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Article

Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock

  • Authors:
    • Jun Feng
    • Lili Wang
    • Yikuan Feng
    • Gang Yu
    • Daixing Zhou
    • Junshuai Wang
  • View Affiliations / Copyright

    Affiliations: Emergency Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Article Number: 362
    |
    Published online on: April 1, 2022
       https://doi.org/10.3892/etm.2022.11289
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Abstract

It has been reported that angiopoietin 2 (Ang‑2) plays an integral role in the pathophysiology of sepsis and many other inflammatory diseases. However, the specific role of Ang‑2 in septic shock has not been defined. The aim of the present study was to assess the predictive value of serum Ang‑2 in patients with septic shock. Clinical data of 85 patients with septic shock and 10 healthy controls admitted to the intensive care unit with a diagnosis of septic shock were collected between January 2020 and October 2020 at Tongji Hospital (Wuhan, China). The serum levels of Ang‑2 mRNA were quantified using a quantitative real‑time PCR assay. Ang‑2, SOFA and APACHE II scores were retrospectively analyzed in relation to 28‑day mortality. The area under the receiver operating characteristic (ROC) curve (AUC) was used to discriminate the accuracy of the prediction. Mean Ang‑2 mRNA levels in the patients with septic shock were significantly higher than those in the healthy controls (P<0.05), and the Ang‑2 levels showed a downwards trend over time following treatment. The three indicators (AUCs, SEMs, P‑values) were Ang‑2 (0.82, 0.03, P<0.01), SOFA score (0.76, 0.04, P<0.01), and APACHE II score (0.73, 0.04, P<0.01). The present study confirmed that Ang‑2 mRNA levels were significantly elevated in septic shock. The Ang‑2 mRNA level at ICU admission in a patient with septic shock could be a predictive biomarker for mortality.
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Copy and paste a formatted citation
Spandidos Publications style
Feng J, Wang L, Feng Y, Yu G, Zhou D and Wang J: Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Exp Ther Med 23: 362, 2022.
APA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., & Wang, J. (2022). Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Experimental and Therapeutic Medicine, 23, 362. https://doi.org/10.3892/etm.2022.11289
MLA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23.5 (2022): 362.
Chicago
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23, no. 5 (2022): 362. https://doi.org/10.3892/etm.2022.11289
Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Wang L, Feng Y, Yu G, Zhou D and Wang J: Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Exp Ther Med 23: 362, 2022.
APA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., & Wang, J. (2022). Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock. Experimental and Therapeutic Medicine, 23, 362. https://doi.org/10.3892/etm.2022.11289
MLA
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23.5 (2022): 362.
Chicago
Feng, J., Wang, L., Feng, Y., Yu, G., Zhou, D., Wang, J."Serum levels of angiopoietin 2 mRNA in the mortality outcome prediction of septic shock". Experimental and Therapeutic Medicine 23, no. 5 (2022): 362. https://doi.org/10.3892/etm.2022.11289
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