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LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice

  • Authors:
    • Yibo Li
    • Ziwei Xi
    • Zheng Yu
    • Chaoyue Yang
    • Chunhua Tan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, General Hospital of Central Theater Command (Hankou District), Wuhan, Hubei 430000, P.R. China, School of Medical Sciences, Army Medical University, Chongqing 400038, P.R. China, Department of Hematoendocrinology, 32295 Army Hospital, Liaoyang, Liaoning 111000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 425
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    Published online on: May 4, 2022
       https://doi.org/10.3892/etm.2022.11352
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Abstract

In patients with diabetes, the Wnt/β‑catenin pathway in vascular smooth muscle cells (VSMCs) is continuously activated by low‑intensity inflammation, which leads to the osteoblastic differentiation of these cells and the deposition of calcium and phosphorus in blood vessels. The aim of the present study was to determine whether long intergenic non‑coding RNA‑erythroid pro‑survival (lincRNA‑EPS) was able to ameliorate vascular calcification (VC) associated with diabetes. VSMCs isolated from C57BL/6 mice were transfected with lincRNA‑EPS overexpression vector in vitro and their osteoblastic differentiation was evaluated under high‑glucose conditions. In addition, a mouse model of diabetes was established, which included a lincRNA‑EPS knockout group and a lincRNA‑EPS high expression group. Blood vessel samples from the mice were examined to determine the degree of calcification. The levels of inflammatory factors in serum were also detected. The VSMCs transfected with lincRNA‑EPS overexpression vector exhibited less osteoblastic differentiation and migration and significantly lower levels of Wnt pathway‑associated proteins than those transfected with empty control. Furthermore, the in vivo experiments revealed that the overexpression of lincRNA‑EPS significantly reduced VC in diabetic mice. Therefore, on the basis of these findings, it is suggested that lincRNA‑EPS overexpression may provide a novel and effective method for the treatment of VC in patients with diabetes.
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1 

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 36 (Suppl 1):S67–S74. 2013.PubMed/NCBI View Article : Google Scholar

2 

Zhang C, Zhang K, Huang F, Feng W, Chen J, Zhang H, Wang J, Luo P and Huang H: Exosomes, the message transporters in vascular calcification. J Cell Mol Med. 22:4024–4033. 2018.PubMed/NCBI View Article : Google Scholar

3 

Neuenschwander M, Ballon A, Weber KS, Norat T, Aune D, Schwingshackl L and Schlesinger S: Role of diet in type 2 diabetes incidence: Umbrella review of meta-analyses of prospective observational studies. BMJ. 366(l2368)2019.PubMed/NCBI View Article : Google Scholar

4 

Li XY, Li QM, Fang Q, Zha XQ, Pan LH and Luo JP: Laminaria japonica polysaccharide inhibits vascular calcification via preventing osteoblastic differentiation of vascular smooth muscle cells. J Agric Food Chem. 66:1821–1827. 2018.PubMed/NCBI View Article : Google Scholar

5 

Zhan JK, Wang YJ, Wang Y, Tang ZY, Tan P, Huang W and Liu YS: The protective effect of GLP-1 analogue in arterial calcification through attenuating osteoblastic differentiation of human VSMCs. Int J Cardiol. 189:188–193. 2015.PubMed/NCBI View Article : Google Scholar

6 

Pedersen BK: Anti-inflammatory effects of exercise: Role in diabetes and cardiovascular disease. Eur J Clin Invest. 47:600–611. 2017.PubMed/NCBI View Article : Google Scholar

7 

Nagano A, Arioka M, Takahashi-Yanaga F, Matsuzaki E and Sasaguri T: Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes. J Pharmacol Sci. 133:18–24. 2017.PubMed/NCBI View Article : Google Scholar

8 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012.PubMed/NCBI View Article : Google Scholar

9 

Ravi R, Noonan KA, Pham V, Bedi R, Zhavoronkov A, Ozerov IV, Makarev E, V Artemov A, Wysocki PT, Mehra R, et al: Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy. Nat Commun. 9(741)2018.PubMed/NCBI View Article : Google Scholar

10 

Bierie B and Moses HL: Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev. 21:49–59. 2010.PubMed/NCBI View Article : Google Scholar

11 

Atianand MK, Hu W, Satpathy AT, Shen Y, Ricci EP, Alvarez-Dominguez JR, Bhatta A, Schattgen SA, McGowan JD, Blin J, et al: A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation. Cell. 165:1672–1685. 2016.PubMed/NCBI View Article : Google Scholar

12 

Ke Z, Lu J, Zhu J, Yang Z, Jin Z and Yuan L: Down-regulation of lincRNA-EPS regulates apoptosis and autophagy in BCG-infected RAW264.7 macrophages via JNK/MAPK signaling pathway. Infect Genet Evol. 77(104077)2020.PubMed/NCBI View Article : Google Scholar

13 

Heydemann A: An overview of murine high fat diet as a model for type 2 diabetes mellitus. J Diabetes Res. 2016(2902351)2016.PubMed/NCBI View Article : Google Scholar

14 

Azushima K, Gurley SB and Coffman TM: Modelling diabetic nephropathy in mice. Nat Rev Nephrol. 14:48–56. 2018.PubMed/NCBI View Article : Google Scholar

15 

Schwarz H, Zhang Y, Zhan C, Malm M, Field R, Turner R, Sellick C, Varley P, Rockberg J and Chotteau V: Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin. J Biotechnol. 309:44–52. 2020.PubMed/NCBI View Article : Google Scholar

16 

Sun X, Li W, Zhang X, Qi M, Zhang Z, Zhang XE and Cui Z: In vivo targeting and imaging of atherosclerosis using multifunctional virus-like particles of simian virus 40. Nano Lett. 16:6164–6171. 2016.PubMed/NCBI View Article : Google Scholar

17 

Grieger JC, Soltys SM and Samulski RJ: Production of recombinant adeno-associated virus vectors using suspension HEK293 cells and continuous harvest of vector from the culture media for GMP FIX and FLT1 clinical vector. Mol Ther. 24:287–297. 2016.PubMed/NCBI View Article : Google Scholar

18 

Chandler RJ, LaFave MC, Varshney GK, Trivedi NS, Carrillo-Carrasco N, Senac JS, Wu W, Hoffmann V, Elkahloun AG, Burgess SM and Venditti CP: Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy. J Clin Invest. 125:870–880. 2015.PubMed/NCBI View Article : Google Scholar

19 

Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X, Ling C and Zhao B: Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. J Biol Chem. 294:14096–14104. 2019.PubMed/NCBI View Article : Google Scholar

20 

Li Y, Wan S, Liu G, Cai W, Huo D, Li G, Yang M, Wang Y, Guan G, Ding N, et al: Netrin-1 promotes inflammation resolution to achieve endothelialization of small-diameter tissue engineering blood vessels by improving endothelial progenitor cells function in situ. Adv Sci (Weinh). 4(1700278)2017.PubMed/NCBI View Article : Google Scholar

21 

Jiao L, Zhuang Y, Jiang M, Zhou JH, Wu M, Chen ZJ, Fang JH and Deng YS: Angiopoietin-like 2 has auxo-action in atherosclerosis by promoting atherosclerotic calcification. Int J Clin Exp Pathol. 10:9084–9091. 2017.PubMed/NCBI

22 

Fang M, Wang CG, Zheng C, Luo J, Hou S, Liu K and Li X: Mir-29b promotes human aortic valve interstitial cell calcification via inhibiting TGF-β3 through activation of wnt3/β-catenin/Smad3 signaling. J Cell Biochem. 119:5175–5185. 2018.PubMed/NCBI View Article : Google Scholar

23 

Zhang B, Li Q, Jia S, Li F, Li Q and Li J: LincRNA-EPS in biomimetic vesicles targeting cerebral infarction promotes inflammatory resolution and neurogenesis. J Transl Med. 18(110)2020.PubMed/NCBI View Article : Google Scholar

24 

Zou Y, Zhang Y, Church J and Liu X: Comparison of β-catenin and LEF1 immunohistochemical stains in desmoid-type fibromatosis and its selected mimickers, with unexpected finding of LEF1 positivity in scars. Appl Immunohistochem Mol Morphol. 26:648–653. 2018.PubMed/NCBI View Article : Google Scholar

25 

Wang Q, Wang G, Wang B and Yang H: Activation of TGR5 promotes osteoblastic cell differentiation and mineralization. Biomed Pharmacother. 108:1797–1803. 2018.PubMed/NCBI View Article : Google Scholar

26 

He J, Zhang N, Zhang J, Jiang B and Wu F: Migration critically meditates osteoblastic differentiation of bone mesenchymal stem cells through activating canonical Wnt signal pathway. Colloids Surf B Biointerfaces. 171:205–213. 2018.PubMed/NCBI View Article : Google Scholar

27 

Shioi A and Ikari Y: Plaque calcification during atherosclerosis progression and regression. J Atheroscler Thromb. 25:294–303. 2018.PubMed/NCBI View Article : Google Scholar

28 

Chiarella E, Aloisio A, Scicchitano S, Lucchino V, Montalcini Y, Galasso O, Greco M, Gasparini G, Mesuraca M, Bond HM and Morrone G: ZNF521 represses osteoblastic differentiation in human adipose-derived stem cells. Int J Mol Sci. 19(4095)2018.PubMed/NCBI View Article : Google Scholar

29 

Liu Y, Lin F, Fu Y, Chen W, Liu W, Chi J, Zhang X and Yin X: Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress. Amino Acids. 48:2671–2681. 2016.PubMed/NCBI View Article : Google Scholar

30 

Rong S, Zhao X, Jin X, Zhang Z, Chen L, Zhu Y and Yuan W: Vascular calcification in chronic kidney disease is induced by bone morphogenetic protein-2 via a mechanism involving the Wnt/β-catenin pathway. Cell Physiol Biochem. 34:2049–2060. 2014.PubMed/NCBI View Article : Google Scholar

31 

Nagashima M, Sakai A, Uchida S, Tanaka S, Tanaka M and Nakamura T: Bisphosphonate (YM529) delays the repair of cortical bone defect after drill-hole injury by reducing terminal differentiation of osteoblasts in the mouse femur. Bone. 36:502–511. 2005.PubMed/NCBI View Article : Google Scholar

32 

Rudijanto A: The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones. 39:86–93. 2007.PubMed/NCBI

33 

Guzik TJ, Korbut R and Adamek-Guzik T: Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 54:469–487. 2003.PubMed/NCBI

34 

Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK and Podolsky DK: Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol. 286:G137–G147. 2004.PubMed/NCBI View Article : Google Scholar

35 

Niedbala W, Besnard AG, Nascimento DC, Donate PB, Sonego F, Yip E, Guabiraba R, Chang HD, Fukada SY, Salmond RJ, et al: Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nat Commun. 5(4575)2014.PubMed/NCBI View Article : Google Scholar

36 

de Seigneux S and Martin PY: Phosphate and FGF23 in the renoprotective benefit of RAAS inhibition. Pharmacol Res. 106:87–91. 2016.PubMed/NCBI View Article : Google Scholar

37 

Jüppner H: Phosphate and FGF-23. Kidney Int Suppl. 79:S24–S27. 2011.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Xi Z, Yu Z, Yang C and Tan C: LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice. Exp Ther Med 23: 425, 2022.
APA
Li, Y., Xi, Z., Yu, Z., Yang, C., & Tan, C. (2022). LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice. Experimental and Therapeutic Medicine, 23, 425. https://doi.org/10.3892/etm.2022.11352
MLA
Li, Y., Xi, Z., Yu, Z., Yang, C., Tan, C."LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice". Experimental and Therapeutic Medicine 23.6 (2022): 425.
Chicago
Li, Y., Xi, Z., Yu, Z., Yang, C., Tan, C."LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice". Experimental and Therapeutic Medicine 23, no. 6 (2022): 425. https://doi.org/10.3892/etm.2022.11352
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Xi Z, Yu Z, Yang C and Tan C: LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice. Exp Ther Med 23: 425, 2022.
APA
Li, Y., Xi, Z., Yu, Z., Yang, C., & Tan, C. (2022). LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice. Experimental and Therapeutic Medicine, 23, 425. https://doi.org/10.3892/etm.2022.11352
MLA
Li, Y., Xi, Z., Yu, Z., Yang, C., Tan, C."LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice". Experimental and Therapeutic Medicine 23.6 (2022): 425.
Chicago
Li, Y., Xi, Z., Yu, Z., Yang, C., Tan, C."LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice". Experimental and Therapeutic Medicine 23, no. 6 (2022): 425. https://doi.org/10.3892/etm.2022.11352
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