Open Access

Adipose‑derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway

  • Authors:
    • Zizhan Li
    • Xinli Fan
    • Xiuying Xu
    • Qin Zhou
    • Guimiao Xing
    • Gangli Liu
  • View Affiliations

  • Published online on: July 22, 2022     https://doi.org/10.3892/etm.2022.11524
  • Article Number: 587
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the effect and mechanism of action of adipose‑derived stem cells (ADSCs) on Sjögren syndrome (SS) to develop novel and more effective methods for SS treatment. ADSCs, dexamethasone or normal saline was injected into the submandibular gland (SMG) of three 12‑week‑old non‑obese diabetic (NOD) mice. The degree of lymphocyte infiltration was considered as a criterion for judging disease progression, hematoxylin and eosin staining was performed to observe the pathological state, and the expression levels of TAZ, E‑cadherin and α‑catenin were assessed by western blotting. ADSC transplantation triggered an inhibitory effect on the progression of SS, which was slightly stronger compared with that of dexamethasone treatment. This was found to be related to the Hippo signaling pathway. In addition, TAZ protein expression levels decreased gradually with the progression of the disease; immunofluorescence staining showed that the expression of E‑cadherin and TAZ followed similar trends. Notably, the expression of TAZ, p‑TAZ, E‑cadherin and α‑catenin in NOD mice were lower compared with that in Control mice. Similarly, the ratio of p‑TAZ/TAZ also decreased, which means that the activation level of Hippo signal pathway decreased. The results suggest that ADSCs may exert a therapeutic effect against SS and may postpone its progression by upregulating the Hippo signaling pathway.

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September-2022
Volume 24 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Z, Fan X, Xu X, Zhou Q, Xing G and Liu G: Adipose‑derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway. Exp Ther Med 24: 587, 2022
APA
Li, Z., Fan, X., Xu, X., Zhou, Q., Xing, G., & Liu, G. (2022). Adipose‑derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway. Experimental and Therapeutic Medicine, 24, 587. https://doi.org/10.3892/etm.2022.11524
MLA
Li, Z., Fan, X., Xu, X., Zhou, Q., Xing, G., Liu, G."Adipose‑derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway". Experimental and Therapeutic Medicine 24.3 (2022): 587.
Chicago
Li, Z., Fan, X., Xu, X., Zhou, Q., Xing, G., Liu, G."Adipose‑derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway". Experimental and Therapeutic Medicine 24, no. 3 (2022): 587. https://doi.org/10.3892/etm.2022.11524