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Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center

  • Authors:
    • Octavian Enciu
    • Adelaida Avino
    • Valentin Calu
    • Elena Adelina Toma
    • Adrian Tulin
    • Raluca Tulin
    • Iulian Slavu
    • Laura Răducu
    • Andra-Elena Balcangiu-Stroescu
    • Daniela-Elena Gheoca Mutu
    • Luminiţa Florentina Tomescu
    • Adrian Miron
  • View Affiliations / Copyright

    Affiliations: Discipline of General Surgery, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania, Discipline of Plastic and Reconstructive Surgery, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania, Discipline of Anatomy, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania, Discipline of Physiology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania, Department of Plastic and Reconstructive Surgery, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest 011356, Romania, Department of Interventional Radiology, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest 011356, Romania
    Copyright: © Enciu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 455
    |
    Published online on: May 20, 2022
       https://doi.org/10.3892/etm.2022.11382
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Abstract

Despite concerns regarding oncologic safety, laparoscopic surgery for colon cancer has been proven in several trials in the lasts decades to be superior to open surgery. In addition, the benefits of laparoscopic surgery can be offered to other patients with malignant disease. The aim of the present study was to compare the quality of oncologic resection for non‑metastatic, resectable colon cancer between laparoscopic and open surgery in terms of specimen margins and retrieved lymph nodes in a medium volume center in Romania. A total of 219 patients underwent surgery for non‑metastatic colon cancer between January 2017 and December 2020. Of these, 52 underwent laparoscopic resection, while 167 had open surgery. None of the patients in the laparoscopic group had positive circumferential margins (P=0.035) while 12 (7.19%) patients in the open group (OG) had positive margins. A total of three patients in the laparoscopic group (5.77%) and seven patients (4.19%) in the OG had invaded axial margins. While the number of retrieved lymph nodes was not correlated with the type of procedure [laparoscopic group 16.12 (14±6.56), OG 17.31 (15±8.42), P=0.448], the lymph node ratio was significantly higher in the OG (P=0.003). Given the results of the present study, it is safe to conclude that laparoscopic surgery is not inferior to open surgery for non‑metastatic colon cancer in a medium volume center.
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1 

Reilly WT, Nelson H, Schroeder G, Wieand HS, Bolton J and O'connell MJ: Wound recurrence following conventional treatment of colorectal cancer. A rare but perhaps underestimated problem. Dis Colon Rectum. 39:200–207. 1996.PubMed/NCBI View Article : Google Scholar

2 

Jacobs M, Verdeja JC and Goldstein HS: Minimally invasive colon resection (laparoscopic colectomy). Surg Laparosc Endosc. 1:144–150. 1991.PubMed/NCBI

3 

Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW Jr, Hellinger M, Flanagan R Jr, Peters W and Nelson H: Clinical Outcomes of Surgical Therapy Study Group. Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg. 246:655–662; discussion 662-4. 2007.PubMed/NCBI View Article : Google Scholar

4 

COLOR Study Group. COLOR: A randomized clinical trial comparing laparoscopic and open resection for colon cancer. Dig Surg. 17:617–622. 2000.PubMed/NCBI View Article : Google Scholar

5 

Colon Cancer Laparoscopic or Open Resection Study Group. Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, Haglind E, Påhlman L, Cuesta MA, Msika S, et al: Survival after laparoscopic surgery versus open surgery for colon cancer: Long-term outcome of a randomised clinical trial. Lancet Oncol. 10:44–52. 2009.PubMed/NCBI View Article : Google Scholar

6 

Veldkamp R, Gholghesaei M, Bonjer HJ, Meijer DW, Buunen M, Jeekel J, Anderberg B, Cuesta MA, Cuschierl A, Fingerhut A, et al: Laparoscopic resection of colon cancer: Consensus of the European Association of Endoscopic Surgery (EAES). Surg Endosc. 18:1163–1185. 2004.PubMed/NCBI View Article : Google Scholar

7 

Hohenberger W, Weber K, Matzel K, Papadopoulos T and Merkel S: Standardized surgery for colonic cancer: Complete mesocolic excision and central ligation-technical notes and outcome. Colorectal Dis. 11:354–364; discussion 364-5. 2009.PubMed/NCBI View Article : Google Scholar

8 

Heald RJ, Moran BJ, Ryall RD, Sexton R and MacFarlane JK: Rectal cancer: The Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg. 133:894–899. 1998.PubMed/NCBI View Article : Google Scholar

9 

Tekkis PP, Senagore AJ, Delaney CP and Fazio VW: Evaluation of the learning curve in laparoscopic colorectal surgery: Comparison of right-sided and left-sided resections. Ann Surg. 242:83–91. 2005.PubMed/NCBI View Article : Google Scholar

10 

West NP, Hohenberger W, Weber K, Perrakis A, Finan PJ and Quirke P: Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol. 28:272–278. 2009.PubMed/NCBI View Article : Google Scholar

11 

Abraham NS, Young JM and Solomon MJ: Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer. Br J Surg. 91:1111–1124. 2004.PubMed/NCBI View Article : Google Scholar

12 

Chang GJ, Rodriguez-Bigas MA, Skibber JM and Moyer VA: Lymph node evaluation and survival after curative resection of colon cancer: Systematic review. J Natl Cancer Inst. 99:433–441. 2007.PubMed/NCBI View Article : Google Scholar

13 

Wiggers T, Jeekel J, Arends JW, Brinkhorst AP, Kluck HM, Luyk CI, Munting JD, Povel JA, Rutten AP, Volovics A, et al: No-Touch isolation technique in colon cancer: A controlled prospective trial. Br J Surg. 75:409–415. 1988.PubMed/NCBI View Article : Google Scholar

14 

Bennett CL, Stryker SJ, Ferreira MR, Adams J and Beart RW: The learning curve for laparoscopic colorectal surgery: Preliminary results from a prospective analysis of 1194 laparoscopic-assisted colectomies. Arch Surg. 132:41–44; discussion 45. 1997.PubMed/NCBI View Article : Google Scholar

15 

Gospodarowicz MK, Brierley JD and Wittekind C (eds): TNM classification of malignant tumours. 8th edition. John Wiley & Sons, Hoboken, NJ, 2017.

16 

Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, et al: Laparoscopic surgery versus open surgery for colon cancer: Short-term outcomes of a randomised trial. Lancet Oncol. 6:477–484. 2005.PubMed/NCBI View Article : Google Scholar

17 

Thompson BS, Coory MD and Lumley JW: National trends in the uptake of laparoscopic resection for colorectal cancer, 2000-2008. Med J Aust. 194:443–447. 2011.PubMed/NCBI View Article : Google Scholar

18 

Gruen RL, Pitt V, Green S, Parkhill A, Campbell D and Jolley D: The effect of provider case volume on cancer mortality: Systematic review and meta-analysis. CA Cancer J Clin. 59:192–211. 2009.PubMed/NCBI View Article : Google Scholar

19 

Huo YR, Phan K, Morris DL and Liauw W: Systematic review and a meta-analysis of hospital and surgeon volume/outcome relationships in colorectal cancer surgery. J Gastrointest Oncol. 8:534–546. 2017.PubMed/NCBI View Article : Google Scholar

20 

Rogers SO Jr, Wolf RE, Zaslavsky AM, Wright WE and Ayanian JZ: Relation of surgeon and hospital volume to processes and outcomes of colorectal cancer surgery. Ann Surg. 244:1003–1011. 2006.PubMed/NCBI View Article : Google Scholar

21 

Birkmeyer JD, Stukel TA, Siewers AE, Goodney PP, Wennberg DE and Lucas FL: Surgeon volume and operative mortality in the United States. N Engl J Med. 349:2117–2127. 2003.PubMed/NCBI View Article : Google Scholar

22 

Schlachta CM, Mamazza J, Seshadri PA, Cadeddu M, Gregoire R and Poulin EC: Defining a learning curve for laparoscopic colorectal resections. Dis Colon Rectum. 44:217–222. 2001.PubMed/NCBI View Article : Google Scholar

23 

Li JC, Hon SS, Ng SS, Lee JF, Yiu RY and Leung KL: The learning curve for laparoscopic colectomy: Experience of a surgical fellow in an university colorectal unit. Surg Endosc. 23:1603–1608. 2009.PubMed/NCBI View Article : Google Scholar

24 

Schofield JB, Mounter NA, Mallett R and Haboubi NY: The importance of accurate pathological assessment of lymph node involvement in colorectal cancer. Colorectal Dis. 8:460–470. 2006.PubMed/NCBI View Article : Google Scholar

25 

Vaccaro CA, Im V, Rossi GL, Quintana GO, Benati ML, de Arenaza DP and Bonadeo FA: Lymph node ratio as prognosis factor for colon cancer treated by colorectal surgeons. Dis Colon Rectum. 52:1244–1250. 2009.PubMed/NCBI View Article : Google Scholar

26 

Moug SJ, Saldanha JD, McGregor JR, Balsitis M and Diament RH: Positive lymph node retrieval ratio optimises patient staging in colorectal cancer. Br J Cancer. 100:1530–1533. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Enciu O, Avino A, Calu V, Toma EA, Tulin A, Tulin R, Slavu I, Răducu L, Balcangiu-Stroescu A, Gheoca Mutu D, Gheoca Mutu D, et al: Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center. Exp Ther Med 24: 455, 2022.
APA
Enciu, O., Avino, A., Calu, V., Toma, E.A., Tulin, A., Tulin, R. ... Miron, A. (2022). Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center. Experimental and Therapeutic Medicine, 24, 455. https://doi.org/10.3892/etm.2022.11382
MLA
Enciu, O., Avino, A., Calu, V., Toma, E. A., Tulin, A., Tulin, R., Slavu, I., Răducu, L., Balcangiu-Stroescu, A., Gheoca Mutu, D., Tomescu, L. F., Miron, A."Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center". Experimental and Therapeutic Medicine 24.1 (2022): 455.
Chicago
Enciu, O., Avino, A., Calu, V., Toma, E. A., Tulin, A., Tulin, R., Slavu, I., Răducu, L., Balcangiu-Stroescu, A., Gheoca Mutu, D., Tomescu, L. F., Miron, A."Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center". Experimental and Therapeutic Medicine 24, no. 1 (2022): 455. https://doi.org/10.3892/etm.2022.11382
Copy and paste a formatted citation
x
Spandidos Publications style
Enciu O, Avino A, Calu V, Toma EA, Tulin A, Tulin R, Slavu I, Răducu L, Balcangiu-Stroescu A, Gheoca Mutu D, Gheoca Mutu D, et al: Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center. Exp Ther Med 24: 455, 2022.
APA
Enciu, O., Avino, A., Calu, V., Toma, E.A., Tulin, A., Tulin, R. ... Miron, A. (2022). Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center. Experimental and Therapeutic Medicine, 24, 455. https://doi.org/10.3892/etm.2022.11382
MLA
Enciu, O., Avino, A., Calu, V., Toma, E. A., Tulin, A., Tulin, R., Slavu, I., Răducu, L., Balcangiu-Stroescu, A., Gheoca Mutu, D., Tomescu, L. F., Miron, A."Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center". Experimental and Therapeutic Medicine 24.1 (2022): 455.
Chicago
Enciu, O., Avino, A., Calu, V., Toma, E. A., Tulin, A., Tulin, R., Slavu, I., Răducu, L., Balcangiu-Stroescu, A., Gheoca Mutu, D., Tomescu, L. F., Miron, A."Laparoscopic vs. open resection for colon cancer‑quality of oncologic resection evaluation in a medium volume center". Experimental and Therapeutic Medicine 24, no. 1 (2022): 455. https://doi.org/10.3892/etm.2022.11382
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