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Epigenetics in inflammatory liver diseases: A clinical perspective (Review)

  • Authors:
    • Teodora Isac
    • Sebastian Isac
    • Razvan Rababoc
    • Mihail Cotorogea
    • Laura Iliescu
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine II, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Anesthesiology and Intensive Care I, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania
    Copyright: © Isac et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 366
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    Published online on: April 4, 2022
       https://doi.org/10.3892/etm.2022.11293
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Abstract

Inflammatory liver diseases are, nowadays, multifactorial and wide‑spread, thus having an important socio‑economic impact. Although the therapeutic algorithms are well‑known in hepatitis, regardless of etiology, strategies to identify inflammatory hepatic lesions in early stages and to develop new epigenetic therapies should be prioritized. The main entities of inflammatory liver disease are: alcoholic and non‑alcoholic fatty liver disease, autoimmune hepatitis, viral hepatitis and Wilson disease. The main epigenetic processes include: DNA methylation/demethylation, which imply changes in DNA tertiary structure; post‑translational histone covalent changes (methylation/demethylation, acetylation/deacetylation, ubiquitination), that cause DNA‑histone instability; synthesis of small, non‑coding RNA molecules, called microRNAs, that modulate translational potential of transcripts (mRNAs) and post‑translational modification of polypeptide chains. Consequently, the epigenetic interactions aforementioned, play an important modulatory role in disease progression and response to conventional therapies The present review focused on the main epigenetic changes in inflammatory liver conditions, considering a new perspective: Epigenetic therapy. This approach is more than welcomed, taking into consideration that conventional therapeutic strategies are almost exhausted.
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1 

Margueron R and Reinberg D: Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet. 11:285–296. 2010.PubMed/NCBI View Article : Google Scholar

2 

Ryšlavá H, Doubnerová V, Kavan D and Vaněk O: Effect of posttranslational modifications on enzyme function and assembly. J Proteomics. 92:80–109. 2013.PubMed/NCBI View Article : Google Scholar

3 

Berger SL, Kouzarides T, Shiekhattar R and Shilatifard A: An operational definition of epigenetics. Genes Dev. 23:781–783. 2009.PubMed/NCBI View Article : Google Scholar

4 

Waddington CH: Towards a Theoretical Biology. Edinburgh University Press, Edinburgh, 1968.

5 

Jeltsch A: On the enzymatic properties of Dnmt1: Specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. Epigenetics. 1:63–66. 2006.PubMed/NCBI View Article : Google Scholar

6 

Fischer A, Sananbenesi F, Mungenast A and Tsai LH: Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci. 31:605–617. 2010.PubMed/NCBI View Article : Google Scholar

7 

Zhu J, He F, Hu S and Yu J: On the nature of human housekeeping genes. Trends Genet. 24:481–484. 2008.PubMed/NCBI View Article : Google Scholar

8 

Bibikova M: Chapter 2. DNA Methylation. Microarrays. In: Epigenomics in Health and Disease. Fraga MF and Fernández AF (eds). Academic Press, Boston, MA, pp19-46, 2016.

9 

Goll MG and Bestor TH: Eukaryotic cytosine methyltransferases. Annu Rev Biochem. 74:481–514. 2005.PubMed/NCBI View Article : Google Scholar

10 

Keil KP and Lein PJ: DNA methylation: A mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet. 2(dvv012)2016.PubMed/NCBI View Article : Google Scholar

11 

Mielcarek M, Zielonka D, Carnemolla A, Marcinkowski JT and Guidez F: HDAC4 as a potential therapeutic target in neurodegenerative diseases: A summary of recent achievements. Front Cell Neurosci. 9(42)2015.PubMed/NCBI View Article : Google Scholar

12 

Saha RN and Pahan K: HATs and HDACs in neurodegeneration: A tale of disconcerted acetylation homeostasis. Cell Death Differ. 13:539–550. 2006.PubMed/NCBI View Article : Google Scholar

13 

Peserico A and Simone C: Physical and functional HAT/HDAC interplay regulates protein acetylation balance. J Biomed Biotechnol. 2011(371832)2011.PubMed/NCBI View Article : Google Scholar

14 

Varela MA, Roberts TC and Wood MJ: Epigenetics and ncRNAs in brain function and disease: Mechanisms and prospects for therapy. Neurotherapeutics. 10:621–631. 2013.PubMed/NCBI View Article : Google Scholar

15 

Kim VN: MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol. 6:376–385. 2005.PubMed/NCBI View Article : Google Scholar

16 

Pasquinelli AE: MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 13:271–282. 2012.PubMed/NCBI View Article : Google Scholar

17 

Isac S, Panaitescu AM, Iesanu MI, Zeca V, Cucu N, Zagrean L, Peltecu G and Zagrean AM: Maternal citicoline-supplemented diet improves the response of the immature hippocampus to perinatal asphyxia in rats. Neonatology. 117:729–735. 2020.PubMed/NCBI View Article : Google Scholar

18 

Isac T, Isac S, Ioanitescu S, Mihaly E, Tanasescu MD, Balan DG, Tulin A and Iliescu L: Dynamics of serum α-fetoprotein in viral hepatitis C without hepatocellular carcinoma. Exp Ther Med. 22(749)2021.PubMed/NCBI View Article : Google Scholar

19 

Wu K, Ye C, Lin L, Chu Y, Ji M, Dai W, Zeng X and Lin Y: Inhibiting miR-21 attenuates experimental hepatic fibrosis by suppressing both the ERK1 pathway in HSC and hepatocyte EMT. Clin Sci (Lond). 130:1469–1480. 2016.PubMed/NCBI View Article : Google Scholar

20 

Popescu I, Ionescu M, Braşoveanu V, Hrehoreţ D, Copca N, Lupaşcu C, Botea F, Dorobanţu B, Alexandrescu S, Grigorie M, et al: The Romanian National program for liver transplantation -852 procedures in 815 patients over 17 years (2000-2017): A continuous evolution to success. Chirurgia (Bucur). 112:229–243. 2017.PubMed/NCBI View Article : Google Scholar

21 

Ahrens M, Ammerpohl O, von Schönfels W, Kolarova J, Bens S, Itzel T, Teufel A, Herrmann A, Brosch M, Hinrichsen H, et al: DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab. 18:296–302. 2013.PubMed/NCBI View Article : Google Scholar

22 

Cao Y, Xue Y, Xue L, Jiang X, Wang X, Zhang Z, Yang J, Lu J, Zhang C, Wang W and Ning G: Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation. J Hepatol. 59:1299–1306. 2013.PubMed/NCBI View Article : Google Scholar

23 

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP and Sassone-Corsi P: The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 134:329–340. 2008.PubMed/NCBI View Article : Google Scholar

24 

Xu F and Guo W: The progress of epigenetics in the development and progression of non-alcoholic fatty liver disease. Liver Res. 4:118–123. 2020.

25 

Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S and Danial NN: HCF-1 regulates de novo lipogenesis through a nutrient-sensitive complex with ChREBP. Mol Cell 25:. 75:357–371.e7. 2019.PubMed/NCBI View Article : Google Scholar

26 

Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, et al: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 122:2871–2883. 2012.PubMed/NCBI View Article : Google Scholar

27 

Calo N, Ramadori P, Sobolewski C, Romero Y, Maeder C, Fournier M, Rantakari P, Zhang FP, Poutanen M, Dufour JF, et al: Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. Gut. 65:1871–1881. 2016.PubMed/NCBI View Article : Google Scholar

28 

Liu X, Zhao J, Liu Q, Xiong X, Zhang Z, Jiao Y, Li X, Liu B, Li Y and Lu Y: MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3. Sci Rep. 6(37170)2016.PubMed/NCBI View Article : Google Scholar

29 

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, et al: Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity. Cell. 171:372–384.e12. 2017.PubMed/NCBI View Article : Google Scholar

30 

Kerkar N and Vergani D: De novo autoimmune hepatitis -is this different in adults compared to children? J Autoimmun. 95:26–33. 2018.PubMed/NCBI View Article : Google Scholar

31 

Behairy BE, El-Araby HA, Abd El Kader HH, Ehsan NA, Salem ME, Zakaria HM and Khedr MA: Assessment of intrahepatic regulatory T cells in children with autoimmune hepatitis. Ann Hepatol. 15:682–690. 2016.PubMed/NCBI View Article : Google Scholar

32 

Bandiera S, Pfeffer S, Baumert TF and Zeisel MB: MiR-122-a key factor and therapeutic target in liver disease. J Hepatol. 62:448–457. 2015.PubMed/NCBI View Article : Google Scholar

33 

Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M, Furukawa H, Abiru S, Yamasaki K, Nagaoka S, et al: Circulating microRNA profiles in patients with type-1 autoimmune hepatitis. PLoS One. 10(e0136908)2015.PubMed/NCBI View Article : Google Scholar

34 

Chen L, Lu FB, Chen DZ, Wu JL, Hu ED, Xu LM, Zheng MH, Li H, Huang Y, Jin XY, et al: BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis. Mol Immunol. 93:38–46. 2018.PubMed/NCBI View Article : Google Scholar

35 

Xia G, Wu S, Wang X and Fu M: Inhibition of microRNA-155 attenuates concanavalin-A-induced autoimmune hepatitis by regulating Treg/Th17 cell differentiation. Can J Physiol Pharmacol. 96:1293–1300. 2018.PubMed/NCBI View Article : Google Scholar

36 

Liu Q, Li Y, Xiong M and Tang R: Epigenetics of autoimmune liver diseases: Current progress and future directions. J Bio-X Res. 2:46–55. 2019.

37 

Chen M, Shirai M, Czaja AJ, Kurokohchi K, Arichi T, Arima K, Kodama T and Nishioka M: Characterization of anti-histone antibodies in patients with type 1 autoimmune hepatitis. J Gastroenterol Hepatol. 13:483–489. 1998.PubMed/NCBI View Article : Google Scholar

38 

Zachou K, Arvaniti P, Lyberopoulou A, Sevdali E, Speletas M, Ioannou M, Koukoulis GK, Renaudineau Y and Dalekos GN: Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis. Liver Int: Feb 2, 2022 (Epub ahead of print).

39 

Nehme Z, Pasquereau S and Herbein G: Control of viral infections by epigenetic-targeted therapy. Clin Epigenetics. 11(55)2019.PubMed/NCBI View Article : Google Scholar

40 

Jain S, Chang TT, Chen S, Boldbaatar B, Clemens A, Lin SY, Yan R, Hu CT, Guo H, Block TM, et al: Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues. Sci Rep. 5(10478)2015.PubMed/NCBI View Article : Google Scholar

41 

Zhang Y, Li C, Zhang Y, Zhu H, Kang Y, Liu H, Wang J, Qin Y, Mao R, Xie Y, et al: Comparative analysis of CpG islands among HBV genotypes. PLoS One. 8(e56711)2013.PubMed/NCBI View Article : Google Scholar

42 

Hong X, Kim ES and Guo H: Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B. Hepatology. 66:2066–2077. 2017.PubMed/NCBI View Article : Google Scholar

43 

Pollicino T, Belloni L, Raffa G, Pediconi N, Squadrito G, Raimondo G and Levrero M: Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology. 130:823–837. 2006.PubMed/NCBI View Article : Google Scholar

44 

Wang TZ, Lin DD, Jin BX, Sun XY and Li N: Plasma microRNA: A novel non-invasive biomarker for HBV-associated liver fibrosis staging. Exp Ther Med. 17:1919–1929. 2019.PubMed/NCBI View Article : Google Scholar

45 

Perez S, Kaspi A, Domovitz T, Davidovich A, Lavi-Itzkovitz A, Meirson T, Alison Holmes J, Dai CY, Huang CF, Chung RT, et al: Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals. PLoS Genet. 15(e1008181)2019.PubMed/NCBI View Article : Google Scholar

46 

Zheng Y, Hlady RA, Joyce BT, Robertson KD, He C, Nannini DR, Kibbe WA, Achenbach CJ, Murphy RL, Roberts LR and Hou L: DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma. Clin Epigenetics. 11(145)2019.PubMed/NCBI View Article : Google Scholar

47 

Weis A, Marquart L, Calvopina DA, Genz B, Ramm GA and Skoien R: Serum MicroRNAs as biomarkers in hepatitis C: Preliminary evidence of a MicroRNA panel for the diagnosis of hepatocellular carcinoma. Int J Mol Sci. 20(864)2019.PubMed/NCBI View Article : Google Scholar

48 

Shrivastava S, Petrone J, Steele R, Lauer GM, Di Bisceglie AM and Ray RB: Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression. Hepatology. 58:863–871. 2013.PubMed/NCBI View Article : Google Scholar

49 

Matsuura K, De Giorgi V, Schechterly C, Wang RY, Farci P, Tanaka Y and Alter HJ: Circulating let-7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C. Hepatology. 64:732–745. 2016.PubMed/NCBI View Article : Google Scholar

50 

El-Diwany R, Wasilewski LN, Witwer KW, Bailey JR, Page K, Ray SC, Cox AL, Thomas DL and Balagopal A: Acute hepatitis C virus infection induces consistent changes in circulating MicroRNAs that are associated with nonlytic hepatocyte release. J Virol. 89:9454–9464. 2015.PubMed/NCBI View Article : Google Scholar

51 

Liu XL, Pan Q, Zhang RN, Shen F, Yan SY, Sun C, Xu ZJ, Chen YW and Fan JG: Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population. World J Gastroenterol. 22:9844–9852. 2016.PubMed/NCBI View Article : Google Scholar

52 

Isac S, Panaitescu AM, Iesanu M, Grigoras IF, Totan A, Udriste A, Cucu N, Peltecu G, Zagrean L and Zagrean AM: Maternal high-fat diet modifies the immature hippocampus vulnerability to perinatal asphyxia in rats. Neonatology. 114:355–361. 2018.PubMed/NCBI View Article : Google Scholar

53 

Lieber CS, Leo MA, Wang X and Decarli LM: Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats. Biochem Biophys Res Commun. 370:44–48. 2008.PubMed/NCBI View Article : Google Scholar

54 

Lee YJ and Shukla SD: Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur J Pharmacol. 573:29–38. 2007.PubMed/NCBI View Article : Google Scholar

55 

Pal-Bhadra M, Bhadra U, Jackson DE, Mamatha L, Park PH and Shukla SD: Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes. Life Sci. 81:979–987. 2007.PubMed/NCBI View Article : Google Scholar

56 

Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA and Tsukamoto H: Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 279:G178–G185. 2000.PubMed/NCBI View Article : Google Scholar

57 

Dannenberg LO, Chen HJ, Tian H and Edenberg HJ: Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. Alcohol Clin Exp Res. 30:928–937. 2006.PubMed/NCBI View Article : Google Scholar

58 

Mandrekar P: Epigenetic regulation in alcoholic liver disease. World J Gastroenterol. 17:2456–2464. 2011.PubMed/NCBI View Article : Google Scholar

59 

Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P and Szabo G: Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 286:1436–1444. 2011.PubMed/NCBI View Article : Google Scholar

60 

Tang Y, Banan A, Forsyth CB, Fields JZ, Lau CK, Zhang LJ and Keshavarzian A: Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res. 32:355–364. 2008.PubMed/NCBI View Article : Google Scholar

61 

Medici V and LaSalle JM: Genetics and epigenetic factors of Wilson disease. Ann Transl Med. 7 (Suppl 2)(S58)2019.PubMed/NCBI View Article : Google Scholar

62 

Li M, Li Y, Chen J, Wei W, Pan X, Liu J, Liu Q, Leu W, Zhang L, Yang X, et al: Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor. Biochemistry. 46:11451–11458. 2007.PubMed/NCBI View Article : Google Scholar

63 

Yin R, Mo J, Dai J and Wang H: Nickel(II) inhibits tet-mediated 5-methylcytosine oxidation by high affinity displacement of the cofactor iron(II). ACS Chem Biol. 12:1494–1498. 2017.PubMed/NCBI View Article : Google Scholar

64 

Le A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, LaSalle JM, Halsted CH, Keen CL and Medici V: Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease. Int J Mol Sci. 15:8004–8023. 2014.PubMed/NCBI View Article : Google Scholar

65 

Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, et al: Wilson disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 11:804–818. 2016.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Isac T, Isac S, Rababoc R, Cotorogea M and Iliescu L: Epigenetics in inflammatory liver diseases: A clinical perspective (Review). Exp Ther Med 23: 366, 2022.
APA
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., & Iliescu, L. (2022). Epigenetics in inflammatory liver diseases: A clinical perspective (Review). Experimental and Therapeutic Medicine, 23, 366. https://doi.org/10.3892/etm.2022.11293
MLA
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., Iliescu, L."Epigenetics in inflammatory liver diseases: A clinical perspective (Review)". Experimental and Therapeutic Medicine 23.5 (2022): 366.
Chicago
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., Iliescu, L."Epigenetics in inflammatory liver diseases: A clinical perspective (Review)". Experimental and Therapeutic Medicine 23, no. 5 (2022): 366. https://doi.org/10.3892/etm.2022.11293
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Spandidos Publications style
Isac T, Isac S, Rababoc R, Cotorogea M and Iliescu L: Epigenetics in inflammatory liver diseases: A clinical perspective (Review). Exp Ther Med 23: 366, 2022.
APA
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., & Iliescu, L. (2022). Epigenetics in inflammatory liver diseases: A clinical perspective (Review). Experimental and Therapeutic Medicine, 23, 366. https://doi.org/10.3892/etm.2022.11293
MLA
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., Iliescu, L."Epigenetics in inflammatory liver diseases: A clinical perspective (Review)". Experimental and Therapeutic Medicine 23.5 (2022): 366.
Chicago
Isac, T., Isac, S., Rababoc, R., Cotorogea, M., Iliescu, L."Epigenetics in inflammatory liver diseases: A clinical perspective (Review)". Experimental and Therapeutic Medicine 23, no. 5 (2022): 366. https://doi.org/10.3892/etm.2022.11293
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