Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2022 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2022 Volume 23 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Role of chemokines in early pregnancy loss

  • Authors:
    • Sefi̇k Gokce
    • Di̇lsad Herki̇loglu
    • Ozge Cevi̇k
    • Volkan Turan
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Gaziosmanpasa Hospital of Yeni Yuzyil University, Istanbul 34245, Turkey, Department of Biochemistry, School of Medicine, Aydin Adnan Menderes University, Aydin 09010, Turkey, Department of Obstetrics and Gynecology, School of Medicine, Health and Technology University, Istanbul 34015, Turkey
    Copyright: © Gokce et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 397
    |
    Published online on: April 14, 2022
       https://doi.org/10.3892/etm.2022.11324
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to compare decidual protein levels and gene expression levels of chemokines between patients with early pregnancy loss and those with voluntary abortion. A total of 15 patients between 6 and 10 gestational weeks, who presented with negative fetal heartbeat to the obstetrics and gynecology outpatient clinics of Gaziosmanpasa Hospital (Yeni Yuzyil University, Istanbul, Turkey) and who had no additional systemic disease and 13 patients between 6 and 10 gestational weeks, who presented with positive fetal heartbeat for voluntary abortion were included in the present study. CX3CL1, CCL17, CXCR4, chemokine ligand 12 (CXCL12) and intercellular adhesion molecule (ICAM)5 protein expression levels were determined by ELISA and gene expression levels by reverse transcription‑quantitative PCR in fresh materials recovered after therapeutic curettage. CX3CL1, CCL17, CXCR4, CXCL12 protein levels were significantly higher and ICAM protein level was significantly lower in pregrant women with missed abortion compared with those with voluntary abortion. While the amount of increase in mean CX3CL1, CCL17, CXCR4 and CXCL12 gene expression levels in the tissues of pregnant women with missed abortion was statistically higher than the pregnant women who underwent voluntary abortion, the amount of increase in ICAM5 gene expression was found to be lower (P<0.001) in those with missed abortion. In conclusion, the findings of the present study suggested that CCL17, CX3CL1, CXCL12, CXCR4 and ICAM5 may be associated with missed abortion and may play an important role in placental invasion and the continuation of pregnancy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Hanschmidt F, Linde K, Hilbert A, Riedel-Heller SG and Kersting A: Abortion stigma: A systematic review. Perspect Sex Reprod Health. 48:169–177. 2016.PubMed/NCBI View Article : Google Scholar

2 

Kapp N and Lohr PA: Modern methods to induce abortion: Safety, efficacy and choice. Best Pract Res Clin Obstet Gynaecol. 63:37–44. 2020.PubMed/NCBI View Article : Google Scholar

3 

Conti J and Cahill EP: Self-managed abortion. Curr Opin Obstet Gynecol. 31:435–440. 2019.PubMed/NCBI View Article : Google Scholar

4 

Griebel CP, Halvorsen J, Golemon TB and Day AA: Management of spontaneous abortion. Am Fam Physician. 72:1243–1250. 2005.PubMed/NCBI

5 

Hughes CE and Nibbs RJB: A guide to chemokines and their receptors. FEBS J. 285:2944–2971. 2018.PubMed/NCBI View Article : Google Scholar

6 

Palomino DC and Marti LC: Chemokines and immunity. Einstein (Sao Paulo). 13:469–473. 2015.PubMed/NCBI View Article : Google Scholar : (İn English, Portuguese).

7 

Legler DF and Thelen M: Chemokines: Chemistry, biochemistry and biological function. Chimia (Aarau). 70:856–859. 2016.PubMed/NCBI View Article : Google Scholar

8 

Kervancioglu Demirci E, Salamonsen LA and Gauster M: The role of CX3CL1 in fetal-maternal interaction during human gestation. Cell Adh Migr. 10:189–196. 2016.PubMed/NCBI View Article : Google Scholar

9 

Ao D, Li DJ and Li MQ: CXCL12 in normal and pathological pregnancies: A review. Am J Reprod Immunol. 84(e13280)2020.PubMed/NCBI View Article : Google Scholar

10 

Gahmberg CG, Ning L and Paetau S: ICAM-5: A neuronal dendritic adhesion molecule involved in immune and neuronal functions. Adv Neurobiol. 8:117–132. 2014.PubMed/NCBI View Article : Google Scholar

11 

Rasmark ER, Bruno V, Nedstrand E, Boij R, Strid CP, Piccione E, Berg G, Svensson-Arvelund J, Jenmalm MC, Rubér M and Ernerudh J: Low-molecular-weight-heparin increases Th1- and Th17-associated chemokine levels during pregnancy in women with unexplained recurrent pregnancy loss: A randomised controlled trial. Sci Rep. 9(12314)2019.PubMed/NCBI View Article : Google Scholar

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

13 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976.PubMed/NCBI View Article : Google Scholar

14 

Zlotnik A and Yoshie O: Chemokines: A new classification system and their role in immunity. Immunity. 12:121–127. 2000.PubMed/NCBI View Article : Google Scholar

15 

Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ and Raines EW: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem. 276:37993–38001. 2001.PubMed/NCBI View Article : Google Scholar

16 

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, et al: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood. 102:1186–1195. 2003.PubMed/NCBI View Article : Google Scholar

17 

Szukiewicz D, Kochanowski J, Mittal TK, Pyzlak M, Szewczyk G and Cendrowski K: Chorioamnionitis (ChA) modifies CX3CL1 (fractalkine) production by human amniotic epithelial cells (HAEC) under normoxic and hypoxic conditions. J Inflamm (Lond). 11(12)2014.PubMed/NCBI View Article : Google Scholar

18 

Szukiewicz D, Kochanowski J, Pyzlak M, Szewczyk G, Stangret A and Mittal TK: Fractalkine (CX3CL1) and its receptor CX3CR1 may contribute to increased angiogenesis in diabetic placenta. Mediators Inflamm. 2013(437576)2013.PubMed/NCBI View Article : Google Scholar

19 

Siwetz M, Dieber-Rotheneder M, Cervar-Zivkovic M, Kummer D, Kremshofer J, Weiss G, Herse F, Huppertz B and Gauster M: Placental fractalkine is up-regulated in severe early-onset preeclampsia. Am J Pathol. 185:1334–1343. 2015.PubMed/NCBI View Article : Google Scholar

20 

Usta A, Turan G, Sancakli Usta C, Avci E and Adali E: Placental fractalkine immunoreactivity in preeclampsia and its correlation with histopathological changes in the placenta and adverse pregnancy outcomes. J Matern Fetal Neonatal Med. 33:806–815. 2020.PubMed/NCBI View Article : Google Scholar

21 

Hannan NJ, Bambang K, Kaitu'u-Lino TJ, Konje JC and Tong S: A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage. PLoS One. 9(e93320)2014.PubMed/NCBI View Article : Google Scholar

22 

Li ZY, Chao HH, Liu HY, Song ZH, Li LL, Zhang YJ, Yang Y and Peng JP: IFN-γ induces aberrant CD49b+ NK cell recruitment through regulating CX3CL1: A novel mechanism by which IFN-γ provokes pregnancy failure. Cell Death Dis. 5(e1512)2014.PubMed/NCBI View Article : Google Scholar

23 

Kumar A, Kumar S, Dinda AK and Luthra K: Differential expression of CXCR4 receptor in early and term human placenta. Placenta. 25:347–351. 2004.PubMed/NCBI View Article : Google Scholar

24 

Schanz A, Red-Horse K, Hess AP, Baston-Büst DM, Heiss C and Krüssel JS: Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression. Placenta. 35:1089–1094. 2014.PubMed/NCBI View Article : Google Scholar

25 

Jaleel MA, Tsai AC, Sarkar S, Freedman PV and Rubin LP: Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival. Mol Hum Reprod. 10:901–909. 2004.PubMed/NCBI View Article : Google Scholar

26 

Wu X, Jin LP, Yuan MM, Zhu Y, Wang MY and Li DJ: Human first-trimester trophoblast cells recruit CD56brightCD16-NK cells into decidua by way of expressing and secreting of CXCL12/stromal cell-derived factor 1. J Immunol. 175:61–68. 2005.PubMed/NCBI View Article : Google Scholar

27 

Barrientos G, Tirado-González I, Freitag N, Kobelt P, Moschansky P, Klapp BF, Thijssen VL and Blois SM: CXCR4(+) dendritic cells promote angiogenesis during embryo implantation in mice. Angiogenesis. 16:417–427. 2013.PubMed/NCBI View Article : Google Scholar

28 

Virgintino D, Errede M, Rizzi M, Girolamo F, Strippoli M, Wälchli T, Robertson D, Frei K and Roncali L: The CXCL12/CXCR4/CXCR7 ligand-receptor system regulates neuro-glio-vascular interactions and vessel growth during human brain development. J Inherit Metab Dis. 36:455–466. 2013.PubMed/NCBI View Article : Google Scholar

29 

Zhu Y and Murakami F: Chemokine CXCL12 and its receptors in the developing central nervous system: Emerging themes and future perspectives. Dev Neurobiol. 72:1349–1362. 2012.PubMed/NCBI View Article : Google Scholar

30 

McIntosh SZ, Maestas MM, Dobson JR, Quinn KE, Runyan CL and Ashley RL: CXCR4 signaling at the fetal-maternal interface may drive inflammation and syncytia formation during ovine pregnancy†. Biol Reprod. 104:468–478. 2021.PubMed/NCBI View Article : Google Scholar

31 

McIntosh SZ, Maxam CJ, Maestas MM, Quinn KE and Ashley RL: Intrauterine inhibition of chemokine receptor 4 signaling modulates local and systemic inflammation in ovine pregnancy. Am J Reprod Immunol. 82(e13181)2019.PubMed/NCBI View Article : Google Scholar

32 

Quinn KE, Prosser SZ, Kane KK and Ashley RL: Inhibition of chemokine (C-X-C motif) receptor four (CXCR4) at the fetal-maternal interface during early gestation in sheep: Alterations in expression of chemokines, angiogenic factors and their receptors. J Anim Sci. 95:1144–11153. 2017.PubMed/NCBI View Article : Google Scholar

33 

Runyan CL, McIntosh SZ, Maestas MM, Quinn KE, Boren BP and Ashley RL: CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium†. Biol Reprod. 101:102–111. 2019.PubMed/NCBI View Article : Google Scholar

34 

Chao HH, Li L, Gao X, Wang C and Yue W: CXCL12 expression in aborted mouse uteri induced by IFN-γ: Potential anti-inflammatory effect involves in endometrial restoration after abortion in mice. Gene. 700:38–46. 2019.PubMed/NCBI View Article : Google Scholar

35 

Dimova I, Rizov M, Giragosyan S, Koprinarova M, Tzoneva D, Belemezova K, Hristova-Savova M, Milachich T, Djonov V and Shterev A: Molecular pathogenesis of spontaneous abortions-Whole genome copy number analysis and expression of angiogenic factors. Taiwan J Obstet Gynecol. 59:99–104. 2020.PubMed/NCBI View Article : Google Scholar

36 

Gahmberg CG, Tian L, Ning L and Nyman-Huttunen H: ICAM-5-a novel two-facetted adhesion molecule in the mammalian brain. Immunol Lett. 117:131–135. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gokce S, Herki̇loglu D, Cevi̇k O and Turan V: Role of chemokines in early pregnancy loss. Exp Ther Med 23: 397, 2022.
APA
Gokce, S., Herki̇loglu, D., Cevi̇k, O., & Turan, V. (2022). Role of chemokines in early pregnancy loss. Experimental and Therapeutic Medicine, 23, 397. https://doi.org/10.3892/etm.2022.11324
MLA
Gokce, S., Herki̇loglu, D., Cevi̇k, O., Turan, V."Role of chemokines in early pregnancy loss". Experimental and Therapeutic Medicine 23.6 (2022): 397.
Chicago
Gokce, S., Herki̇loglu, D., Cevi̇k, O., Turan, V."Role of chemokines in early pregnancy loss". Experimental and Therapeutic Medicine 23, no. 6 (2022): 397. https://doi.org/10.3892/etm.2022.11324
Copy and paste a formatted citation
x
Spandidos Publications style
Gokce S, Herki̇loglu D, Cevi̇k O and Turan V: Role of chemokines in early pregnancy loss. Exp Ther Med 23: 397, 2022.
APA
Gokce, S., Herki̇loglu, D., Cevi̇k, O., & Turan, V. (2022). Role of chemokines in early pregnancy loss. Experimental and Therapeutic Medicine, 23, 397. https://doi.org/10.3892/etm.2022.11324
MLA
Gokce, S., Herki̇loglu, D., Cevi̇k, O., Turan, V."Role of chemokines in early pregnancy loss". Experimental and Therapeutic Medicine 23.6 (2022): 397.
Chicago
Gokce, S., Herki̇loglu, D., Cevi̇k, O., Turan, V."Role of chemokines in early pregnancy loss". Experimental and Therapeutic Medicine 23, no. 6 (2022): 397. https://doi.org/10.3892/etm.2022.11324
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team