Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2022 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2022 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4

  • Authors:
    • Haipeng Song
    • Na Xu
    • Shan Jin
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jinan First People's Hospital, Ji'nan, Shandong 250012, P.R. China, Department of Emergency, Jinan First People's Hospital, Ji'nan, Shandong 250012, P.R. China, Department of Neurology, The 960th Hospital of The Chinese People's Liberation Army, Ji'nan, Shandong 250031, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 492
    |
    Published online on: June 7, 2022
       https://doi.org/10.3892/etm.2022.11419
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

microRNAs (miRNAs or miRs) have been reported to regulate the pathology of intracerebral hemorrhage (ICH). Therefore, the present study aimed to investigate the function of miR‑30e‑5p in rats with ICH with specific focus on Toll‑like receptor (TLR)4. In the present study, collagenase type IV was used for the establishment of the ICH model in rats, prior to which the rats were injected with miR‑30e‑5p mimic or miR‑30e‑5p mimic + pcDNA3.1‑TLR4 plasmid. The expression levels of miR‑30e‑5p and TLR4 were then measured using reverse transcription‑quantitative PCR and western blotting. The potential interaction between miR‑30e‑5p and TLR4 was tested using the MicroRNA Target Prediction Database and dual‑luciferase reporter and RNA immunoprecipitation assay. In addition, the concentration of TNF‑α, IL‑6 and IL‑1β was measured using ELISA. The protein expression levels of TLR4/myeloid differentiation factor 88 (MyD88)/TIR‑domain‑containing adapter‑inducing interferon‑β (TRIF) signaling‑associated molecules were measured by western blotting. Following induction of ICH, miR‑30e‑5p expression was downregulated, while TLR4 expression was upregulated. By contrast, injection with miR‑30e‑5p mimic rescued neuronal function while suppressing neuronal inflammation in rats following ICH; these effects were reversed by co‑overexpression of TLR4. Furthermore, overexpression of miR‑30e‑5p inactivated TLR4/MyD88/TRIF signaling in rats with ICH; this was also reversed by overexpression of TLR4. Taken together, these results suggested that overexpression of miR‑30e‑5p exerted a protective role against neuronal deficit and inflammation caused by ICH in rats by targeting TLR4 and inactivating TLR4/MyD88/TRIF signaling.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Xi G, Strahle J, Hua Y and Keep RF: Progress in translational research on intracerebral hemorrhage: Is there an end in sight? Prog Neurobiol. 115:45–63. 2014.PubMed/NCBI View Article : Google Scholar

2 

Ziai WC and Carhuapoma JR: Intracerebral hemorrhage. Continuum (Minneap Minn). 24:1603–1622. 2018.PubMed/NCBI View Article : Google Scholar

3 

van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A and Klijn CJ: Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: A systematic review and meta-analysis. Lancet Neurol. 9:167–176. 2010.PubMed/NCBI View Article : Google Scholar

4 

Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H and Hanley DF: Spontaneous intracerebral hemorrhage. N Engl J Med. 344:1450–1460. 2001.PubMed/NCBI View Article : Google Scholar

5 

Rymer MM: Hemorrhagic stroke: Intracerebral hemorrhage. Mo Med. 108:50–54. 2011.PubMed/NCBI

6 

Rodríguez JA, Sobrino T, López-Arias E, Ugarte A, Sánchez-Arias JA, Vieites-Prado A, de Miguel I, Oyarzabal J, Páramo JA, Campos F, et al: cM352 reduces brain damage and improves functional recovery in a rat model of intracerebral hemorrhage. J Am Heart Assoc. 6(e006042)2017.PubMed/NCBI View Article : Google Scholar

7 

Sheth KN and Rosand J: Targeting the immune system in intracerebral hemorrhage. JAMA Neurol. 71:1083–1084. 2014.PubMed/NCBI View Article : Google Scholar

8 

Zhou Y, Wang Y, Wang J, Anne Stetler R and Yang QW: Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation. Prog Neurobiol. 115:25–44. 2014.PubMed/NCBI View Article : Google Scholar

9 

Rivest S: Regulation of innate immune responses in the brain. Nat Rev Immunol. 9:429–439. 2009.PubMed/NCBI View Article : Google Scholar

10 

Fang H, Wang PF, Zhou Y, Wang YC and Yang QW: Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury. J Neuroinflammation. 10(27)2013.PubMed/NCBI View Article : Google Scholar

11 

Zhang D, Shen X, Pang K, Yang Z and Yu A: VSIG4 alleviates intracerebral hemorrhage induced brain injury by suppressing TLR4-regulated inflammatory response. Brain Res Bull. 176:67–75. 2021.PubMed/NCBI View Article : Google Scholar

12 

Sansing LH, Harris TH, Welsh FA, Kasner SE, Hunter CA and Kariko K: Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Annal Neurol. 70:646–656. 2011.PubMed/NCBI View Article : Google Scholar

13 

Wang YC, Wang PF, Fang H, Chen J, Xiong XY and Yang QW: Toll-like receptor 4 antagonist attenuates intracerebral hemorrhage-induced brain injury. Stroke. 44:2545–2552. 2013.PubMed/NCBI View Article : Google Scholar

14 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004.PubMed/NCBI View Article : Google Scholar

15 

Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G and Sharp FR: Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 30:92–101. 2010.PubMed/NCBI View Article : Google Scholar

16 

Wang Y, Song Y, Pang Y, Yu Z, Hua W, Gu Y, Qi J and Wu H: miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression. Aging (Albany NY). 12:12869–12895. 2020.PubMed/NCBI View Article : Google Scholar

17 

Nie H, Hu Y, Guo W, Wang W, Yang Q, Dong Q, Tang Y, Li Q and Tang Z: miR-331-3p inhibits inflammatory response after intracerebral hemorrhage by directly targeting NLRP6. Biomed Res Int. 2020(6182464)2020.PubMed/NCBI View Article : Google Scholar

18 

Wang J, Zhu Y, Jin F, Tang L and He Z and He Z: Differential expression of circulating microRNAs in blood and haematoma samples from patients with intracerebral haemorrhage. J Int Med Res. 44:419–432. 2016.PubMed/NCBI View Article : Google Scholar

19 

Zhang S, Li G, Liu C, Lu S, Jing Q, Chen X, Zheng H, Ma H, Zhang D, Ren S, et al: miR-30e-5p represses angiogenesis and metastasis by directly targeting AEG-1 in squamous cell carcinoma of the head and neck. Cancer Sci. 111:356–368. 2020.PubMed/NCBI View Article : Google Scholar

20 

Zhang Z, Qin H, Jiang B, Chen W, Cao W, Zhao X, Yuan H, Qi W, Zhuo D and Guo H: miR-30e-5p suppresses cell proliferation and migration in bladder cancer through regulating metadherin. J Cell Biochem. 120:15924–15932. 2019.PubMed/NCBI View Article : Google Scholar

21 

Mo B, Wu X, Wang X, Xie J, Ye Z and Li L: miR-30e-5p mitigates hypoxia-induced apoptosis in human stem cell-derived cardiomyocytes by suppressing Bim. Int J Biol Sci. 15:1042–1051. 2019.PubMed/NCBI View Article : Google Scholar

22 

Chen Y, Yin Y and Jiang H: miR-30e-5p alleviates inflammation and cardiac dysfunction after myocardial infarction through targeting PTEN. Inflammation. 44:769–779. 2021.PubMed/NCBI View Article : Google Scholar

23 

Li W, Li X, Li T, Jiang MG, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, et al: Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell. 14:404–414. 2014.PubMed/NCBI View Article : Google Scholar

24 

Li T, Shuai L, Mao J, Wang X, Wang M, Zhang X, Wang L, Li Y, Li W and Zhou Q: Efficient production of fluorescent transgenic rats using the piggyBac Transposon. Sci Rep. 6(33225)2016.PubMed/NCBI View Article : Google Scholar

25 

Jung KH, Chu K, Jeong SW, Han SY, Lee ST, Kim JY, Kim M and Roh JK: HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage. Stroke. 35:1744–1749. 2004.PubMed/NCBI View Article : Google Scholar

26 

Ge XT, Lei P, Wang HC, Zhang AL, Han ZL, Chen X, Li SH, Jiang RC, Kang CS and Zhang JN: miR-21 improves the neurological outcome after traumatic brain injury in rats. Sci Rep. 4(6718)2014.PubMed/NCBI View Article : Google Scholar

27 

Bachour SP, Hevesi M, Bachour O, Sweis BM, Mahmoudi J, Brekke JA and Divani AA: Comparisons between Garcia, Modo, and Longa rodent stroke scales: Optimizing resource allocation in rat models of focal middle cerebral artery occlusion. J Neurol Sci. 364:136–140. 2016.PubMed/NCBI View Article : Google Scholar

28 

Yue X, Liu L, Yan H, Gui Y, Zhao J and Zhang P: Intracerebral hemorrhage induced brain injury is mediated by the interleukin-12 receptor in rats. Neuropsychiatr Dis Treat. 16:891–900. 2020.PubMed/NCBI View Article : Google Scholar

29 

Liu H, Shen H, Harvey BK, Castillo P, Lu H, Yang Y and Wang Y: Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats. NeuroImage. 56:280–289. 2011.PubMed/NCBI View Article : Google Scholar

30 

Han J, Zhang J, Zhong Z, Li Z, Pang W, Hu J and Chen L: Gualou Guizhi decoction promotes neurological functional recovery and neurogenesis following focal cerebral ischemia/reperfusion. Neural Regen Res. 13:1408–1416. 2018.PubMed/NCBI View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

32 

Molteni M, Gemma S and Rossetti C: The role of toll-like receptor 4 in infectious and noninfectious inflammation. Mediators Inflamm. 2016(6978936)2016.PubMed/NCBI View Article : Google Scholar

33 

Laudato S, Patil N, Abba ML, Leupold JH, Benner A, Gaiser T, Marx A and Allgayer H: P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1. Int J Cancer. 141:1879–1890. 2017.PubMed/NCBI View Article : Google Scholar

34 

Dieter C, Assmann TS, Costa AR, Canani LH, de Souza BM, Bauer AC and Crispim D: MiR-30e-5p and MiR-15a-5p expressions in plasma and urine of type 1 diabetic patients with diabetic kidney disease. Front Genet. 10(563)2019.PubMed/NCBI View Article : Google Scholar

35 

Dong Y, Fan X, Wang Z, Zhang L and Guo S: Circ_HECW2 functions as a miR-30e-5p sponge to regulate LPS-induced endothelial-mesenchymal transition by mediating NEGR1 expression. Brain Res. 1748(147114)2020.PubMed/NCBI View Article : Google Scholar

36 

Wang SD, Cui YJ, Xu JQ and Gao H: miR-140-5p attenuates neuroinflammation and brain injury in rats following intracerebral hemorrhage by targeting TLR4. Inflammation. 42:1869–1877. 2019.PubMed/NCBI View Article : Google Scholar

37 

Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY and Yang QW: Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflamm. 9(46)2012.PubMed/NCBI View Article : Google Scholar

38 

Miyake K: Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock. Curr Drug Targets Inflamm Allergy. 3:291–297. 2004.PubMed/NCBI View Article : Google Scholar

39 

Takeda K and Akira S: TLR signaling pathways. Semin Immunol. 16:3–9. 2004.PubMed/NCBI View Article : Google Scholar

40 

Zhang W, Tian Y, Gao Q, Li X, Li Y, Zhang J, Yao C, Wang Y, Wang H, Zhao Y, et al: Inhibition of apoptosis reduces diploidization of haploid mouse embryonic stem cells during differentiation. Stem Cell Reports. 15:185–197. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song H, Xu N and Jin S: miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4. Exp Ther Med 24: 492, 2022.
APA
Song, H., Xu, N., & Jin, S. (2022). miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4. Experimental and Therapeutic Medicine, 24, 492. https://doi.org/10.3892/etm.2022.11419
MLA
Song, H., Xu, N., Jin, S."miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4". Experimental and Therapeutic Medicine 24.2 (2022): 492.
Chicago
Song, H., Xu, N., Jin, S."miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4". Experimental and Therapeutic Medicine 24, no. 2 (2022): 492. https://doi.org/10.3892/etm.2022.11419
Copy and paste a formatted citation
x
Spandidos Publications style
Song H, Xu N and Jin S: miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4. Exp Ther Med 24: 492, 2022.
APA
Song, H., Xu, N., & Jin, S. (2022). miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4. Experimental and Therapeutic Medicine, 24, 492. https://doi.org/10.3892/etm.2022.11419
MLA
Song, H., Xu, N., Jin, S."miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4". Experimental and Therapeutic Medicine 24.2 (2022): 492.
Chicago
Song, H., Xu, N., Jin, S."miR‑30e‑5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4". Experimental and Therapeutic Medicine 24, no. 2 (2022): 492. https://doi.org/10.3892/etm.2022.11419
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team