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Immunological signature of chronic spontaneous urticaria (Review)

  • Authors:
    • Carmen-Teodora Dobrican
    • Ioana Adriana Muntean
    • Irena Pintea
    • Carina Petricău
    • Diana-Mihaela Deleanu
    • Gabriela Adriana Filip
  • View Affiliations / Copyright

    Affiliations: Discipline of Allergology and Immunology, Department of Functional Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, 400162 Cluj‑Napoca, Romania, Discipline of Physiology, Department of Functional Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, 400162 Cluj‑Napoca, Romania
    Copyright: © Dobrican et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 381
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    Published online on: April 8, 2022
       https://doi.org/10.3892/etm.2022.11309
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Abstract

Chronic urticaria (CU) is a condition characterized by intensely pruritic, edematous, erythematous papules lasting for more than 6 weeks. Over half of the cases have concomitant swelling of deeper tissues, known as angioedema. The socio‑economic burden of the disease is significant. Unfortunately, patients with severe CU, refractory to conventional treatment, have limited and expensive therapeutic options. The pathogenesis of CU is not yet completely understood. Therefore, elucidating the pathophysiological mechanisms involved would potentially identify new therapeutic targets. It has been accepted in recent years that mast cells and their activation, followed by excessive degranulation represent the key pathophysiological events in chronic spontaneous urticaria (CSU). The triggering events and the complexity of the effector mechanisms, however, remain intensely debated topics with conflicting studies. One pathogenetic mechanism incriminated in chronic spontaneous urticaria is the response mediated by the high‑affinity receptor for IgE (FcεRI) expressed on mast cells. Increasing recognition of chronic spontaneous urticaria as an autoimmune disease linked to the cytokine‑chemokine network imbalance resulting from alteration of innate immune response is another pathogenetic explanation. It is likely that these different pathological mechanisms are more interconnected, both acting synergistically, rather than separately, to produce the clinical expression of CU. The discovery and understanding of pathogenic mechanisms represent the premise for the development of safe and effective immunomodulators and targeted biological treatment for severe, refractory CU.
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Copy and paste a formatted citation
Spandidos Publications style
Dobrican C, Muntean IA, Pintea I, Petricău C, Deleanu D and Filip GA: Immunological signature of chronic spontaneous urticaria (Review). Exp Ther Med 23: 381, 2022.
APA
Dobrican, C., Muntean, I.A., Pintea, I., Petricău, C., Deleanu, D., & Filip, G.A. (2022). Immunological signature of chronic spontaneous urticaria (Review). Experimental and Therapeutic Medicine, 23, 381. https://doi.org/10.3892/etm.2022.11309
MLA
Dobrican, C., Muntean, I. A., Pintea, I., Petricău, C., Deleanu, D., Filip, G. A."Immunological signature of chronic spontaneous urticaria (Review)". Experimental and Therapeutic Medicine 23.6 (2022): 381.
Chicago
Dobrican, C., Muntean, I. A., Pintea, I., Petricău, C., Deleanu, D., Filip, G. A."Immunological signature of chronic spontaneous urticaria (Review)". Experimental and Therapeutic Medicine 23, no. 6 (2022): 381. https://doi.org/10.3892/etm.2022.11309
Copy and paste a formatted citation
x
Spandidos Publications style
Dobrican C, Muntean IA, Pintea I, Petricău C, Deleanu D and Filip GA: Immunological signature of chronic spontaneous urticaria (Review). Exp Ther Med 23: 381, 2022.
APA
Dobrican, C., Muntean, I.A., Pintea, I., Petricău, C., Deleanu, D., & Filip, G.A. (2022). Immunological signature of chronic spontaneous urticaria (Review). Experimental and Therapeutic Medicine, 23, 381. https://doi.org/10.3892/etm.2022.11309
MLA
Dobrican, C., Muntean, I. A., Pintea, I., Petricău, C., Deleanu, D., Filip, G. A."Immunological signature of chronic spontaneous urticaria (Review)". Experimental and Therapeutic Medicine 23.6 (2022): 381.
Chicago
Dobrican, C., Muntean, I. A., Pintea, I., Petricău, C., Deleanu, D., Filip, G. A."Immunological signature of chronic spontaneous urticaria (Review)". Experimental and Therapeutic Medicine 23, no. 6 (2022): 381. https://doi.org/10.3892/etm.2022.11309
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