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Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway

  • Authors:
    • Yuan Zhao
    • Jie Yu
    • Fan Ping
    • Lingling Xu
    • Wei Li
    • Huabing Zhang
    • Yuxiu Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 439
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    Published online on: May 11, 2022
       https://doi.org/10.3892/etm.2022.11366
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Abstract

Insulin and liraglutide have been demonstrated to control blood glucose and exert neuroprotective effects. However, the impact of liraglutide or insulin alone or in combination on brain pathology in type 1 diabetes mellitus (T1DM) and their underlying mechanisms are unclear. In the present study, diabetes mellitus (DM) was induced via intraperitoneal injection of streptozotocin in mice and subsequently mice were treated with insulin, liraglutide, a combination of the two drugs or saline. Changes in body weight and blood glucose were assessed weekly. The pathological changes in the brain tissue and the apoptosis of neurons were assessed using H&E staining and TUNEL staining. The mRNA and protein expression levels of apoptosis‑related proteins were detected using reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting, respectively. Moreover, Ki67 protein expression was analyzed using immunohistochemistry and the mRNA and protein expression levels of Wnt/β‑catenin signaling pathway‑related proteins were examined using RT‑qPCR and western blotting, respectively. The results of the present study suggested that DM mice developed hyperglycemia and weight loss and also exhibited significantly increased neural cell apoptosis and significantly reduced numbers of Ki67‑positive cells. Liraglutide significantly decreased blood glucose levels in DM mice, whereas both insulin and the combination of the two drugs failed to control blood glucose well. Insulin, liraglutide and their combination also failed to control body weight well, but significantly attenuated brain pathological changes and activation of the pro‑apoptotic proteins Caspase‑3 and Bax, which may have resulted in the significant increase in the expression levels of Wnt/β‑catenin signaling pathway‑associated molecules such as Wnt3a and S9‑pGSK‑3β. Liraglutide also promoted the protein expression of the neurogenesis marker of Ki67 and the antiapoptotic factor Bcl‑2. These results suggested that insulin and liraglutide may improve brain damage via upregulation of the Wnt/β‑catenin signaling pathway and could be of therapeutic relevance for improvement of cognitive impairment in patients with DM.
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1 

Biessels GJ, Staekenborg S, Brunner E, Brayne C and Scheltens P: Risk of dementia in diabetes mellitus: A systematic review. Lancet Neurol. 5:64–74. 2006.PubMed/NCBI View Article : Google Scholar

2 

Wang C, Lv H, Li Q, Gong K, Yang LL, Wei Z, Pan Y and Wang M: RNA sequencing of peripheral blood revealed that the neurotropic TRK receptor signaling pathway shows apparent correlation in recovery following spinal cord injury at small cohort. J Mol Neurosci. 68:221–233. 2019.PubMed/NCBI View Article : Google Scholar

3 

Marini C, Baldassarre M, Russo T, De Santis F, Sacco S, Ciancarelli I and Carolei A: Burden of first-ever ischemic stroke in the oldest old: Evidence from a population-based study. Neurology. 62:77–81. 2004.PubMed/NCBI View Article : Google Scholar

4 

Ho N, Sommers MS and Lucki I: Effects of diabetes on hippocampal neurogenesis: Links to cognition and depression. Neurosci Biobehav Rev. 37:1346–1362. 2013.PubMed/NCBI View Article : Google Scholar

5 

Salem MA, Budzyńska B, Kowalczyk J, El Sayed NS and Mansour SM: Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. Toxicol Appl Pharmacol. 429(115697)2021.PubMed/NCBI View Article : Google Scholar

6 

Dubey SK, Lakshmi KK, Krishna KV, Agrawal M, Singhvi G, Saha RN, Saraf S, Saraf S, Shukla R and Alexander A: Insulin mediated novel therapies for the treatment of Alzheimer's disease. Life Sci. 249(117540)2020.PubMed/NCBI View Article : Google Scholar

7 

Drucker DJ and Nauck MA: The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 368:1696–1705. 2006.PubMed/NCBI View Article : Google Scholar

8 

Lovshin JA and Drucker DJ: Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol. 5:262–269. 2009.PubMed/NCBI View Article : Google Scholar

9 

Darsalia V, Nathanson D, Nyström T, Klein T, Sjöholm Å and Patrone C: GLP-1R activation for the treatment of stroke: Updating and future perspectives. Rev Endocr Metab Disord. 15:233–242. 2014.PubMed/NCBI View Article : Google Scholar

10 

Batista AF, Bodart-Santos V, De Felice FG and Ferreira ST: Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases. CNS Drugs. 33:209–223. 2019.PubMed/NCBI View Article : Google Scholar

11 

Kong FJ, Wu JH, Sun SY, Ma LL and Zhou JQ: Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes. Neuropharmacology. 131:316–325. 2018.PubMed/NCBI View Article : Google Scholar

12 

Yan W, Pang M, Yu Y, Gou X, Si P, Zhawatibai A, Zhang Y, Zhang M, Guo T, Yi X and Chen L: The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis. Life Sci. 231(116566)2019.PubMed/NCBI View Article : Google Scholar

13 

Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW and Hong JT: Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation. 5(37)2008.PubMed/NCBI View Article : Google Scholar

14 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012.PubMed/NCBI View Article : Google Scholar

15 

Jia L, Piña-Crespo J and Li Y: Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease. Mol Brain. 12(104)2019.PubMed/NCBI View Article : Google Scholar

16 

Xu D, Li F, Xue G, Hou K, Fang W and Li Y: Effect of Wnt signaling pathway on neurogenesis after cerebral ischemia and its therapeutic potential. Brain Res Bull. 164:1–13. 2020.PubMed/NCBI View Article : Google Scholar

17 

Xu Y, Zhang G, Kang Z, Xu Y, Jiang W and Zhang S: Cornin increases angiogenesis and improves functional recovery after stroke via the Ang1/Tie2 axis and the Wnt/β-catenin pathway. Arch Pharm Res. 39:133–142. 2016.PubMed/NCBI View Article : Google Scholar

18 

Commission SSaT: Regulations for the administration of affairs concerning experimental animals. In: Decree No. 2 of the State Science and Technology Commission China Legal System Publishing House. State Science and Technology Commission, China, 2011.

19 

National Research Council (US): Committee for the Update of the Guide for the Care and Use of Laboratory Animals: The National Academies Collection: Reports funded by National Institutes of Health. In: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US). National Academy of Sciences, Washington, DC, 2011.

20 

Kilkenny C, Browne W, Cuthill IC, Emerson M and Altman DG: National Centre for the Replacement, Refinement and Reduction of Amimals in Research. Animal research: Reporting in vivo experiments-the ARRIVE guidelines. J Cereb Blood Flow Metab. 31:991–993. 2011.PubMed/NCBI View Article : Google Scholar

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

22 

Yu J, Shi YC, Ping F, Li W, Zhang HB, He SL, Zhao Y, Xu LL and Li YX: Liraglutide inhibits osteoclastogenesis and improves bone loss by downregulating Trem2 in female type 1 diabetic mice: Findings from transcriptomics. Front Endocrinol (Lausanne). 12(763646)2021.PubMed/NCBI View Article : Google Scholar

23 

Shalimova A, Graff B, Gąsecki D, Wolf J, Sabisz A, Szurowska E, Jodzio K and Narkiewicz K: Cognitive dysfunction in type 1 diabetes mellitus. J Clin Endocrinol Metab. 104:2239–2249. 2019.PubMed/NCBI View Article : Google Scholar

24 

Cameron FJ, Northam EA and Ryan CM: The effect of type 1 diabetes on the developing brain. Lancet Child Adolesc Health. 3:427–436. 2019.PubMed/NCBI View Article : Google Scholar

25 

Perkins BA, Lovblom LE, Lanctôt SO, Lamb K and Cherney DZI: Discoveries from the study of longstanding type 1 diabetes. Diabetologia. 64:1189–1200. 2021.PubMed/NCBI View Article : Google Scholar

26 

Darwish MA, Abo-Youssef AM, Messiha BAS, Abo-Saif AA and Abdel-Bakky MS: Resveratrol inhibits macrophage infiltration of pancreatic islets in streptozotocin-induced type 1 diabetic mice via attenuation of the CXCL16/NF-κΒ p65 signaling pathway. Life Sci. 272(119250)2021.PubMed/NCBI View Article : Google Scholar

27 

Madrakhimov SB, Yang JY, Kim JH, Han JW and Park TK: mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy. Cell Commun Signal. 19(29)2021.PubMed/NCBI View Article : Google Scholar

28 

Palleria C, Leo A, Andreozzi F, Citraro R, Iannone M, Spiga R, Sesti G, Constanti A, De Sarro G, Arturi F and Russo E: Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects. Behav Brain Res. 321:157–169. 2017.PubMed/NCBI View Article : Google Scholar

29 

Hölscher C: The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease. Alzheimers Dement. 10 (Suppl 1):S47–S54. 2014.PubMed/NCBI View Article : Google Scholar

30 

Barman J, Kumar R, Saha G, Tiwari K and Dubey VK: Apoptosis: Mediator molecules, interplay with other cell death processes and therapeutic potentials. Curr Pharm Biotechnol. 19:644–663. 2018.PubMed/NCBI View Article : Google Scholar

31 

Singh R, Letai A and Sarosiek K: Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 20:175–193. 2019.PubMed/NCBI View Article : Google Scholar

32 

Pratchayasakul W, Thongnak LO, Chattipakorn K, Lungaphin A, Pongchaidecha A, Satjaritanun P, Jaiwongkam T, Kerdphoo S and Chattipakorn SC: Atorvastatin and insulin equally mitigate brain pathology in diabetic rats. Toxicol Appl Pharmacol. 342:79–85. 2018.PubMed/NCBI View Article : Google Scholar

33 

Malekiyan R, Abdanipour A, Sohrabi D and Jafari Anarkooli I: Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomed Rep. 10:47–54. 2019.PubMed/NCBI View Article : Google Scholar

34 

Irfannuddin I, Sarahdeaz SFP, Murti K, Santoso B and Koibuchi N: The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus. J Physiol Sci. 71(3)2021.PubMed/NCBI View Article : Google Scholar

35 

El-Akabawy G and El-Kholy W: Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats. Ann Anat. 196:119–128. 2014.PubMed/NCBI View Article : Google Scholar

36 

ALmohaimeed HM, Mohammedsaleh ZM, Batawi AH, Balgoon MJ, Ramadan OI, Baz HA, Al Jaouni S and Ayuob NN: Synergistic anti-inflammatory and neuroprotective effects of cinnamomum cassia and zingiber officinale alleviate diabetes-induced hippocampal changes in male albino rats: Structural and molecular evidence. Front Cell Dev Biol. 9(727049)2021.PubMed/NCBI View Article : Google Scholar

37 

Haas CB, Kalinine E, Zimmer ER, Hansel G, Brochier AW, Oses JP, Portela LV and Muller AP: Brain insulin administration triggers distinct cognitive and neurotrophic responses in young and aged rats. Mol Neurobiol. 53:5807–5817. 2016.PubMed/NCBI View Article : Google Scholar

38 

Fares J, Bou Diab Z, Nabha S and Fares Y: Neurogenesis in the adult hippocampus: History, regulation, and prospective roles. Int J Neurosci. 129:598–611. 2019.PubMed/NCBI View Article : Google Scholar

39 

Foulquier S, Daskalopoulos EP, Lluri G, Hermans KCM, Deb A and Blankesteijn WM: WNT signaling in cardiac and vascular disease. Pharmacol Rev. 70:68–141. 2018.PubMed/NCBI View Article : Google Scholar

40 

Kim DY, Jung SY, Kim K and Kim CJ: Treadmill exercise ameliorates Alzheimer disease-associated memory loss through the Wnt signaling pathway in the streptozotocin-induced diabetic rats. J Exerc Rehabil. 12:276–283. 2016.PubMed/NCBI View Article : Google Scholar

41 

Xu D, Hou K, Li F, Chen S, Fang W and Li Y: XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/β-catenin signaling dependent way. Life Sci. 235(116844)2019.PubMed/NCBI View Article : Google Scholar

42 

Zhao C, Liang J, Yang Y, Yu M and Qu X: The impact of glucagon-like peptide-1 on bone metabolism and its possible mechanisms. Front Endocrinol (Lausanne). 8(98)2017.PubMed/NCBI View Article : Google Scholar

43 

Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G and Kahn CR: Cross-talk between insulin and Wnt signaling in preadipocytes: Role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem. 287:12016–12026. 2012.PubMed/NCBI View Article : Google Scholar

44 

Yang S, Zhang Y, Zhang Z, Dan J, Zhou Q, Wang X, Li W, Zhou L, Yang L and Xie L: Insulin promotes corneal nerve repair and wound healing in type 1 diabetic mice by enhancing Wnt/β-catenin signaling. Am J Pathol. 190:2237–2250. 2020.PubMed/NCBI View Article : Google Scholar

45 

Doble BW and Woodgett JR: GSK-3: Tricks of the trade for a multi-tasking kinase. J Cell Sci. 116:1175–1186. 2003.PubMed/NCBI View Article : Google Scholar

46 

He W, Tian X, Lv M and Wang H: Liraglutide protects neurite outgrowth of cortical neurons under oxidative stress though activating the Wnt pathway. J Stroke Cerebrovasc Dis. 27:2696–2702. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Yu J, Ping F, Xu L, Li W, Zhang H and Li Y: Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway. Exp Ther Med 24: 439, 2022.
APA
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., & Li, Y. (2022). Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 24, 439. https://doi.org/10.3892/etm.2022.11366
MLA
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., Li, Y."Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 24.1 (2022): 439.
Chicago
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., Li, Y."Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 24, no. 1 (2022): 439. https://doi.org/10.3892/etm.2022.11366
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Yu J, Ping F, Xu L, Li W, Zhang H and Li Y: Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway. Exp Ther Med 24: 439, 2022.
APA
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., & Li, Y. (2022). Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 24, 439. https://doi.org/10.3892/etm.2022.11366
MLA
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., Li, Y."Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 24.1 (2022): 439.
Chicago
Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., Li, Y."Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 24, no. 1 (2022): 439. https://doi.org/10.3892/etm.2022.11366
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