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Review Open Access

Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)

  • Authors:
    • Elena Bălășescu
    • Andreea-Cristina Gheorghe
    • Andreea Moroianu
    • Gabriela Turcu
    • Alice Brînzea
    • Mihaela Antohe
    • Anastasia Hodorogea
    • Lorena Manea
    • Mihaela Balaban
    • Răzvan Andrei
    • Ionela Hulea
    • Cristiana Gabriela Popp
    • Luciana Nichita
    • Mirela Daniela Cioplea
    • Sabina Andrada Zurac
    • Daniela Adriana Ion
    • Roxana Ioana Nedelcu
  • View Affiliations / Copyright

    Affiliations: 2nd Clinical Department, Pathophysiology II, National Institute of Infectious Diseases ‘Prof. Dr. Matei Balș’, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 021105 Bucharest, Romania, Derma 360 Clinic, 011273 Bucharest, Romania, Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania
    Copyright: © Bălășescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 383
    |
    Published online on: April 11, 2022
       https://doi.org/10.3892/etm.2022.11308
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Abstract

Non‑melanoma skin cancer (NMSC) is the most common type of neoplasm affecting Caucasian individuals, with squamous‑cell carcinoma (cSCC) being the second most common type of NMSC after basal‑cell carcinoma. The immunohistochemical study of cSCC is of particular importance, especially for the diagnosis of its rare forms, for which accurate and early diagnosis is crucial for survival. In the present review of the literature, the potentially significant value of immunohistochemical markers were highlighted to more accurately assess the biological behaviour, the prognosis of cSCC and to optimize case management. The immunohistochemical markers were classified from a pathophysiological point of view in order to present the mechanism by which carcinogenesis occurs with its subsequent evolution and therefore, to develop a more accurate novel risk staging criteria for this type of neoplasm.
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Bălășescu E, Gheorghe A, Moroianu A, Turcu G, Brînzea A, Antohe M, Hodorogea A, Manea L, Balaban M, Andrei R, Andrei R, et al: Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review). Exp Ther Med 23: 383, 2022.
APA
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M. ... Nedelcu, R.I. (2022). Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review). Experimental and Therapeutic Medicine, 23, 383. https://doi.org/10.3892/etm.2022.11308
MLA
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M., Hodorogea, A., Manea, L., Balaban, M., Andrei, R., Hulea, I., Popp, C. G., Nichita, L., Cioplea, M. D., Zurac, S. A., Ion, D. A., Nedelcu, R. I."Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)". Experimental and Therapeutic Medicine 23.6 (2022): 383.
Chicago
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M., Hodorogea, A., Manea, L., Balaban, M., Andrei, R., Hulea, I., Popp, C. G., Nichita, L., Cioplea, M. D., Zurac, S. A., Ion, D. A., Nedelcu, R. I."Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)". Experimental and Therapeutic Medicine 23, no. 6 (2022): 383. https://doi.org/10.3892/etm.2022.11308
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Spandidos Publications style
Bălășescu E, Gheorghe A, Moroianu A, Turcu G, Brînzea A, Antohe M, Hodorogea A, Manea L, Balaban M, Andrei R, Andrei R, et al: Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review). Exp Ther Med 23: 383, 2022.
APA
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M. ... Nedelcu, R.I. (2022). Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review). Experimental and Therapeutic Medicine, 23, 383. https://doi.org/10.3892/etm.2022.11308
MLA
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M., Hodorogea, A., Manea, L., Balaban, M., Andrei, R., Hulea, I., Popp, C. G., Nichita, L., Cioplea, M. D., Zurac, S. A., Ion, D. A., Nedelcu, R. I."Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)". Experimental and Therapeutic Medicine 23.6 (2022): 383.
Chicago
Bălășescu, E., Gheorghe, A., Moroianu, A., Turcu, G., Brînzea, A., Antohe, M., Hodorogea, A., Manea, L., Balaban, M., Andrei, R., Hulea, I., Popp, C. G., Nichita, L., Cioplea, M. D., Zurac, S. A., Ion, D. A., Nedelcu, R. I."Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous‑cell carcinomas (Review)". Experimental and Therapeutic Medicine 23, no. 6 (2022): 383. https://doi.org/10.3892/etm.2022.11308
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