Open Access

Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients

  • Authors:
    • Sergiu-Ciprian Matei
    • Mervat Matei
    • Flavia Medana Anghel
    • Emma Carabenciov
    • Marius-Sorin Murariu
    • Sorin Olariu
  • View Affiliations

  • Published online on: July 14, 2022     https://doi.org/10.3892/etm.2022.11508
  • Article Number: 571
  • Copyright: © Matei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic venous disease (CVD) is a frequently encountered disease that progresses with age. Although the principal method of evaluation and diagnosis is Doppler ultrasound, routine laboratory tests may be an easier and more accessible way to evaluate CVD progression. The present retrospective study evaluated the laboratory results of 256 patients diagnosed with CVD. According to the Clinical, Etiological, Anatomical and Pathophysiological classification, depending on the CVD stage, patients were stratified into three groups: Group 1 (C2‑C3; mild disease), Group 2 (C4; moderate to severe disease) and Group 3 (C5‑C6; severe disease). The considered parameters were age, red blood cell count (RBC), white blood cell count (WBC) and platelet count (PLT), percentage of neutrophils and lymphocytes, neutrophil‑to‑lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), C‑reactive protein (CRP), fibrinogen, prothrombin time (in percentages and seconds), internal normalized ratio, activated partial thromboplastin time, creatine kinase (CK), CK myocardial band, alanine transaminase, aspartate transaminase, total bilirubin and urea. No significant differences among the groups were noted in RBC, WBC, PLT and coagulation factors; on the other hand, inflammatory markers exhibited differences among the groups. Several differences were observed in hepatic, metabolic and muscle tissue markers. Intraluminal thrombus formation in the case of varicose veins (thrombophlebitis) may be due to conditions of turbulent flow, stasis and endothelial inflammation, rather than hypercoagulability. The results of the present study confirmed the implication of inflammatory factors in pathophysiological modifications, including thickening of venous walls and valvular modification, as well as the appearance of intraluminal thrombi and trophic lesions. NLR, ESR, CRP and fibrinogen were increased with CVD progression and may be considered useful markers in evaluating CVD progression. Simple blood tests may provide phlebologists with additional insight for the management of those patients.

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September-2022
Volume 24 Issue 3

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Spandidos Publications style
Matei S, Matei M, Anghel FM, Carabenciov E, Murariu M and Olariu S: Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients. Exp Ther Med 24: 571, 2022
APA
Matei, S., Matei, M., Anghel, F.M., Carabenciov, E., Murariu, M., & Olariu, S. (2022). Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients. Experimental and Therapeutic Medicine, 24, 571. https://doi.org/10.3892/etm.2022.11508
MLA
Matei, S., Matei, M., Anghel, F. M., Carabenciov, E., Murariu, M., Olariu, S."Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients". Experimental and Therapeutic Medicine 24.3 (2022): 571.
Chicago
Matei, S., Matei, M., Anghel, F. M., Carabenciov, E., Murariu, M., Olariu, S."Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients". Experimental and Therapeutic Medicine 24, no. 3 (2022): 571. https://doi.org/10.3892/etm.2022.11508