
COVID‑19: Main findings after a year and half of unease and the proper scientific progress (Review)
- Authors:
- Marius Traian Leretter
- Dan Dumitru Vulcanescu
- Florin George Horhat
- Anamaria Matichescu
- Mircea Rivis
- Laura-Cristina Rusu
- Alexandra Roi
- Robert Racea
- Ioana Badea
- Cristina Adriana Dehelean
- Alexandra Mocanu
- Delia Ioana Horhat
-
Affiliations: Department of Prosthodontics, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance (MULTI‑REZ), ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Preventive Dentistry, Community and Oral Health, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Toxicology, Research Center for Pharmaco‑Toxicological Evaluation, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department XIII, Discipline of Infectious Diseases, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Department of Otorhinolaryngology, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timisoara, Romania - Published online on: May 4, 2022 https://doi.org/10.3892/etm.2022.11350
- Article Number: 424
-
Copyright: © Leretter et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
WHO COVID-19 Situation report 51. 11 March 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf?sfvrsn=1ba62e57_10, Accessed June 15, 2020. | |
V'kovski P, Kratzel A, Steiner S, Stalder H and Thiel V: Coronavirus biology and replication: Implications for SARS-CoV-2. Nat Rev Microbiol. 19:155–170. 2021.PubMed/NCBI View Article : Google Scholar | |
Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S and Ma K: A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect. 54:12–16. 2021.PubMed/NCBI View Article : Google Scholar | |
Singh D and Yi SV: On the origin and evolution of SARS-CoV-2. Exp Mol Med. 53:537–547. 2021.PubMed/NCBI View Article : Google Scholar | |
Izda V, Jeffries MA and Sawalha AH: COVID-19: A review of therapeutic strategies and vaccine candidates. Clin Immunol. 222(108634)2021.PubMed/NCBI View Article : Google Scholar | |
Ita K: Coronavirus disease (COVID-19): Current status and prospects for drug and vaccine development. Arch Med Res. 52:15–24. 2021.PubMed/NCBI View Article : Google Scholar | |
Cappanera S, Palumbo M, Kwan SH, Priante G, Martella LA, Saraca LM, Sicari F, Vernelli C, Di Giuli C, Andreani P, et al: When does the cytokine storm begin in COVID-19 patients? A quick score to recognize it. J Clin Med. 10(297)2021.PubMed/NCBI View Article : Google Scholar | |
Asakura H and Ogawa H: COVID-19-associated coagulopathy and disseminated intravascular coagulation. Int J Hematol. 113:45–57. 2021.PubMed/NCBI View Article : Google Scholar | |
O'Shea JJ, Gadina M and Siegel R: Cytokines and cytokine receptors. In: Principles of Immune Response. Elsevier, Amsterdam, pp108-135, 2013. | |
Shah S, Shah K, Patel SB, Patel FS, Osman M, Velagapudi P, Turagam MK, Lakkireddy D and Garg J: Elevated D-dimer levels are associated with increased risk of mortality in Coronavirus disease 2019: A systematic review and meta-analysis. Cardiol Rev. 28:295–302. 2020.PubMed/NCBI View Article : Google Scholar | |
Yokota S, Itoh Y, Morio T, Sumitomo N, Daimaru K and Minota S: Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis under treatment with tocilizumab. J Rheumatol. 42:712–722. 2015.PubMed/NCBI View Article : Google Scholar | |
Huang LM, Hu Q, Huang X, Qian Y and Lai XH: Preconditioning rats with three lipid emulsions prior to acute lung injury affects cytokine production and cell apoptosis in the lung and liver. Lipids Health Dis. 19(19)2020.PubMed/NCBI View Article : Google Scholar | |
Li Y, Zhou W, Yang L and You R: Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Pharmacol Res. 157(104833)2020.PubMed/NCBI View Article : Google Scholar | |
Yan Y, Chang L and Wang L: Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures. Rev Med Virol. 30(e2106)2020.PubMed/NCBI View Article : Google Scholar | |
Liya G, Yuguang W, Jian L, Huaiping Y, Xue H, Jianwei H, Jiaju M, Youran L, Chen M and Yiqing J: Studies on viral pneumonia related to novel coronavirus SARS-CoV-2, SARS-CoV, and MERS-CoV: A literature review. APMIS. 128:423–432. 2020.PubMed/NCBI View Article : Google Scholar | |
Gabutti G, d'Anchera E, Sandri F, Savio M and Stefanati A: Coronavirus: Update related to the current outbreak of COVID-19. Infect Dis Ther. 9:1–13. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang W, Sirajuddin A, Zhang X, Zhang X, Liu G, Teng Z, Zhao S and Lu M: The role of imaging in 2019 novel coronavirus pneumonia (COVID-19). Eur Radiol. 30:4874–4882. 2020.PubMed/NCBI View Article : Google Scholar | |
Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RB, Paul van Schayck JP, Mykytyn AZ, Duimel HQ, et al: SARS-CoV-2 productively infects human gut enterocytes. Science. 369:50–54. 2020.PubMed/NCBI View Article : Google Scholar | |
WHO COVID-19 Situation report 37. 26 February 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19.pdf?sfvrsn=2146841e_2, Accessed June 15, 2020. | |
WHO COVID-19 Situation report 75. 4 April 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200404-sitrep-75-covid-19.pdf?sfvrsn=99251b2b_4, Accessed June 15, 2020. | |
WHO COVID-19 Situation report 87. 16 April 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200416-sitrep-87-covid-19.pdf?sfvrsn=9523115a_2, Accessed June 15, 2020. | |
Mohamadian M, Chiti H, Shoghli A, Biglari S, Parsamanesh N and Esmaeilzadeh A: COVID-19: Virology, biology and novel laboratory diagnosis. J Gene Med. 23(e3303)2021.PubMed/NCBI View Article : Google Scholar | |
Chung JY, Thone MN and Kwon YJ: COVID-19 vaccines: The status and perspectives in delivery points of view. Adv Drug Deliv Rev. 170:1–25. 2021.PubMed/NCBI View Article : Google Scholar | |
Yesudhas D, Srivastava A and Gromiha MM: COVID-19 outbreak: History, mechanism, transmission, structural studies and therapeutics. Infection. 49:199–213. 2021.PubMed/NCBI View Article : Google Scholar | |
WHO COVID-19 Situation report 102. 1 May 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200501-covid-19-sitrep.pdf?sfvrsn=742f4a18_4, Accessed June 15, 2020. | |
WHO COVID-19 Situation report 116. 15 May 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200515-covid-19-sitrep-116.pdf?sfvrsn=8dd60956_2, Accessed June 15, 2020. | |
WHO Multisystem inflammatory syndrome in children and adolescents with COVID-19. 15. May 2020. Available from: https://www.who.int/publications/i/item/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19, Accessed June 15, 2020. | |
WHO COVID-19 Situation report 133. 1 June 2020. Avalable from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200601-covid-19-sitrep-133.pdf?sfvrsn=9a56f2ac_4, Accessed June 15, 2020. | |
Kaur N, Singh R, Dar Z, Bijarnia RK, Dhingra N and Kaur T: Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2. Infect Genet Evol. 89(104490)2021.PubMed/NCBI View Article : Google Scholar | |
Lednicky JA, Tagliamonte MS, White SK, Elbadry MA, Alam MM, Stephenson CJ, Bonny TS, Loeb JC, Telisma T, Chavannes S, et al: Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution. medRxiv: Mar 25, 2021 (Epub ahead of print). doi: 10.1101/2021.03.19.21253391. | |
Callaway E: Delta coronavirus variant: Scientists brace for impact. Nature. 595:17–18. 2021.PubMed/NCBI View Article : Google Scholar | |
Torjesen I: Covid-19: Delta variant is now UK's most dominant strain and spreading through schools. BMJ. 373(n1445)2021.PubMed/NCBI View Article : Google Scholar | |
Tufan A, Avanoğlu Güler A and Matucci-Cerinic M: COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med Sci. 50:620–632. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Geng X, Tan Y, Li Q, Xu C, Xu J, Hao L, Zeng Z, Luo X, Liu F and Wang H: New understanding of the damage of SARS-CoV-2 infection outside the respiratory system, Biomed. Pharmacother. 127(110195)2020.PubMed/NCBI View Article : Google Scholar | |
Salian VS, Wright JA, Vedell PT, Nair S, Li C, Kandimalla M, Tang X, Carmona Porquera EM, Kalari KR and Kandimalla KK: COVID-19 transmission, current treatment, and future therapeutic strategies. Mol Pharm. 18:754–771. 2021.PubMed/NCBI View Article : Google Scholar | |
Morawska L and Cao J: Airborne transmission of SARS-CoV-2: The world should face the reality. Environ Int. 139(105730)2020.PubMed/NCBI View Article : Google Scholar | |
Sahu KK, Mishra AK and Lal A: Trajectory of the COVID-19 pandemic: Chasing a moving target. Ann Transl Med. 8(694)2020.PubMed/NCBI View Article : Google Scholar | |
Song F, Zhang X, Zha Y and Liu W: COVID-19: Recommended sampling sites at different stages of the disease. J Med Virol. 92:1383–1385. 2020.PubMed/NCBI View Article : Google Scholar | |
Lin C, Xiang J, Yan M, Li H, Huang S and Shen C: Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19). Clin Chem Lab Med. 58:1089–1094. 2020.PubMed/NCBI View Article : Google Scholar | |
Azzi L, Carcano G, Gianfagna F, Grossi P, Gasperina DD, Genoni A, Fasano M, Sessa F, Tettamanti L, Carinci F, et al: Saliva is a reliable tool to detect SARS-CoV-2. J Infect. 81:e45–e50. 2020.PubMed/NCBI View Article : Google Scholar | |
Song C, Wang Y, Li W, Hu B, Chen G, Xia P, Wang W, Li C, Diao F, Hu Z, et al: Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients. Biol Reprod. 103:4–6. 2020.PubMed/NCBI View Article : Google Scholar | |
Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V and D'Antonio F: Outcome of Coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: A systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2(100107)2020.PubMed/NCBI View Article : Google Scholar | |
FDA-Important Information on the Use of Serological (Antibody) Tests for COVID-19-Letter to Health Care Providers. https://www.fda.gov/medical-devices/letters-health-care-providers/important-information-use-serological-antibody-tests-covid-19-letter-health-care-providers. Accessed June 16, 2020. | |
CDC Interim Guidelines for COVID-19 Antibody Testing. 23 May. https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html. Accessed June 17, 2020. | |
CDC Using Antibody Tests for COVID-19, 28 May. https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests.html. Accessed June 17, 2020. | |
Ruan Q, Yang K, Wang W, Jiang L and Song J: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 46:846–848. 2020.PubMed/NCBI View Article : Google Scholar | |
Kluytmans M, Buiting A, Pas S, Bentvelsen R, van den Bijllaardt W, van Oudheusden A, van Rijen M, Verweij J, Koopmans M and Kluytmans J: SARS-CoV-2 infection in 86 healthcare workers in two Dutch hospitals in March 2020. medRxiv: Mar 31, 2020 doi: 10.1101/2020.03.23.20041913. | |
Chen X, Tang Y, Mo Y, Li S, Lin D, Yang Z, Yang Z, Sun H, Qiu J, Liao Y, et al: A diagnostic model for coronavirus disease 2019 (COVID-19) based on radiological semantic and clinical features: A multi-center study. Eur Radiol. 30:4893–4902. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang P, Wang X, Liu P, Wei C, He B, Zheng J and Zhao D: Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. J Clin Virol. 127(104356)2020.PubMed/NCBI View Article : Google Scholar | |
Liu D, Li L, Wu X, Zheng D, Wang J, Yang L and Zheng C: Pregnancy and perinatal outcomes of women with Coronavirus disease (COVID-19) Pneumonia: A preliminary analysis. AJR Am J Roentgenol. 215:127–132. 2020.PubMed/NCBI View Article : Google Scholar | |
Gupta N, Agrawal S, Ish P, Mishra S, Gaind R, Usha G, Singh B and Sen MK: Safdarjung Hospital Covid Working Group: Clinical and epidemiologic profile of the initial COVID-19 patients at a Tertiary Care Centre in India. Monaldi Arch Chest Dis: Apr 10, 2020 (Epub ahead of print). doi: 10.4081/monaldi.2020.1294. | |
Kim GU, Kim MJ, Ra SH, Lee J, Bae S, Jung J and Kim SH: Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19 Clin Microbiol. Infect. 26:948.e1–948.e3. 2020.PubMed/NCBI View Article : Google Scholar | |
Li R, Tian J, Yang F, Lv L, Yu J, Sun G, Ma Y, Yang X and Ding J: Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China J Clin. Virol. 127(104363)2020.PubMed/NCBI View Article : Google Scholar | |
Garg S, Kim L, Whitaker M, O'Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, et al: Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed Coronavirus disease 2019-COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 69:458–464. 2020.PubMed/NCBI View Article : Google Scholar | |
Shi X, Lu Y, Li R, Tang Y, Shi N, Song F, Shan F, Chen G, Song P and Shi Y: Evaluation of antiviral therapies for coronavirus disease 2019 pneumonia in Shanghai, China. J Med Virol. 92:1922–1931. 2020.PubMed/NCBI View Article : Google Scholar | |
Docea AO, Tsatsakis A, Albulescu D, Cristea O, Zlatian O, Vinceti M, Moschos SA, Tsoukalas D, Goumenou M, Drakoulis N, et al: A new threat from an old enemy: Re-emergence of coronavirus (Review). Int J Mol Med. 45:1631–1643. 2020.PubMed/NCBI View Article : Google Scholar | |
Calina D, Docea AO, Petrakis D, Egorov AM, Ishmukhametov AA, Gabibov AG, Shtilman MI, Kostoff R, Carvalho F, Vinceti M, et al: Towards effective COVID-19 vaccines: Updates, perspectives and challenges (Review). Int J Mol Med. 46:3–16. 2020.PubMed/NCBI View Article : Google Scholar | |
Deng Q, Hu B, Zhang Y, Wang H, Zhou X, Hu W, Cheng Y, Yan J, Ping H and Zhou Q: Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China. Int J Cardiol. 311:116–121. 2020.PubMed/NCBI View Article : Google Scholar | |
Du W, Yu J, Wang H, Zhang X, Zhang S, Li Q and Zhang Z: Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. 48:445–452. 2020.PubMed/NCBI View Article : Google Scholar | |
Hu L, Chen S, Fu Y, Gao Z, Long H, Wang JM, Ren HW, Zuo Y, Li H, Wang J, et al: Risk factors associated with clinical outcomes in 323 COVID-19 hospitalized patients in Wuhan, China. Clin Infect Dis. 71:2089–2098. 2020.PubMed/NCBI View Article : Google Scholar | |
CDC COVID-19 Response Team. Characteristics of health care personnel with COVID-19-United States, February 12-April 9, 2020. MMWR Morb Mortal Wkly Rep. 69:477–481. 2020.PubMed/NCBI View Article : Google Scholar | |
Colombi D, Bodini F, Petrini M, Maffi G, Morelli N, Milanese G, Silva M, Sverzellati N and Michieletti E: Well-aerated lung on admitting chest CT to predict adverse outcome in COVID-19 Pneumonia. Radiology. 296:E86–E96. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang F, Shi S, Zhu J, Shi J, Dai K and Chen X: Analysis of 92 deceased patients with COVID-19. J Med Virol. 92:2511–2515. 2020.PubMed/NCBI View Article : Google Scholar | |
Pedersen HP, Hildebrandt T, Poulsen A, Uslu B, Knudsen HH, Roed J, Poulsen TD and Nielsen HB: Initial experiences from patients with COVID-19 on ventilatory support in Denmark. Dan Med J. 67(A04200232)2020.PubMed/NCBI | |
Gong J, Ou J, Qiu X, Jie Y, Chen Y, Yuan L, Cao J, Tan M, Xu W, Zheng F, et al: A tool to early predict severe Corona Virus disease 2019 (COVID-19): A multicenter study using the risk nomogram in Wuhan and Guangdong, China. Clin Infect Dis. 71:833–840. 2020.PubMed/NCBI View Article : Google Scholar | |
Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, Long D and Yu L: Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 31:490–496. 2020.PubMed/NCBI View Article : Google Scholar | |
Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, et al: Detectable serum severe acute respiratory syndrome coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in Critically Ill patients with coronavirus disease 2019. Clin Infect Dis. 71:1937–1942. 2020.PubMed/NCBI View Article : Google Scholar | |
Yu T, Cai S, Zheng Z, Cai X, Liu Y, Yin S, Peng J and Xu X: Association between clinical manifestations and prognosis in patients with COVID-19. Clin Ther. 42:964–972. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z and Zhang Z: D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 18:1324–1329. 2020.PubMed/NCBI View Article : Google Scholar | |
Borba MG, Val FF, Sampaio VS, Alexandre MAA, Melo GC, Brito M, Mourão MPG, Brito-Sousa JD, Baía-da-Silva D, Guerra MV, et al: Effect of high vs. low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: A randomized clinical trial. JAMA Netw Open. 3(e208857)2020.PubMed/NCBI View Article : Google Scholar | |
Huang Y, Cai C, Zang J, Xie J, Xu D, Zheng F, Zhan T, Huang K, Wang Y, Wang X, et al: Treatment strategies of hospitalized patients with Coronavirus disease-19. Aging (Albany NY). 12:11224–11237. 2020.PubMed/NCBI View Article : Google Scholar | |
Lai CKC and Lam W: Laboratory testing for the diagnosis of COVID-19. Biochem Biophys Res Commun. 538:226–230. 2021.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Klein SL, Garibaldi BT, Li H, Wu C, Osevala NM, Li T, Margolick JB, Pawelec G and Leng SX: Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev. 65(101205)2021.PubMed/NCBI View Article : Google Scholar | |
Iftimie S, López-Azcona AF, Vallverdú I, Hernández-Flix S, de Febrer G, Parra S, Hernández-Aguilera A, Riu F, Joven J, Andreychuk N, et al: First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. PLoS One. 16(e0248029)2021.PubMed/NCBI View Article : Google Scholar | |
Contou D, Fraissé M, Pajot O, Tirolien JA, Mentec H and Plantefève G: Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave? Crit Care. 25(3)2021.PubMed/NCBI View Article : Google Scholar | |
Taboada M, González M, Alvarez A, Eiras M, Costa J, Álvarez J and Seoane-Pillado T: First, second and third wave of COVID-19. What have we changed in the ICU management of these patients? J Infect. 82:e14–e15. 2021.PubMed/NCBI View Article : Google Scholar | |
Bager P, Wohlfahrt J, Rasmussen M, Albertsen M and Krause TG: Hospitalisation associated with SARS-CoV-2 delta variant in Denmark. Lancet Infect Dis. 21(1351)2021.PubMed/NCBI View Article : Google Scholar | |
Shereen MA, Khan S, Kazmi A, Bashir N and Siddique R: COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 24:91–98. 2020.PubMed/NCBI View Article : Google Scholar | |
Fan C, Li K, Ding Y, Lu WL and Wang J: ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 patients. Front Med (Lausanne). 7(563893)2020.PubMed/NCBI View Article : Google Scholar | |
Aaroe A, Majd N, Weathers SP and de Groot J: Potential neurologic and oncologic implications of the novel Coronavirus. Neuro Oncol. 22:1050–1051. 2020.PubMed/NCBI View Article : Google Scholar | |
Xu P, Zhou Q and Xu J: Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 99:1205–1208. 2020.PubMed/NCBI View Article : Google Scholar | |
He X, Lau EHY, Wu P, Deng X, Wang J, Hao X, Lau YC, Wong JY, Guan Y, Tanet X, et al: Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 26:672–675. 2020.PubMed/NCBI View Article : Google Scholar | |
Jiang F, Deng L, Zhang L, Cai Y, Cheung CW and Xia Z: Review of the clinical characteristics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med. 35:1545–1549. 2020.PubMed/NCBI View Article : Google Scholar | |
Gao J, Zheng P, Jia Y, Chen H, Mao Y, Chen S, Wang Y, Fu H and Dai J: Mental health problems and social media exposure during COVID-19 outbreak. PLoS One. 15(e0231924)2020.PubMed/NCBI View Article : Google Scholar | |
Lee S, Jobe M and Mathis A: Mental health characteristics associated with dysfunctional coronavirus anxiety. Psychol Med: Apr 16, 2020 (Epub ahead of print). doi: 10.1017/S003329172000121X. | |
Raptis CA, Hammer MM, Short RG, Shah A, Bhalla S, Bierhals AJ, Filev PD, Hope MD, Jeudy J, Kligerman SJ and Henry TS: Chest CT and Coronavirus Disease (COVID-19): A critical review of the literature to date. AJR Am J Roentgenol. 215:839–842. 2020.PubMed/NCBI View Article : Google Scholar | |
Rai P, Kumar BK, Deekshit VK and Karunasagar I and Karunasagar I: Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol. 105:441–455. 2021.PubMed/NCBI View Article : Google Scholar | |
Yüce M, Filiztekin E and Özkaya KG: COVID-19 diagnosis-A review of current methods. Biosens Bioelectron. 172(112752)2021.PubMed/NCBI View Article : Google Scholar | |
NIH-Oxygenation and Ventilation. Available from: https://www.covid19 treatmentguidelines.nih.gov/critical-care/oxygenation-and-ventilation/. Accessed June 16, 2020. | |
Fu B, Xu X and Wei H: Why tocilizumab could be an effective treatment for severe COVID-19? J Transl Med. 18(164)2020.PubMed/NCBI View Article : Google Scholar | |
Regional Center for Poison Control and Prevention-Chloroquine Toxicology Review. 25, 2003. http://www.maripoisoncenter.com/wp-content/uploads/2015/03/CTR-Chloroquine.pdf. Accessed June 17, 2020. | |
Smit C, Peeters MY, van den Anker JN and Knibbe CA: Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties. Clin Pharmacokinet. 59:659–669. 2020.PubMed/NCBI View Article : Google Scholar | |
Krumm ZA, Lloyd GM, Francis CP, Nasif LH, Mitchell DA, Golde TE, Giasson BI and Xia Y: Precision therapeutic targets for COVID-19. Virol J. 18(66)2021.PubMed/NCBI View Article : Google Scholar | |
Hodgson SH, Mansatta K, Mallett G, Harris V, Emary KR and Pollard AJ: What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect Dis. 21:e26–e35. 2021.PubMed/NCBI View Article : Google Scholar | |
Soiza RL, Scicluna C and Thomson EC: Efficacy and safety of COVID-19 vaccines in older people. Age Ageing. 50:279–283. 2021.PubMed/NCBI View Article : Google Scholar | |
Young B, Tan TT and Leo YS: The place for remdesivir in COVID-19 treatment. Lancet Infect Dis. 21:20–21. 2021.PubMed/NCBI View Article : Google Scholar | |
Hajissa K and Mussa A: Positive aspects of the mRNA platform for SARS-CoV-2 vaccines. Hum Vaccin Immunother. 17:2445–2447. 2021.PubMed/NCBI View Article : Google Scholar | |
Dai L and Gao GF: Viral targets for vaccines against COVID-19. Nat Rev Immunol. 21:73–82. 2021.PubMed/NCBI View Article : Google Scholar | |
Forni G and Mantovani A: COVID-19 Commission of Accademia Nazionale dei Lincei, Rome. COVID-19 vaccines: Where we stand and challenges ahead. Cell Death Differ. 28:626–639. 2021.PubMed/NCBI View Article : Google Scholar | |
Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, et al: Efficacy and safety of the Mrna-1273 SARS-CoV-2 vaccine. N Engl J Med. 384:403–416. 2021.PubMed/NCBI View Article : Google Scholar |