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LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy

  • Authors:
    • Qifei Shang
    • Yanhua Yang
    • Hangzhu Li
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Fuyang People's Hospital, Hangzhou, Zhejiang 311400, P.R. China
    Copyright: © Shang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 343
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    Published online on: March 22, 2022
       https://doi.org/10.3892/etm.2022.11273
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Abstract

Glaucoma is an irreversible disease that causes blindness. Formation of a hypertrophic scar (HS) is the main cause of failure of glaucoma surgery. The long non‑coding RNA LINC01605 is closely associated with the formation of HS; however, the function of LINC01605 in the formation and development of HS remains unclear. For this study, firstly, human Tenon's capsule fibroblasts (HTFs) and corneal epithelial cells (control cells) were collected from patients (n=5) with POAG who underwent glaucoma filtration surgery at Fuyang People's Hospital. Immunofluorescence analysis was performed to detect the expression levels of vimentin (one of the main components of medium fiber and plays an important role in the cytoskeleton and motility), keratin (the main component of cytoskeletal proteins) and LC3 (an autophagy marker). In addition, reverse transcription‑quantitative PCR analysis was performed to detect LINC01605 expression. Besides, the Cell Counting Kit‑8 assay was performed to assess the viability of human Tenon's capsule fibroblasts (HTFs). Next, flow cytometry was performed to detect HTF apoptosis. Furthermore, western blot analysis was performed for Bax, Bcl‑2, Pro‑caspase‑3, cleaved caspase‑3, phosphorylated (p‑)Smad2, Smad2, α‑SMA, MMP9, ATG7, p62, beclin 1, p‑AMPK and AMPK in HTFs to determine the mechanism by which LINC01605 regulates the formation and development of HS. Moreover, a Transwell assay was performed to detect the migratory ability of HTFs. The results demonstrated that LINC01605 was significantly upregulated in HS tissues compared with that in normal (control/healthy) tissues. In addition, vimentin was highly expressed in HTFs, whereas keratin was expressed at a low level. Also, in HTFs, LINC01605 knockdown inhibited cell viability by inducing apoptosis, decreasing Smad2 activation and inhibiting autophagy. Furthermore, LINC01605 knockdown significantly inhibited the migratory ability of HTFs. Transfection with LINC01605 small interference RNAs significantly downregulated the expression levels of p‑Smad2, α‑SMA and MMP9 in HTFs. Furthermore, LINC01605 knockdown notably inhibited the viability and migration, and induced the apoptosis of HTFs, the effects of which were reversed following treatment with TGF‑β. Taken together, the results of the present study suggested that LINC01605 knockdown may inhibit the viability of HTFs by inducing the apoptotic pathway. These findings may provide novel directions for the treatment of HS.
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1 

Bluwol E: Glaucoma treatment. Rev Prat. 66:508–513. 2016.PubMed/NCBI(In French).

2 

Weinreb RN, Aung T and Medeiros FA: The pathophysiology and treatment of glaucoma: A review. JAMA. 311:1901–1911. 2014.PubMed/NCBI View Article : Google Scholar

3 

Sihota R, Angmo D, Ramaswamy D and Dada T: Simplifying ‘target’ intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma. Indian J Ophthalmol. 66:495–505. 2018.PubMed/NCBI View Article : Google Scholar

4 

Swogger J, Conner IP, Rosano M, Kemmerer M, Happ-Smith C, Wells A, Schuman JS and Yates CC: Injected versus sponge-applied mitomycin C (MMC) during modified trabeculectomy in New Zealand white rabbit model. Transl Vis Sci Technol. 9(23)2020.PubMed/NCBI View Article : Google Scholar

5 

Vajaranant TS, Wu S, Torres M and Varma R: The changing face of primary open-angle glaucoma in the United States: Demographic and geographic changes from 2011 to 2050. Am J Ophthalmol. 154:303–314.e3. 2012.PubMed/NCBI View Article : Google Scholar

6 

Ma X and Liu L: Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy. Mol Med Rep. 23(204)2021.PubMed/NCBI View Article : Google Scholar

7 

Wu X, Wang Z, Wu G, Xu X, Zhang J, Li Y, Zhang H and Guo S: Tetramethylpyrazine induces apoptosis and inhibits proliferation of hypertrophic scar-derived fibroblasts via inhibiting the phosphorylation of AKT. Front Pharmacol. 11(602)2020.PubMed/NCBI View Article : Google Scholar

8 

Lee HJ and Jang YJ: Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci. 19(711)2018.PubMed/NCBI View Article : Google Scholar

9 

Wang P, Luo ML, Song E, Zhou Z, Ma T, Wang J, Jia N, Wang G, Nie S, Liu Y and Hou F: Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway. Sci Transl Med. 10(eaat2039)2018.PubMed/NCBI View Article : Google Scholar

10 

Jiang R, Tang J, Chen Y, Deng L, Ji J, Xie Y, Wang K, Jia W, Chu WM and Sun B: The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nat Commun. 8(15129)2017.PubMed/NCBI View Article : Google Scholar

11 

Zheng M, Zheng Y, Gao M, Ma H, Zhang X, Li Y, Wang F and Huang H: Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Exp Ther Med. 19:1329–1335. 2020.PubMed/NCBI View Article : Google Scholar

12 

Cissé Y, Bai L and Meng T: LncRNAs in genetic basis of glaucoma. BMJ Open Ophthalmol. 3(e000131)2018.PubMed/NCBI View Article : Google Scholar

13 

Nong Q, Li S, Wu Y and Liu D: LncRNA COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21/Smad7 pathway. Biochem Biophys Res Commun. 495:319–324. 2018.PubMed/NCBI View Article : Google Scholar

14 

Li J, Chen L, Cao C, Yan H, Zhou B, Gao Y, Li Q and Li J: The long non-coding RNA LncRNA8975-1 is upregulated in hypertrophic scar fibroblasts and controls collagen expression. Cell Physiol Biochem. 40:326–334. 2016.PubMed/NCBI View Article : Google Scholar

15 

Zhu Z, Chen B, Peng L, Gao S, Guo J and Zhu X: Blockade of LINC01605-enriched exosome generation in M2 macrophages impairs M2 macrophage-induced proliferation, migration, and invasion of human dermal fibroblasts. Int J Immunopathol Pharmacol. 35(20587384211016724)2021.PubMed/NCBI View Article : Google Scholar

16 

Wang XC, Wang T, Zhang Y, Wang LL, Zhao RY and Tan W: Tacrolimus inhibits proliferation and induces apoptosis by decreasing survivin in scar fibroblasts after glaucoma surgery. Eur Rev Med Pharmacol Sci. 22:2934–2940. 2018.PubMed/NCBI View Article : Google Scholar

17 

Jammal AA, Berchuck SI, Thompson AC, Costa VP and Medeiros FA: The effect of age on increasing susceptibility to retinal nerve fiber layer loss in glaucoma. Invest Ophthalmol Vis Sci. 61(8)2020.PubMed/NCBI View Article : Google Scholar

18 

Deflorin C, Hohenauer E, Stoop R, van Daele U, Clijsen R and Taeymans J: Physical management of scar tissue: A systematic review and meta-analysis. J Altern Complement Med. 26:854–865. 2020.PubMed/NCBI View Article : Google Scholar

19 

Seong GJ, Hong S, Jung SA, Lee JJ, Lim E, Kim SJ and Lee JH: TGF-beta-induced interleukin-6 participates in transdifferentiation of human Tenon's fibroblasts to myofibroblasts. Mol Vis. 15:2123–2128. 2009.PubMed/NCBI

20 

Trelford CB, Denstedt JT, Armstrong JJ and Hutnik CML: The pro-fibrotic behavior of human Tenon's capsule fibroblasts in medically treated glaucoma patients. Clin Ophthalmol. 14:1391–1402. 2020.PubMed/NCBI View Article : Google Scholar

21 

Ran W, Zhu D and Feng Q: TGF-β2 stimulates Tenon's capsule fibroblast proliferation in patients with glaucoma via suppression of miR-29b expression regulated by Nrf2. Int J Clin Exp Pathol. 8:4799–4806. 2015.PubMed/NCBI

22 

Song L, Liu H, Ma L, Zhang X, Jiang Z and Jiang C: Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells. Oncol Lett. 6:1031–1038. 2013.PubMed/NCBI View Article : Google Scholar

23 

Wang J, Xiao L, Luo CH, Zhou H, Zeng L, Zhong J, Tang Y, Zhao XH, Zhao M and Zhang Y: CD44v6 promotes β-catenin and TGF-β expression, inducing aggression in ovarian cancer cells. Mol Med Rep. 11:3505–3510. 2015.PubMed/NCBI View Article : Google Scholar

24 

Wang T, Gao X, Chen S, Li D, Chen S, Xie M, Xu Z and Yang G: Genome-wide identification and expression analysis of ethylene responsive factor family transcription factors in Juglans regia. PeerJ. 9(e12429)2021.PubMed/NCBI View Article : Google Scholar

25 

Lassance L, Marino GK, Medeiros CS, Thangavadivel S and Wilson SE: Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury. Exp Eye Res. 170:177–187. 2018.PubMed/NCBI View Article : Google Scholar

26 

Battaglia RA, Delic S, Herrmann H and Snider NT: Vimentin on the move: New developments in cell migration. F1000Res 7: F1000 Faculty Rev-1796, 2018.

27 

Patteson AE, Carroll RJ, Iwamoto DV and Janmey PA: The vimentin cytoskeleton: When polymer physics meets cell biology. Phys Biol. 18(011001)2020.PubMed/NCBI View Article : Google Scholar

28 

Polari L, Alam CM, Nyström JH, Heikkilä T, Tayyab M, Baghestani S and Toivola DM: Keratin intermediate filaments in the colon: Guardians of epithelial homeostasis. Int J Biochem Cell Biol. 129(105878)2020.PubMed/NCBI View Article : Google Scholar

29 

Wu Y, Lu S, Huang X, Liu Y, Huang K, Liu Z, Xu W, Zhu W, Hou J, Liu H and Zhang X: Targeting cIAPs attenuates CCl(4)-induced liver fibrosis by increasing MMP9 expression derived from neutrophils. Life Sci. 289(120235)2022.PubMed/NCBI View Article : Google Scholar

30 

Li CY, Zhang JR, Li XX, Zhao L, Xi H, Hu WN and Li SN: Lefty1 ameliorates post-infarction fibrosis by suppressing p-Smad2 and p-ERK1/2 signaling pathways. J Cardiovasc Transl Res. 14:636–646. 2021.PubMed/NCBI View Article : Google Scholar

31 

Chang J, Lan T, Li C, Ji X, Zheng L, Gou H, Ou Y, Wu T, Qi C, Zhang Q, et al: Activation of Slit2-Robo1 signaling promotes liver fibrosis. J Hepatol. 63:1413–1420. 2015.PubMed/NCBI View Article : Google Scholar

32 

Li MY, Zhu XL, Zhao BX, Shi L, Wang W, Hu W, Qin SL, Chen BH, Zhou PH, Qiu B, et al: Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis. Cell Death Dis. 10(489)2019.PubMed/NCBI View Article : Google Scholar

33 

Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J and Wang J: SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol. 235:8839–8851. 2020.PubMed/NCBI View Article : Google Scholar

34 

Cao H, Jia Q, Yan L, Chen C, Xing S and Shen D: Quercetin suppresses the progression of atherosclerosis by regulating MST1-mediated autophagy in ox-LDL-Induced RAW264.7 macrophage foam cells. Int J Mol Sci. 20(6093)2019.PubMed/NCBI View Article : Google Scholar

35 

He Z, Guo L, Shu Y, Fang Q, Zhou H, Liu Y, Liu D, Lu L, Zhang X, Ding X, et al: Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy. 13:1884–1904. 2017.PubMed/NCBI View Article : Google Scholar

36 

Xia Y, Li J, Chen K, Feng J and Guo C: Bergenin attenuates hepatic fibrosis by regulating autophagy mediated by the PPAR-γ/TGF-β pathway. PPAR Res. 2020(6694214)2020.PubMed/NCBI View Article : Google Scholar

37 

Wang X, Song W, Zhang F and Huang R: Dihydroartemisinin Inhibits TGF-β-induced fibrosis in human tenon fibroblasts via inducing autophagy. Drug Des Devel Ther. 15:973–981. 2021.PubMed/NCBI View Article : Google Scholar

38 

Correction: High LINC01605 expression predicts poor prognosis and promotes tumor progression via upregulation of MMP9 in bladder cancer. Biosci Rep 40: BSR-20180562_COR, 2020.

39 

Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, Holmes JW, Longaker MT, Yee H and Gurtner GC: Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 21:3250–3261. 2007.PubMed/NCBI View Article : Google Scholar

40 

Jiang D, Guo B, Lin F, Lin S and Tao K: MiR-205 inhibits the development of hypertrophic scars by targeting THBS1. Aging (Albany NY). 12:22046–22058. 2020.PubMed/NCBI View Article : Google Scholar

41 

Zhang Y, Yang X, Ge X and Zhang F: Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice. Biomed Pharmacother. 109:726–733. 2019.PubMed/NCBI View Article : Google Scholar

42 

Dolka I, Król M and Sapierzyński R: Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study. Res Vet Sci. 105:124–133. 2016.PubMed/NCBI View Article : Google Scholar

43 

Zhao T, Fu Y, Sun H and Liu X: Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. IUBMB Life. 70:60–70. 2018.PubMed/NCBI View Article : Google Scholar

44 

Tanida I, Ueno T and Kominami E: LC3 and autophagy. Methods Mol Biol. 445:77–88. 2008.PubMed/NCBI View Article : Google Scholar

45 

Schaaf MB, Keulers TG, Vooijs MA and Rouschop KM: LC3/GABARAP family proteins: Autophagy-(un)related functions. FASEB J. 30:3961–3978. 2016.PubMed/NCBI View Article : Google Scholar

46 

Tanida I, Ueno T and Kominami E: LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 36:2503–2518. 2004.PubMed/NCBI View Article : Google Scholar

47 

Runwal G, Stamatakou E, Siddiqi FH, Puri C, Zhu Y and Rubinsztein DC: LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep. 9(10147)2019.PubMed/NCBI View Article : Google Scholar

48 

Maiuri MC, Zalckvar E, Kimchi A and Kroemer G: Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 8:741–752. 2007.PubMed/NCBI View Article : Google Scholar

49 

Fernández A, Ordóñez R, Reiter RJ, González-Gallego J and Mauriz JL: Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis. J Pineal Res. 59:292–307. 2015.PubMed/NCBI View Article : Google Scholar

50 

Lv W, Jiang J, Li Y, Fu L, Meng F and Li J: MiR-302a-3p aggravates myocardial ischemia-reperfusion injury by suppressing mitophagy via targeting FOXO3. Exp Mol Pathol. 117(104522)2020.PubMed/NCBI View Article : Google Scholar

51 

Chakrabarti M and Ray SK: Anti-tumor activities of luteolin and silibinin in glioblastoma cells: Overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo. Apoptosis. 21:312–328. 2016.PubMed/NCBI View Article : Google Scholar

52 

Cao C, Wang W, Lu L, Wang L, Chen X, Guo R, Li S and Jiang J: Inactivation of Beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts. Exp Dermatol. 27:58–63. 2018.PubMed/NCBI View Article : Google Scholar

53 

Deng X, Zhao F, Zhao D, Zhang Q, Zhu Y, Chen Q, Qiang L, Xie N, Ma J, Pan X, et al: Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. Int Wound J: Nov 8, 2021 (Epub ahead of print).

54 

Jia L, Sun P, Gao H, Shen J, Gao Y, Meng C, Fu S, Yao H and Zhang G: Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF-β1/Smad2/3 pathway. J Pharm Pharmacol. 71:1017–1028. 2019.PubMed/NCBI View Article : Google Scholar

55 

Zhang Q, Chang X, Wang H, Liu Y, Wang X, Wu M, Zhan H, Li S and Sun Y: TGF-β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro. Environ Toxicol. 35:419–429. 2020.PubMed/NCBI View Article : Google Scholar

56 

Nam SA, Kim WY, Kim JW, Park SH, Kim HL, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, et al: Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway. Cell Death Dis. 10(78)2019.PubMed/NCBI View Article : Google Scholar

57 

Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, et al: Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways. Sci Rep. 7(9289)2017.PubMed/NCBI View Article : Google Scholar

58 

Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J and Zhou Y: Isorhamnetin inhibits liver fibrosis by reducing autophagy and inhibiting extracellular matrix formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK pathways. Mediators Inflamm. 2019(6175091)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shang Q, Yang Y and Li H: LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy. Exp Ther Med 23: 343, 2022.
APA
Shang, Q., Yang, Y., & Li, H. (2022). LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy. Experimental and Therapeutic Medicine, 23, 343. https://doi.org/10.3892/etm.2022.11273
MLA
Shang, Q., Yang, Y., Li, H."LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy". Experimental and Therapeutic Medicine 23.5 (2022): 343.
Chicago
Shang, Q., Yang, Y., Li, H."LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy". Experimental and Therapeutic Medicine 23, no. 5 (2022): 343. https://doi.org/10.3892/etm.2022.11273
Copy and paste a formatted citation
x
Spandidos Publications style
Shang Q, Yang Y and Li H: LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy. Exp Ther Med 23: 343, 2022.
APA
Shang, Q., Yang, Y., & Li, H. (2022). LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy. Experimental and Therapeutic Medicine, 23, 343. https://doi.org/10.3892/etm.2022.11273
MLA
Shang, Q., Yang, Y., Li, H."LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy". Experimental and Therapeutic Medicine 23.5 (2022): 343.
Chicago
Shang, Q., Yang, Y., Li, H."LINC01605 knockdown induces apoptosis in human Tenon's capsule fibroblasts by inhibiting autophagy". Experimental and Therapeutic Medicine 23, no. 5 (2022): 343. https://doi.org/10.3892/etm.2022.11273
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