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Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis

  • Authors:
    • Ying Zhang
    • Wei Gao
    • Xia Li
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    Affiliations: Department of Blood Dialysis Room, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 480
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    Published online on: June 1, 2022
       https://doi.org/10.3892/etm.2022.11407
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Abstract

Patients with end‑stage renal disease (ESRD) are characterized by augmented oxidative stress (OS) due to the imbalance between the generation of increased concentrations of oxidative molecules and decreased antioxidant capacity. Vitamin E‑coated dialyzer membranes (VEMs) have previously been reported to alleviate the imbalance of redox metabolism in patients with ESRD undergoing hemodialysis (HD); however, their effect on the deformability of red blood cells (RBCs) remains unknown. In the present study, 48 patients with ESRD undergoing HD were enrolled and randomly assigned into two groups: HD with VEMs (VEM group; n=24) and HD with polysulfone dialyzer membranes (PM group; n=24), and another 24 healthy volunteers served as the control group. The present study investigated the morphological changes and deformability of RBCs in patients with ESRD and healthy volunteers. The concentration of serum vitamin E, the parameters of antioxidant stress and OS, and the degree of oxidative phosphorylation and clustering of anion exchanger 1 (Band 3) in RBCs were measured. The results obtained suggested that VEM treatment markedly ameliorated the abnormalities of RBC morphology and deformability in patients with ESRD undergoing HD. Mechanistic studies showed that VEM treatment led to a marked improvement in the concentration of serum vitamin E, which was positively associated with the restored antioxidant capacity, and decreased oxidative phosphorylation and clustering of Band 3 in RBCs of patients with ESRD undergoing HD. Taken together, the results of the present study have demonstrated that VEM treatment effectively restored the imbalance of redox metabolism, and improved the oxidative phosphorylation and clustering of Band 3 in RBCs of patients with ESRD undergoing HD via delivering vitamin E, which may alleviate the abnormal morphological and mechanical properties of RBCs. These findings are anticipated to be useful with respect to improving the nursing care and cure rate of patients with ESRD.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Gao W and Li X: Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis. Exp Ther Med 24: 480, 2022.
APA
Zhang, Y., Gao, W., & Li, X. (2022). Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis. Experimental and Therapeutic Medicine, 24, 480. https://doi.org/10.3892/etm.2022.11407
MLA
Zhang, Y., Gao, W., Li, X."Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis". Experimental and Therapeutic Medicine 24.1 (2022): 480.
Chicago
Zhang, Y., Gao, W., Li, X."Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 480. https://doi.org/10.3892/etm.2022.11407
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Gao W and Li X: Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis. Exp Ther Med 24: 480, 2022.
APA
Zhang, Y., Gao, W., & Li, X. (2022). Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis. Experimental and Therapeutic Medicine, 24, 480. https://doi.org/10.3892/etm.2022.11407
MLA
Zhang, Y., Gao, W., Li, X."Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis". Experimental and Therapeutic Medicine 24.1 (2022): 480.
Chicago
Zhang, Y., Gao, W., Li, X."Vitamin E‑coated dialyzer alleviates erythrocyte deformability dysfunction in patients with end‑stage renal disease undergoing hemodialysis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 480. https://doi.org/10.3892/etm.2022.11407
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