Application and evaluation of sacubitril/valsartan in patients with cardiac insufficiency during perioperative period of cardiac surgery

  • Authors:
    • Wenxing Peng
    • Xiaoxi Li
    • Yang Lin
  • View Affiliations

  • Published online on: June 8, 2022     https://doi.org/10.3892/etm.2022.11431
  • Article Number: 504
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Abstract

Sacubitril/valsartan is the first angiotensin II receptor blocker neprilysin inhibitor, which inhibits both angiotensin II receptor and neprilysin. In recent years, a series of clinical studies have shown that sacubitril/valsartan has a good therapeutic effect on heart failure. The present study was conducted to investigate the therapeutic effect and safety of sacubitril/valsartan in patients with cardiac insufficiency during the perioperative period of cardiac surgery. A total of 59 patients were divided into two groups: Heart failure with reduced ejection fraction (HFrEF) group and heart failure with preserved ejection fraction (HFpEF) group. The therapeutic effect on patients with sacubitril/valsartan was assessed by the values of left ventricular ejection fraction (LVEF) and left ventricular end‑diastolic diameter (LVED). The renal safety of patients was assessed by serum creatinine (Cr) and blood urea nitrogen (BUN). Sacubitril/valsartan decreased LVED in HFrEF group and HFpEF group. And it showed a significant increase of LVEF in the HFrEF group. There was no significant change in Cr and BUN. Sacubitril/valsartan showed a good therapeutic effect on cardiac function for the perioperative period of cardiac surgery.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Peng W, Li X and Lin Y: Application and evaluation of sacubitril/valsartan in patients with cardiac insufficiency during perioperative period of cardiac surgery. Exp Ther Med 24: 504, 2022
APA
Peng, W., Li, X., & Lin, Y. (2022). Application and evaluation of sacubitril/valsartan in patients with cardiac insufficiency during perioperative period of cardiac surgery. Experimental and Therapeutic Medicine, 24, 504. https://doi.org/10.3892/etm.2022.11431
MLA
Peng, W., Li, X., Lin, Y."Application and evaluation of sacubitril/valsartan in patients with cardiac insufficiency during perioperative period of cardiac surgery". Experimental and Therapeutic Medicine 24.2 (2022): 504.
Chicago
Peng, W., Li, X., Lin, Y."Application and evaluation of sacubitril/valsartan in patients with cardiac insufficiency during perioperative period of cardiac surgery". Experimental and Therapeutic Medicine 24, no. 2 (2022): 504. https://doi.org/10.3892/etm.2022.11431