed/NCBI View Article : Google Scholar

11 

Gradinaru D, Borsa C, Ionescu C, Margina D, Prada GI and Jansen E: Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus. Aging Clin Exp Res. 24:595–602. 2012.PubMed/NCBI View Article : Google Scholar

12 

Mizwicki MT, Menegaz D, Zhang J, Barrientos-Durán A, Tse S, Cashman JR, Griffin PR and Fiala M: Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 Promotes the Recovery of Amyloid-β Phagocytosis by Alzheimer's Disease Macrophages. J Alzheimers Dis. 29:51–62. 2012.PubMed/NCBI View Article : Google Scholar

13 

Mizwicki MT, Liu G, Fiala M, Magpantay L, Sayre J, Siani A, Mahanian M, Weitzman R, Hayden EY, Rosenthal MJ, et al: 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis. 34:155–170. 2013.PubMed/NCBI View Article : Google Scholar

14 

Gezen-Ak D, Dursun E and Yilmazer S: The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons. PLoS One. 6(e17553)2011.PubMed/NCBI View Article : Google Scholar

15 

Cui X, Gooch H, Petty A, McGrath JJ and Eyles D: Vitamin D and the brain: Genomic and non-genomic actions. Mol Cell Endocrinol. 453:131–143. 2017.PubMed/NCBI View Article : Google Scholar

16 

Gezen-Ak D, Dursun E, Ertan T, Hanagasi H, Gurvit H, Emre M, Eker E, Ozturk M, Engin F and Yilmazer S: Association between Vitamin D receptor gene polymorphism and Alzheimer's disease. Tohoku J Exp Med. 212:275–282. 2007.PubMed/NCBI View Article : Google Scholar

17 

Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK and Smith AD: The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett. 504:79–82. 2011.PubMed/NCBI View Article : Google Scholar

18 

Esfehani NT, Rahgozar M and Biglarian A: Identification of genetic polymorphism interactions in sporadic Alzheimer's disease using logic regression. Iran Rehabil J. 9:45–50. 2011.

19 

Gezen-Ak D, Dursun E, Bilgic B, Hanagasi H, Ertan T, Gurvit H, Emre M, Eker E, Ulutin T, Uysal O and Yilmazer S: Vitamin D receptor gene haplotype is associated with late onset Alzheimer's disease. Tohoku J Exp Med. 228:189–196. 2012.PubMed/NCBI View Article : Google Scholar

20 

Khorram Khorshid HR, Gozalpour E, Saliminejad K, Karimloo M, Ohadi M and Kamali K: Vitamin D receptor (VDR) polymorphisms and late-onset Alzheimer's disease: An association study. Iran J Publ Health. 42:1253–1258. 2013.PubMed/NCBI

21 

Łaczmański L, Jakubik M, Bednarek-Tupikowska G, Rymaszewska J, Słoka N and Lwow F: Vitamin D receptor gene polymorphisms in Alzheimer's disease patients. Exp Gerontol. 69:142–147. 2015.PubMed/NCBI View Article : Google Scholar

22 

Oliveira ACR, Magalhães CA, Loures CMG, Fraga VG, de Souza LC, Guimarães HC, Cintra MTG, Bicalho MA, Sousa MCR, Silveira JN, et al: BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline. Arq Neuropsiquiatr. 76:760–766. 2018.PubMed/NCBI View Article : Google Scholar

23 

Poduslo SE and Yin X: Chromosome 12 and late-onset Alzheimer's disease. Neurosci Lett. 310:188–190. 2001.PubMed/NCBI View Article : Google Scholar

24 

Gezen-Ak D and Dursun E: Molecular basis of vitamin D action in neurodegeneration: The story of a team perspective. Hormones (Athens). 18:17–21. 2019.PubMed/NCBI View Article : Google Scholar

25 

Gezen-Ak D, Atasoy IL, Candaş E, Alaylioglu M, Yılmazer S and Dursun E: Vitamin D receptor regulates amyloid beta 1-42 production with protein disulfide isomerase A3. ACS Chem Neurosci. 8:2335–2346. 2017.PubMed/NCBI View Article : Google Scholar

26 

Sutherland MK, Somerville MJ, Yoong LK, Bergeron C, Haussler MR and McLachlan DR: Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to huntington hippocampus: Correlation with calbindin-28k mRNA levels. Brain Res Mol Brain Res. 13:239–250. 1992.PubMed/NCBI View Article : Google Scholar

27 

Landel V, Millet P, Baranger K, Loriod B and Féron F: Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease. Mol Neurodegener. 11(22)2016.PubMed/NCBI View Article : Google Scholar

28 

Gubandru M, Margina D, Tsitsimpikou C, Goutzourelas N, Tsarouhas K, Ilie M, Tsatsakis AM and Kouretas D: Alzheimer's disease treated patients showed different patterns for oxidative stress and inflammation markers. Food Chem Toxicol. 61:209–214. 2013.PubMed/NCBI View Article : Google Scholar

29 

Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Gradinaru D, Tsatsakis A, Tsoukalas D, et al: The Akt pathway in oncology therapy and beyond (Review). Int J Oncol. 53:2319–2331. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zaulkffali AS, Md Razip NN, Syed Alwi SS, Abd Jalil A, Abd Mutalib MS, Gopalsamy B, Chang SK, Zainal Z, Ibrahim NN, Zakaria ZA and Khaza'ai H: Vitamins D and E stimulate the PI3K-AKT signalling pathway in insulin-resistant SK-N-SH neuronal cells. Nutrients. 11(2525)2019.PubMed/NCBI View Article : Google Scholar

31 

Zhang D, Wang L, Zhang R and Li S: Association of vitamin D receptor gene polymorphisms and the risk of multiple sclerosis: A meta-analysis. Arch Med Res. 50:350–361. 2019.PubMed/NCBI View Article : Google Scholar

32 

Niu MY, Wang L and Xie AM: ApaI, BsmI, FokI, and TaqI polymorphisms in the vitamin D receptor gene and Parkinson's disease. Chin Med J (Engl). 128:1809–1814. 2015.PubMed/NCBI View Article : Google Scholar

33 

Papasavva M, Vikelis M, Siokas V, Katsarou MS, Dermitzakis E, Raptis A, Dardiotis E and Drakoulis N: VDR gene polymorphisms and cluster headache susceptibility: Case-control study in a Southeastern European caucasian population. J Mol Neurosci. 72:382–392. 2022.PubMed/NCBI View Article : Google Scholar

34 

Geng J, Zhang J, Yao F, Liu X, Liu J and Huang Y: A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders. Aging Clin Exp Res. 32:21–27. 2020.PubMed/NCBI View Article : Google Scholar

35 

Mun MJ, Kim MS, Kim JH and Jang WC: A TaqI polymorphism of vitamin D receptor is associated with Alzheimer's disease in Korean population: A case-control study. Int J Clin Exp Med. 9:19268–19279. 2016.

36 

Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RG and Van Heemst D: VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging. 30:466–473. 2009.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dimitrakis E, Katsarou M, Lagiou M, Papastefanopoulou V, Stanitsa E, Spandidos DA, Tsatsakis A, Papageorgiou S, Moutsatsou P, Antoniou K, Antoniou K, et al: Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population. Exp Ther Med 23: 341, 2022.
APA
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D.A. ... Drakoulis, N. (2022). Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population. Experimental and Therapeutic Medicine, 23, 341. https://doi.org/10.3892/etm.2022.11271
MLA
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D. A., Tsatsakis, A., Papageorgiou, S., Moutsatsou, P., Antoniou, K., Kroupis, C., Drakoulis, N."Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population". Experimental and Therapeutic Medicine 23.5 (2022): 341.
Chicago
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D. A., Tsatsakis, A., Papageorgiou, S., Moutsatsou, P., Antoniou, K., Kroupis, C., Drakoulis, N."Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population". Experimental and Therapeutic Medicine 23, no. 5 (2022): 341. https://doi.org/10.3892/etm.2022.11271
Copy and paste a formatted citation
x
Spandidos Publications style
Dimitrakis E, Katsarou M, Lagiou M, Papastefanopoulou V, Stanitsa E, Spandidos DA, Tsatsakis A, Papageorgiou S, Moutsatsou P, Antoniou K, Antoniou K, et al: Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population. Exp Ther Med 23: 341, 2022.
APA
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D.A. ... Drakoulis, N. (2022). Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population. Experimental and Therapeutic Medicine, 23, 341. https://doi.org/10.3892/etm.2022.11271
MLA
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D. A., Tsatsakis, A., Papageorgiou, S., Moutsatsou, P., Antoniou, K., Kroupis, C., Drakoulis, N."Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population". Experimental and Therapeutic Medicine 23.5 (2022): 341.
Chicago
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D. A., Tsatsakis, A., Papageorgiou, S., Moutsatsou, P., Antoniou, K., Kroupis, C., Drakoulis, N."Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population". Experimental and Therapeutic Medicine 23, no. 5 (2022): 341. https://doi.org/10.3892/etm.2022.11271
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team