Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2022 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2022 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis

  • Authors:
    • Ingrid-Andrada Vasilache
    • Alexandru Carauleanu
    • Demetra Socolov
    • Roxana Matasariu
    • Ioana Pavaleanu
    • Dragos Nemescu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Vasilache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 370
    |
    Published online on: April 5, 2022
       https://doi.org/10.3892/etm.2022.11297
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Placental protein‑13 (PP‑13) is a member of the galectin group involved in placental implantation, maternal artery remodeling, and placental inflammatory processes. Its levels are lower in the first trimester for pregnancies later affected by ischemic placental disease, and slowly increase during the second and third trimesters of pregnancy. The aim of the present meta‑analysis is to assess the predictive performance of PP‑13 in first trimester preeclampsia screening. PubMed, Web of Science, Scopus, Embase, BIOSIS, and Cochrane databases were used to find relevant studies. All prospective and retrospective observational studies that evaluated the accuracy of PP‑13 in predicting preeclampsia were assessed. The investigation revealed that the quantitative synthesis was based on 14 studies with a total number of 8,239 women. The pooled sensitivity of PP‑13 for the prediction of preeclampsia was 0.53 [95% (confidence interval (CI), 0.08‑0.99], and the pooled specificity was 0.83 (95% CI, 0.38‑1.29). Further analysis revealed a higher accuracy of PP‑13 for the screening of late‑onset preeclampsia [pooled sensitivity of 0.58 [95% CI, ‑0.17‑1.33) with a specificity of 0.85 (95% CI, 0.10‑1.60)] when compared with early‑onset preeclampsia [pooled sensitivity of 0.51 (95% CI, ‑0.04‑1.05) with a specificity of 0.88 (95% CI, 0.33‑1.42)]. In conclusion, PP‑13 appears to be a promising biomarker for evaluating the risk of developing preeclampsia during the first trimester of pregnancy. As a result, incorporating it into future predictive models is a viable option.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Figure 14

Figure 15

View References

1 

Ananth CV, Keyes KM and Wapner RJ: Pre-eclampsia rates in the United States, 1980-2010: Age-period-cohort analysis. BMJ. 347(f6564)2013.PubMed/NCBI View Article : Google Scholar

2 

Barondes SH, Castronovo V, Cooper DN, Cummings RD, Drickamer K, Feizi T, Gitt MA, Hirabayashi J, Hughes C, Kasai K, et al: Galectins: A family of animal beta-galactoside-binding lectins. Cell. 76:597–598. 1994.PubMed/NCBI View Article : Google Scholar

3 

Kang HG, Kim DH, Kim SJ, Cho Y, Jung J, Jang W and Chun KH: Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain. Oncotarget. 7:68229–68241. 2016.PubMed/NCBI View Article : Google Scholar

4 

Sammar M, Drobnjak T, Mandala M, Gizurarson S, Huppertz B and Meiri H: Galectin 13 (PP13) facilitates remodeling and structural stabilization of maternal vessels during pregnancy. Int J Mol Sci. 20(3192)2019.PubMed/NCBI View Article : Google Scholar

5 

Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. BMJ. 372(n160)2021.PubMed/NCBI View Article : Google Scholar

6 

National Center for Biotechnology Information (NCBI). PubMed database. https://pubmed.ncbi.nlm.nih.gov/. Accessed February 28, 2021.

7 

Clarivate. Web of Science database. https://clarivate.com/webofsciencegroup/solutions/web-of-science/. Accessed on 28.02.2021.

8 

Elsevier. Scopus database. https://www.scopus.com/home.uri. Accessed February 28, 2021.

9 

Elsevier. Embase database. https://www.embase.com/landing?status=grey. Accessed February 28, 2021.

10 

Clarivate. BIOSISCitationIndex. https://clarivate.com/webofsciencegroup/solutions/webodscience-biosis-citation-index/. Accessed February 28, 2021.

11 

Cochrane Library. Cochrane database. https://www.cochranelibrary.com/. Accessed February 28, 2021.

12 

Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM and Kleijnen J: The development of QUADAS: A tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 3(25)2003.PubMed/NCBI View Article : Google Scholar

13 

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA and Bossuyt PM: QUADAS-2 Group. QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529–536. 2011.PubMed/NCBI View Article : Google Scholar

14 

DerSimonian R and Laird N: Meta-analysis in clinical trials revisited. Contemp Clin Trials. 45:139–145. 2015.PubMed/NCBI View Article : Google Scholar

15 

Spencer K, Cowans NJ, Chefetz I, Tal J and Meiri H: First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia. Ultrasound Obstet Gynecol. 29:128–134. 2007.PubMed/NCBI View Article : Google Scholar

16 

Chafetz I, Kuhnreich I, Sammar M, Tal Y, Gibor Y, Meiri H, Cuckle H and Wolf M: First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol. 197:35.e1–e7. 2007.PubMed/NCBI View Article : Google Scholar

17 

Gonen R, Shahar R, Grimpel YI, Chefetz I, Sammar M, Meiri H and Gibor Y: Placental protein 13 as an early marker for pre-eclampsia: A prospective longitudinal study. BJOG. 115:1465–1472. 2008.PubMed/NCBI View Article : Google Scholar

18 

Khalil A, Cowans NJ, Spencer K, Goichman S, Meiri H and Harrington K: First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk. Prenat Diagn. 29:781–789. 2009.PubMed/NCBI View Article : Google Scholar

19 

Akolekar R, Syngelaki A, Beta J, Kocylowski R and Nicolaides KH: Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia. Prenat Diagn. 29:1103–1108. 2009.PubMed/NCBI View Article : Google Scholar

20 

Khalil A, Cowans NJ, Spencer K, Goichman S, Meiri H and Harrington K: First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk. Ultrasound Obstet Gynecol. 35:671–679. 2010.PubMed/NCBI View Article : Google Scholar

21 

Wortelboer EJ, Koster MP, Cuckle HS, Stoutenbeek PH, Schielen PC and Visser GH: First-trimester placental protein 13 and placental growth factor: Markers for identification of women destined to develop early-onset pre-eclampsia. BJOG. 117:1384–1389. 2010.PubMed/NCBI View Article : Google Scholar

22 

Odibo AO, Zhong Y, Goetzinger KR, Odibo L, Bick JL, Bower CR and Nelson DM: First-trimester placental protein 13, PAPP-A, uterine artery Doppler and maternal characteristics in the prediction of pre-eclampsia. Placenta. 32:598–602. 2011.PubMed/NCBI View Article : Google Scholar

23 

Schneuer FJ, Nassar N, Khambalia AZ, Tasevski V, Guilbert C, Ashton AW, Morris JM and Roberts CL: First trimester screening of maternal placental protein 13 for predicting preeclampsia and small for gestational age: In-house study and systematic review. Placenta. 33:735–740. 2012.PubMed/NCBI View Article : Google Scholar

24 

Deurloo KL, Linskens IH, Heymans MW, Heijboer AC, Blankenstein MA and van Vugt JM: ADAM12s and PP13 as first trimester screening markers for adverse pregnancy outcome. Clin Chem Lab Med. 51:1279–1284. 2013.PubMed/NCBI View Article : Google Scholar

25 

Meiri H, Sammar M, Herzog A, Grimpel YI, Fihaman G, Cohen A, Kivity V, Sharabi-Nov A and Gonnen R: Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin. J Perinat Med. 42:591–601. 2014.PubMed/NCBI View Article : Google Scholar

26 

Luo Q and Han X: Second-trimester maternal serum markers in the prediction of preeclampsia. J Perinat Med. 45:809–816. 2017.PubMed/NCBI View Article : Google Scholar

27 

Asiltas B, Surmen-Gur E and Uncu G: Prediction of first-trimester preeclampsia: Relevance of the oxidative stress marker MDA in a combination model with PP-13, PAPP-A and beta-HCG. Pathophysiology. 25:131–135. 2018.PubMed/NCBI View Article : Google Scholar

28 

Soongsatitanon A and Phupong V: Prediction of preeclampsia using first trimester placental protein 13 and uterine artery Doppler. J Matern Fetal Neonatal Med: Nov 16, 2020 (Epub ahead of print).

29 

North RA, McCowan LM, Dekker GA, Poston L, Chan EH, Stewart AW, Black MA, Taylor RS, Walker JJ, Baker PN and Kenny LC: Clinical risk prediction for pre-eclampsia in nulliparous women: Development of model in international prospective cohort. BMJ. 342(d1875)2011.PubMed/NCBI View Article : Google Scholar

30 

Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H and Gonen R: Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia. Reprod Sci. 19:16–30. 2012.PubMed/NCBI View Article : Google Scholar

31 

Redman CW, Sargent IL and Staff AC: IFPA Senior award lecture: Making sense of pre-eclampsia-two placental causes of preeclampsia? Placenta. 35 (Suppl 1):S20–S25. 2014.PubMed/NCBI View Article : Google Scholar

32 

Monte S: Biochemical markers for prediction of preclampsia: Review of the literature. J Prenat Med. 5:69–77. 2011.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Vasilache I, Carauleanu A, Socolov D, Matasariu R, Pavaleanu I and Nemescu D: Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Exp Ther Med 23: 370, 2022.
APA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., & Nemescu, D. (2022). Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 23, 370. https://doi.org/10.3892/etm.2022.11297
MLA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23.6 (2022): 370.
Chicago
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23, no. 6 (2022): 370. https://doi.org/10.3892/etm.2022.11297
Copy and paste a formatted citation
x
Spandidos Publications style
Vasilache I, Carauleanu A, Socolov D, Matasariu R, Pavaleanu I and Nemescu D: Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Exp Ther Med 23: 370, 2022.
APA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., & Nemescu, D. (2022). Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 23, 370. https://doi.org/10.3892/etm.2022.11297
MLA
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23.6 (2022): 370.
Chicago
Vasilache, I., Carauleanu, A., Socolov, D., Matasariu, R., Pavaleanu, I., Nemescu, D."Predictive performance of first trimester serum galectin‑13/PP‑13 in preeclampsia screening: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 23, no. 6 (2022): 370. https://doi.org/10.3892/etm.2022.11297
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team