Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2022 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2022 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells

  • Authors:
    • Jiachen Li
    • Jianmin Pan
    • Yang Liu
    • Xiaohui Luo
    • Cheng Yang
    • Wangfa Xiao
    • Qishang Li
    • Lihui Yang
    • Xiaodong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Nursing, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 520
    |
    Published online on: June 16, 2022
       https://doi.org/10.3892/etm.2022.11447
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Aerobic glycolysis is commonly observed in tumor cells, including triple‑negative breast cancer (TNBC) cells, and the rate of aerobic glycolysis is higher in TNBC cells than in non‑TNBC cells. Hexokinase 2 (HK2) is a key enzyme in the glycolytic pathway and a target of the transcription factor c‑Myc, which is highly expressed in TNBC and promotes aerobic glycolysis by enhancing HK2 expression. As an inhibitor of HK2, 3‑bromopyruvic acid (3‑BrPA) exhibits good therapeutic efficacy in intrahepatic and extrahepatic tumors and inhibits the proliferation of human tumor cells with high expression levels of c‑Myc in vivo and in vitro. In addition, 3‑BrPA combines with photodynamic therapy to inhibit TNBC cell migration. Thioredoxin‑interacting protein (TXNIP) competes with c‑Myc to reduce glucose consumption in tumor cells to restrain cell proliferation. A comparative analysis was performed in the present study in TNBC (HCC1143) and non‑TNBC (MCF‑7) cell lines to explore the effect of 3‑BrPA on energy metabolism in TNBC cells and to investigate the possible mechanism of action. Cell viability and apoptosis were detected through Cell Counting Kit‑8 and flow cytometry assays, respectively. Expression levels of HK2, glucose transporter 1, TXNIP, c‑Myc and mitochondria‑regulated apoptosis pathway proteins were measured through western blotting. 3‑BrPA inhibited cell proliferation, downregulated c‑Myc and HK2 expression, and upregulated TXNIP expression in TNBC cells, but it doesn't have the same effect on non‑TNBC cells. Furthermore, 3‑BrPA induced the typical manifestations of mitochondrial‑mediated apoptosis such as decreasing Bcl‑2 expression and increasing Bax, Cyt‑C and Caspase‑3 expression. The present results suggested that 3‑BrPA promoted TXNIP protein expression and reduced HK2 expression in TNBC cells by downregulating c‑Myc expression, inhibiting glycolysis including suppressing lactate generation, intracellular ATP generation and HK activity, inducing mitochondrial‑mediated apoptosis and eventually suppressing TNBC cell proliferation. These findings may reveal a novel therapeutic target for the clinical treatment of TNBC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Woolston C: Breast cancer. Nature. 527(S101)2015.PubMed/NCBI View Article : Google Scholar

2 

Waks AG and Winer EP: Breast cancer treatment: A review. JAMA. 321:288–300. 2019.PubMed/NCBI View Article : Google Scholar

3 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010.PubMed/NCBI View Article : Google Scholar

4 

Pelicano H, Zhang W, Liu J, Hammoudi N, Dai J, Xu RH, Pusztai L and Huang P: Mitochondrial dysfunction in some triple-negative breast cancer cell lines: Role of mTOR pathway and therapeutic potential. Breast Cancer Res. 16(434)2014.PubMed/NCBI View Article : Google Scholar

5 

Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956.PubMed/NCBI View Article : Google Scholar

6 

Long JP, Li XN and Zhang F: Targeting metabolism in breast cancer: How far we can go? World J Clin Oncol. 7:122–130. 2016.PubMed/NCBI View Article : Google Scholar

7 

Tan VP and Miyamoto S: HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. Autophagy. 11:963–964. 2015.PubMed/NCBI View Article : Google Scholar

8 

Oronsky BT, Reid T, Knox SJ and Scicinski JJ: The scarlet letter of alkylation: A mini review of selective alkylating agents. Transl Oncol. 5:226–229. 2012.PubMed/NCBI View Article : Google Scholar

9 

Feng X, Wang P, Liu Q, Zhang T, Mai B and Wang X: Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration. J Bioenerg Biomembr. 47:189–197. 2015.PubMed/NCBI View Article : Google Scholar

10 

Gan L, Xiu R, Ren P, Yue M, Su H, Guo G, Xiao D, Yu J, Jiang H, Liu H, et al: Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters. Oncogene. 35:3037–3048. 2016.PubMed/NCBI View Article : Google Scholar

11 

Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee T, Mak SY, Ho YS, Lam KP, et al: Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology. 5(e1191731)2016.PubMed/NCBI View Article : Google Scholar

12 

Thorens B and Mueckler M: Glucose transporters in the 21st Century. Am J Physiol Endocrinol Metab. 298:E141–E145. 2010.PubMed/NCBI View Article : Google Scholar

13 

Choi J, Jung WH and Koo JS: Metabolism-related proteins are differentially expressed according to the molecular subtype of invasive breast cancer defined by surrogate immunohistochemistry. Pathobiology. 80:41–52. 2013.PubMed/NCBI View Article : Google Scholar

14 

Yadav S, Pandey SK, Kumar A, Kujur PK, Singh RP and Singh SM: Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism. Chem Biol Interact. 270:73–89. 2017.PubMed/NCBI View Article : Google Scholar

15 

Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, et al: AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 49:1167–1175. 2013.PubMed/NCBI View Article : Google Scholar

16 

Alhawiti NM, Al Mahri S, Aziz MA, Malik SS and Mohammad S: TXNIP in metabolic regulation: Physiological role and therapeutic outlook. Curr Drug Targets. 18:1095–1103. 2017.PubMed/NCBI View Article : Google Scholar

17 

O'Shea JM and Ayer DE: Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks. Cold Spring Harb Perspect Med. 3(a014258)2013.PubMed/NCBI View Article : Google Scholar

18 

Zhou J, Yu Q and Chng WJ: TXNIP (VDUP-1, TBP-2): A major redox regulator commonly suppressed in cancer by epigenetic mechanisms. Int J Biochem Cell Biol. 43:1668–1673. 2011.PubMed/NCBI View Article : Google Scholar

19 

Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, et al: Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res. 12(R44)2010.PubMed/NCBI View Article : Google Scholar

20 

Chen JL, Merl D, Peterson CW, Wu J, Liu PY, Yin H, Muoio DM, Ayer DE, West M and Chi JT: Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet. 6(e1001093)2010.PubMed/NCBI View Article : Google Scholar

21 

Shen L, O'Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, Welm AL and Ayer DE: Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci USA. 112:5425–5430. 2015.PubMed/NCBI View Article : Google Scholar

22 

Iqbal MA, Chattopadhyay S, Siddiqui FA, Ur Rehman A, Siddiqui S, Prakasam G, Khan A, Sultana S and Bamezai RN: Silibinin induces metabolic crisis in triple-negative breast cancer cells by modulating EGFR-MYC-TXNIP axis: Potential therapeutic implications. FEBS J. 288:471–485. 2021.PubMed/NCBI View Article : Google Scholar

23 

Rabinowitz JD and Enerbäck S: Lactate: The ugly duckling of energy metabolism. Nat Metab. 2:566–571. 2020.PubMed/NCBI View Article : Google Scholar

24 

Ganapathy-Kanniappan S and Geschwind JF: Tumor glycolysis as a target for cancer therapy: Progress and prospects. Mol Cancer. 12(152)2013.PubMed/NCBI View Article : Google Scholar

25 

Jiang M, Liu S, Lin J, Hao W, Wei B, Gao Y, Kong C, Yu M and Zhu Y: A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors. Life Sci. 264(118669)2021.PubMed/NCBI View Article : Google Scholar

26 

Howlader N, Cronin KA, Kurian AW and Andridge R: Differences in breast cancer survival by molecular subtypes in the United States. Cancer Epidemiol Biomarkers Prev. 27:619–626. 2018.PubMed/NCBI View Article : Google Scholar

27 

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y and Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 121:2750–2767. 2011.PubMed/NCBI View Article : Google Scholar

28 

Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, et al: Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Autophagy. 14:671–684. 2018.PubMed/NCBI View Article : Google Scholar

29 

Fan T, Sun G, Sun X, Zhao L, Zhong R and Peng Y: Tumor energy metabolism and Potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: Implications in tumor treatment. Cancers (Basel). 11(317)2019.PubMed/NCBI View Article : Google Scholar

30 

Nikravesh H, Khodayar MJ, Behmanesh B, Mahdavinia M, Teimoori A, Alboghobeish S and Zeidooni L: The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis. BMC Cancer. 21(903)2021.PubMed/NCBI View Article : Google Scholar

31 

Niedźwiecka K, Dyląg M, Augustyniak D, Majkowska-Skrobek G, Cal-Bąkowska M, Ko YH, Pedersen PL, Goffeau A and Ułaszewski S: Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma. Oncotarget. 7:65614–65626. 2016.PubMed/NCBI View Article : Google Scholar

32 

Ko YH, Verhoeven HA, Lee MJ, Corbin DJ, Vogl TJ and Pedersen PL: A translational study ‘case report’ on the small molecule ‘energy blocker’ 3-bromopyruvate (3BP) as a potent anticancer agent: From bench side to bedside. J Bioenerg Biomembr. 44:163–170. 2012.PubMed/NCBI View Article : Google Scholar

33 

Lis P, Dyląg M, Niedźwiecka K, Ko YH, Pedersen PL, Goffeau A and Ułaszewski S: The HK2 dependent ‘Warburg Effect’ and mitochondrial oxidative phosphorylation in cancer: Targets for effective therapy with 3-bromopyruvate. Molecules. 21(1730)2016.PubMed/NCBI View Article : Google Scholar

34 

Wilson JE: Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function. J Exp Biol. 206 (Pt 12):2049–2057. 2003.PubMed/NCBI View Article : Google Scholar

35 

Patra KC and Hay N: Hexokinase 2 as oncotarget. Oncotarget. 4:1862–1863. 2013.PubMed/NCBI View Article : Google Scholar

36 

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, et al: Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell. 24:213–228. 2013.PubMed/NCBI View Article : Google Scholar

37 

Marini C, Salani B, Massollo M, Amaro A, Esposito AI, Orengo AM, Capitanio S, Emionite L, Riondato M, Bottoni G, et al: Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer. Cell Cycle. 12:3490–3499. 2013.PubMed/NCBI View Article : Google Scholar

38 

Park JW, Lee SH, Woo GH, Kwon HJ and Kim DY: Downregulation of TXNIP leads to high proliferative activity and estrogen-dependent cell growth in breast cancer. Biochem Biophys Res Commun. 498:566–572. 2018.PubMed/NCBI View Article : Google Scholar

39 

Qu X, Sun J, Zhang Y, Li J, Hu J, Li K, Gao L and Shen L: c-Myc-driven glycolysis via TXNIP suppression is dependent on glutaminase-MondoA axis in prostate cancer. Biochem Biophys Res Commun. 504:415–421. 2018.PubMed/NCBI View Article : Google Scholar

40 

Chen H, Liu H and Qing G: Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct Target Ther. 3(5)2018.PubMed/NCBI View Article : Google Scholar

41 

Stasevich EM, Murashko MM, Zinevich LS, Demin DE and Schwartz AM: The Role of Non-Coding RNAs in the regulation of the proto-oncogene MYC in different types of cancer. Biomedicines. 9(921)2021.PubMed/NCBI View Article : Google Scholar

42 

Chauhan A, Paul R, Debnath M, Bessi I, Mandal S, Schwalbe H and Dash J: Synthesis of fluorescent binaphthyl amines that Bind c-MYC G-Quadruplex DNA and Repress c-MYC expression. J Med Chem. 59:7275–7281. 2016.PubMed/NCBI View Article : Google Scholar

43 

Gao Y, Miles SL, Dasgupta P, Rankin GO, Cutler S and Chen YC: Trichodermin Induces G0/G1 cell cycle arrest by inhibiting c-Myc in ovarian cancer cells and tumor xenograft-bearing mice. Int J Mol Sci. 22(5022)2021.PubMed/NCBI View Article : Google Scholar

44 

McMahon SB: MYC and the control of apoptosis. Cold Spring Harb Perspect Med. 4(a014407)2014.PubMed/NCBI View Article : Google Scholar

45 

Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, et al: cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 25:429–444. 2015.PubMed/NCBI View Article : Google Scholar

46 

Liu Y, Xiang F, Huang Y, Shi L, Hu C, Yang Y, Wang D, He N, Tao K, Wu K and Wang G: Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells. Oncotarget. 8:25372–25383. 2017.PubMed/NCBI View Article : Google Scholar

47 

Yu P, Li AX, Chen XS, Tian M, Wang HY, Wang XL, Zhang Y, Wang KS and Cheng Y: PKM2-c-Myc-survivin cascade regulates the cell proliferation, migration, and tamoxifen resistance in breast cancer. Front Pharmacol. 11(550469)2020.PubMed/NCBI View Article : Google Scholar

48 

Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC and Lu Z: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 14:1295–1304. 2012.PubMed/NCBI View Article : Google Scholar

49 

Feng J, Li J, Wu L, Yu Q, Ji J, Wu J, Dai W and Guo C: Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 39(126)2020.PubMed/NCBI View Article : Google Scholar

50 

Dhanasekaran R, Deutzmann A, Mahauad-Fernandez WD, Hansen AS, Gouw AM and Felsher DW: The MYC oncogene - the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol. 19:23–36. 2022.PubMed/NCBI View Article : Google Scholar

51 

Skaripa-Koukelli I, Hauton D, Walsby-Tickle J, Thomas E, Owen J, Lakshminarayanan A, Able S, McCullagh J, Carlisle RC and Vallis KA: 3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation. Cancer Metab. 9(37)2021.PubMed/NCBI View Article : Google Scholar

52 

Pereira-Vieira J, Azevedo-Silva J, Preto A, Casal M and Queirós O: MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions. Biol Chem. 400:787–799. 2019.PubMed/NCBI View Article : Google Scholar

53 

Shen S, Yao T, Xu Y, Zhang D, Fan S and Ma J: CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc. Mol Cancer. 19(151)2020.PubMed/NCBI View Article : Google Scholar

54 

Meyer N and Penn LZ: Reflecting on 25 years with MYC. Nat Rev Cancer. 8:976–990. 2008.PubMed/NCBI View Article : Google Scholar

55 

Kaadige MR, Yang J, Wilde BR and Ayer DE: MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol Cell Biol. 35:101–110. 2015.PubMed/NCBI View Article : Google Scholar

56 

Peterson CW, Stoltzman CA, Sighinolfi MP, Han KS and Ayer DE: Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer. Mol Cell Biol. 30:2887–2895. 2010.PubMed/NCBI View Article : Google Scholar

57 

Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, et al: BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition. Oncogene. 37:6341–6356. 2018.PubMed/NCBI View Article : Google Scholar

58 

Gao YH, Zhang HP, Yang SM, Yang Y, Ma YY, Zhang XY and Yang YM: Inactivation of Akt by arsenic trioxide induces cell death via mitochondrial-mediated apoptotic signaling in SGC-7901 human gastric cancer cells. Oncol Rep. 31:1645–1652. 2014.PubMed/NCBI View Article : Google Scholar

59 

Brunelle JK and Letai A: Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci. 122:437–441. 2009.PubMed/NCBI View Article : Google Scholar

60 

Pistritto G, Trisciuoglio D, Ceci C, Garufi A and D'Orazi G: Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging.(Albany NY). 8:603–619. 2016.PubMed/NCBI View Article : Google Scholar

61 

Yu C, Du F, Zhang C, Li Y, Liao C, He L, Cheng X and Zhang X: Salmonella enterica serovar Typhimurium sseK3 induces apoptosis and enhances glycolysis in macrophages. BMC Microbiol. 20(151)2020.PubMed/NCBI View Article : Google Scholar

62 

Krasnov GS, Dmitriev AA, Lakunina VA, Kirpiy AA and Kudryavtseva AV: Targeting VDAC-bound hexokinase II: A promising approach for concomitant anti-cancer therapy. Expert Opin Ther Targets. 17:1221–1233. 2013.PubMed/NCBI View Article : Google Scholar

63 

Kwiatkowska E, Wojtala M, Gajewska A, Soszyński M, Bartosz G and Sadowska-Bartosz I: Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells. J Bioenerg Biomembr. 48:23–32. 2016.PubMed/NCBI View Article : Google Scholar

64 

Wu L, Xu J, Yuan W, Wu B, Wang H, Liu G, Wang X, Du J and Cai S: The reversal effects of 3-bromopyruvate on multidrug resistance in vitro and in vivo derived from human breast MCF-7/ADR cells. PLoS One. 9(e112132)2014.PubMed/NCBI View Article : Google Scholar

65 

Akins NS, Nielson TC and Le HV: Inhibition of glycolysis and glutaminolysis: An emerging drug discovery approach to combat cancer. Curr Top Med Chem. 18:494–504. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li J, Pan J, Liu Y, Luo X, Yang C, Xiao W, Li Q, Yang L and Zhang X: 3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells. Exp Ther Med 24: 520, 2022.
APA
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W. ... Zhang, X. (2022). 3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells. Experimental and Therapeutic Medicine, 24, 520. https://doi.org/10.3892/etm.2022.11447
MLA
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W., Li, Q., Yang, L., Zhang, X."3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells". Experimental and Therapeutic Medicine 24.2 (2022): 520.
Chicago
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W., Li, Q., Yang, L., Zhang, X."3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells". Experimental and Therapeutic Medicine 24, no. 2 (2022): 520. https://doi.org/10.3892/etm.2022.11447
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Pan J, Liu Y, Luo X, Yang C, Xiao W, Li Q, Yang L and Zhang X: 3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells. Exp Ther Med 24: 520, 2022.
APA
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W. ... Zhang, X. (2022). 3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells. Experimental and Therapeutic Medicine, 24, 520. https://doi.org/10.3892/etm.2022.11447
MLA
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W., Li, Q., Yang, L., Zhang, X."3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells". Experimental and Therapeutic Medicine 24.2 (2022): 520.
Chicago
Li, J., Pan, J., Liu, Y., Luo, X., Yang, C., Xiao, W., Li, Q., Yang, L., Zhang, X."3‑Bromopyruvic acid regulates glucose metabolism by targeting the c‑Myc/TXNIP axis and induces mitochondria‑mediated apoptosis in TNBC cells". Experimental and Therapeutic Medicine 24, no. 2 (2022): 520. https://doi.org/10.3892/etm.2022.11447
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team