Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report

Cuzmici‑Barabaș,Zina; Cătană,Andreea; Militaru,Mariela Sanda; Garbea,Oana; Cătană,Iuliu Vlad; Pop,Ioan Victor

doi:10.3892/etm.2022.11314

Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report

Authors:
- Zina Cuzmici‑Barabaș
- Andreea Cătană
- Mariela Sanda Militaru
- Oana Garbea
- Iuliu Vlad Cătană
- Ioan Victor Pop
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Affiliations: Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj‑Napoca, Romania, Department of Otorhynolaringology, ‘Venart’ Clinic, 400486 Cluj Napoca, Romania
Published online on: April 12, 2022 https://doi.org/10.3892/etm.2022.11314
Article Number: 387
Copyright: © Cuzmici‑Barabaș et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sensorineural hearing loss (SSHL) with a sudden onset is frequently encountered as a medical emergency in the ear, nose and throat (ENT) practice. The exact pathophysiology of the disease remains unknown, with the most likely etiologies being viral infection, inflammation, drug toxicity, trauma, or autoimmune response. Even though thrombophilia and cerebrovascular complications may lead, among others, to sudden neurosensorial hearing loss, its diagnosis is most often made following the onset of thrombotic complications. A case of a young female patient with unknown congenital hypercoagulation status complicated with lateral sinus thrombosis and unilateral drug‑induced reversible hearing loss is presented. Molecular testing confirmed the diagnosis of genetic thrombophilia, due to the homozygous V Leiden, homozygous MTHFR A1298C, and heterozygous MTHFR C677T mutations. Although hereditary thrombophilia is a well‑known topic in medical practice, current guidelines require continuous improvement, especially among patients treated in departments where this pathology is more difficult to recognize and manage.

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1	Colucci G and Tsakiris DA: Thrombophilia screening revisited: An issue of personalized medicine. J Thromb Thrombolysis. 49:618–629. 2020.PubMed/NCBI View Article : Google Scholar
2	Di Paola JA: Cerebral venous thrombosis: Incidence in prothrombotic states. Semin Cerebrovasc Dis Stroke. 2:102–110. 2002.
3	Cohen W, Castelli C, Suchon P, Bouvet S, Aillaud MF, Brunet D, Barthet MC, Alessi MC, Trégouët DA and Morange PE: Risk assessment of venous thrombosis in families with known hereditary thrombophilia: The MARseilles-NImes prediction model. J Thromb Haemost. 12:138–146. 2014.PubMed/NCBI View Article : Google Scholar
4	Wu O, Robertson L, Twaddle S, Lowe G, Clark P, Walker I, Brenkel I, Greaves M, Langhorne P, Regan L, et al: Screening for thrombophilia in high-risk situations: A meta-analysis and cost-effectiveness analysis. Br J Haematol. 131:80–90. 2015.PubMed/NCBI View Article : Google Scholar
5	Raja K, Parida PK, Alexander A and Surianarayanan G: Otogenic lateral sinus thrombosis: A review of fifteen patients and changing trends in the management. Int Arch Otorhinolaryngol. 22:208–213. 2018.PubMed/NCBI View Article : Google Scholar
6	Viswanatha B and Naseeruddin K: Lateral sinus thrombosis in otology: A review. Mediterr J Hematol Infect Dis. 2(e2010027)2010.PubMed/NCBI View Article : Google Scholar
7	Heit JA, Sobell JL, Li H and Sommer SS: The incidence of venous thromboembolism among Factor V Leiden carriers: A community-based cohort study. J Thromb Haemost. 3:305–311. 2005.PubMed/NCBI View Article : Google Scholar
8	Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM, Brown SR, Fife TD, Ford P, Ganiats TG, et al: Clinical practice guideline: Sudden hearing loss. Otolaryngol Head Neck. 146 (Suppl 3):S1–S35. 2012.PubMed/NCBI View Article : Google Scholar
9	Rauch SD: Clinical practice. Idiopathic sudden sensorineural hearing loss. N Engl J Med. 359:833–840. 2008.PubMed/NCBI View Article : Google Scholar
10	Ishak MN, Nik-Abdul-Ghani NM and Mohamad I: Sudden bilateral sensorineural hearing loss secondary to cerebral venous thrombosis. Iran J Otorhinolaryngol. 30:113–116. 2018.PubMed/NCBI
11	Haberkamp TJ and Tanyeri HM: Management of idiopathic sudden sensorineural hearing loss. Am J Otol. 20:587–595. 1999.PubMed/NCBI
12	Kim SH, Kim SJ, Im H, Kim TH, Song JJ and Chae SW: A trend in sudden sensorineural hearing loss: Data from a population-based study. Audiol Neurotol. 22:311–316. 2017.PubMed/NCBI View Article : Google Scholar
13	Heilbrun ME, Salzman KL, Glastonbury CM, Harnsberger HR, Kennedy RJ and Shelton C: External auditory canal cholesteatoma: Clinical and imaging spectrum. AJNR Am J Neuroradiol. 24:751–756. 2003.PubMed/NCBI
14	Baráth K, Huber AM, Stämpfli P, Varga Z and Kollias S: Neuroradiology of cholesteatomas. AJNR Am J Neuroradiol. 32:221–229. 2011.PubMed/NCBI View Article : Google Scholar
15	Stevens SM, Woller SC, Bauer KA, Kasthuri R, Cushman M, Streiff M, Lim W and Douketis JD: Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis. 41:154–164. 2016.PubMed/NCBI View Article : Google Scholar
16	Liu N, Vigod SN, Farrugia MM, Urquia ML and Ray JG: Venous thromboembolism after induced abortion: A population-based, propensity-score-matched cohort study in Canada. Lancet Haematol. 5:e279–e288. 2018.PubMed/NCBI View Article : Google Scholar
17	Baglin T, Gray E, Greaves M, Hunt BJ, Keeling D, Machin S, Mackie I, Makris M, Nokes T, Perry D, et al: Clinical guidelines for testing for heritable thrombophilia. Br J Haematol. 149:209–220. 2010.PubMed/NCBI View Article : Google Scholar
18	Dentali F, Crowther M and Ageno W: Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: A meta-analysis. Blood. 107:2766–2773. 2006.PubMed/NCBI View Article : Google Scholar
19	Habib G, Zahra S, Shahram S and Soltanpour MS: Association study of methylenetetrahydrofolate reductase A1298C mutation with cerebral venous thrombosis risk in an Iranian population. Int J Appl Basic Med Res. 5:172–176. 2015.PubMed/NCBI View Article : Google Scholar
20	Moll S: Thrombophilia: Clinical-practical aspects. J Thromb Thrombolysis. 39:367–378. 2015.PubMed/NCBI View Article : Google Scholar
21	Schünemann HJ, Cushman M, Burnett AE, Kahn SR, Beyer-Westendorf J, Spencer FA, Rezende SM, Zakai NA, Bauer KA, Dentali F, et al: American Society of Hematology 2018 guidelines for management of venous thromboembolism: Prophylaxis for hospitalized and nonhospitalized medical patients. Blood Adv. 2:3198–3225. 2018.PubMed/NCBI View Article : Google Scholar