Open Access

Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis

  • Authors:
    • Ingrid-Andrada Vasilache
    • Alexandru Carauleanu
    • Demetra Socolov
    • Roxana Matasariu
    • Ioana Pavaleanu
    • Dragos Nemescu
  • View Affiliations

  • Published online on: April 5, 2022     https://doi.org/10.3892/etm.2022.11297
  • Article Number: 370
  • Copyright: © Vasilache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Placental protein‑13 (PP‑13) is a member of the galectin group involved in placental implantation, maternal artery remodeling, and placental inflammatory processes. Its levels are lower in the first trimester for pregnancies later affected by ischemic placental disease, and slowly increase during the second and third trimesters of pregnancy. The aim of the present meta‑analysis is to assess the predictive performance of PP‑13 in first trimester preeclampsia screening. PubMed, Web of Science, Scopus, Embase, BIOSIS, and Cochrane databases were used to find relevant studies. All prospective and retrospective observational studies that evaluated the accuracy of PP‑13 in predicting preeclampsia were assessed. The investigation revealed that the quantitative synthesis was based on 14 studies with a total number of 8,239 women. The pooled sensitivity of PP‑13 for the prediction of preeclampsia was 0.53 [95% (confidence interval (CI), 0.08‑0.99], and the pooled specificity was 0.83 (95% CI, 0.38‑1.29). Further analysis revealed a higher accuracy of PP‑13 for the screening of late‑onset preeclampsia [pooled sensitivity of 0.58 [95% CI, ‑0.17‑1.33) with a specificity of 0.85 (95% CI, 0.10‑1.60)] when compared with early‑onset preeclampsia [pooled sensitivity of 0.51 (95% CI, ‑0.04‑1.05) with a specificity of 0.88 (95% CI, 0.33‑1.42)]. In conclusion, PP‑13 appears to be a promising biomarker for evaluating the risk of developing preeclampsia during the first trimester of pregnancy. As a result, incorporating it into future predictive models is a viable option.

Introduction

Preeclampsia (PE) is a form of ischemic placental disease and its physiopathology remains unclear, although recent advances have been made in increasing its understanding. Despite being a rare disorder, which affects between 2-10% of pregnant women, PE is still a significant cause of maternal and perinatal morbidity and mortality (1).

Galectins are carbohydrate-binding proteins that control cell growth, proliferation, differentiation, apoptosis, signal transduction, mRNA splicing, and extracellular matrix interactions (2). To date, approximately 20 members of the galectin family have been identified, and one in particular, protein-galectin-13 or placental protein-13 (PP-13), has gained recognition as an important factor in the pathogenesis of preeclampsia (3). It seems that PP-13 is involved in deep placentation, vascular remodeling and immune tolerance (4). Therefore, the background for its use in preeclampsia screening with or without intrauterine growth restriction has been proposed.

In the present systematic review and meta-analysis, we aimed to assess the predictive performance of PP-13 for preeclampsia screening in the first trimester of pregnancy.

Research methods

From the onset of each database through March 14, 2021, we conducted a comprehensive manual and electronic search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) to discover literature on the predictive value of PP-13 in preeclampsia (5).

PubMed, Web of Science, Scopus, Embase, BIOSIS, and Cochrane Library were used (6-11). ‘Preeclampsia’, ‘first trimester’, ‘screening’, ‘placental protein 13’, ‘PP-13’, and ‘galectin-13’ were employed as medical topic headings (MeSH) or key words, which were combined with Boolean operators AND and OR. There were no restrictions on the type of study or the language used. The bibliographies of the selected publications were rechecked to ensure that all relevant studies were included. The inclusion criteria (summarized in Table I) were: observational studies, such as cross-sectional, case-control, or cohort studies that analyzed the predictive performance of PP-13 in the first trimester of pregnancy; studies published until March 2021. Studies that did not fulfill the abovementioned criteria were excluded from our review.

Table I

Inclusion criteria of the studies.

Table I

Inclusion criteria of the studies.

Study designObservational study with a well-defined study population
SourcePeer-reviewed journals
LanguageAny
DiseasePreeclampsia
Sample typeBlood, serum, or plasma
Gestational ageFirst trimester
Assay typeAny
Onset of preeclampsiaAny (early or late)
Sample size≥50

The full-text papers were independently reviewed by two physician investigators (DN and IAV) to establish their eligibility for the review. Any differences between the two were remedied through conversation. A third reviewer (AC) added a casting vote if a consensus could not be reached.

Two reviewers (DN and IAV) retrieved data from the eligible studies separately using a standard process. Most of the published research used various cut-offs to assess the level of PP-13 at various gestational ages. Data concerning the first author, publication year, study design, characteristics of the population examined, number of cases and controls, gestational age at sampling, cut-offs used, test kits, and the information needed to create a 2x2 table were obtained.

Two independent reviewers assessed the methodological quality of the included studies using the QUADAS-2 technique (Quality Assessment of Diagnostic Accuracy Studies-2) (12,13).

The number of pregnant women with true-positive, true-negative, false-positive, and false-negative test results were retrieved from all of the studies. A 2x2 diagnosis table was created by calculating the accuracy measures, the illness prevalence, and the sample size stated in the study. Each study's sensitivity, specificity, positive, and negative probability ratios were determined using a 95% confidence interval (CI).

For hierarchical modeling, a hierarchical summary receiver operating characteristic (HSROC) model was utilized to generate equal summary estimates for sensitivity and specificity, taking into account variability both between and within studies (heterogeneity) (random sampling error). The Der Simonian-Laird approach was used to estimate random effects (14). The Q test was used to assess statistical heterogeneity among the studies, and the I2 statistic was used to measure the degree of heterogeneity.

The area under the summary receiver operating characteristic curve (AUC) was determined using the accuracy data from all the included investigations, which were plotted on a summary receiver operating characteristic SROC with sensitivity on the x-axis and specificity on the y-axis. This is the same as the summary diagnostic odds ratio (OR), which measures the strength of the link between the test and the disease. The random-effects model was adopted because of the expected clinical and statistical heterogeneity among the trials. StataMP 16.0 (StataCorp) was used to statistically analyze all of the data.

Results

A total of 82 studies were identified. After screening the titles and abstracts, the systematic review and meta-analysis comprised 14 studies (15-28) (Fig. 1).

The quality assessment of these studies is summarized in Table II. In most of the studies, there was good reporting with a prospective design, consecutive recruitment, adequate description of the selection criteria, patient spectrum, test, and use of appropriate reference standards.

Table II

Quality analysis of the included studies.

Table II

Quality analysis of the included studies.

 Risk of biasApplicability concerns
Authors of the study (Refs.)Patient selectionIndex testReference standardFlow and timingPatient selectionIndex testReference standard
Spencer et al (15)Low riskLow riskLow riskLow riskLow riskLow riskLow risk
Chafetz et al (16)Low riskLow riskLow riskLow riskLow riskLow riskLow risk
Gonen et al (17)Low riskHigh riskLow riskLow riskLow riskLow riskLow risk
Khalil et al (18)Low riskHigh riskLow riskLow riskLow riskLow riskLow risk
Akolekar et al (19)Low riskUnclear riskLow riskLow riskLow riskLow riskLow risk
Khalil et al (20)Low riskUnclear riskLow riskLow riskLow riskUnclear riskLow risk
Wortelboer et al (21)Low riskUnclear riskLow riskLow riskLow riskLow riskLow risk
Odibo et al (22)Low riskUnclear riskLow riskLow riskLow riskUnclear riskLow risk
Schneuer et al (23)Low riskUnclear riskLow riskLow riskLow riskLow riskLow risk
Deurloo et al (24)Low riskUnclear riskLow riskHigh riskLow riskLow riskLow risk
Meiri et al (25)Low riskUnclear riskLow riskHigh riskLow riskLow riskLow risk
Luo and Han (26)Low riskUnclear riskLow riskHigh riskLow riskLow riskLow risk
Asiltas et al (27)Low riskUnclear riskLow riskHigh riskLow riskLow riskLow risk
Soongsatitanon and Phupong (28)Low riskUnclear riskLow riskHigh riskLow riskLow riskLow risk

Early-(EO-PE) or late-onset (LO-PE) preeclampsia and preeclampsia associated with small for gestational age fetuses (PE-SGA) were considered separate study groups and studied individually. Table III summarizes the study characteristics.

Table III

Characteristics of the included studies.

Table III

Characteristics of the included studies.

Authors of the study (Refs.)YearCountryStudy designCharacteristics of the populationDisease endpointSample typeAssay usedage (week)Gestational Cases (n)Controls (n)
Spencer et al (15)2006UKProspectiveScreening in ANCAll PE, EO-PESerumELISA11-13+6All PE (88) EO-PE (44)446
Chafetz et al (16)2007USAProspectiveScreening in ANCAll PESerumELISA9-1247290
Gonen et al (17)2008IsraelProspectiveScreening in ANCAll PE, EO-PE, LO-PESerumELISA6-10All PE (20) EO-PE (5) LO-PE (5)1,178
Khalil et al (18)2009UKProspectiveWomen with high risk of PEEO-PE, term and preterm PESerumELISA11-13+6EO-PE (14) Preterm PE (36) Term PE (6)210
Akolekar et al (19)2009UKProspectiveScreening in ANCEO-PESerumDELFIA11-13+648416
Khalil et al (20)2010UKProspectiveWomen with high risk of PEAll PE, EO-PE, PE+SGASerumELISA11-13+6All PE (42) EO-PE (14) PE+SGA (13)210
Wortelboer et al (21)2010The NetherlandsProspectiveScreening in ANCEO-PESerumDELFIA8-13+645480
Odibo et al (22)2011USAProspectiveScreening in ANCAll PE, EO-PESerumDELFIA11-14All PE (42) EO-PE-12410
Schneuer et al (23)2012AustraliaProspectiveScreening in ANCAll PE, EO-PESerumDELFIA10-14All PE (71) EO-PE (5)2,423
Deurloo et al (24)2013AmsterdamRetrospectiveScreeening in ANCAll PESerumELISA9-13+617165
Meiri et al (25)2014IsraelProspectiveScreening in ANCAll PESerumELISA8-1463757
Luo and Han (26)2017ChinaProspectiveScreening in ANCAll PESerumELISA9-13+63371
Asiltas et al (27)2018TurkeyProspectiveScreening in ANCAll PESerumELISA11-13+638122
Soongsatitanon and Phupong (28)2020ThailandProspectiveScreening in ANCAll PESerumELISA11-13+629324

[i] ALL-PE, all types of preeclampsia; EO-PE, early-onset preeclampsia; LO-PE, late-onset preeclampsia; SGA, small for gestational age; ANC, antenatal clinic.

The 14 publications studied were published between 2006 and 2020 and were worldwide, with no preference for one region. The meta-analysis included a total of 737 cases of preeclampsia and 7,502 controls.

The mean value of PP-13 expressed in multiples of median (MoM) and standard deviation was 0.92±0.95 for all preeclampsia group, 0.62±0.22 for the early-onset preeclampsia (EO-PE) group, and 0.5±0.19 for the late-onset preeclampsia (LO-PE) or small for gestational age and preeclampsia group (PE + SGA) group, respectively. No statistically significant difference was observed between the groups regarding the cut-off value of PP-13 (P=0.414). The accuracy of the test in the various studies is tabulated in Table IV.

Table IV

Diagnostic accuracy of PP-13 for the prediction of PE in the various studies.

Table IV

Diagnostic accuracy of PP-13 for the prediction of PE in the various studies.

Authors of the study (Refs.)YearType of PELR(+)LR(-)DOR
Spencer et al (15)2006All PE2.220.703.19
Chafetz et al (16)2007All PE7.870.2433.30
Khalil et al (18)2009All PE6.900.3420.08
Odibo et al (22)2011All PE6.350.738.74
Odibo et al (22)2011All PE4.520.617.43
Odibo et al (22)2011All PE2.500.634.00
Schneuer et al (23)2012All PE3.100.893.49
Deurloo et al (24)2013All PE1.180.961.23
Meiri et al (25)2014All PE3.690.2614.02
Meiri et al (25)2014All PE5.220.539.86
Luo and Han (26)2017All PE3.070.496.26
Asiltas et al (27)2018All PE9.100.1277.92
Soongsatitanon and Phupong (28)2020All PE1.510.732.06
Spencer et al (15)2006EO-PE2.510.624.01
Gonen et al (17)2008EO-PE3.990.2515.97
Gonen et al (17)2009EO-PE7.140.3222.50
Khalil et al (20)2010EO-PE6.430.4016.20
Akolekar et al (19)2009EO-PE4.130.834.95
Akolekar et al (19)2009EO-PE3.710.705.34
Wortelboer et al (21)2010EO-PE4.890.806.15
Wortelboer et al (21)2010EO-PE4.000.676.00
Odibo et al (22)2011EO-PE3.750.3112.00
Schneuer et al (23)2012EO-PE4.000.844.76
Spencer et al (15)2006LO-PE/PE + SGA1.940.772.53
Gonen et al (17)2008LO-PE/PE + SGA3.990.2515.97
Khalil et al (18)2009LO-PE/PE + SGA5.000.569.00
Khalil et al (18)2009LO-PE/PE + SGA6.110.4314.14
Khalil et al (20)2010LO-PE/PE + SGA6.150.4314.40

[i] All-PE, all types of preeclampsia; EO-PE, early onset preeclampsia; LO-PE, late onset preeclampsia; PE + SGA, preeclampsia and small for gestational age; LR(+), positive likelihood ratio; LR(-), negative likelihood ratio; DOR, diagnostic odds ratio.

In studies that analyzed women with PE without sub-classifying the population into EO-PE and LO-PE (n=10), the pooled sensitivity of PP-13 was 0.53 (95% CI, 0.08-0.99, I2 0.0%) and the pooled specificity of PP-13 was 0.83 (95% CI, 0.38-1.29, I2 0.0%) (Figs. 2 and 3). The summary receiver operating characteristic curve (SROC) was 0.88 (95% CI, 0.80-0.94) (Fig. 4).

In the group of studies that categorized EO-PE separately, the pooled sensitivity of PP-13 was 0.51 (95% CI, -0.04-1.05, I2 0.0%) with a specificity of 0.88 (95% CI, 0.33-1.42, I2 0.0%) (Figs. 5 and 6). The area under the SROC was 0.69 (95% CI, 0.54-0.81) (Fig. 7).

In the LO-PE/PE + SGA groups, the pooled sensitivity of PP-13 was 0.58 (95% CI, -0.17-1.33, I2 0.0%) with a specificity of 0.85 (95% CI, 0.10-1.60, I2 0.0%) (Figs. 8 and 9). The area under the SROC was 0.77 (95% CI, 0.63-0.87) (Fig. 10).

According to the Fagan nomogram, for a given pre-test probability of 25% for the preeclampsia group, the post-test probability was 66 and 19% for positive and negative PP-13 biomarker readings, respectively (Fig. 11).

According to the Fagan nomogram, the positive and negative results of the PP-13 biomarker had a post-test probability of 69 and 22%, respectively, for the specified pre-test probability of 25% for the EO-PE group (Fig. 12).

Finally, the Fagan nomogram revealed that, for a given pre-test probability of 25% for the LO-PE/PE + SGA groups, the post-test probability for positive and negative PP-13 biomarker values was 71 and 22%, respectively (Fig. 13).

Simple and contour-enhanced funnel plots did not indicate a risk of publication bias (Figs. 14 and 15).

Discussion

Preeclampsia is a multisystem condition with a complex etiology. As a consequence, much research has been conducted to identify the women at risk to improve pregnancy outcomes. Clinical criteria alone, such as previous medical and obstetric history, are ineffective in predicting the condition (29). Therefore, it is important to develop integrative algorithms to predict preeclampsia. These include the use of novel biomarkers, sonographic features, and maternal characteristics to obtain higher detection rates.

Protein-galectin-13 or placental protein-13 (PP-13), a protein linked to cell differentiation and inflammatory processes in the placenta, seems to be an effective biomarker for preeclampsia screening (16,30).

This work is the first meta-analysis that offers an overview of the discriminatory performance and predictive capacity of the PP-13 biomarker for first trimester preeclampsia screening.

A total of 14 studies met the inclusion criteria and were subjected to quality testing using the QUADAS-2 tool. Our results demonstrated good overall test accuracy in disease prediction. Given the sensitivity and specificity of this marker, the findings of this meta-analysis showed that maternal PP-13 concentration was lower in preeclampsia and could serve as a valuable diagnostic marker (0.53 and 0.83, respectively).

The diagnostic accuracies in the various subgroups further highlight the importance of PP-13 in preeclampsia. Studies have demonstrated that the two forms of preeclampsia, early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE), have different physiopathological backgrounds. EO-PE manifests secondary to poor placentation, while LO-PE appears to be a placental malperfusion, caused by limited uterine vascular capacity (31).

It is the EO-PE disease that contributes most to perinatal morbidity, mortality and long-term maternal complications, and therefore numerous efforts are put into its recognition.

Our meta-analysis demonstrated that the predictive performance of PP-13 in LO-PE was higher, although not statistically significant, than that of EO-PE, indicating a good screening performance of this biomarker for both forms of the disease. Moreover, PP-13 had a good negative post-test probability for all included groups (preeclampsia group, 19%; EO-PE group, 22%; LO-PE/PE + SGA group, 22%).

The predictive performance of PP-13 could be increased when using this biomarker in conjunction with maternal characteristics and uterine artery Doppler parameters as shown by previous studies (28,32).

Studies linking PP-13 to fetal growth restriction (FGR) and oxidative stress indices in preeclamptic women suggest the importance of PP-13 as a biomarker of poor placentation throughout the prenatal period. In our meta-analysis, the summary receiver operating characteristic curve (SROC) for the LO-PE and the preeclampsia associated with small for gestational age fetuses (PE-SGA) groups was 0.77.

Our meta-analysis has several limitations. Because the results of our analysis were based mostly on case-control and retrospective studies that examined PP-13 serum levels, the possibility of selection bias must be considered. Furthermore, as PP-13 serum levels were assessed during the first trimester of pregnancy, its prognostic usefulness during the second and third trimesters remains unknown.

The present meta-analysis could serve as a pilot for future research as it provides substantial evidence that can be employed in the design of future studies, especially when it comes to assessing the predictive accuracy of the various cut-offs that have been offered to date. This way, the possibility of bias will be reduced, and comparable results will be produced, allowing for the generalization of findings. PP-13 should be investigated in multivariate models alongside other emerging biomarkers to develop algorithms for providing the best predictive efficacy.

PP-13 could be used as a promising biomarker in preeclampsia screening from the first trimester of pregnancy. Compared to EO-PE, its predictive performance seems better for LO-PE, but the difference between the two was not found to be statistically significant. Because the current data is based on first-trimester readings, more research is needed to determine its prognostic accuracy later in pregnancy.

Given this information, more well-designed prospective studies are needed to shed light on patient phenotypes that appear to demonstrate the most noticeable differences (those with severe, early-onset preeclampsia and those who are prone to developing eclampsia).

The inclusion of PP-13 in predictive models with existing biomarkers could aid in determining its potential additional value in predicting disease and the severity of the associated consequences.

Acknowledgements

Not applicable.

Funding

Funding: No funding was received.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

This meta-analysis was written as part of the doctoral program for IAV at ‘Grigore T. Popa’ University. DN, AC and IAV performed the systematic review, analyzed data, and wrote the manuscript; AC, DN and DS interpreted the data; DN, IAV, RM and IP developed the study concept and design. DN and DS carried out the literature search, and were assisted by AC and IAV, who retrieved the evidence and chose the papers. The data were extracted by AC, IAV and DS. The final version of the publication was written by IAV, AC, DN and DS. A final inspection of the manuscript was entrusted to IAV and DN. All authors read and approved the final manuscript for publication.

Ethics approval and consent to participate

Not applicable.

Patient consent for publication

Not applicable.

Competing interests

All authors report no competing interests.

References

1 

Ananth CV, Keyes KM and Wapner RJ: Pre-eclampsia rates in the United States, 1980-2010: Age-period-cohort analysis. BMJ. 347(f6564)2013.PubMed/NCBI View Article : Google Scholar

2 

Barondes SH, Castronovo V, Cooper DN, Cummings RD, Drickamer K, Feizi T, Gitt MA, Hirabayashi J, Hughes C, Kasai K, et al: Galectins: A family of animal beta-galactoside-binding lectins. Cell. 76:597–598. 1994.PubMed/NCBI View Article : Google Scholar

3 

Kang HG, Kim DH, Kim SJ, Cho Y, Jung J, Jang W and Chun KH: Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain. Oncotarget. 7:68229–68241. 2016.PubMed/NCBI View Article : Google Scholar

4 

Sammar M, Drobnjak T, Mandala M, Gizurarson S, Huppertz B and Meiri H: Galectin 13 (PP13) facilitates remodeling and structural stabilization of maternal vessels during pregnancy. Int J Mol Sci. 20(3192)2019.PubMed/NCBI View Article : Google Scholar

5 

Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ. 372(n160)2021.PubMed/NCBI View Article : Google Scholar

6 

National Center for Biotechnology Information (NCBI). PubMed database. https://pubmed.ncbi.nlm.nih.gov/. Accessed February 28, 2021.

7 

Clarivate. Web of Science database. https://clarivate.com/webofsciencegroup/solutions/web-of-science/. Accessed on 28.02.2021.

8 

Elsevier. Scopus database. https://www.scopus.com/home.uri. Accessed February 28, 2021.

9 

Elsevier. Embase database. https://www.embase.com/landing?status=grey. Accessed February 28, 2021.

10 

Clarivate. BIOSISCitationIndex. https://clarivate.com/webofsciencegroup/solutions/webodscience-biosis-citation-index/. Accessed February 28, 2021.

11 

Cochrane Library. Cochrane database. https://www.cochranelibrary.com/. Accessed February 28, 2021.

12 

Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM and Kleijnen J: The development of QUADAS: A tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 3(25)2003.PubMed/NCBI View Article : Google Scholar

13 

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA and Bossuyt PM: QUADAS-2 Group. QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529–536. 2011.PubMed/NCBI View Article : Google Scholar

14 

DerSimonian R and Laird N: Meta-analysis in clinical trials revisited. Contemp Clin Trials. 45:139–145. 2015.PubMed/NCBI View Article : Google Scholar

15 

Spencer K, Cowans NJ, Chefetz I, Tal J and Meiri H: First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia. Ultrasound Obstet Gynecol. 29:128–134. 2007.PubMed/NCBI View Article : Google Scholar

16 

Chafetz I, Kuhnreich I, Sammar M, Tal Y, Gibor Y, Meiri H, Cuckle H and Wolf M: First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol. 197:35.e1–e7. 2007.PubMed/NCBI View Article : Google Scholar

17 

Gonen R, Shahar R, Grimpel YI, Chefetz I, Sammar M, Meiri H and Gibor Y: Placental protein 13 as an early marker for pre-eclampsia: A prospective longitudinal study. BJOG. 115:1465–1472. 2008.PubMed/NCBI View Article : Google Scholar

18 

Khalil A, Cowans NJ, Spencer K, Goichman S, Meiri H and Harrington K: First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk. Prenat Diagn. 29:781–789. 2009.PubMed/NCBI View Article : Google Scholar

19 

Akolekar R, Syngelaki A, Beta J, Kocylowski R and Nicolaides KH: Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia. Prenat Diagn. 29:1103–1108. 2009.PubMed/NCBI View Article : Google Scholar

20 

Khalil A, Cowans NJ, Spencer K, Goichman S, Meiri H and Harrington K: First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk. Ultrasound Obstet Gynecol. 35:671–679. 2010.PubMed/NCBI View Article : Google Scholar

21 

Wortelboer EJ, Koster MP, Cuckle HS, Stoutenbeek PH, Schielen PC and Visser GH: First-trimester placental protein 13 and placental growth factor: Markers for identification of women destined to develop early-onset pre-eclampsia. BJOG. 117:1384–1389. 2010.PubMed/NCBI View Article : Google Scholar

22 

Odibo AO, Zhong Y, Goetzinger KR, Odibo L, Bick JL, Bower CR and Nelson DM: First-trimester placental protein 13, PAPP-A, uterine artery Doppler and maternal characteristics in the prediction of pre-eclampsia. Placenta. 32:598–602. 2011.PubMed/NCBI View Article : Google Scholar

23 

Schneuer FJ, Nassar N, Khambalia AZ, Tasevski V, Guilbert C, Ashton AW, Morris JM and Roberts CL: First trimester screening of maternal placental protein 13 for predicting preeclampsia and small for gestational age: In-house study and systematic review. Placenta. 33:735–740. 2012.PubMed/NCBI View Article : Google Scholar

24 

Deurloo KL, Linskens IH, Heymans MW, Heijboer AC, Blankenstein MA and van Vugt JM: ADAM12s and PP13 as first trimester screening markers for adverse pregnancy outcome. Clin Chem Lab Med. 51:1279–1284. 2013.PubMed/NCBI View Article : Google Scholar

25 

Meiri H, Sammar M, Herzog A, Grimpel YI, Fihaman G, Cohen A, Kivity V, Sharabi-Nov A and Gonnen R: Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin. J Perinat Med. 42:591–601. 2014.PubMed/NCBI View Article : Google Scholar

26 

Luo Q and Han X: Second-trimester maternal serum markers in the prediction of preeclampsia. J Perinat Med. 45:809–816. 2017.PubMed/NCBI View Article : Google Scholar

27 

Asiltas B, Surmen-Gur E and Uncu G: Prediction of first-trimester preeclampsia: Relevance of the oxidative stress marker MDA in a combination model with PP-13, PAPP-A and beta-HCG. Pathophysiology. 25:131–135. 2018.PubMed/NCBI View Article : Google Scholar

28 

Soongsatitanon A and Phupong V: Prediction of preeclampsia using first trimester placental protein 13 and uterine artery Doppler. J Matern Fetal Neonatal Med: Nov 16, 2020 (Epub ahead of print).

29 

North RA, McCowan LM, Dekker GA, Poston L, Chan EH, Stewart AW, Black MA, Taylor RS, Walker JJ, Baker PN and Kenny LC: Clinical risk prediction for pre-eclampsia in nulliparous women: Development of model in international prospective cohort. BMJ. 342(d1875)2011.PubMed/NCBI View Article : Google Scholar

30 

Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H and Gonen R: Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia. Reprod Sci. 19:16–30. 2012.PubMed/NCBI View Article : Google Scholar

31 

Redman CW, Sargent IL and Staff AC: IFPA Senior award lecture: Making sense of pre-eclampsia-two placental causes of preeclampsia? Placenta. 35 (Suppl 1):S20–S25. 2014.PubMed/NCBI View Article : Google Scholar

32 

Monte S: Biochemical markers for prediction of preclampsia: Review of the literature. J Prenat Med. 5:69–77. 2011.PubMed/NCBI

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Vasilache I, Carauleanu A, Socolov D, Matasariu R, Pavaleanu I and Nemescu D: Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Exp Ther Med 23: 370, 2022
APA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., & Nemescu, D. (2022). Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 23, 370. https://doi.org/10.3892/etm.2022.11297
MLA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23.6 (2022): 370.
Chicago
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23, no. 6 (2022): 370. https://doi.org/10.3892/etm.2022.11297