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Article Open Access

Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome

  • Authors:
    • Bin Ouyang
    • Dayu Han
    • Zexin Guo
    • Junhong Deng
    • Weilong Li
    • Liangliang Huang
    • Jianming Liu
    • Zhouda Cai
    • Jun Bian
    • Shaoming Huang
  • View Affiliations / Copyright

    Affiliations: Department of Andrology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China, Department of Andrology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Reproductive Centre, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Urology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China, Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China, Department of Andrology, Ganzhou Municipal Hospital, Ganzhou, Jiangxi 341000, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 382
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    Published online on: April 8, 2022
       https://doi.org/10.3892/etm.2022.11310
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Abstract

Chronic pelvic pain syndrome (CPPS) and chronic prostatitis (CP) is difficult to distinguish from each other, herein termed CP/CPPS. The present study aimed at gaining further insight into the change in extracellular vesicles (EVs) in the prostatic fluid of males with CPPS. From December 2019 to November 2020, after clinical screening, 24 patients with CPPS without obvious urinary symptoms and 13 healthy male participants were included. EVs were isolated from expressed prostatic secretion (EPS) of all subjects. The small non‑coding ribonucleic acid (sncRNA) expression of EVs was sequenced, analyzed, and validated by quantitative real‑time polymerase chain reaction (qPCR) assays. The results showed that numerous sncRNAs were differentially expressed between the patients and healthy participants. Further qPCR assays validated that several chronic pain‑related miRNAs, including miR‑204‑5p, let‑7d‑3p, let‑7b‑3p, let‑7c‑3p, miR‑146a‑5p, and miR‑320a‑5p, were differentially expressed. Series sncRNAs including several chronic pain‑related miRNAs were altered in EVs in prostatic fluid of patients with CPPS, which may serve as diagnostic markers for CPPS.
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1 

Habermacher GM, Chason JT and Schaeffer AJ: Prostatitis/chronic pelvic pain syndrome. Annu Rev Med. 57:195–206. 2006.PubMed/NCBI View Article : Google Scholar

2 

Bernal RM and Pontari MA: Evaluation of chronic pelvic pain syndrome in men: Is it chronic prostatitis? Curr Urol Rep. 10:295–301. 2009.PubMed/NCBI View Article : Google Scholar

3 

Stamatiou K, Samara E, Lacroix RN, Moschouris H, Perletti G and Magri V: One, No one and one hundred thousand: Patterns of chronic prostatic inflammation and infection. Exp Ther Med. 22(966)2021.PubMed/NCBI View Article : Google Scholar

4 

Merchant ML, Rood IM, Deegens JKJ and Klein JB: Isolation and characterization of urinary extracellular vesicles: Implications for biomarker discovery. Nat Rev Nephrol. 13:731–749. 2017.PubMed/NCBI View Article : Google Scholar

5 

Minciacchi VR, Zijlstra A, Rubin MA and Di Vizio D: Extracellular vesicles for liquid biopsy in prostate cancer: Where are we and where are we headed? Prostate Cancer Prostatic Dis. 20:251–258. 2017.PubMed/NCBI View Article : Google Scholar

6 

Zijlstra C and Stoorvogel W: Prostasomes as a source of diagnostic biomarkers for prostate cancer. J Clin Invest. 126:1144–1151. 2016.PubMed/NCBI View Article : Google Scholar

7 

Burden HP, Holmes CH, Persad R and Whittington K: Prostasomes-their effects on human male reproduction and fertility. Hum Reprod Update. 12:283–292. 2006.PubMed/NCBI View Article : Google Scholar

8 

Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, et al: Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 351:397–400. 2016.PubMed/NCBI View Article : Google Scholar

9 

Zhao B, Zheng J, Qiao Y, Wang Y, Luo Y, Zhang D, Cai Q, Xu Y, Zhou Z and Shen W: Prostatic fluid exosome-mediated microRNA-155 promotes the pathogenesis of type IIIA chronic prostatitis. Transl Androl Urol. 10:1976–1987. 2021.PubMed/NCBI View Article : Google Scholar

10 

Shoskes DA, Nickel JC, Dolinga R and Prots D: Clinical phenotyping of patients with chronic prostatitis/chronic pelvic pain syndrome and correlation with symptom severity. Urology. 73:538–542; discussion 542-3. 2009.PubMed/NCBI View Article : Google Scholar

11 

Ouyang B, Xie Y, Zhang C and Deng C, Lv L, Yao J, Zhang Y, Liu G, Deng J and Deng C: Extracellular vesicles from human urine-derived stem cells ameliorate erectile dysfunction in a diabetic rat model by delivering proangiogenic MicroRNA. Sex Med. 7:241–250. 2019.PubMed/NCBI View Article : Google Scholar

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

13 

Wang L, Feng Z, Wang X, Wang X and Zhang X: DEGseq: An R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 26:136–138. 2010.PubMed/NCBI View Article : Google Scholar

14 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012.PubMed/NCBI View Article : Google Scholar

15 

Punab M, Kullisaar T and Mandar R: Male infertility workup needs additional testing of expressed prostatic secretion and/or post-massage urine. PLoS One. 8(e82776)2013.PubMed/NCBI View Article : Google Scholar

16 

Chen J, Xu Z, Zhao H and Jiang X: Citrate in expressed prostatic secretions has the feasibility to be used as a useful indicator for the diagnosis of category IIIB prostatitis. Urol Int. 78:230–234. 2007.PubMed/NCBI View Article : Google Scholar

17 

Shahed AR and Shoskes DA: Correlation of beta-endorphin and prostaglandin E2 levels in prostatic fluid of patients with chronic prostatitis with diagnosis and treatment response. J Urol. 166:1738–1741. 2001.PubMed/NCBI

18 

Desireddi NV, Campbell PL, Stern JA, Sobkoviak R, Chuai S, Shahrara S, Thumbikat P, Pope RM, Landis JR, Koch AE and Schaeffer AJ: Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome. J Urol. 179:1857–1861; discussion 1861-2. 2008.PubMed/NCBI View Article : Google Scholar

19 

Arai T, Fuse M, Goto Y, Kaga K, Kurozumi A, Yamada Y, Sugawara S, Okato A, Ichikawa T, Yamanishi T and Seki N: Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets. J Hum Genet. 63:543–554. 2018.PubMed/NCBI View Article : Google Scholar

20 

Pierdomenico M, Cesi V, Cucchiara S, Vitali R, Prete E, Costanzo M, Aloi M, Oliva S and Stronati L: NOD2 Is Regulated By Mir-320 in physiological conditions but this control is altered in inflamed tissues of patients with inflammatory bowel disease. Inflamm Bowel Dis. 22:315–326. 2016.PubMed/NCBI View Article : Google Scholar

21 

Wang Y, Ye F, Huang C, Xue F, Li Y, Gao S, Qiu Z, Li S, Chen Q, Zhou H, et al: Bioinformatic analysis of potential biomarkers for spinal cord-injured patients with intractable neuropathic pain. Clin J Pain. 34:825–830. 2018.PubMed/NCBI View Article : Google Scholar

22 

Li H, Wang J, Liu X and Cheng Q: MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R. Biochem Cell Biol. 97:109–117. 2019.PubMed/NCBI View Article : Google Scholar

23 

Lu Y, Cao DL, Jiang BC, Yang T and Gao YJ: MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord. Brain Behav Immun. 49:119–129. 2015.PubMed/NCBI View Article : Google Scholar

24 

Dong Z, Jiang H, Jian X and Zhang W: Change of miRNA expression profiles in patients with knee osteoarthritis before and after celecoxib treatment. J Clin Lab Anal. 33(e22648)2019.PubMed/NCBI View Article : Google Scholar

25 

He Y and Wang ZJ: Let-7 microRNAs and opioid tolerance. Front Genet. 3(110)2012.PubMed/NCBI View Article : Google Scholar

26 

Brandenburger T, Castoldi M, Brendel M, Grievink H, Schlösser L, Werdehausen R, Bauer I and Hermanns H: Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain. Neurosci Lett. 506:281–286. 2012.PubMed/NCBI View Article : Google Scholar

27 

Riffo-Campos AL, Riquelme I and Brebi-Mieville P: Tools for sequence-based miRNA target prediction: What to choose? Int J Mol Sci. 17(1987)2016.PubMed/NCBI View Article : Google Scholar

28 

Ruffolo RR Jr: Distribution and function of peripheral alpha-adrenoceptors in the cardiovascular system. Pharmacol Biochem Behav. 22:827–833. 1985.PubMed/NCBI View Article : Google Scholar

29 

Caine M, Raz S and Zeigler M: Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol. 47:193–202. 1975.PubMed/NCBI View Article : Google Scholar

30 

Herlemann A, Keller P, Schott M, Tamalunas A, Ciotkowska A, Rutz B, Wang Y, Yu Q, Waidelich R, Strittmatter F, et al: Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate. Am J Physiol Renal Physiol. 314:F47–F57. 2018.PubMed/NCBI View Article : Google Scholar

31 

Nickel JC: Role of alpha1-blockers in chronic prostatitis syndromes. BJU Int. 101 (Suppl 3):S11–S16. 2008.PubMed/NCBI View Article : Google Scholar

32 

Arbilla S and Langer SZ: Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: Effects of metanephrine and tolazoline. Br J Pharmacol. 64:259–264. 1978.PubMed/NCBI View Article : Google Scholar

33 

Iwasaki YW, Siomi MC and Siomi H: PIWI-Interacting RNA: Its biogenesis and functions. Annu Rev Biochem. 84:405–433. 2015.PubMed/NCBI View Article : Google Scholar

34 

Wang S, Wang Z, Tao R, He G, Liu J, Li C and Hou Y: The potential use of Piwi-interacting RNA biomarkers in forensic body fluid identification: A proof-of-principle study. Forensic Sci Int Genet. 39:129–135. 2019.PubMed/NCBI View Article : Google Scholar

35 

Cui L, Fang L, Shi B, Qiu S and Ye Y: Spermatozoa expression of piR-31704, piR-39888, and piR-40349 and their correlation to sperm concentration and fertilization rate after ICSI. Reprod Sci. 25:733–739. 2018.PubMed/NCBI View Article : Google Scholar

36 

Balatti V, Pekarsky Y and Croce CM: Role of the tRNA-derived small RNAs in cancer: New potential biomarkers and target for therapy. Adv Cancer Res. 135:173–187. 2017.PubMed/NCBI View Article : Google Scholar

37 

Hua M, Liu W, Chen Y, Zhang F, Xu B, Liu S, Chen G, Shi H and Wu L: Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization. Cell Discov. 5(20)2019.PubMed/NCBI View Article : Google Scholar

38 

Fu W, Zhou Z, Liu S, Li Q, Yao J, Li W and Yan J: The effect of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on semen parameters in human males: A systematic review and meta-analysis. PLoS One. 9(e94991)2014.PubMed/NCBI View Article : Google Scholar

39 

Ronquist G and Brody I: The prostasome: Its secretion and function in man. Biochim Biophys Acta. 822:203–218. 1985.PubMed/NCBI View Article : Google Scholar

40 

Chen Y, Chen S, Zhang J, Wang Y, Jia Z, Zhang X, Han X, Guo X, Sun X, Shao C, et al: Expression profile of microRNAs in expressed prostatic secretion of healthy men and patients with IIIA chronic prostatitis/chronic pelvic pain syndrome. Oncotarget. 9:12186–12200. 2018.PubMed/NCBI View Article : Google Scholar

41 

Carlsson L, Nilsson O, Larsson A, Stridsberg M, Sahlen G and Ronquist G: Characteristics of human prostasomes isolated from three different sources. Prostate. 54:322–330. 2003.PubMed/NCBI View Article : Google Scholar

42 

Aalberts M, Stout TA and Stoorvogel W: Prostasomes: Extracellular vesicles from the prostate. Reproduction. 147:R1–R14. 2013.PubMed/NCBI View Article : Google Scholar

43 

Grinberg K, Sela Y and Nissanholtz-Gannot R: New insights about chronic pelvic pain syndrome (CPPS). Int J Environ Res Public Health. 17(3005)2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ouyang B, Han D, Guo Z, Deng J, Li W, Huang L, Liu J, Cai Z, Bian J, Huang S, Huang S, et al: Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome. Exp Ther Med 23: 382, 2022.
APA
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L. ... Huang, S. (2022). Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome. Experimental and Therapeutic Medicine, 23, 382. https://doi.org/10.3892/etm.2022.11310
MLA
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L., Liu, J., Cai, Z., Bian, J., Huang, S."Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 23.6 (2022): 382.
Chicago
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L., Liu, J., Cai, Z., Bian, J., Huang, S."Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 23, no. 6 (2022): 382. https://doi.org/10.3892/etm.2022.11310
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang B, Han D, Guo Z, Deng J, Li W, Huang L, Liu J, Cai Z, Bian J, Huang S, Huang S, et al: Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome. Exp Ther Med 23: 382, 2022.
APA
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L. ... Huang, S. (2022). Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome. Experimental and Therapeutic Medicine, 23, 382. https://doi.org/10.3892/etm.2022.11310
MLA
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L., Liu, J., Cai, Z., Bian, J., Huang, S."Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 23.6 (2022): 382.
Chicago
Ouyang, B., Han, D., Guo, Z., Deng, J., Li, W., Huang, L., Liu, J., Cai, Z., Bian, J., Huang, S."Altered small non‑coding RNA expression profiles of extracellular vesicles in the prostatic fluid of patients with chronic pelvic pain syndrome". Experimental and Therapeutic Medicine 23, no. 6 (2022): 382. https://doi.org/10.3892/etm.2022.11310
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